scholarly journals Late-Onset Neutropenia after Rituximab Treatment for Adult-Onset Nephrotic Syndrome

2019 ◽  
Vol 2019 ◽  
pp. 1-4 ◽  
Author(s):  
Mayuko Yamazaki ◽  
Hidekazu Sugiura ◽  
Yosuke Iwatani ◽  
Mizuki Kyoda ◽  
Hirohiko Nokiba ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Renal Biopsy ◽  
Late Onset ◽  
Spontaneous Remission ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change ◽  
Adult Onset ◽  
The Future

A 41-year-old woman developed nephrotic syndrome at the age of 32 and was diagnosed with minimal change nephrotic syndrome based on a renal biopsy. Although remission was achieved with administration of prednisolone (PSL) and cyclosporine, the nephrotic syndrome recurred. She was also started on rituximab (RTX). She developed late-onset neutropenia after RTX treatment (R-LON) and improved 17 days later. Although the majority of R-LON cases undergo spontaneous remission, cases of death have been reported. This report is intended to warn about R-LON, since the use of RTX for adult-onset nephrotic syndrome is expected to increase in the future.

scholarly journals Clinical Characteristics and Outcomes of Adults with Nephrotic Syndrome Due to Minimal Change Disease

2021 ◽  
Vol 10 (16) ◽  
pp. 3632
Author(s):  
Sophia Lionaki ◽  
Evangelos Mantios ◽  
Ioanna Tsoumbou ◽  
Smaragdi Marinaki ◽  
George Makris ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Nephrotic Syndrome ◽  
Minimal Change Disease ◽  
Kidney Injury ◽  
Spontaneous Remission ◽  
Minimal Change ◽  
Adult Onset ◽  
Potential Risk Factors ◽  
The Mean ◽  
End Stage

Purpose: Minimal change disease (MCD) is considered a relatively benign glomerulopathy, as it rarely progresses to end-stage kidney disease. The aim of this study was to describe the characteristics and outcomes of adults with MCD and identify potential risk factors for relapse. Patients & Methods: We retrospectively studied a cohort of adults with biopsy-proven MCD in terms of clinical features and treatment outcomes. Baseline characteristics and outcomes were recorded and predictors of relapse were analyzed using logistic regression multivariate analysis. Results: 59 patients with adult-onset primary MCD with nephrotic syndrome were included. Mean serum creatinine at diagnosis was 0.8 mg/dL (±2.5) and estimated GFR (eGFR) was 87 mL/min/1.73 m2 (±29.5). Mean serum albumin was 2.5 g/dL (±0.8) and 24 h proteinuria 6.8 g (±3.7). Microscopic hematuria was detected in 35 (58.5%) patients. 42 patients received prednisone alone, six patients received prednisone plus cyclophosphamide, five patients received prednisone plus cyclosporine, one patient received prednisone plus rituximab and five patients did not receive immunosuppression at all since they achieved spontaneous remission. During a mean follow up time of 34.7(22.1) months, 46.1% of patients experienced at least one episode of relapse. The mean age of patients who did not experience a relapse was significantly higher than that of patients who relapsed while relapsers had a significantly longer duration of 24 h proteinuria prior to biopsy compared to non-relapsers. Overall, 10% of patients experienced acute kidney injury while the mean eGFR at the end was 82 mL/min/1.73 m2 (±29.1) and one patient ended up in chronic dialysis. Overall, the proportion of non-relapsers, who experienced acute kidney injury (17%) was significantly higher than the one recorded among relapsers (0%).Conclusion: In this series of patients, almost 46% of adult-onset nephrotic MCD patients experienced a relapse, although their renal progression was rare. Younger onset age was an independent risk factor for relapse in adult-onset MCD patients.

Adult-Onset minimal-change nephrotic syndrome: A benign disease

1987 ◽  
Vol 156 (9) ◽  
pp. 268-269 ◽  
Author(s):  
T. W. O’Neill ◽  
A. A. J. O’Brien ◽  
M. Brennan ◽  
J. A. B. Keogh
Keyword(s):  
Nephrotic Syndrome ◽  
Minimal Change Nephrotic Syndrome ◽  
Benign Disease ◽  
Minimal Change ◽  
Adult Onset

scholarly journals Spontaneous remission of minimal change nephrotic syndrome in an elderly man

2021 ◽  
Author(s):  
Yuki Chiba ◽  
Tasuku Nagasawa ◽  
Saori Kin ◽  
Kei Takahashi ◽  
Mai Yoshida ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Spontaneous Remission ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change

scholarly journals Adult–onset minimal change nephrotic syndrome: A long–term follow–up

1986 ◽  
Vol 29 (6) ◽  
pp. 1215-1223 ◽  
Author(s):  
Fernando Nolasco ◽  
J. Stewart Cameron ◽  
E.F. Heywood ◽  
Jackie Hicks ◽  
Chisholm Ogg ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change ◽  
Adult Onset ◽  
Long Term Follow Up

The characteristics of relapse in adult-onset minimal-change nephrotic syndrome

2007 ◽  
Vol 11 (3) ◽  
pp. 214-217 ◽  
Author(s):  
Takashi Takei ◽  
Minako Koike ◽  
Koichi Suzuki ◽  
Satsuki Shirota ◽  
Mitsuyo Itabashi ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change ◽  
Adult Onset

Steroid responsiveness and frequency of relapse in adult-onset minimal change nephrotic syndrome

2002 ◽  
Vol 39 (3) ◽  
pp. 503-512 ◽  
Author(s):  
Masaru Nakayama ◽  
Ritsuko Katafuchi ◽  
Tetsuro Yanase ◽  
Kiyoshi Ikeda ◽  
Hiroshi Tanaka ◽  
...  
Keyword(s):  
Nephrotic Syndrome ◽  
Minimal Change Nephrotic Syndrome ◽  
Minimal Change ◽  
Adult Onset ◽  
Steroid Responsiveness
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