scholarly journals Renal Tubular Acidosis and Hypokalemic Paralysis as a First Presentation of Primary Sjögren’s Syndrome

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Arun Sedhain ◽  
Kiran Acharya ◽  
Alok Sharma ◽  
Amir Khan ◽  
Shital Adhikari
Keyword(s):  
Metabolic Acidosis ◽  
Sjögren’S Syndrome ◽  
Renal Tubular Acidosis ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Periodic Paralysis ◽  
Hypokalemic Periodic Paralysis ◽  
Renal Tubular ◽  
Sjögren‘S Syndrome

Sjögren’s syndrome is an autoimmune disease with multisystem involvement and varying clinical presentation. We report the clinical course and outcome of a case who presented with repeated episodes of hypokalemia mimicking hypokalemic periodic paralysis and metabolic acidosis, which was later diagnosed as distal renal tubular acidosis secondary to primary Sjögren’s syndrome. A 50-year-old lady, who was previously diagnosed as hypokalemic periodic paralysis, presented with generalized weakness and fatigue. She was found to have severe hypokalemia with normal anion-gap metabolic acidosis consistent with distal renal tubular acidosis. Subsequent evaluation revealed Sjögren’s syndrome as the cause of her problems. Kidney biopsy done to evaluate significant proteinuria revealed nonproliferative morphology with patchy acute tubular injury and significant chronic interstitial nephritis. The patient responded well to potassium supplementation and oral prednisolone. Presentation of this case highlights the necessity of close vigilance while managing a case of repeated hypokalemia, which could be one of the rare clinical manifestations of Sjögren’s syndrome.

scholarly journals FP004HYPOKALEMIC PERIODIC PARALYSIS - A RARE PRESENTATION OF DISTAL RENAL TUBULAR ACIDOSIS IN SJOGREN'S SYNDROME

2015 ◽  
Vol 30 (suppl_3) ◽  
pp. iii67-iii67
Author(s):  
Shankar Prasad Nagaraju ◽  
Naresh Kumar ◽  
Srinivas Kosuru ◽  
Ravindra Attur Prabhu ◽  
Dharshan Rangaswamy ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Renal Tubular Acidosis ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Periodic Paralysis ◽  
Distal Renal Tubular Acidosis ◽  
Rare Presentation ◽  
Renal Tubular ◽  
Sjögren‘S Syndrome

scholarly journals Type I renal tubular acidosis caused by Sjögren’s syndrome with hypokalemia as the first symptom: a case report

2019 ◽  
Vol 48 (2) ◽  
pp. 030006051988076
Author(s):  
Yanjun Zhou ◽  
Nanqu Huang ◽  
Guangyu Cao ◽  
Yong Luo
Keyword(s):  
Sjögren’S Syndrome ◽  
Renal Tubular Acidosis ◽  
Sjögren's Syndrome ◽  
Distal Tubule ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Periodic Paralysis ◽  
Type I ◽  
Renal Tubular ◽  
Sjögren‘S Syndrome

Sjögren’s syndrome is a chronic inflammatory autoimmune disease characterized by exocrine gland involvement and marked lymphocytic infiltration. Numerous reports of patients with Sjögren’s syndrome have described kidney damage, mainly involving distal tubule dysfunction, severe renal calcification, kidney stones, and rickets. We herein describe a patient with primary Sjögren’s syndrome who developed type I renal tubular acidosis with hypokalemia as the first symptom. This case highlights the possibility that an underlying autoimmune disorder should be considered in a patient presenting with distal tubular acidosis or recurrent hypokalemic periodic paralysis because treatment of the primary disease improves the outcome.

