scholarly journals Durable Control of Mycosis Fungoides after Sepsis: “Coley’s Toxin?” Case Report and Review of the Literature

2019 ◽  
Vol 2019 ◽  
pp. 1-4
Author(s):  
Benjamin Heyman ◽  
Chris R. Kelsey ◽  
Anne Beaven
Keyword(s):  
Staphylococcus Aureus ◽  
Immune Response ◽  
Mycosis Fungoides ◽  
Cell Lymphoma ◽  
Single Agent ◽  
Severe Infection ◽  
Advanced Stage ◽  
Cutaneous T Cell Lymphoma ◽  
Review Of The Literature ◽  
Durable Response

Mycosis fungoides, along with Sezary syndrome, is the most common subtype of cutaneous T-cell lymphoma. In this report, we present a patient with advanced-stage mycosis fungoides, who after successful treatment of methicillin-resistantStaphylococcus aureusbacteremia had prolonged disease control off systemic therapy. While this may have been due to single-agent gemcitabine, which can result in long remission, we hypothesize that our patient’s durable response was in part due to the immune response elicited after treatment of her severe infection.

Woringer-Kolopp Disease of the Foot: A Case Report

2020 ◽  
Vol 110 (6) ◽  
Author(s):  
James J. LaPolla ◽  
Lawrence A. DiDomenico ◽  
Robert T. Brodell ◽  
Michael L. Casteel
Keyword(s):  
Case Report ◽  
T Cell ◽  
Mycosis Fungoides ◽  
Rare Variant ◽  
Cell Lymphoma ◽  
Treatment Options ◽  
T Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Review Of The Literature ◽  
Intralesional Steroids

Woringer-Kolopp disease is a rare variant of mycosis fungoides, a type of cutaneous T-cell lymphoma. Described is a case of a small annular plaque on the foot diagnosed histologically as Woringer-Kolopp disease and treated successfully with topical and intralesional steroids. In addition, a brief review of the literature and treatment options is provided.

scholarly journals Association of Erythrodermic Cutaneous T-Cell Lymphoma, Superantigen-Positive Staphylococcus aureus, and Oligoclonal T-Cell Receptor Vβ Gene Expansion

Blood ◽  
1997 ◽  
Vol 89 (1) ◽  
pp. 32-40 ◽  
Author(s):  
Clotilde M. Jackow ◽  
Jennifer C. Cather ◽  
Vicki Hearne ◽  
Arisa T. Asano ◽  
James M. Musser ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
T Cell ◽  
Mycosis Fungoides ◽  
T Cell Receptor ◽  
Cell Lymphoma ◽  
Cell Receptor ◽  
T Cell Lymphoma ◽  
Sézary Syndrome ◽  
Cutaneous T Cell Lymphoma ◽  
T Cell Receptor Vβ

Forty-two patients with cutaneous T-cell lymphoma, including 31 with exfoliative erythroderma or Sezary syndrome and 11 with mycosis fungoides, were studied for the occurrence of staphylococcal infection. Thirty-two of 42 (76%) had a positive staphylococcal culture from skin or blood. One half of the patients with positive cultures grew Staphylococcus aureus. This group included 11 with Sezary syndrome and 5 with rapidly enlarging mycosis fungoides plaques or tumors. All of the S aureus carried enterotoxin genes. Surprisingly, 6 of 16 strains were the same toxic shock toxin-1 (TSST-1)-positive clone, designated electrophoretic type (ET)-41. Analysis of the T-cell receptor Vβ repertoire in 14 CTCL patients found that only 4 had the expected monoclonal expansion of a specific Vβ gene, whereas 10 had oligoclonal or polyclonal expansion of several Vβ families. All patients with TSST-1+S aureus had overexpansion of Vβ 2 in blood and/or skin lesions. These studies show that S aureus containing superantigen enterotoxins are commonly found in patients with CTCL, especially individuals with erythroderma where they could exacerbate and/or perpetuate stimulate chronic T-cell expansion and cutaneous inflammation. Attention to toxigenic S aureus in CTCL patients would be expected to improve the quality of care and outcome of this patient population.

scholarly journals Successful Treatment of Erythrodermic Mycosis Fungoides with Mogamulizumab Followed by Etoposide Monotherapy

