scholarly journals Rhinogenic Optic Neuritis Caused by Sphenoid Mucocele with Sinusitis

2018 ◽  
Vol 2018 ◽  
pp. 1-4 ◽  
Author(s):  
Sasitorn Siritho ◽  
Weerachai Tantinikorn ◽  
Paithoon Wichiwaniwate ◽  
Krit Pongpirul
Keyword(s):  
General Practice ◽  
Optic Nerve ◽  
Optic Neuritis ◽  
Visual Loss ◽  
Delayed Diagnosis ◽  
Steroid Treatment ◽  
High Dose ◽  
Atypical Presentation ◽  
Retrobulbar Optic Neuritis ◽  
Optic Nerve Compression

A 59-year-old male who presented with a nonspecific headache at the vertex, resembling retrobulbar optic neuritis, was treated as such but did not show any improvement. Although optic nerve compression from sphenoid mucocele was finally discovered, the delayed diagnosis and improper treatment led to a permanent visual loss. Optic neuritis could be caused by a common problem, “mucocele/sinusitis,” but might be easily overlooked in general practice. Rhinogenic optic neuropathy should, therefore, be considered in every case of optic neuritis whenever atypical presentation occurs or is unresponsive to high-dose steroid treatment.

Retrobulbar optic neuritis due to diseases of the posterior sinuses

1927 ◽  
Vol 23 (9) ◽  
pp. 973-973
Author(s):  
N. A. Khristianov
Keyword(s):  
Optic Nerve ◽  
Optic Neuritis ◽  
Circulatory System ◽  
Nerve Lesions ◽  
Retrobulbar Optic Neuritis ◽  
Anatomical Connection

Close anatomical connection between the optic nerve and the posterior nasal appendages and the commonality of their circulatory system explain optic nerve lesions in purulent and catarrhal processes in the posterior sinuses. N.A. Khristianov describes a case of left-sided retrobulbar optic neuritis cured by opening the middle and posterior lattices of the same side, affected by chronic catarrh.

scholarly journals Optic nerve compression in allergic fungal sinusitis

2011 ◽  
Vol 125 (4) ◽  
pp. 381-385 ◽  
Author(s):  
A Thakar ◽  
P Lal ◽  
M Dhiwakar ◽  
S Bahadur
Keyword(s):  
Optic Nerve ◽  
Visual Loss ◽  
Univariate Analysis ◽  
Tertiary Care ◽  
Nerve Compression ◽  
Fungal Sinusitis ◽  
Tertiary Care Centre ◽  
Allergic Fungal Sinusitis ◽  
Urgent Surgery ◽  
Optic Nerve Compression

AbstractObjective:To describe the syndrome of optic nerve involvement in cases of allergic fungal sinusitis.Setting:Academic tertiary care centre.Methods:Analysis of prospectively accrued data for 10 consecutive cases (three bilateral, giving 13 eyes) with visual loss secondary to optic nerve compression, from a total of 70 cases of allergic fungal sinusitis undergoing surgical treatment between June 1997 and May 2007.Results:The mean duration of rhinological symptoms prior to the onset of visual loss was 22 months. At presentation, visual loss ranged from a visual acuity of 6/12 to complete loss of light perception. Bilateral involvement was noted in three of the 10 cases. Urgent surgical decompression with removal of all fungal debris and decompression of the optic nerve resulted in visual recovery in seven of the 13 eyes. On univariate analysis, recovery was less likely in cases with long standing visual loss, and in cases with complete visual loss.Conclusion:Long standing allergic fungal sinusitis may be complicated by visual loss due to compression of the optic nerve. Urgent surgery to clear the sinuses and decompress the optic nerve is successful in reversing visual loss in cases with partial visual loss.

scholarly journals Effects of high dose prednisolone on optic nerve head blood flow in patients with acute optic neuritis

2007 ◽  
Vol 7 (Suppl 2) ◽  
pp. A30
Author(s):  
Hemma Resch ◽  
Günther Weigert ◽  
Gerhard Garhöfer ◽  
Karl Kircher ◽  
Guido T Dorner ◽  
...  
Keyword(s):  
Blood Flow ◽  
Optic Nerve ◽  
Optic Neuritis ◽  
Optic Nerve Head ◽  
High Dose ◽  
Acute Optic Neuritis

scholarly journals MD1003 (High-Dose Pharmaceutical-Grade Biotin) for the Treatment of Chronic Visual Loss Related to Optic Neuritis in Multiple Sclerosis: A Randomized, Double-Blind, Placebo-Controlled Study

