scholarly journals Effect of Induced Membrane Formation Followed by Polymethylmethacrylate Implantation on Diabetic Foot Ulcer Healing When Revascularization Is Not Feasible

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Chao Liu ◽  
Jia-Xing You ◽  
Yi-Xin Chen ◽  
Wei-Fen Zhu ◽  
Ying Wang ◽  
...  
Keyword(s):  
Surgical Approach ◽  
Diabetic Foot ◽  
Patient Survival ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Major Amputation ◽  
Amputation Rate ◽  
Conventional Group ◽  
Induced Membrane

No study has investigated the role of induced membrane (IM) formation in treating diabetic foot ulcer (DFU). This retrospective study was aimed (1) at evaluating the potential role of a two-staged surgical approach, comprising polymethylmethacrylate (PMMA) implantation and IM formation, in the treatment of DFU and (2) at comparing the results of those with routine wound debridement in patients with DFUs and nonrevascularized peripheral arterial disease (PAD). Fifty patients with infected DFUs who were not candidates for vascular interventions were enrolled between February 2016 and April 2018 and assigned to the PMMA group (n=28) and conventional group (n=22). The healing rate, major amputation rate, duration of healing, frequency of debridement procedures, patient survival rate, and reulceration of DFUs were determined. The Mann-Whitney U test, independent sample t-test, and χ2 or Fisher exact test were used in statistical analysis. Overall clinical outcomes were statistically different between the groups (Z=−2.495, P=0.013). In the PMMA group, 16 patients (57.1%) with intact IM formation achieved ulceration healing at 13.1±3.7 weeks with a mean number of debridements of 1.3±0.4, which were significantly different compared to those values in 5 patients of the conventional group (22.7%, P=0.014; healing duration: 26.4±7.8 weeks, P=0.016; mean number of debridements: 3.6±0.5, P≤0.001). At a mean 16.8±4.3-month follow-up, patient survival rates were 92.9% and 68.2% in the PMMA and conventional groups, respectively (P=0.032). The major amputation rate and reulceration of DFUs were similar between the groups. The two-staged surgical approach is an available, effective modality for improving healing of DFUs. This study provides preliminary information of IM formation followed by PMMA implantation in the management of DFUs in PAD when revascularization is not feasible.

scholarly journals Role of toll like receptor-9 (1237 T/C) gene polymorphism in patients with type 2 diabetes and diabetic foot ulcer

2021 ◽  
Vol 1879 (2) ◽  
pp. 022012
Author(s):  
Furqan Naeem Al-Karawi ◽  
Naji Al-Hasnawiand Abeer Thaher ◽  
Thekra Abd Jebur Al-Kashwan
Keyword(s):  
Type 2 Diabetes ◽  
Gene Polymorphism ◽  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Toll Like Receptor

Osteomyelitis, diabetic foot ulcers and the role of the community nurse

2021 ◽  
Vol 26 (Sup6) ◽  
pp. S6-S9
Author(s):  
Melanie Lumbers
Keyword(s):  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Holistic Approach ◽  
Diabetic Patients ◽  
Positive Outcomes ◽  
Community Nurse ◽  
Complex Needs ◽  
Health And Wellbeing

Community nurses face numerous challenges in both diagnosing and effectively treating their patients. The diabetic patient has complex needs requiring a holistic approach. With a reported increase in diabetic patients, and a possible decline in some routine screening following Covid-19 pandemic, complications in diabetic patients are likely to rise. It is estimated that 25% of diabetic patients will develop a diabetic foot ulcer (DFU), with a reported 43% of DFU already infected at first presentation to a health professional. NICE categorise the level of infection in DFU based on standardised assessments such as SINBAD. A high categorised DFU has the possibility of osteomyelitis. It is imperative that osteomyelitis is treated immediately to achieve positive outcomes, benefitting the patients' health and wellbeing in addition to reducing the financial implications to the NHS.

scholarly journals Role of Serum Vitamin D Level in Progression of Diabetic Foot Ulcer

2019 ◽  
Author(s):  
Farzad Najafipour ◽  
Naser Aghamohammadza ◽  
Neda Razzaghi Zonouz ◽  
Jalil Houshyar
Keyword(s):  
Vitamin D ◽  
Diabetic Foot ◽  
Serum Vitamin ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Serum Vitamin D

scholarly journals “ ASSESSMENT OF SEVERITY OF DIABETIC FOOT ULCERS USING DIABETIC ULCER SEVERITY SCORE.”

