scholarly journals Synchronous Leydig Cell Tumor and Seminoma in the Ipsilateral Testis

2018 ◽  
Vol 2018 ◽  
pp. 1-4
Author(s):  
Ifeyinwa E. Obiorah ◽  
Alexandra Kyrillos ◽  
Metin Ozdemirli
Keyword(s):  
Leydig Cell ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Testicular Neoplasms ◽  
Therapeutic Management ◽  
Germinal Epithelium ◽  
Testicular Tumors ◽  
Concurrent Development ◽  
Disease Entities ◽  
Leydig Cell Tumors

Leydig cell tumor is a rare sex cord tumor that accounts for 1–3% of all testicular neoplasms. Seminomas are more common and occur in 30–40% of testicular tumors. Leydig cell tumors are derived from undifferentiated gonadal mesenchyme and the concurrent development of the tumor and a seminoma which are derived from germinal epithelium in an ipsilateral testis is extremely rare. Here we report a case of ipsilateral Leydig cell tumor and seminoma occurring in a 38-year-old man with a left testicular mass. The key to diagnosis is dependent on histopathology and immunohistochemistry. To our knowledge, this is the first diagnosis of the two disease entities in a unilateral testis using immunohistochemistry. Increased awareness of the entity is important in order to distinguish Leydig cell tumor and seminomas from other malignancies due to difference in therapeutic management.

Cytologic Identification of Reinke Crystalloids in Scrapings and Imprints of Fresh Testicular Tumors: A Simple and Rapid Technique for Intraoperative Use

2005 ◽  
Vol 129 (3) ◽  
pp. e65-e66 ◽  
Author(s):  
Kambridge P. Hribar ◽  
Nancy E. Warner ◽  
Andy E. Sherrod
Keyword(s):  
Leydig Cell ◽  
Leydig Cells ◽  
Frozen Section ◽  
Rapid Identification ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Testicular Tumors ◽  
Intraoperative Diagnosis ◽  
Rapid Technique ◽  
Leydig Cell Tumors

Abstract Although not required for the diagnosis, crystalloids of Reinke are pathognomonic for Leydig cell tumor. However, conventional frozen section rarely reveals their presence. A method of rapid identification of crystalloids of Reinke could improve the intraoperative diagnosis. We tested the efficacy of touch imprints and scrape smears for the identification of crystalloids in 2 cases of Leydig cell tumor of the testis. Intraoperative smears of the tumors yielded abundant crystals. Scrape cytologic testing was the better method. We speculate that the process of scraping, and to a lesser extent touch imprinting, disrupts the cytoplasm of the Leydig cells and releases the crystalloids. We conclude that cytologic testing is an effective method of identifying crystalloids of Reinke in Leydig cell tumors of the testis.

scholarly journals Tumor de Células de Leydig num Doente com Criptorquidia Contralateral: Uma Associação Rara

2020 ◽  
Vol 33 (13) ◽  
Author(s):  
Ricardo Capitão ◽  
Catarina Saraiva ◽  
Clara Cunha ◽  
Mónica Martins
Keyword(s):  
Leydig Cell ◽  
Previous History ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Timely Manner ◽  
Testicular Tumors ◽  
History Of ◽  
The Right ◽  
Subsequent Improvement ◽  
Leydig Cell Tumors

Gynecomastia is a frequent sign that may be physiological or caused by various benign or malignant diseases. In rare cases, it may be caused by testicular tumors. We describe a case of progressive gynecomastia at age 20 due to a Leydig cell tumor of the right testicle in a patient with a previous history of left-sided cryptorchidism. The patient underwent orchidectomy and testicular prosthesis placement, with subsequent improvement of gynecomastia and normalization of estrogen. Our case, in addition to demonstrating that gynecomastia may regress if the underlying cause is treated in a timely manner, shows that cryptorchidism may be related with the development of Leydig cell tumors in the same way as it is in other testicular tumors.

scholarly journals Retiform Sertoli-Leydig Cell Tumor in a 38-Year-Old Woman: A Case Report, Retrospective Review, and Review of Current Literature

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Laura C. Nwogu ◽  
Josh A. Showalter ◽  
Suvra Roy ◽  
Michael T. Deavers ◽  
Bihong Zhao
Keyword(s):  
Leydig Cell ◽  
Stromal Cells ◽  
Ovarian Neoplasms ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Ovarian Mass ◽  
Immunohistochemical Examination ◽  
Stromal Tumors ◽  
Sex Cord Stromal Tumors ◽  
Leydig Cell Tumors

Ovarian sex cord-stromal tumors arise from the stromal cells that surround and support the oocytes. Sertoli-Leydig cell tumors belong to this category of ovarian neoplasms. We present the case of a 38-year-old woman who was found to have a right ovarian mass. The mass was resected and diagnosed as Stage I Sertoli-Leydig cell tumor, retiform variant, following histopathologic and immunohistochemical examination. This case is unusual given the rarity of the retiform variant of Sertoli-Leydig cell tumor and the atypically older age of 38 years at presentation.

