scholarly journals Prevalence, Infectivity, and Associated Risk Factors of Hepatitis B Virus among Pregnant Women in Yirgalem Hospital, Ethiopia: Implication of Screening to Control Mother-to-Child Transmission

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Anteneh Amsalu ◽  
Getachew Ferede ◽  
Setegn Eshetie ◽  
Agete Tadewos ◽  
Demissie Assegu
Keyword(s):  
Risk Factors ◽  
Hepatitis B ◽  
Pregnant Women ◽  
Multiple Sexual Partners ◽  
Hiv Coinfection ◽  
B Virus ◽  
History Of ◽  
Hbv Prevention ◽  
Associated Risk Factors ◽  
Prevention Methods

Background. Hepatitis B surface antigen (HBsAg) and hepatitis B e antigen (HBeAg) positive mother has up to 90% likelihood of mother-to-child transmission (MTCT) of hepatitis B virus (HBV) to newborns in the absence of any prophylaxis or antiviral therapy utilization. However, routine antenatal screening and intervention strategies are not yet practiced in Ethiopia. Therefore, this study was conducted to determine the prevalence, infectivity, and associated risk factors of HBV among pregnant women. Methods. A cross-sectional study was conducted from October 2015 to August 2016 in Yirgalem Hospital. A total of 475 pregnant women were recruited, and data on sociodemography and potential risk factors were collected using a structured questionnaire. In addition, blood samples were tested for HBsAg, and HBsAg positive samples were retested for HBeAg using commercially available strip test. The status of HIV was collected from the records. Results. The seroprevalence of HBsAg was 34 (7.2%), of whom 13 (38.8%) were positive for HBeAg. The prevalence of HIV infection was 10.1% (48/475). Ten out of 34 HBV positive cases (29.4%) were coinfected with HIV. The overall HBV/HIV coinfection rate was 2.1% (10/475). Women with history of multiple sexual partners and being HIV positive were significantly associated with HBsAg positivity. Among the study participants, 35.4% were aware of MTCT of HBV and only 12 (2.5%) have taken HBV vaccine. Conclusions. High prevalence of HBsAg and HBeAg as well as low awareness and practices of HBV prevention methods suggests that perinatal transmission of HBV might be the prevailing mode of HBV transmission in the study area. Thus, screening of all pregnant women, particularly those who had history of multiple sexual partners and HIV coinfection, and provision of health education about HBV prevention methods are inevitable.

scholarly journals Seroepidemiology and associated risk factors of hepatitis B and C virus infections among pregnant women attending maternity wards at two hospitals in Swabi, Khyber Pakhtunkhwa, Pakistan

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0255189
Author(s):  
Muhammad Israr ◽  
Fawad Ali ◽  
Arif Nawaz ◽  
Muhammad Idrees ◽  
Aishma Khattak ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Transfusion ◽  
Hepatitis B ◽  
Pregnant Women ◽  
Vertical Transmission ◽  
Educational Level ◽  
Khyber Pakhtunkhwa ◽  
History Of ◽  
Associated Risk Factors ◽  
Pregnant Mothers

Background & aim Hepatitis B and C infections are global issues that are associated with a massive financial burden in developing countries where vertical transmission is the major mode and remains high. This cross-sectional study was designed to investigate the seroepidemiology and associated risk factors of hepatitis B virus (HBV) and hepatitis C virus (HCV) infections among 375 pregnant women attending antenatal care health facilities at Bacha Khan Medical Complex (BKMC) Shahmansoor and District Head Quarter (DHQ) Hospital Swabi, Khyber Pakhtunkhwa, Pakistan. Methodology From a total of 375 pregnant women selected using systematic random sampling from both hospitals, 10 ml of blood samples were collected and alienated serum was examined for indicators identification through the Immuno-Chromatographic Test (ICT) and 3rd Generation Enzyme-Linked Immunosorbent Assay (ELISA). A pre-structured questionnaire was used to collect the socio-demographic data and possible risk factors. The data was analyzed via SPSS 23.0 statistical software. A chi-square analysis was performed to determine the association between variables. P-value < 0.05 was set statistically significant. Results The overall frequency of HBV and HCV among 375 pregnant women involved in the study was 3.7% and 2.1% respectively. None of the pregnant women were co-infected with HBV and HCV. Dental extraction (P = 0.001) and blood transfusion (P = 0.0005) were significantly allied with HBV infection while surgical procedure (P = 0.0001) was significantly associated with HCV infection. Moreover the sociodemographic characteristics: residential status (P = 0.017) and educational level (P = 0.048) were found significant risk factors of HBsAg and maternal age (P = 0.033) of anti-HCV, respectively. Conclusion & recommendation HBV and HCV infections are intermediary endemic in the study area. A higher prevalence of HBV was detected among pregnant mothers with a history of dental extraction, history of blood transfusion, resident to the urban area and low educational level. The age and surgical procedures were the potential risk factors found significantly associated with HCV positivity among pregnant mothers in our setup. Future negotiations to control vertical transmission should include routine antenatal screening for these infections early in pregnancy and the requirement of efficient preventive tools including the birth dose of the hepatitis B vaccine in combination with hepatitis B immune globulins to the neonate.

scholarly journals Risk factors associated with Hepatitis B virus infection among pregnant women attending antenatal clinic at Felegehiwot referral hospital, Northwest Ethiopia, 2018: An institution based cross sectional study