2020 ◽  
pp. 19-21
Author(s):  
Aarushi Mishra ◽  
Anilkumar P. Bellad ◽  
M.I. Uppin
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Foot ◽  
Severity Score ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Major Amputation ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Diabetic Ulcer ◽  
The Past

INTRODUCTION : Diabetes mellitus is a common metabolic disorder, prevalence steadily increasing over the past few decades. The complications associated with it , hence , has also increased. Diabetic foot ulcer is one of the most serious complications , utilizing resources, significantly contributing to the morbidity of the patient. There is hence, a need to correctly identify the severity of the diabetic foot ulcer so as to plan the appropriate management and to help in counselling of such patients. AIM : To assess severity in diabetic foot ulcer using diabetic ulcer severity score. MATERIAL AND METHODOLOGY : This is a hospital based longitudinal study , conducted on 93 study subjects admitted with diabetic foot ulcers. Diabetic ulcer severity score was calculated for each patient . The score was calculated by adding scores of the respective parameters constituting site of ulcer, number of ulcers, presence/absence of pedal pulsations, presence/ absence of bone involvement. Each patient was followed up for a period of 6 months , or earlier in case of patient undergoing minor/major amputation. After the study was conducted , analysis was done by calculating various percentages of healing /amputation with respect to the score. RESULTS : Out of the total 93 study subjects , 74.2% were males. The mean age was calculated to be 59.6 years with maximum number of subjects being in 55-60 years of age group range. Majority of them had diabetic ulcer severity score of 2 (42%). Out of the total study subjects , 58% had a complete healing , 28% underwent minor amputation whereas 14% underwent major amputation. 100% of the study participants with score 0 had healing of ulcer which decreased to 85% for score 1 , 53.8% for score 2 , 6.25% for score 3 and 0% for score 4. This was suggestive of poorer chances of healing as the diabetic ulcer severity score increases. CONCLUSION : With the increasing incidence of patients diagnosed with diabetes mellitus , the rate of complications of diabetes has also increased over the past few decades including the risk and occurence of diabetic foot ulcers There is an increasing need for diabetic foot ulcer prognostication systems and universal use of the same. Thus ,we recommend the use of diabetic ulcer severity score as a prognostic tool to assess the severity of the diabetic foot which will further enhance communication and counselling of the patient and will help in providing the appropriate treatment to such patients.

scholarly journals A clinicopathogical study on diabetic foot ulcer with special reference to the causative factors and its management

2019 ◽  
Vol 6 (5) ◽  
pp. 1540
Author(s):  
Sailendranath Paul ◽  
Dilip Kumar Das
Keyword(s):  
Diabetic Foot ◽  
Age Of Onset ◽  
Management Strategies ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Major Amputation ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
E Coli ◽  
Related Risk

Background: Diabetic ulcers are the most common foot injuries leading to lower extremity amputation. The present study was done to identify the incidence and related risk factors of diabetic foot ulcers in study participants.Methods: This was a prospective done on 50 patients with diabetic foot ulcers. All the patients were examined thoroughly and related laboratory investigations were done. Wound culture and sensitivity was done in all cases.Results: Mean age of onset with foot ulcers was 53.5 yrs in male and 55 yrs in females. Nephropathy was present in 12 (24%) patients. Sensorimotor neuropathy was present in 29 (58%) cases and autonomic neuropathy was present in 06 (12%) cases. Most common infection identified in diabetic foot ulcers was due to gram-negative bacteria (E. coli in 45 cases). Major amputation was done in 2 (4%) patients.Conclusions: Implementation of management strategies at early stages prevents the development of complications related to diabetic foot ulcers in patients. 

scholarly journals The Role of VEGF, PDGF and IL-6 on Diabetic Foot Ulcer after Platelet Rich Fibrin + Hyaluronic Therapy

Heliyon ◽  
2021 ◽  
pp. e07934
Author(s):  
Ronald W. Kartika ◽  
Idrus Alwi ◽  
Franciscus D. Suyatna ◽  
Em Yunir ◽  
Sarwono Waspadji ◽  
...  
Keyword(s):  
Diabetic Foot ◽  
Foot Ulcer ◽  
Diabetic Foot Ulcer ◽  
Platelet Rich Fibrin
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