scholarly journals Serum Tumor Necrosis Factor-αand Interferon-γLevels in PediatricMycoplasma pneumoniaePneumonia: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Ying Wang ◽  
Yongsheng Zhang ◽  
Wenting Lu ◽  
Liying Wang
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Meta Analysis ◽  
Random Effect ◽  
Diagnostic Methods ◽  
Cochrane Library ◽  
Significant Heterogeneity ◽  
Healthy Children ◽  
Necrosis Factor ◽  
Serum Tumor Necrosis

Background.Mycoplasma pneumoniaepneumonia (MPP) is one of the most common forms of community-acquired pneumonia in children. The objective of this study was to explore potential changes in levels of serum tumor necrosis factor-α(TNF-α) and interferon-γ(IFN-γ) associated with pediatric MPP.Methods. This protocol has been registered (PROSPERO 2017: CRD42017077979). A literature search was performed in October 2017 using PubMed, Embase, the Cochrane Library, and other Chinese medical databases to identify studies. The meta-analysis was performed using Review Manager 5.3 software. Random-effect models were used to estimate mean differences (MDs) and 95% confidence intervals (CIs) of cytokine levels.Results. Twelve studies were included in the meta-analysis, encompassing 2,422 children with MPP and 454 healthy control children. Serum TNF-αlevels were significantly higher in children with MPP compared with healthy children (MD = 22.5, 95% CI = 13.78–31.22,P<0.00001), and there was significant heterogeneity across studies (I2 = 100%,P<0.00001). Subgroup analyses showed no evidence for a difference in serum TNF-αlevels between children with refractory and nonrefractory MPP. Serum IFN-γlevels did not significantly differ in children with MPP compared with healthy children (MD = 4.83, 95% CI = −3.27–12.93,P=0.24).Conclusions. Our meta-analysis showed that serum TNF-αand IFN-γlevels were significantly elevated and unchanged, respectively, in pediatric MPP. Because infection by different pathogens has variable effects on serum TNF-αand IFN-γlevels, the finding could be helpful in developing novel diagnostic methods.

scholarly journals Association between five types of Tumor Necrosis Factor-α Gene Polymorphism and Hepatocellular Carcinoma Risk: A Meta-Analysis

2020 ◽  
Author(s):  
Citrawati Dyah Kencono Wungu ◽  
Fis Citra Ariyanto ◽  
Gwenny Ichsan Prabowo ◽  
Soetjipto Soetjipto ◽  
Retno Handajani
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Meta Analysis ◽  
Random Effect ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Α ◽  
The Relationship ◽  
Necrosis Factor

Abstract Background: Research focusing on the relationship between five types of tumor necrosis factor-alpha (TNF-α) SNPs and the risk of hepatocellular carcinoma (HCC) were still controversial. Hereby, we performed a meta-analysis to determine the association between TNF-α promoter SNPs: -1031 T/C, -863 C/A, -857 C/T, -308 G/A, and -238 G/A with HCC risk. Methods: We interrogated articles from journal database: PubMed, Pro-Quest, EBSCO, Science Direct, and Springer to determine the relationship between five types of SNPs in TNF-α gene with HCC risk. RevMan 5.3 software was used for analysis in fixed/random effect models. Results: This meta-analysis included 23 potential articles from 2004-2018 with 3,237 HCC cases and 4,843 controls. We found that SNP -863 C/A were associated with a significantly increased HCC risk (A vs C, OR=1.31, 95% CI=1.03-1.67). Similar results were obtained in -857 C/T (TT/CT vs CC, OR=1.31, 95% CI=1.06-1.62), -308 G/A (AA vs GG, OR=3.14, 95% CI=2.06-4.79), and -238 G/A (AA vs GG, OR=3.87, 95% CI=1.32-11.34). While no associations were observed between SNP TNF-α -1031 T/C and HCC risk.Conclusions: The present meta-analysis showed that TNFα SNPs -863C/A, -857 C/T, -308 G/A, and -238 G/A were associated with the risk of HCC.

scholarly journals Association between five types of Tumor Necrosis Factor-α Gene Polymorphism and Hepatocellular Carcinoma Risk: A Meta-Analysis