2018 ◽  
Vol 11 (1) ◽  
pp. 29-32 ◽  
Author(s):  
Taku Fujimura ◽  
Kayo Tanita ◽  
Yota Sato ◽  
Yumi Kambayashi ◽  
Sadanori Furudate ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cell ◽  
Mycosis Fungoides ◽  
Successful Treatment ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Antitumor Immune Response ◽  
Cutaneous T Cell Lymphoma ◽  
Lymphoma Cells ◽  
Dependent Cell

Mogamulizumab induces cytotoxicity against CCR4+ lymphoma cells by antibody-dependent cell-mediated cytotoxicity in advanced cutaneous T-cell lymphoma patients. Since the efficacy of mogamulizumab in mycosis fungoides (28.6%) is lower than that in Sézary syndrome (47.1%), reagents that enhance the antitumor immune response induced by mogamulizumab are needed to further optimize its use for the treatment of erythrodermic mycosis fungoides. In this report, we present a case of erythrodermic mycosis fungoides successfully treated with mogamulizumab followed by etoposide monotherapy.

scholarly journals Modern concepts of the mycosis fungoides pathogenesis

2018 ◽  
Vol 13 (3) ◽  
pp. 39-46
Author(s):  
A. A. Vorontsova ◽  
A. E. Karamova ◽  
L. F. Znamenskaya
Keyword(s):  
T Cell ◽  
T Lymphocytes ◽  
Mycosis Fungoides ◽  
Cell Lymphoma ◽  
Epigenetic Mechanisms ◽  
Cutaneous T Cell Lymphoma ◽  
Cellular Composition ◽  
Review Of The Literature ◽  
Lymphoproliferative Diseases

Mycosis fungoides – the most common form of cutaneous T-cell lymphoma. The pathogenesis of this disease is complex and remains unclear. The article contains a review of the literature devoted to the main mechanisms of T-lymphocytes malignant proliferation, known to date. Data on dysregulation of immune, genetic and epigenetic mechanisms, as well as the role of microenvironment cells in the proliferation of T lymphocytes, are given. Immunophenotypic characteristics and cellular composition of the infiltrate in patients with mycosis fungoides, are described depending on the stage of the disease. Prospective directions in studying molecular-biological predictors of malignant lymphoproliferative diseases development are highlighted.

scholarly journals Association of Erythrodermic Cutaneous T-Cell Lymphoma, Superantigen-Positive Staphylococcus aureus, and Oligoclonal T-Cell Receptor Vβ Gene Expansion

Blood ◽  
1997 ◽  
Vol 89 (1) ◽  
pp. 32-40 ◽  
Author(s):  
Clotilde M. Jackow ◽  
Jennifer C. Cather ◽  
Vicki Hearne ◽  
Arisa T. Asano ◽  
James M. Musser ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
T Cell ◽  
Mycosis Fungoides ◽  
T Cell Receptor ◽  
Cell Lymphoma ◽  
Cell Receptor ◽  
T Cell Lymphoma ◽  
Sézary Syndrome ◽  
Cutaneous T Cell Lymphoma ◽  
T Cell Receptor Vβ

Abstract Forty-two patients with cutaneous T-cell lymphoma, including 31 with exfoliative erythroderma or Sezary syndrome and 11 with mycosis fungoides, were studied for the occurrence of staphylococcal infection. Thirty-two of 42 (76%) had a positive staphylococcal culture from skin or blood. One half of the patients with positive cultures grew Staphylococcus aureus. This group included 11 with Sezary syndrome and 5 with rapidly enlarging mycosis fungoides plaques or tumors. All of the S aureus carried enterotoxin genes. Surprisingly, 6 of 16 strains were the same toxic shock toxin-1 (TSST-1)-positive clone, designated electrophoretic type (ET)-41. Analysis of the T-cell receptor Vβ repertoire in 14 CTCL patients found that only 4 had the expected monoclonal expansion of a specific Vβ gene, whereas 10 had oligoclonal or polyclonal expansion of several Vβ families. All patients with TSST-1+S aureus had overexpansion of Vβ 2 in blood and/or skin lesions. These studies show that S aureus containing superantigen enterotoxins are commonly found in patients with CTCL, especially individuals with erythroderma where they could exacerbate and/or perpetuate stimulate chronic T-cell expansion and cutaneous inflammation. Attention to toxigenic S aureus in CTCL patients would be expected to improve the quality of care and outcome of this patient population.

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