scholarly journals Corrigendum to “Yokukansan Alleviates Cancer Pain by Suppressing Matrix Metalloproteinase-9 in a Mouse Bone Metastasis Model”

2019 ◽  
Vol 2019 ◽  
pp. 1-2
Author(s):  
Kenta Nakao ◽  
Atsushi Fujiwara ◽  
Nobuyasu Komasawa ◽  
Denan Jin ◽  
Manabu Kitano ◽  
...  
Keyword(s):  
Bone Metastasis ◽  
Matrix Metalloproteinase ◽  
Cancer Pain ◽  
Matrix Metalloproteinase 9 ◽  
Metastasis Model ◽  
Metalloproteinase 9

scholarly journals Yokukansan Alleviates Cancer Pain by Suppressing Matrix Metalloproteinase-9 in a Mouse Bone Metastasis Model

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Kenta Nakao ◽  
Atsushi Fujiwara ◽  
Nobuyasu Komasawa ◽  
Denan Jin ◽  
Manabu Kitano ◽  
...  
Keyword(s):  
Bone Metastasis ◽  
Matrix Metalloproteinase ◽  
Cancer Pain ◽  
Weight Bearing ◽  
Intraperitoneal Administration ◽  
Herbal Medicines ◽  
Bone Cancer ◽  
Pain Behavior ◽  
Bone Cancer Pain ◽  
Metastasis Model

Bone cancer pain control is difficult because it includes various characteristics of pain such as nociceptic and neuropathic pain. In this study, we investigated the effect of yokukansan (YKS), one of the traditional Japanese herbal medicines, on cancer pain in mouse bone metastasis model. Oral administration of YKS significantly alleviated pain behavior measured by quantitative body weight bearing. Furthermore, the pain behavior was also significantly alleviated by intrathecal and intraperitoneal administration of matrix metalloproteinase- (MMP-) 9 inhibitor, but not of MMP-2 inhibitor. MMP-9 expression was significantly elevated in the bone tissue on day 3 after carcinoma cell injection and in the ipsilateral spinal cord on day 7, which was suppressed by YKS administration. Taken together, these results suggest that YKS alleviates cancer pain via suppressing MMP-9 expression in bone metastasis model in mice.

473 Adenosine stimulates matrix metalloproteinase-9 secretion by THP-1-derived macrophages

2007 ◽  
Vol 6 (1) ◽  
pp. 102-102
Author(s):  
E VELOT ◽  
I ERNENS ◽  
B HAAS ◽  
C JEANTY ◽  
D ROUY ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9

Die Bedeutung der Matrix-Metalloproteinase–9 für die Leberhomöostase – Ein induzierbares transgenes Mausmodell

2005 ◽  
Vol 43 (05) ◽  
Author(s):  
F Thieringer ◽  
E Meyer ◽  
P Czochra ◽  
U Schmitt ◽  
JF Garcia-Lazaro ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Matrix Metalloproteinase 9 ◽  
Metalloproteinase 9
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