Hypokalemic paralysis and renal tubular acidosis: Initial presentation of Sjogren’s syndrome

2021 ◽  
Vol 32 (2) ◽  
pp. 145-148
Author(s):  
Tania Tofail ◽  
Sharmin Jahan ◽  
Mohd Abul Hasnat
Keyword(s):  
Sjögren’S Syndrome ◽  
Renal Tubular Acidosis ◽  
Sjögren's Syndrome ◽  
Symptomatic Treatment ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Periodic Paralysis ◽  
Autoimmune Hypothyroidism ◽  
Renal Tubular ◽  
Sjögren‘S Syndrome

Sjogren’s syndrome is a rare autoimmune disease affecting multiple systems with varying clinical features.We report a case of 37 year old woman who presented with recurrent episodes of quadriparesis which was attributable to hypokalemia and initially labelled as hypokalemic periodic paralysis. Later on she was found to have metabolic acidosis rather than alkalosis which pointed towards the diagnosis of renal tubular acidosis (RTA) in the absence of apparent gastrointestinal tract loss. Once the diagnosis of RTA was established, an attempt to search the aetiology revealed that she was having primary Sjogren’s syndrome (pSS) though she did not have any symptom at the time of diagnosis. She was found positive for anti-SSA. Lip biopsy revealed lymphocytic infiltration in periductal as well as parenchymal region. Schirmer test confirmed presence of severe dry eye. A concomitant existence of autoimmune hypothyroidism was a noteworthy association. She responded well with potassium supplementation and symptomatic treatment. Presentation of this case reminds the importance of vigilance while managing a case of recurrent hypokalemia which might be a rare presenting feature of pSS. Bangladesh J Medicine July 2021; 32(2) : 145-148

scholarly journals A FAMILY WITH SJÖGREN'S SYNDROME ASSOCIATED WITH RENAL TUBULAR ACIDOSIS

1980 ◽  
Vol 69 (10) ◽  
pp. 1320-1326
Author(s):  
Tatsuhiko KODAMA ◽  
Toshitaka AKATSUKA ◽  
Kazuhiko YAMAMOTO ◽  
Tadao CHIHARA ◽  
Yasushi YUKIYAMA ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Renal Tubular Acidosis ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Renal Tubular ◽  
Sjögren‘S Syndrome

scholarly journals Hypokalemic quadriparesis due to renal tubular acidosis in a patient with Sjögren’s syndrome: A case series

2014 ◽  
Vol 3 (1) ◽  
pp. 30-33
Author(s):  
Abhishek Maskey ◽  
Neeraj Singh ◽  
Santosh Gautam ◽  
Prashant Bhattarai ◽  
Prakash Poudyal ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Renal Tubular Acidosis ◽  
Sjögren's Syndrome ◽  
Renal Involvement ◽  
Case Series ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Life Threatening ◽  
Renal Tubular ◽  
Sjögren‘S Syndrome

We report two cases of female patients presented with hypokalemia secondary to renal tubular acidosis. Sjögren’s syndrome was diagnosed in both the patients on the basis of histopathological and autoantibodies tests. The patients were treated with potassium and bicarbonate supplementation. Renal involvement in Sjögren’s syndrome is not uncommon and may precede sicca complaints. The pathology in most cases is a tubulointerstitial nephritis causing distal renal tubular acidosis and rarely, hypokalemic paralysis. The complications of renal tubular acidosis include life threatening hypokalemia, nephrolithiasis, chronic renal failure, growth retardation and osteomalacia. These consequences can be avoided if the diagnosis is made early and lifelong potassium and alkali supplementation is initiated. Primary Sjögren’s syndrome should be considered in women with acute weakness and hypokalemia. DOI: http://dx.doi.org/10.3126/jaim.v3i1.10701 Journal of Advances in Internal Medicine 2014;03(01):30-33

Renal Tubular Acidosis in Sjögren's Syndrome: A Case Series

2014 ◽  
Vol 40 (2) ◽  
pp. 123-130 ◽  
Author(s):  
Rapur Ram ◽  
Gudithi Swarnalatha ◽  
Kaligotla Venkata Dakshinamurty
Keyword(s):  
Sjögren’S Syndrome ◽  
Renal Tubular Acidosis ◽  
Sjögren's Syndrome ◽  
Case Series ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Renal Tubular ◽  
Sjögren‘S Syndrome
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