scholarly journals Prediction of Chemotherapy Response of Osteosarcoma Using Baseline 18F-FDG Textural Features Machine Learning Approaches with PCA

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Su Young Jeong ◽  
Wook Kim ◽  
Byung Hyun Byun ◽  
Chang-Bae Kong ◽  
Won Seok Song ◽  
...  

Purpose. Patients with high-grade osteosarcoma undergo several chemotherapy cycles before surgical intervention. Response to chemotherapy, however, is affected by intratumor heterogeneity. In this study, we assessed the ability of a machine learning approach using baseline 18F-fluorodeoxyglucose (18F-FDG) positron emitted tomography (PET) textural features to predict response to chemotherapy in osteosarcoma patients. Materials and Methods. This study included 70 osteosarcoma patients who received neoadjuvant chemotherapy. Quantitative characteristics of the tumors were evaluated by standard uptake value (SUV), total lesion glycolysis (TLG), and metabolic tumor volume (MTV). Tumor heterogeneity was evaluated using textural analysis of 18F-FDG PET scan images. Assessments were performed at baseline and after chemotherapy using 18F-FDG PET; 18F-FDG textural features were evaluated using the Chang-Gung Image Texture Analysis toolbox. To predict the chemotherapy response, several features were chosen using the principal component analysis (PCA) feature selection method. Machine learning was performed using linear support vector machine (SVM), random forest, and gradient boost methods. The ability to predict chemotherapy response was evaluated using the area under the receiver operating characteristic curve (AUC). Results. AUCs of the baseline 18F-FDG features SUVmax, TLG, MTV, 1st entropy, and gray level co-occurrence matrix entropy were 0.553, 0538, 0.536, 0.538, and 0.543, respectively. However, AUCs of the machine learning features linear SVM, random forest, and gradient boost were 0.72, 0.78, and 0.82, respectively. Conclusion. We found that a machine learning approach based on 18F-FDG textural features could predict the chemotherapy response using baseline PET images. This early prediction of the chemotherapy response may aid in determining treatment plans for osteosarcoma patients.

2021 ◽  
Vol 11 (21) ◽  
pp. 9927
Author(s):  
Qiuying Chen ◽  
SangJoon Lee

Health authorities have recommended the use of digital tools for home workouts to stay active and healthy during the COVID-19 pandemic. In this paper, a machine learning approach is proposed to assess the activity of users on a home workout platform. Keep is a home workout application dedicated to providing one-stop exercise solutions such as fitness teaching, cycling, running, yoga, and fitness diet guidance. We used a data crawler to collect the total training set data of 7734 Keep users and compared four supervised learning algorithms: support vector machine, k-nearest neighbor, random forest, and logistic regression. The receiver operating curve analysis indicated that the overall discrimination verification power of random forest was better than that of the other three models. The random forest model was used to classify 850 test samples, and a correct rate of 88% was obtained. This approach can predict the continuous usage of users after installing the home workout application. We considered 18 variables on Keep that were expected to affect the determination of continuous participation. Keep certification is the most important variable that affected the results of this study. Keep certification refers to someone who has verified their identity information and can, therefore, obtain the Keep certification logo. The results show that the platform still needs to be improved in terms of real identity privacy information and other aspects.


Energies ◽  
2018 ◽  
Vol 11 (9) ◽  
pp. 2328 ◽  
Author(s):  
Md Shafiullah ◽  
M. Abido ◽  
Taher Abdel-Fattah

Precise information of fault location plays a vital role in expediting the restoration process, after being subjected to any kind of fault in power distribution grids. This paper proposed the Stockwell transform (ST) based optimized machine learning approach, to locate the faults and to identify the faulty sections in the distribution grids. This research employed the ST to extract useful features from the recorded three-phase current signals and fetches them as inputs to different machine learning tools (MLT), including the multilayer perceptron neural networks (MLP-NN), support vector machines (SVM), and extreme learning machines (ELM). The proposed approach employed the constriction-factor particle swarm optimization (CF-PSO) technique, to optimize the parameters of the SVM and ELM for their better generalization performance. Hence, it compared the obtained results of the test datasets in terms of the selected statistical performance indices, including the root mean squared error (RMSE), mean absolute percentage error (MAPE), percent bias (PBIAS), RMSE-observations to standard deviation ratio (RSR), coefficient of determination (R2), Willmott’s index of agreement (WIA), and Nash–Sutcliffe model efficiency coefficient (NSEC) to confirm the effectiveness of the developed fault location scheme. The satisfactory values of the statistical performance indices, indicated the superiority of the optimized machine learning tools over the non-optimized tools in locating faults. In addition, this research confirmed the efficacy of the faulty section identification scheme based on overall accuracy. Furthermore, the presented results validated the robustness of the developed approach against the measurement noise and uncertainties associated with pre-fault loading condition, fault resistance, and inception angle.


