scholarly journals Bartonella Endocarditis Mimicking Crescentic Glomerulonephritis with PR3-ANCA Positivity

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Joseph Vercellone ◽  
Lisa Cohen ◽  
Saima Mansuri ◽  
Ping L. Zhang ◽  
Paul S. Kellerman
Keyword(s):  
Crescentic Glomerulonephritis ◽  
Bartonella Henselae ◽  
Kidney Injury ◽  
Flank Pain ◽  
Cat Scratch Disease ◽  
Urinary Sediment ◽  
Appropriate Treatment ◽  
Antibody Titers ◽  
Complex Deposition ◽  
Culture Negative

Bartonella henselae is a fastidious organism that causes cat scratch disease, commonly associated with fever and lymphadenopathy but, in rare instances, also results in culture-negative infectious endocarditis. We describe a patient who presented with flank pain, splenic infarct, and acute kidney injury with an active urinary sediment, initially suspicious for vasculitis, which was subsequently diagnosed as B. henselae endocarditis. Bartonella endocarditis may present with a crescentic glomerulonephritis (GN) and elevated PR3-ANCA antibody titers, mimicking ANCA-associated GN, with 54 cases reported in the literature. Unique to our case in this series is a positive PR3-ANCA antibody despite a negative IIF-ANCA. Thus, the presentation of Bartonella can mimic ANCA-associated GN, and renal biopsy showing immune complex deposition is critical for diagnosis and appropriate treatment.

scholarly journals Bartonella-Associated Endocarditis with Severe Active Crescentic Glomerulonephritis and Acute Renal Failure

2021 ◽  
Vol 2021 ◽  
pp. 1-4
Author(s):  
Ramanath Dukkipati ◽  
Benjamin Lawson ◽  
Cynthia C. Nast ◽  
Anuja Shah
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Aortic Valve ◽  
Immune Complex ◽  
Kidney Failure ◽  
Crescentic Glomerulonephritis ◽  
Kidney Biopsy ◽  
Acute Kidney Failure ◽  
Complex Deposition ◽  
Culture Negative

We report a case of severe acute kidney failure due to crescentic glomerulonephritis who presented initially with culture-negative endocarditis with vegetations on the aortic valve. Anti-nuclear and anti-phospholipid antibodies were positive with initially negative anti-neutrophil cytoplasmic antibodies (ANCAs). Kidney biopsy revealed severe acute crescentic glomerulonephritis with mesangial immune complex deposition. PR3-ANCA subsequently become positive, and the patient developed worsening kidney failure requiring hemodialysis. This case illustrates that Bartonella can present as culture-negative endocarditis with severe crescentic glomerulonephritis with positive PR-3 ANCAs and can mimic ANCA-associated crescentic glomerulonephritis.

scholarly journals Atypical Presentation of Cat-Scratch Disease in an Immunocompetent Child with Serological and Pathological Evidence

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Serkan Atıcı ◽  
Eda Kepenekli Kadayıfcı ◽  
Ayşe Karaaslan ◽  
Muhammed Hasan Toper ◽  
Cigdem Ataizi Celikel ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Early Diagnosis ◽  
Bartonella Henselae ◽  
Atypical Presentation ◽  
Cat Scratch Disease ◽  
Pathological Findings ◽  
Immunocompetent Child ◽  
Hepatic Mass ◽  
Appropriate Treatment

Typical cat-scratch disease (CSD) is characterized by local lymphadenopathy following the scratch or bite from a cat or kitten. An atypical presentation which includes liver and/or spleen lesions is rarely reported in an immunocompetent child. Systemic CSD may mimic more serious disorders like malignancy or tuberculosis. Although a diagnosis is difficult to establish in systemic CSD, an early diagnosis and an appropriate treatment are important to prevent complications.Bartonella henselaeis difficult to culture, and culture is not routinely recommended. Clinical, serological, radiological, and pathological findings are used for the diagnosis of CSD. Herein we present a case of systemic CSD presenting with hepatic mass in an immunocompetent child. The differential diagnosis is made by serological and pathological evidence. He was successfully treated with gentamicin (7.5 mg/kg) and rifampin (15 mg/kg) for six weeks.

scholarly journals Bartonella henselae Antibodies in Serum and Oral Fluid Specimens from Cats

