scholarly journals Characteristics of Peripheral Immune Function in Reproductive Females with Uterine Leiomyoma

2019 ◽  
Vol 2019 ◽  
pp. 1-12
Author(s):  
Zhi-Qin Liu ◽  
Mei-Yin Lu ◽  
Ru-Liang Sun ◽  
Zhi-nan Yin ◽  
Bin Liu ◽  
...  
Keyword(s):  
T Cells ◽  
Immune Function ◽  
Uterine Leiomyoma ◽  
Menstrual Period ◽  
Proof Of Concept ◽  
Menstrual Cycles ◽  
Clinical Phenotypes ◽  
Reproductive Females ◽  
Pelvic Lesions ◽  
Healthy Females

Inflammation and immunity are thought as risk factors for uterine leiomyoma; however, detailed reports on this topic are scarce. The present study aimed to analyze the characteristics of immune function and clinical significance of circulating CD4/CD8 T, NK, and γδ T cells in reproductive females with uterine leiomyoma. We analyzed the above-mentioned cells in 30 reproductive females with uterine leiomyoma and 68 healthy females using flow cytometry. After that, the correlation between function of immune cells and clinical phenotypes was analyzed. Compared with healthy controls, central memory (CM) CD4/CD8 T cells as well as Treg and Tfh cells were notably increased in leiomyoma patients; however, NK and γδ T cells were decreased in patients. Moreover, such alterations of these cells in patients with leiomyoma were associated with shorter menstrual cycles, longer menstrual period, anemia, pelvic lesions, more and larger myomas, and higher levels of CA125. Additionally, the increased Tfh1/Tfh2 ratio and Tfh17 were significantly associated with longer menstrual period, more myomas, and higher CA125 levels independent of age in patients with uterine leiomyoma. In conclusion, hallmarks of peripheral immune function are remarkably correlated with clinical phenotypes in reproductive females with uterine leiomyoma. This preliminary work may provide proof-of-concept for evaluating efficacy of treatment and prognosis of reproductive females with uterine leiomyoma with the help of quantitative analysis of peripheral immune function, which may inspire performing further investigations on the relevance of immune function with different diseases.

scholarly journals Restoration of HBV-specific CD8+ T-cell responses by sequential low-dose IL-2 treatment in non-responder patients after IFN-α therapy

2021 ◽  
Vol 6 (1) ◽  
Author(s):  
Dongyao Wang ◽  
Binqing Fu ◽  
Xiaokun Shen ◽  
Chuang Guo ◽  
Yanyan Liu ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Hepatitis B ◽  
Immune Function ◽  
Low Dose ◽  
Hbeag Seroconversion ◽  
Interleukin 2 ◽  
Unmet Need ◽  
T Cell Response ◽  
Serological Response

AbstractPatients with chronic hepatitis B (CHB) undergoing interferon (IFN)-α-based therapies often exhibit a poor HBeAg serological response. Thus, there is an unmet need for new therapies aimed at CHB. This study comprised two clinical trials, including 130 CHB patients, who were treatment-naïve; in the first, 92 patients were systematically analyzed ex vivo for interleukin-2 receptor (IL-2R) expression and inhibitory molecules expression after receiving Peg-IFN-α-2b therapy. In our second clinical trial, 38 non-responder patients, in whom IFN-α therapy had failed, were treated with or without low-dose IL-2 for 24 weeks. We then examined the hepatitis B virus (HBV)-specific CD8+ T-cell response and the clinical outcome, in these patients. Although the majority of the participants undergoing Peg-IFN-α-2b therapy were non-responders, we observed a decrease in CD25 expression on their CD4+ T cells, suggesting that IFN-α therapy may provide a rationale for sequential IL-2 treatment without increasing regulatory T cells (Tregs). Following sequential therapy with IL-2, we demonstrated that the non-responders experienced a decrease in the numbers of Tregs and programmed cell death protein 1 (PD-1) expression. In addition, sequential IL-2 administration rescued effective immune function, involving signal transducer and activator of transcription 1 (STAT1) activation. Importantly, IL-2 therapy significantly increased the frequency and function of HBV-specific CD8+ T cells, which translated into improved clinical outcomes, including HBeAg seroconversion, among the non-responder CHB patients. Our findings suggest that sequential IL-2 therapy shows efficacy in rescuing immune function in non-responder patients with refractory CHB.

scholarly journals Effects of Parathyroid Hormone on Immune Function

2010 ◽  
Vol 2010 ◽  
pp. 1-10 ◽  
Author(s):  
Abdallah Sassine Geara ◽  
Mario R. Castellanos ◽  
Claude Bassil ◽  
Georgia Schuller-Levis ◽  
Eunkue Park ◽  
...  
Keyword(s):  
T Cells ◽  
Parathyroid Hormone ◽  
Immune Function ◽  
Clinical Significance ◽  
Uremic Toxins ◽  
Immunomodulatory Effects ◽  
Uremic Patients

Parathyroid hormone (PTH) function as immunologic mediator has become interesting with the recent usage of PTH analogue (teriparatide) in the management of osteoporosis. Since the early 1980s, PTH receptors were found on most immunologic cells (neutrophils, B and T cells). The in vitro evaluations for a possible role of PTH as immunomodulator have shown inconsistent results mainly due to methodological heterogeneity of these studies: it used different PTH formulations (rat, bovine, and human), at different dosages and different incubating periods. In some of these studies, the lymphocytes were collected from uremic patients or animals, which renders the interpretation of the results problematic due to the effect of uremic toxins. Parathyroidectomy has been found to reverse the immunologic defect in patients with high PTH levels. Nonetheless, the clinical significance of these findings is unclear. Further studies are needed to define if PTH does have immunomodulatory effects.