2019 ◽  
Author(s):  
Getnet Gedefaw ◽  
Fikadu Waltengus ◽  
Almaz Akililu ◽  
Kihinetu Gelaye
Keyword(s):  
Risk Factors ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Pregnant Women ◽  
Cross Sectional Study ◽  
Hepatitis B Virus Infection ◽  
Cross Sectional ◽  
B Virus ◽  
History Of

Abstract Objective This study aimed to determine the magnitude of serum HBsAg and the risk factors for Hepatitis B virus infection among pregnant women in Bahir Dar. An institution based cross sectional study was implemented from February 1 to May 1, 2018 among 338 pregnant women attending antenatal care clinic at Felegehiwot referral hospital, Bahir Dar, 2018. Systematic random sampling technique was implemented. Blood sample was taken from 338 study participants and serum was tested for Hepatitis B surface antigen (HBsAg) using Enzyme Linked ImmunoSorbent Assay.Results The overall prevalence of hepatitis B virus infection among pregnant women were 16(4.7%) (95% CI= 2.7, 7.7). Having a history of blood transfusion (AOR=5.2; 95% CI=1.2-22.3), having a history of multiple sexual partners (AOR=4.6; 95% CI=1.1-19.6) and having a history tonsillectomy (traditional surgical procedure) AOR=3.4; 95% CI=1.1-10.1) were the significant risk factors for Hepatitis B virus infection.

Hepatitis B virus infection and associated risk factors among pregnant women attending antenatal care in health facilities of Tigray, Northern Ethiopia

2017 ◽  
Vol 90 (3) ◽  
pp. 503-509 ◽  
Author(s):  
Tadele Araya Mezgebo ◽  
Selam Niguse ◽  
Atsebaha Gebrekidan Kahsay ◽  
Haftamu Hailekiros ◽  
Nega Berhe ◽  
...  
Keyword(s):  
Risk Factors ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Antenatal Care ◽  
Pregnant Women ◽  
Northern Ethiopia ◽  
Hepatitis B Virus Infection ◽  
B Virus ◽  
Associated Risk Factors

scholarly journals Hepatitis B virus infection among pregnant mothers and children after the introduction of the universal vaccination program in Central Vietnam

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Masami Miyakawa ◽  
Lay-Myint Yoshida ◽  
Hien-Anh Thi Nguyen ◽  
Kensuke Takahashi ◽  
Tho Huu Le ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cohort Study ◽  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Pregnant Women ◽  
Hbv Infection ◽  
Birth Cohort Study ◽  
Central Vietnam ◽  
B Virus ◽  
Associated Risk Factors

AbstractA birth cohort study was conducted in Khan Hoa Province, central Vietnam between 2009 and 2012 to determine the seroprevalence of hepatitis B virus (HBV) in pregnant women and their children, and associated risk factors. We enrolled 1987 pregnant women with their babies at the birth phase, and 12.6% (95% confidence interval [CI]: 11.1–14.0) of mothers were hepatitis B surface antigen (HBsAg)+. At 2-year follow-up phase, 1339 (67.4%) children were enrolled of whom 76.6% completed hepatitis B vaccines (HepB) and 1.9% (95% CI: 1.2–2.7) were HBsAg+. When mothers were hepatitis B e antigen (HBeAg)+, 28.3% of children have got infected even with complete HepB. HBV infection in mothers, hepatitis B surface antibody (anti-HBs antibody) below the seroprotective level in children, and mothers with pre-pregnancy low body mass index were associated with HBV infection in children. Meanwhile, HBV infection in children, older maternal age, no or incomplete doses of HepB, and boys were associated with anti-HBs antibody below the seroprotective level in children. Our birth cohort study determined a low rate of congenital HBV infection and associated risk factors in Vietnam, however further studies are needed to advance prevention including anti-viral therapy in pregnant women at high risk.

scholarly journals Risk factors associated with Hepatitis B virus infection among pregnant women attending antenatal clinic at Felegehiwot referral hospital, Northwest Ethiopia, 2018: An institution based cross sectional study

2019 ◽  
Author(s):  
Getnet Gedefaw ◽  
Fikadu Waltengus ◽  
Almaz Akililu ◽  
Kihinetu Gelaye
Keyword(s):  
Risk Factors ◽  
Hepatitis B Virus ◽  
Virus Infection ◽  
Hepatitis B ◽  
Pregnant Women ◽  
Cross Sectional Study ◽  
Hepatitis B Virus Infection ◽  
Cross Sectional ◽  
B Virus ◽  
History Of

Abstract Objective This study aimed to determine the magnitude of serum HBsAg and the risk factors for Hepatitis B virus infection among pregnant women in Bahir Dar. An institution based cross sectional study was implemented from February 1 to May 1, 2018 among 338 pregnant women attending antenatal care clinic at Felegehiwot referral hospital, Bahir Dar, 2018. Systematic random sampling technique was implemented. Blood sample was taken from 338 study participants and serum was tested for Hepatitis B surface antigen (HBsAg) using Enzyme Linked ImmunoSorbent Assay.Results The overall prevalence of hepatitis B virus infection among pregnant women were 16(4.7%) (95% CI= 2.7, 7.7). Having a history of blood transfusion (AOR=5.2; 95% CI=1.2-22.3), having a history of multiple sexual partners (AOR=4.6; 95% CI=1.1-19.6) and having a history tonsillectomy (traditional surgical procedure) AOR=3.4; 95% CI=1.1-10.1) were the significant risk factors for Hepatitis B virus infection.

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