2020 ◽  
Author(s):  
Citrawati Dyah Kencono Wungu ◽  
Fis Citra Ariyanto ◽  
Gwenny Ichsan Prabowo ◽  
Soetjipto Soetjipto ◽  
Retno Handajani
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Meta Analysis ◽  
Random Effect ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Α ◽  
The Relationship ◽  
Necrosis Factor

Abstract Background: Research focusing on the relationship between five types of tumor necrosis factor-alpha (TNF-α) SNPs and the risk of hepatocellular carcinoma (HCC) were still controversial. Hereby, we performed a meta-analysis to determine the association between TNF-α promoter SNPs: -1031 T/C, -863 C/A, -857 C/T, -308 G/A, and -238 G/A with HCC risk. Methods: We interrogated articles from journal database: PubMed, Pro-Quest, EBSCO, Science Direct, and Springer to determine the relationship between five types of SNPs in TNF-α gene with HCC risk. RevMan 5.3 software was used for analysis in fixed/random effect models. Results: This meta-analysis included 23 potential articles from 2004-2018 with 3,237 HCC cases and 4,843 controls. We found that SNP -863 C/A were associated with a significantly increased HCC risk (A vs C, OR=1.31, 95% CI=1.03-1.67; CA/AA vs CC, OR=1.19, 95% CI=1.03-1.36). Similar results were obtained in -857 C/T (TT/CT vs CC, OR=1.31, 95% CI=1.06-1.62), -308 G/A (G vs A, OR=1.98, 95% CI=1.62-2.42; AA/GA vs GG, OR=1.95, 95% CI=1.53-2.49; GG/GA vs AA, OR=2.52, 95% CI=1.69-3.76; AA vs GG, OR=3.14, 95% CI=2.06-4.79; and GA vs GG, OR=2.07, 95% CI=1.60-2.68), and -238 G/A (A vs G, OR=1.50, 95% CI=1.16-1.94; AA vs GG, OR=3.87, 95% CI=1.32-11.34; GA/GG vs AA, OR=2.67, 95% CI=1.17-6.10). While no associations were observed between SNP TNF-α -1031 T/C and HCC risk. Conclusions: The present meta-analysis showed that TNFα SNPs -863C/A, -857 C/T, -308 G/A, and -238 G/A were associated with the risk of HCC.

scholarly journals Association between five types of Tumor Necrosis Factor-α gene polymorphism and hepatocellular carcinoma risk: a meta-analysis

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Citrawati Dyah Kencono Wungu ◽  
Fis Citra Ariyanto ◽  
Gwenny Ichsan Prabowo ◽  
Soetjipto ◽  
Retno Handajani
Keyword(s):  
Hepatocellular Carcinoma ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Meta Analysis ◽  
Random Effect ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Α ◽  
The Relationship ◽  
Necrosis Factor

Abstract Background Research focusing on the relationship between five types of tumor necrosis factor-alpha (TNF-α) SNPs and the risk of hepatocellular carcinoma (HCC) were still controversial. Hereby, we performed a meta-analysis to determine the association between TNF-α promoter SNPs: -1031 T/C, − 863 C/A, − 857 C/T, − 308 G/A, and − 238 G/A with HCC risk. Methods We interrogated articles from journal database: PubMed, Pro-Quest, EBSCO, Science Direct, and Springer to determine the relationship between five types of SNPs in TNF-α gene with HCC risk. RevMan 5.3 software was used for analysis in fixed/random effect models. Results This meta-analysis included 23 potential articles from 2004 to 2018 with 3237 HCC cases and 4843 controls. We found that SNP − 863 C/A were associated with a significantly increased HCC risk (A vs C, OR = 1.31, 95% CI = 1.03–1.67). Similar results were obtained in − 857 C/T (TT/CT vs CC, OR = 1.31, 95% CI = 1.06–1.62), − 308 G/A (AA vs GG, OR = 3.14, 95% CI = 2.06–4.79), and − 238 G/A (AA vs GG, OR = 3.87, 95% CI = 1.32–11.34). While no associations were observed between SNP TNF-α − 1031 T/C and HCC risk. Conclusions The present meta-analysis showed that TNFα SNPs -863C/A, − 857 C/T, − 308 G/A, and − 238 G/A were associated with the risk of HCC.

