scholarly journals Aortic Aneurysm as a Complication of Granulomatosis with Polyangiitis Successfully Treated with Prednisolone and Cyclophosphamide: A Case Report and Review of the Literature

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Naoko Niimi ◽  
Tomoko Miyashita ◽  
Kana Tanji ◽  
Takuya Hirai ◽  
Kozo Watanabe ◽  
...  
Keyword(s):  
Aortic Aneurysm ◽  
Lung Biopsy ◽  
Granulomatosis With Polyangiitis ◽  
Clinical Presentation ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Review Of The Literature ◽  
Laboratory Findings ◽  
Abdominal Aortic ◽  
Old Japanese

A 57-year-old Japanese man was admitted to the hospital with back pain and fever, multiple lung nodules, and abdominal aortic aneurysm (AAA). Laboratory tests performed at admission showed an increased proteinase 3 anti-neutrophil cytoplasmic antibody (PR3-ANCA) level. Video-associated thoracoscopic lung biopsy was performed; pathologic examination showed granulation tissue with necrosis and multinucleated giant cells. The diagnosis of granulomatosis with polyangiitis (GPA) was confirmed on the basis of the clinical presentation, laboratory findings, and lung biopsy. All symptoms were ameliorated, and the serum level of PR3-ANCA declined following treatment with prednisolone and cyclophosphamide. Although the association of GPA with AAA is rare, GPA may be included among the large vessel vasculitides that can give rise to aortic aneurysm.

Aneurysmal Bone Cyst of the Larynx Presenting With Hypoglottic Obstruction

2001 ◽  
Vol 125 (5) ◽  
pp. 673-676
Author(s):  
Duilio Della Libera ◽  
Gillian Redlich ◽  
Lucia Bittesini ◽  
Giovanni Falconieri
Keyword(s):  
Aneurysmal Bone Cyst ◽  
Radical Surgery ◽  
Bone Cyst ◽  
Giant Cells ◽  
Multinucleated Giant Cells ◽  
Review Of The Literature ◽  
Osteoid Tissue ◽  
Spindle Cells ◽  
Apparent Relationship

Abstract We report a new case of aneurysmal bone cyst of the larynx occurring in a 22-year-old man. The lesion manifested with progressive breathing discomfort and appeared as a polypoid pedunculated mass attached to the subglottic mucosa. Microscopically, it featured numerous mononuclear and multinucleated giant cells surrounding cavernous spaces filled with blood. Foci of proliferating spindle cells and mature osteoid tissue could be recognized. There was no apparent relationship with the cricoid perichondrium. Clinical follow-up was negative for local recurrence. Based on this report and a review of the literature, we conclude that aneurysmal bone cyst of the larynx is phenotypically comparable to its bone homologue; however, its microscopic recognition may be difficult, especially on small biopsy fragments. Since it can be confused with several lesions, including telangiectatic osteosarcoma, awareness of this rare appearance of aneurysmal bone cyst is important to avoid unnecessary radical surgery.

Role of metalloproteinases and their inhibitors in the development of abdominal aortic aneurysm: current insights and systematic review of the literature

Chirurgia ◽  
2017 ◽  
Vol 30 (5) ◽  
Author(s):  
Lucia Butrico ◽  
Andrea Barbetta ◽  
Salvatore Ciranni ◽  
Michele Andreucci ◽  
Pasquale Mastroroberto ◽  
...  
Keyword(s):  
Systematic Review ◽  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Review Of The Literature ◽  
Abdominal Aortic

scholarly journals Aneurysm-related disseminated intravascular coagulation successfully treated by endovascular repair

2019 ◽  
Vol 11 (4) ◽  
Author(s):  
Miguel Lemos Gomes ◽  
Alice Lopes ◽  
Ana Parente Freixo ◽  
Gonçalo Sobrinho ◽  
Ruy Fernandes ◽  
...  
Keyword(s):  
Aortic Aneurysm ◽  
Disseminated Intravascular Coagulation ◽  
Endovascular Aneurysm Repair ◽  
Underlying Disease ◽  
Abdominal Aneurysm ◽  
Laboratory Findings ◽  
Intravascular Coagulation ◽  
Abdominal Aortic ◽  
Internal Iliac ◽  
Aneurysm Repair

Aortic abdominal aneurysm (AAA) is an uncommon etiology of disseminated intravascular coagulation (DIC). The authors report a case of an 81-year-old male patient who presented with hematuria, intraoral hemorrhage, melaenas and ecchymosis of the lower back and of the abdominal wall, after being medicated with etoricoxib for a back pain. During the study, an abdominal aortic aneurysm, which prolonged to the left common and internal iliac artery, was discovered. The diagnosis of AAA induced DIC was made. After endovascular aneurysm repair (EVAR), the patient’s hemorrhagic manifestations disappeared and the laboratory findings normalized. In conclusion, the state-of-the-art treatment of DIC is the elimination of the underlying disease; in this case, EVAR was proven to be effective in treating the aortic aneurysm and the AAA-related DIC.

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