scholarly journals Two Years of Gynecomastia Caused by Leydig Cell Tumor

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Philip Zeuschner ◽  
Christian Veith ◽  
Johannes Linxweiler ◽  
Michael Stöckle ◽  
Julia Heinzelbecker
Keyword(s):  
Leydig Cell ◽  
Incidental Finding ◽  
Small Mass ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Hormonal Status ◽  
Rare Entity ◽  
Endocrine Disturbance ◽  
Leydig Cell Tumors

Gynecomastia is a common incidental finding in males that can be caused by various benign or malignant diseases. In rare cases, it results from Leydig cell tumors, a rare entity accounting for 3% of all testicular neoplasms. Some of them are hormonally active but seldom cause symptomatic endocrine disturbance. Here we report on a 32-year-old male presenting with gynecomastia which he had already been suffering from for two years. Although he had been seen by three other specialists, including a urologist, none of them found the small mass in the upper pole of his right testis. We decided to perform testis-sparing surgery which confirmed the diagnosis of a hormonally active Leydig cell tumor. During follow-up, hormonal status normalized, and gynecomastia began to resolve.

scholarly journals Testicular Leydig Cell Tumor with Metachronous Lesions: Outcomes after Metastasis Resection and Cryoablation

2015 ◽  
Vol 2015 ◽  
pp. 1-4
Author(s):  
Julio J. Geminiani ◽  
Stephen D. Marshall ◽  
Tammy S. Ho ◽  
Steven B. Brandes
Keyword(s):  
Case Report ◽  
Surgical Treatment ◽  
Leydig Cell ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Surgical Pathology ◽  
Radiographic Findings ◽  
Prepubertal Boys ◽  
Chemotherapeutic Treatment ◽  
Leydig Cell Tumors

Leydig cell tumors represent 3% of testicular masses and usually occur in prepubertal boys and men between 30 and 60 years of age. Leydig cell tumors are benign in children but can be malignant in 10% of adults. This case report describes a 41-year-old patient who was diagnosed with a Leydig cell tumor that originated in his right testicle that subsequently metastasized to his liver, lungs, and retroperitoneum. We discuss the patient’s presentation and review the radiographic findings, surgical treatment, surgical pathology, chemotherapeutic treatment, and published literature on this rare pathology.

Metastatic Leydig Cell Tumor With Sarcomatoid Differentiation

1999 ◽  
Vol 123 (11) ◽  
pp. 1104-1107 ◽  
Author(s):  
H. Evin Gulbahce ◽  
Arthur T. Lindeland ◽  
William Engel ◽  
Tamera J. Lillemoe
Keyword(s):  
Leydig Cell ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Fat Tissue ◽  
The Right ◽  
Initial Metastasis ◽  
Leydig Cell Tumors ◽  
Perirenal Fat ◽  
Biphasic Tumor ◽  
Sarcomatoid Differentiation

Abstract Leydig cell tumors of the testis are uncommon. Only about 10% of cases have a malignant course. It has been stated that the only definite criterion for malignancy is presence of metastasis. We present a 47-year-old patient with metastatic Leydig cell tumor 17 years after initial diagnosis, to our knowledge the longest reported interval between diagnosis and the development of metastasis. The primary tumor did not exhibit convincing features of malignancy. The initial metastasis in the right perirenal fat tissue showed a biphasic tumor with sarcomatoid differentiation not described previously in a metastatic Leydig cell tumor.

FOXL2 Mutations in Granulosa Cell Tumors Occurring in Males

2012 ◽  
Vol 136 (7) ◽  
pp. 825-828 ◽  
Author(s):  
Joema F. Lima ◽  
Long Jin ◽  
Ana Rose C. de Araujo ◽  
Michele R. Erikson-Johnson ◽  
Andre M. Oliveira ◽  
...  
Keyword(s):  
Granulosa Cell ◽  
Leydig Cell ◽  
Granulosa Cell Tumor ◽  
Cell Tumor ◽  
Testicular Tumors ◽  
Adult Type ◽  
Male Adult ◽  
Granulosa Cell Tumors ◽  
Juvenile Granulosa Cell Tumor ◽  
Leydig Cell Tumors

Context.—Granulosa cell tumors comprise less than 5% of ovarian tumors in women and are much rarer in men, with only about 20 cases reported, to our knowledge. Recently, a somatic mutation of FOXL2 was reported in virtually all adult-type granulosa cell tumors in women. Objective.—To investigate FOXL2 mutations in granulosa cell tumors occurring in males. Design.—Five cases of an adult-type granulosa cell tumor from males were selected from the files of the Mayo Clinic. Nine other testicular tumors (1 juvenile granulosa cell tumor, 5 Leydig cell tumors, and 3 Sertoli-Leydig cell tumors) were evaluated for comparison. Inhibin immunostain was performed in all cases. DNA was extracted from formalin-fixed, paraffin-embedded tissue, followed by polymerase chain reaction and direct sequencing of FOXL2. Results.—All 5 cases had classic histopathologic features of the adult-type granulosa cell tumor. Inhibin was diffusely positive in all cases. FOXL2 402C→G (C134W) was identified in 40% (2 of 5) of the male, adult-type granulosa cell tumors. Of the 2 tumors positive for the mutation, 1 occurred in the testis of a man, and the other one affected the abdominal ovaries of a phenotypically male patient. All other testicular tumors were negative for the mutation. Conclusions.—The FOXL2 402C→G (C134W) mutation is also present in adult-type granulosa cell tumors occurring in men, although in a smaller proportion when compared with the rates reported in women. FOXL2 mutational analysis can be a helpful in the diagnosis of granulosa cell tumors of the testis.

