scholarly journals Cardiac Arrhythmia in a Patient with Sickle Cell Anemia and Falciparum Malaria Treated with Intravenous Artesunate

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Abdulrahman Hummadi ◽  
Sultan Mubarki ◽  
Ayel yahay ◽  
Awad Mohammed Al-Qahtani
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Ventricular Arrhythmias ◽  
Pulmonary Complications ◽  
Artemisinin Derivatives ◽  
Sickle Cell Anemia Patient ◽  
Wide Complex Tachycardia ◽  
Probability Of Precipitation ◽  
Anemia Patient ◽  
Electrocardiographic Abnormalities

Treatment of severe malaria with artemisinin derivatives in patients with comorbid conditions such as sickle cell anemia must be considered with precaution. We report here a case of possibly undocumented ventricular arrhythmia in a sickle cell anemia patient diagnosed with Plasmodium falciparum malaria and treated with intravenous artesunate. The patient suffered from wide complex tachycardia after treatment with artesunate 170 mg (2.4 mg/kg) i.v. bolus, tachycardia was managed with amiodarone (150 mg i.v. for 10 minutes). Electrocardiographic abnormalities, including QT prolongation, are common in patients with sickle cell anemia. The mortality rate in sickle cell anemia patients due to cardiovascular and pulmonary complications remains high. The probability of precipitation of ventricular arrhythmias may increase in patients with sickle cell anemia, diagnosed with malaria and treated with artemisinin derivatives.

Polyostotic osteomyelitis in a sickle cell anemia patient

2017 ◽  
Vol 8 (1) ◽  
pp. 54
Author(s):  
JohnAyodele Olaniyi ◽  
AkinyinkaOluwafemi Akinwunmi
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Sickle Cell Anemia Patient ◽  
Anemia Patient

scholarly journals Identical nucleotide sequences of the 3'A gamma globin gene enhancer elements from four different chromosomes

Blood ◽  
1989 ◽  
Vol 73 (3) ◽  
pp. 845-848 ◽  
Author(s):  
IS Han ◽  
HJ Huang ◽  
YT Zeng ◽  
KD Lanclos ◽  
TH Huisman
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Globin Gene ◽  
Fetal Hemoglobin ◽  
Enhancer Element ◽  
Gamma Globin ◽  
Sickle Cell Anemia Patient ◽  
Gene Enhancer ◽  
Identical Nucleotide ◽  
Anemia Patient

Abstract We have determined the nucleotide sequence of the 2,360-bp long EcoRI fragment from four chromosomes; this fragment is located 3′ to the A gamma globin gene and is considered to contain the enhancer element identified by Bodine and Ley. The chromosomes were from an Arabian sickle cell anemia patient with high Hb F and a homozygosity for haplotype No 31 and from a black sickle cell anemia patient with low Hb F and a homozygosity for haplotype No 19. A third chromosome carried the determinant for a nondeletional hereditary persistence of fetal hemoglobin seen in a Chinese subject, and the fourth was a normal chromosome from a Yugoslavian subject. Twenty-one differences were observed when a comparison was made with the published sequence; no differences were seen between the sequences of the four different samples except for an additional mutation in the Chinese. These data make it unlikely that specific mutations within this sequence are associated with increases in G gamma and A gamma production.

scholarly journals Mycobacterium avium Complex-Associated Hemophagocytic Lymphohistiocytosis in a Sickle Cell Patient: An Unusual Fatal Association

2013 ◽  
Vol 2013 ◽  
pp. 1-3 ◽  
Author(s):  
Mohammed A. R. Chamsi-Pasha ◽  
M. Chadi Alraies ◽  
Abdul Hamid Alraiyes ◽  
Eric D. Hsi
Keyword(s):  
Sickle Cell ◽  
Mycobacterium Avium ◽  
Sickle Cell Anemia ◽  
Hemophagocytic Lymphohistiocytosis ◽  
Mycobacterium Avium Complex ◽  
Sickle Cell Anemia Patient ◽  
Anemia Patient

Hemophagocytic lymphohistiocytosis (HLH) is a rare hyperinflammatory syndrome, characterized clinically by fever, splenomegaly, cytopenia, and high ferritin. Infectious causes have been associated with secondary HLH, with viruses being the most common. We report a case ofMycobacterium avium complex-associated HLH in a sickle cell anemia patient. To the best of our knowledge, this association has never been reported in sickle cell anemia.

scholarly journals An unexpected full neurological recovery after cardiac arrest in a sickle cell anemia patient with bilateral cervical carotid artery disease

2015 ◽  
Vol 37 (4) ◽  
pp. 272-274
Author(s):  
Aline Cristina Peluccio Martins ◽  
Gisele Sampaio Silva ◽  
Samuel Ademola Adegoke ◽  
Daniela Laranja Gomes Rodrigues ◽  
Josefina Aparecida Pellegrini Braga ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Carotid Artery ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Carotid Artery Disease ◽  
Neurological Recovery ◽  
Sickle Cell Anemia Patient ◽  
Full Neurological Recovery ◽  
Artery Disease ◽  
Anemia Patient

scholarly journals Identical nucleotide sequences of the 3'A gamma globin gene enhancer elements from four different chromosomes

Blood ◽  
1989 ◽  
Vol 73 (3) ◽  
pp. 845-848
Author(s):  
IS Han ◽  
HJ Huang ◽  
YT Zeng ◽  
KD Lanclos ◽  
TH Huisman
Keyword(s):  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Globin Gene ◽  
Fetal Hemoglobin ◽  
Enhancer Element ◽  
Gamma Globin ◽  
Sickle Cell Anemia Patient ◽  
Gene Enhancer ◽  
Identical Nucleotide ◽  
Anemia Patient

We have determined the nucleotide sequence of the 2,360-bp long EcoRI fragment from four chromosomes; this fragment is located 3′ to the A gamma globin gene and is considered to contain the enhancer element identified by Bodine and Ley. The chromosomes were from an Arabian sickle cell anemia patient with high Hb F and a homozygosity for haplotype No 31 and from a black sickle cell anemia patient with low Hb F and a homozygosity for haplotype No 19. A third chromosome carried the determinant for a nondeletional hereditary persistence of fetal hemoglobin seen in a Chinese subject, and the fourth was a normal chromosome from a Yugoslavian subject. Twenty-one differences were observed when a comparison was made with the published sequence; no differences were seen between the sequences of the four different samples except for an additional mutation in the Chinese. These data make it unlikely that specific mutations within this sequence are associated with increases in G gamma and A gamma production.

scholarly journals Myofibroblastic sarcoma in a sickle cell anemia patient: A case report from Sokoto, North-Western, Nigeria

2017 ◽  
Vol 14 (3) ◽  
pp. 152
Author(s):  
Ibrahim Abdulqadir ◽  
MuhammadAlhaji Ndakotsu ◽  
AbubakarUmar Musa ◽  
Umar Mohammed
Keyword(s):  
Case Report ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Myofibroblastic Sarcoma ◽  
Sickle Cell Anemia Patient ◽  
North Western ◽  
Anemia Patient
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