Pathogens ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 329
Author(s):  
Alejandra Álvarez-Fernández ◽  
Marta Baxarias ◽  
David Prandi ◽  
Edward B. Breitschwerdt ◽  
Laia Solano-Gallego
Keyword(s):  
Oral Fluid ◽  
Bartonella Henselae ◽  
Diagnostic Testing ◽  
Serum Antibody ◽  
Reservoir Host ◽  
Cat Scratch Disease ◽  
Antibody Assays ◽  
Antibody Titers ◽  
Kappa Agreement ◽  
Immunofluorescence Antibody

Cats are the primary reservoir host for Bartonella henselae(B. henselae), an etiological agent of human bartonellosis, including cat scratch disease. Although Bartonella DNA has been amplified from salivary swabs from cats, dogs and humans, we are not aware of studies investigating Bartonella antibodies in oral fluid (OF). Using inhouse and commercial immunofluorescence antibody assays (IFA), the objective of this study was to detect and compare antibodies against B. henselae in paired OF and serum specimens from cats. Specimens were collected from shelter and client-owned cats. For serum specimens, B. henselae seroreactivity was 78% for both the inhouse and commercial IFA assays and 56.8% for OF specimens. Comparing serum and OF specimens, there was moderate Kappa agreement (Cohen’s k = 0.434) for detection of B. henselae antibodies. Oral fluid antibodies were more likely measurable in cats with high B. henselae serum antibody titers when compared with low antibody titers. In conclusion, B. henselae OF IFA antibody measurements were less sensitive compared to serum IFA measurements of ≥1:64. Oral fluid antibodies were detected more often in cats with high B. henselae serum antibody titers. Therefore, OF antibodies, detectable by IFA, is of limited utility for epidemiological or diagnostic testing in cats.

scholarly journals Cytomegalovirus in urinary sediment in patients with acute kidney injury

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Sahra Pajenda ◽  
Sebastian Kapps ◽  
Daniela Gerges ◽  
Gregor Hoermann ◽  
Ludwig Wagner ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Renal Allograft ◽  
Quantitative Polymerase Chain Reaction ◽  
Rna Extraction ◽  
Kidney Injury ◽  
Solid Organ ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Urine Sediment ◽  
Urinary Sediment

Abstract Background Immunosuppression in solid organ transplantation is associated with frequent infections. Renal allograft recipients are susceptible to opportunistic infections and can acquire human cytomegalovirus (HCMV) infections even within the allograft. There, HCMV can be found in both the glomerulus and tubular cells, but is mostly restricted to specific and circumscribed sites. Therefore, not all organ infections are identifiable by immunohistology for HCMV proteins in fine needle core biopsies. Thus, we performed a urinalysis study to search for HCMV-specific RNA transcripts in the urine sediment of patients with acute kidney injury. Methods Urinary sediment of 90 patients with acute kidney injury (AKI), including 48 renal transplant recipients (RTX) and 42 non-transplant recipients (nRTX), was collected from morning urine for RNA extraction and reverse transcription. The copy number of HCMV transcripts was evaluated using a UL132 HCMV-specific probe set and by real-time quantitative polymerase chain reaction (RT-qPCR). Results Of the 48 RTX patients, ten showed HCMV copies in their urine sediment cells. Within this group, three recipients had negative HCMV serology and received an allograft from an HCMV-seropositive donor. In addition, all three RTX patients on a belatacept-based immunosuppressive regimen had HCMV transcripts in their urine. Of the 42 nRTX patients, only two had detectable HCMV transcripts in urine sediment cells and both were under immunosuppression. Conclusions Ten immunosuppressed renal allograft recipients and two immunosuppressed non-transplant patients with AKI showed HCMV copies in urine sediment. Thus, HCMV positivity in urinary sediment appears to be associated with immunosuppression. This study describes a novel noninvasive method for detection of HCMV in urinary sediment. Whether all HCMV infections can be detected or only those with viral replication warrants further investigation.

scholarly journals Cervical Cat Scratch Disease Lymphadenitis in a Patient with Immunoglobulin M Antibodies to Toxoplasma gondii