scholarly journals Leydig cell tumor of testis- a rare case report

2017 ◽  
Vol 4 (11) ◽  
pp. 3795
Author(s):  
Sheetal Arora ◽  
Mukta Pujani ◽  
Deepshikha Rana ◽  
Narendra Chaudhaury
Keyword(s):  
Leydig Cell ◽  
Histopathological Examination ◽  
Young Patients ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Positive Staining ◽  
Historical Series ◽  
Endocrine Profile ◽  
Leydig Cell Tumors

Leydig cell tumors(LCTs) of testis are rare testicular tumors of male gonadal interstitium. Although rare, they are most common sex cord stromal tumors and comprise 1-3 % of all testicular neoplasms. They usually occur in fourth to sixth decade. In young patients, they are mostly benign and in adults it can be malignant in about 10 % cases. The incidence of Leydig cell tumors is gradually increasing every year which might be attributed to increased use of radiological techniques and subsequent early detection of tumors that have not been found in historical series. Here we report a case of benign Leydig cell tumor testis in a 45-year-old male who presented with left sided testicular mass. The patient subsequently underwent high inguinal orchidectomy. Histopathological examination showed benign pure Leydig cell tumor. Serological investigations revealed normal testosterone levels, DHEA and androstenedione levels. Immunohistochemical staining for inhibin showed fine granular cytoplasmic positivity and diffuse positive staining for Melan-A which further confirmed the diagnosis. The endocrine profile and imaging investigations of such patients might be normal and patients can be totally asymptomatic. However periodic follow up of endocrine profile and imaging must be done as many cases have been reported which had deranged endocrine levels and appearance of atypical symptoms even after years of unilateral orchidectomy. Our case also presents with normal hormonal levels, henceforth for a better prognosis we must identify benign LCTs and do long term follow up.

scholarly journals ПАТОМОРФОЛОГІЧНІ ОСОБЛИВОСТІ ЛЕЙДИГОМИ СОБАК

2016 ◽  
Vol 18 (2(66)) ◽  
pp. 217-220
Author(s):  
N.I. Shestiaieva ◽  
Y.V. Osadchuk
Keyword(s):  
Leydig Cell ◽  
Germ Cell Tumors ◽  
Clinical Signs ◽  
Leydig Cell Tumor ◽  
Cell Tumor ◽  
Histological Structure ◽  
Testicular Tumors ◽  
Stromal Tumors ◽  
Eosinophilic Cytoplasm ◽  
Sex Cord Stromal Tumors

The research for the study of morphological, clinical and macroscopic characteristics of the different histological types of canine testicular tumors. Material was obtained during a routine surgery for the removal of testicular tumors in dogs in clinics of veterinary medicine in Kiev. Tumors were divided into sex-cord stromal tumors and germ cell tumors. Among the sex-cord stromal tumors recorded leydig (interstitial) and sertoli cell tumors. Macroscopical and histologic characteristics of canine interstitial (Leydig) cell tumor are described. It is 12.5% of all testicular tumors. The average age of dogs is 9 years. Largest share is breeds dog such as foxterriers and toyterriers. Interstitial (Leydig) cell tumor has a slower growth compared to other tumors the testicle, no metastases. Half the animals had no clinical signs. Mostinterstitial (Leydig) cell tumor go together with the pathology of adnexal structures. This is because Leydig cell tumor lead to increased levels of androgens. This fact may cause pathology of adnexal structures. Neoplasms are recorded both on the right and the left testis. Leydig cell tumor was not related to the cryptorchid testicles. Most tumors regular oval, brown or gray color, different texture and size with no signs of necrosis or ulceration. The average volume of tumors ranged from 2 to 20 cm2. Microscopically, the tumor is composed of cells that resemble Leydig cells and that are arranged into islands or tubular structures. Find polygonal eosinophilic cells with granular or vacuolated, which contains lipids. Nuclei were round mesh of chromatin and distinct nucleolus. Sometimes noted the large cells with 1, 2 or more nucleoli. In some cases, found elongated fusiform cells with small nuclei and granular eosinophilic cytoplasm. Tumor stroma characterized by calcification. Note mitotically active cells. Cysts lined by tumor cells are present in some tumors. Distinction between benign and malignant forms on purely histological criteria, in the absence of metastasis, often is difficult. Studies on the features of histological structure of testicular tumors will optimize the histological diagnosis of neoplasms.

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