scholarly journals TGF-β-responsive CAR-T cells promote anti-tumor immune function

2018 ◽  
Vol 3 (2) ◽  
pp. 75-86 ◽  
Author(s):  
Andrew J. Hou ◽  
ZeNan L. Chang ◽  
Michael H. Lorenzini ◽  
Eugenia Zah ◽  
Yvonne Y. Chen
Keyword(s):  
T Cells ◽  
Immune Function ◽  
Car T Cells ◽  
Car T

scholarly journals Uterine Lipoleiomyoma: a rare variant of benign uterine neoplasm

2019 ◽  
Vol 8 (6) ◽  
pp. 2553
Author(s):  
Sunil V. Jagtap ◽  
Abhijit Phalke ◽  
Nitin S. Kshirsagar ◽  
Shubham S. Jagtap ◽  
Nitesh Nasre
Keyword(s):  
Uterine Leiomyoma ◽  
Benign Tumor ◽  
Clinical Presentation ◽  
Clinical Course ◽  
Histopathological Examination ◽  
Benign Neoplasms ◽  
Women Authors ◽  
Menstrual Cycles ◽  
Uterine Neoplasm ◽  
Lipomatous Tumors

The lipomatous tumors are very rare benign neoplasms of the uterus. Lipoleiomyoma is a benign tumor which is variant of leiomyoma. It has similar clinical course and presentation like uterine leiomyoma and is typically found in postmenopausal women. Authors report a case of 45 years female presented with a complaint of increased frequency of menstrual cycles and generalized weakness since 5- 6 months. On ultrasonography abdomen - pelvis a single large lobulated hyperechoic mass was noted in the fundal myometrium measuring 5 x 4.6 cm. The finding was suggestive of fibroid uterus. On histopathological examination showed variable proportions of lobules of mature adipocytes and interlacing bundles of benign smooth muscle cells which was diagnostic of lipoleiomyoma. Authors are presenting this case for its rarity, clinical presentation, imaging and histopathological finding with differential diagnosis.

scholarly journals Bone marrow function. I. Peripheral T cells are responsible for the increased auto-antiidiotype response of older mice.

1985 ◽  
Vol 161 (5) ◽  
pp. 1237-1242 ◽  
Author(s):  
Y T Kim ◽  
E A Goidl ◽  
C Samarut ◽  
M E Weksler ◽  
G J Thorbecke ◽  
...  
Keyword(s):  
Bone Marrow ◽  
T Cells ◽  
Immune Function ◽  
Lethal Dose ◽  
Enzyme Linked Immunosorbent Assay ◽  
Spleen Cells ◽  
Peripheral T Cells ◽  
Bone Marrow Function ◽  
Low Levels

After immunization with trinitrophenyl (TNP)-Ficoll, mice produced both anti-TNP antibodies and auto-anti-idiotype (auto-anti-Id) antibodies specific for the anti-TNP antibody. Older animals produced more auto-anti-Id than did young animals. When mice were exposed to a normally lethal dose of irradiation while their bone marrow (BM) was partially shielded, they survived and slowly (6 wk) regained immune function, as indicated by the number of nucleated cells in their spleen and the in vitro primary plaque-forming cell (PFC) response of their spleen cells to TNP-treated aminoethylated polyacrylamide beads. Recovery is presumably the result of repopulation of the peripheral lymphoid system by cells originating in the BM. By enzyme-linked immunosorbent assay (ELISA), and by hapten-augmentable PFC assay, we show that, after recovery from irradiation with their BM shielded, old animals produce low auto-anti-Id responses, like those of young animals. The transfer of splenic T cells into mice irradiated with their BM shielded provided evidence that the magnitude of the auto-anti-Id response is controlled by the peripheral T cells. Thus, mice that received splenic T cells from aged donors produced high levels of auto-anti-Id while those that received splenic T cells from young donors produce low levels of auto-anti-Id.

scholarly journals Role of selenium-containing proteins in T-cell and macrophage function

2010 ◽  
Vol 69 (3) ◽  
pp. 300-310 ◽  
Author(s):  
Bradley A. Carlson ◽  
Min-Hyuk Yoo ◽  
Rajeev K. Shrimali ◽  
Robert Irons ◽  
Vadim N. Gladyshev ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Immune Function ◽  
Inflammatory Responses ◽  
Inflammatory Diseases ◽  
Cell Receptor ◽  
Lymphoid Tissues ◽  
Protein Gel ◽  
Species Production

Selenium (Se) has been known for many years to have played a role in boosting the immune function, but the manner in which this element acts at the molecular level in host defence and inflammatory diseases is poorly understood. To elucidate the role of Se-containing proteins in the immune function, we knocked out the expression of this protein class in T-cells or macrophages of mice by targeting the removal of the selenocysteine tRNA gene using loxP-Cre technology. Mice with selenoprotein-less T-cells manifested reduced pools of mature and functional T-cells in lymphoid tissues and an impairment in T-cell-dependent antibody responses. Furthermore, selenoprotein deficiency in T-cells led to an inability of these cells to suppress reactive oxygen species production, which in turn affected their ability to proliferate in response to T-cell receptor stimulation. Selenoprotein-less macrophages, on the other hand, manifested mostly normal inflammatory responses, but this deficiency resulted in an altered regulation in extracellular matrix-related gene expression and a diminished migration of macrophages in a protein gel matrix. These observations provided novel insights into the role of selenoproteins in the immune function and tissue homeostasis.

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