2002 ◽  
Vol 9 (2) ◽  
pp. 496-498
Author(s):  
Mardjan Arvand ◽  
Ilkay Kazak ◽  
Sergije Jovanovic ◽  
Hans-Dieter Foss ◽  
Oliver Liesenfeld
Keyword(s):  
Toxoplasma Gondii ◽  
Clinical Symptoms ◽  
Bartonella Henselae ◽  
Cervical Lymphadenopathy ◽  
Immunoglobulin M ◽  
Cat Scratch Disease ◽  
Specific Immunoglobulin ◽  
Acute Toxoplasmosis

ABSTRACT We report on a young patient with chronic cervical lymphadenopathy and serological and histological evidence for infection with Bartonella henselae and Toxoplasma gondii. Serological follow-up studies, including testing for avidity of Toxoplasma-specific immunoglobulin G antibodies, assisted in the determination of the cause of the acute lymphadenitis. Our results suggest that the clinical symptoms were most likely due to cat scratch disease rather than to acute toxoplasmosis.

Positional Hand Pallor and Isolated Epitrochlear Lymphadenitis Secondary to Bartonella henselae Infection.

2021 ◽  
Vol 20 (4) ◽  
pp. 914-917
Author(s):  
Siti Nuradliah Jamil ◽  
Ilham Ameera Ismail ◽  
Siti Fatimah Badlishah Sham ◽  
Norliana Dalila Mohamad Ali
Keyword(s):  
Lymph Node ◽  
Communicable Disease ◽  
Bartonella Henselae ◽  
Medical Science ◽  
Neck Region ◽  
Rare Condition ◽  
Cat Scratch Disease ◽  
Serological Evidence ◽  
External Compression ◽  
Head And Neck Region

Cat scratch disease is a communicable disease caused by the Bartonella henselae bacteria. Regional lymphadenopathy is the hallmark of cat scratch disease and about 75% of lymphadenopathy cases are localized in the head and neck region. An epitrochlear lymphadenopathy is a rare condition at any age and often misdiagnosed as it is not normally palpable. External compression of an enlarged epitrochlear lymph node compromising vascularity was not mentioned in any literature before. We present a case of a 13-year-old girl with right positional ipsilateral hand pallor and epitrochlear lymphadenitis with serological evidence of Bartonella henselae infection. Bangladesh Journal of Medical Science Vol.20(4) 2021 p.914-917

A Case of Fatal Disseminated Bartonella henselae Infection (Cat-Scratch Disease) With Encephalitis

2007 ◽  
Vol 131 (10) ◽  
pp. 1591-1594
Author(s):  
Brandy Fouch ◽  
Susan Coventry
Keyword(s):  
Bartonella Henselae ◽  
Neurologic Manifestations ◽  
Cat Scratch Disease ◽  
Systemic Dissemination ◽  
Lymphocytic Infiltrates ◽  
The Brain ◽  
Limited Process

Abstract Cat-scratch disease resulting from Bartonella henselae infection is usually a benign, self-limited process in immunocompetent children. Even the rare cases associated with neurologic manifestations are not generally fatal. We report a case of a previously healthy 6-year-old boy with cat-scratch disease, systemic dissemination, and encephalitis that led to his death. Autopsy revealed perivascular lymphocytic infiltrates and microglial nodules in the brain. To our knowledge, this finding has not been previously reported in B henselae infection, possibly because of the paucity of material available for complete neuropathologic evaluation. This case illustrates the extreme severity of the spectrum with which cat-scratch disease can present and provides evidence of brain histopathology that may be representative of the disease.

scholarly journals Bartonella henselae prevalence in domestic cats in California: risk factors and association between bacteremia and antibody titers.

1995 ◽  
Vol 33 (9) ◽  
pp. 2445-2450 ◽  
Author(s):  
B B Chomel ◽  
R C Abbott ◽  
R W Kasten ◽  
K A Floyd-Hawkins ◽  
P H Kass ◽  
...  
Keyword(s):  
Risk Factors ◽  
Bartonella Henselae ◽  
Domestic Cats ◽  
Antibody Titers

scholarly journals Culture-Negative Endocarditis Due to Houston Complex Bartonella henselae Acquired in Noumea, New Caledonia

2004 ◽  
Vol 42 (4) ◽  
pp. 1846-1848 ◽  
Author(s):  
D. Rodrick ◽  
B. Dillon ◽  
M. Dexter ◽  
I. Nicholson ◽  
S. Marcel ◽  
...  
Keyword(s):  
New Caledonia ◽  
Bartonella Henselae ◽  
Culture Negative
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