scholarly journals Repetitive Transcranial Magnetic Stimulation Does Not Improve the Sequence Effect in Freezing of Gait

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Jinghong Ma ◽  
Linlin Gao ◽  
Taomian Mi ◽  
Junyan Sun ◽  
Piu Chan ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Beneficial Effect ◽  
High Frequency ◽  
Magnetic Stimulation ◽  
Supplementary Motor Area ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Freezing Of Gait ◽  
Sequence Effect ◽  
Beneficial Effects ◽  
Gait Parameters

Introduction. The sequence effect (SE) is a reason contributing to freezing of gait (FOG) in Parkinson’s disease (PD) patients. There is no effective treatment for the SE. The objective of the current study is to investigate the effect of repetitive transcranial magnetic stimulation (rTMS) on the SE in PD patients with FOG. Methods. 28 PD patients with FOG received either real or sham 10-Hz rTMS over the supplementary motor area (SMA). The effects of rTMS on the SE, FOG, and some gait parameters were evaluated. Results. rTMS did not improve the SE. Real rTMS had beneficial effects on FOG and some gait parameters, and this effect lasted for at least four weeks. Conclusions. High-frequency rTMS over the SMA cannot alleviate the SE in PD patients with FOG. rTMS has a long-lasting beneficial effect on FOG; however, this effect is not achieved by improving the SE but may be through improving some other gait parameters.

scholarly journals Modulation of the Left Prefrontal Cortex with High Frequency Repetitive Transcranial Magnetic Stimulation Facilitates Gait in Multiple Sclerosis

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Amer M. Burhan ◽  
Priya Subramanian ◽  
Luljeta Pallaveshi ◽  
Brittany Barnes ◽  
Manuel Montero-Odasso
Keyword(s):  
Multiple Sclerosis ◽  
Prefrontal Cortex ◽  
Transcranial Magnetic Stimulation ◽  
High Frequency ◽  
Magnetic Stimulation ◽  
Demyelinating Disease ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Repeated Measure ◽  
Gait Velocity ◽  
Gait Parameters

Multiple Sclerosis (MS) is a chronic central nervous system (CNS) demyelinating disease. Gait abnormalities are common and disabling in patients with MS with limited treatment options available. Emerging evidence suggests a role of prefrontal attention networks in modulating gait. High-frequency repetitive transcranial magnetic stimulation (rTMS) is known to enhance cortical excitability in stimulated cortex and its correlates. We investigated the effect of high-frequency left prefrontal rTMS on gait parameters in a 51-year-old Caucasian male with chronic relapsing/remitting MS with residual disabling attention and gait symptoms. Patient received 6 Hz, rTMS at 90% motor threshold using figure of eight coil centered onF3location (using 10-20 electroencephalography (EEG) lead localization system). GAITRite gait analysis system was used to collect objective gait measures before and after one session and in another occasion three consecutive daily sessions of rTMS. Two-tailed within subject repeated measuret-test showed significant enhancement in ambulation time, gait velocity, and cadence after three consecutive daily sessions of rTMS. Modulating left prefrontal cortex excitability using rTMS resulted in significant change in gait parameters after three sessions. To our knowledge, this is the first report that demonstrates the effect of rTMS applied to the prefrontal cortex on gait in MS patients.

scholarly journals Repetitive Transcranial Magnetic Stimulation in the Treatment of Alzheimer’s Disease and Other Dementias

Healthcare ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 949
Author(s):  
Athina-Maria Aloizou ◽  
Georgia Pateraki ◽  
Konstantinos Anargyros ◽  
Vasileios Siokas ◽  
Christos Bakirtzis ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Lewy Body Dementia ◽  
Standard Of Care ◽  
Central Position ◽  
Beneficial Effects ◽  
Dorsolateral Prefrontal

Dementia is a debilitating impairment of cognitive functions that affects millions of people worldwide. There are several diseases belonging to the dementia spectrum, most prominently Alzheimer’s disease (AD), vascular dementia (VD), Lewy body dementia (LBD) and frontotemporal dementia (FTD). Repetitive transcranial magnetic stimulation (rTMS) is a safe, non-invasive form of brain stimulation that utilizes a magnetic coil to generate an electrical field and induce numerous changes in the brain. It is considered efficacious for the treatment of various neuropsychiatric disorders. In this paper, we review the available studies involving rTMS in the treatment of these dementia types. The majority of studies have involved AD and shown beneficial effects, either as a standalone, or as an add-on to standard-of-care pharmacological treatment and cognitive training. The dorsolateral prefrontal cortex seems to hold a central position in the applied protocols, but several parameters still need to be defined. In addition, rTMS has shown potential in mild cognitive impairment as well. Regarding the remaining dementias, research is still at preliminary phases, and large, randomized studies are currently lacking.

scholarly journals The effect of bilateral high frequency repetitive transcranial magnetic stimulation on cognitive functions in schizophrenia

2020 ◽  
Vol 22 ◽  
pp. 100183
Author(s):  
Mehmet Diyaddin Güleken ◽  
Taner Akbaş ◽  
Selime Çelik Erden ◽  
Veysel Akansel ◽  
Zeliha Cengiz Al ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Cognitive Functions ◽  
High Frequency ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation
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