scholarly journals Tumor Necrosis Factor-αas a Diagnostic Marker for Neonatal Sepsis: A Meta-Analysis

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Bokun Lv ◽  
Jie Huang ◽  
Haining Yuan ◽  
Wenying Yan ◽  
Guang Hu ◽  
...  
Keyword(s):  
Tumor Necrosis Factor ◽  
Neonatal Sepsis ◽  
Tumor Necrosis ◽  
Late Onset ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Life Threatening ◽  
Study Population ◽  
The Cochrane Library ◽  
Necrosis Factor

Neonatal sepsis (NS) is an important cause of mortality in newborns and life-threatening disorder in infants. The meta-analysis was performed to investigate the diagnosis value of tumor necrosis factor-α(TNF-α) test in NS. Our collectible studies were searched from PUBMED, EMBASE, and the Cochrane Library between March 1994 and August 2013. Accordingly, 347 studies were collected totally, in which 15 articles and 23 trials were selected to study the NS in our meta-analysis. The TNF-αtest showed moderate accuracy of the diagnosis of NS both in early-onset neonatal sepsis (sensitivity = 0.66, specificity = 0.76,Q*= 0.74) and in late-onset neonatal sepsis (sensitivity = 0.68, specificity = 0.89,Q*= 0.87). We also found the northern hemisphere group in the test has higher sensitivity (0.84) and specificity (0.83). A diagnostic OR analysis found that the study population may be the major reason for the heterogeneity. Accordingly, we suggest that TNF-αis also a valuable marker in the diagnosis of NS.

scholarly journals Association of tumor necrosis factor-alpha -308 G/A and -238 G/A polymorphism with diabetic retinopathy: a systematic review and updated meta-analysis.

2020 ◽  
Author(s):  
Wenna Gao ◽  
Ruilin Zhu ◽  
liu yang
Keyword(s):  
Diabetic Retinopathy ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Tumor Necrosis ◽  
Meta Analysis ◽  
Entire Group ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Factor Alpha ◽  
Necrosis Factor

Background: Mounting evidence has suggested tumor necrosis factor-alpha (TNF-α) can promote the development of diabetic retinopathy (DR), and TNF-α gene variants may influence DR risk. However, the results are quite different. Objectives: To comprehensively address this issue, we performed the meta-analysis to evaluate the association of TNF-α-308 G/A and -238 G/A polymorphism with DR. Method: Data were retrieved in a systematic manner and analyzed using STATA Statistical Software. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of associations. Allelic and genotypic comparisons between cases and controls were evaluated. Results: For the TNF-α-308 G/A polymorphism, overall analysis suggested a marginal association with DR [the OR(95%CI) of (GA versus GG), (GA + AA) versus GG, and (A versus G) are 1.21(1.04, 1.41), 1.20(1.03, 1.39), and 1.14(1.01, 1.30), respectively]. And the subgroup analysis indicated an enhanced association among the European population. For the TNF-α-238 G/A polymorphism, there was mild correlation in the entire group [the OR(95%CI) of (GA versus GG) is 1.55(1.14,2.11) ], which was strengthened among the Asian population. Conclusion: The meta-analysis suggested that -308 A and -238 A allele in TNF-α gene potentially increased DR risk and showed a discrepancy in different ethnicities.

Pleural fluid tumor necrosis factor for diagnosis of pleural tuberculosis: A systematic review and meta-analysis

Cytokine ◽  
2021 ◽  
Vol 141 ◽  
pp. 155467
Author(s):  
Ashutosh Nath Aggarwal ◽  
Ritesh Agarwal ◽  
Sahajal Dhooria ◽  
Kuruswamy Thurai Prasad ◽  
Inderpaul Singh Sehgal ◽  
...  
Keyword(s):  
Systematic Review ◽  
Tumor Necrosis Factor ◽  
Pleural Fluid ◽  
Tumor Necrosis ◽  
Meta Analysis ◽  
Pleural Tuberculosis ◽  
Necrosis Factor
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