2021 ◽  
Author(s):  
Merlin James Rukshan Dennis

Distributed Denial of Service (DDoS) attack is a serious threat on today’s Internet. As the traffic across the Internet increases day by day, it is a challenge to distinguish between legitimate and malicious traffic. This thesis proposes two different approaches to build an efficient DDoS attack detection system in the Software Defined Networking environment. SDN is the latest networking approach which implements centralized controller, which is programmable. The central control and the programming capability of the controller are used in this thesis to implement the detection and mitigation mechanisms. In this thesis, two designed approaches, statistical approach and machine-learning approach, are proposed for the DDoS detection. The statistical approach implements entropy computation and flow statistics analysis. It uses the mean and standard deviation of destination entropy, new flow arrival rate, packets per flow and flow duration to compute various thresholds. These thresholds are then used to distinguish normal and attack traffic. The machine learning approach uses Random Forest classifier to detect the DDoS attack. We fine-tune the Random Forest algorithm to make it more accurate in DDoS detection. In particular, we introduce the weighted voting instead of the standard majority voting to improve the accuracy. Our result shows that the proposed machine-learning approach outperforms the statistical approach. Furthermore, it also outperforms other machine-learning approach found in the literature.


Author(s):  
Mokhtar Al-Suhaiqi ◽  
Muneer A. S. Hazaa ◽  
Mohammed Albared

Due to rapid growth of research articles in various languages, cross-lingual plagiarism detection problem has received increasing interest in recent years. Cross-lingual plagiarism detection is more challenging task than monolingual plagiarism detection. This paper addresses the problem of cross-lingual plagiarism detection (CLPD) by proposing a method that combines keyphrases extraction, monolingual detection methods and machine learning approach. The research methodology used in this study has facilitated to accomplish the objectives in terms of designing, developing, and implementing an efficient Arabic – English cross lingual plagiarism detection. This paper empirically evaluates five different monolingual plagiarism detection methods namely i)N-Grams Similarity, ii)Longest Common Subsequence, iii)Dice Coefficient, iv)Fingerprint based Jaccard Similarity  and v) Fingerprint based Containment Similarity. In addition, three machine learning approaches namely i) naïve Bayes, ii) Support Vector Machine, and iii) linear logistic regression classifiers are used for Arabic-English Cross-language plagiarism detection. Several experiments are conducted to evaluate the performance of the key phrases extraction methods. In addition, Several experiments to investigate the performance of machine learning techniques to find the best method for Arabic-English Cross-language plagiarism detection. According to the experiments of Arabic-English Cross-language plagiarism detection, the highest result was obtained using SVM   classifier with 92% f-measure. In addition, the highest results were obtained by all classifiers are achieved, when most of the monolingual plagiarism detection methods are used. 


DYNA ◽  
2020 ◽  
Vol 87 (212) ◽  
pp. 63-72
Author(s):  
Jorge Iván Pérez Rave ◽  
Favián González Echavarría ◽  
Juan Carlos Correa Morales

The objective of this work is to develop a machine learning model for online pricing of apartments in a Colombian context. This article addresses three aspects: i) it compares the predictive capacity of linear regression, regression trees, random forest and bagging; ii) it studies the effect of a group of text attributes on the predictive capability of the models; and iii) it identifies the more stable-important attributes and interprets them from an inferential perspective to better understand the object of study. The sample consists of 15,177 observations of real estate. The methods of assembly (random forest and bagging) show predictive superiority with respect to others. The attributes derived from the text had a significant relationship with the property price (on a log scale). However, their contribution to the predictive capacity was almost nil, since four different attributes achieved highly accurate predictions and remained stable when the sample change.


2020 ◽  
Vol 10 (16) ◽  
pp. 5673 ◽  
Author(s):  
Daniela Cardone ◽  
David Perpetuini ◽  
Chiara Filippini ◽  
Edoardo Spadolini ◽  
Lorenza Mancini ◽  
...  

Traffic accidents determine a large number of injuries, sometimes fatal, every year. Among other factors affecting a driver’s performance, an important role is played by stress which can decrease decision-making capabilities and situational awareness. In this perspective, it would be beneficial to develop a non-invasive driver stress monitoring system able to recognize the driver’s altered state. In this study, a contactless procedure for drivers’ stress state assessment by means of thermal infrared imaging was investigated. Thermal imaging was acquired during an experiment on a driving simulator, and thermal features of stress were investigated with comparison to a gold-standard metric (i.e., the stress index, SI) extracted from contact electrocardiography (ECG). A data-driven multivariate machine learning approach based on a non-linear support vector regression (SVR) was employed to estimate the SI through thermal features extracted from facial regions of interest (i.e., nose tip, nostrils, glabella). The predicted SI showed a good correlation with the real SI (r = 0.61, p = ~0). A two-level classification of the stress state (STRESS, SI ≥ 150, versus NO STRESS, SI < 150) was then performed based on the predicted SI. The ROC analysis showed a good classification performance with an AUC of 0.80, a sensitivity of 77%, and a specificity of 78%.


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