CNS Drugs ◽  
2018 ◽  
Vol 32 (7) ◽  
pp. 661-672 ◽  
Author(s):  
Ayman Tourbah ◽  
Olivier Gout ◽  
Alain Vighetto ◽  
Véronique Deburghgraeve ◽  
Jean Pelletier ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optic Neuritis ◽  
Visual Loss ◽  
Controlled Study ◽  
High Dose ◽  
Double Blind ◽  
Double Blind Placebo

scholarly journals Influence of retrobulbar neuritis and papillitis on echographically measured optic nerve diameter

2010 ◽  
Vol 67 (1) ◽  
pp. 32-35 ◽  
Author(s):  
Ivan Stefanovic ◽  
Milos Jovanovic ◽  
Bojana Dacic-Krnjaja ◽  
Dragan Veselinovic ◽  
Predrag Jovanovic
Keyword(s):  
Visual Acuity ◽  
Optic Nerve ◽  
Optic Neuritis ◽  
Significant Negative Correlation ◽  
Optic Disk ◽  
Partial Loss ◽  
Retrobulbar Neuritis ◽  
Optic Nerve Diameter ◽  
Ophthalmologic Examination ◽  
Retrobulbar Optic Neuritis

Background/Aim. Retrobulbar (optic) neuritis is inflammation of the optic nerve that may cause a complete or partial loss of vision. This inflammation can affect a part of the nerve within the eyeball (neuropapillitis) or a part of the nerve behind the eyeball (retrobulbar neuritis). The aim of this study was to establish whether there is a correlation between the diameter of a retrobulbar part of the optic nerve and either visual acuity, prominence of the optic disk (papillitis), or nature of the neuritis (papillitis or retrobulbar). Methods. We tested 23 patients with retrobulbar neuritis and papillitis. In addition to a complete ophthalmologic examination, the diameter of retrobulbar region of the optic nerve was measured by the B-scan method. Following this, the 30-degree test was carried out. Results. We found an increased thickness of the retrobulbar region in 22 patients and different responses to the 30-degree test, as well as a statistically significant negative correlation between the thickness of retrobulbar part of the optic nerve and visual acuity. Conclusion. The retrobulbar part of the optic nerve is thicker in 94% of the patients with retrobulbar neuritis and in all the patients with papillitis. There is a correlation between the reduction of visual acuity and thickening of a retrobulbar part.

scholarly journals Bilateral Syphilitic Optic Neuropathy with Secondary Autoimmune Optic Neuropathy and Poor Visual Outcome

2019 ◽  
Vol 10 (1) ◽  
pp. 81-88 ◽  
Author(s):  
Tanya Kowalski ◽  
Dujon  Fuzzard ◽  
Isla Williams ◽  
Jonathan Darby ◽  
Heather Gwen Mack
Keyword(s):  
Visual Acuity ◽  
Optic Nerve ◽  
Optic Neuropathy ◽  
Nerve Palsy ◽  
Visual Loss ◽  
Visual Outcome ◽  
High Dose ◽  
Optic Nerve Atrophy ◽  
Poor Visual Outcome ◽  
Appropriate Treatment

We describe the case of a 65-year-old man who suffered progressive visual loss despite appropriate treatment of ocular syphilis. Our patient initially presented with a unilateral 6th nerve palsy and associated double vision, which self-resolved over 6 months. His ophthalmic examination was otherwise normal. 12 months after the initial complaint, he represented with dyschromatopsia, reduced visual acuity, tonic pupils, and optic nerve atrophy. He tested positive for syphilis and was admitted for treatment of neurosyphilis with high-dose benzylpenicillin. Despite treatment, at a 4-month review his visual acuity remained poor and progression of optic nerve atrophy was noted alongside the development of bilateral central scotomas. Further testing was congruent with a diagnosis of autoimmune optic retinopathy. We propose this to be secondary to his syphilitic infection. Syphilis is known as the “great mimicker,” and despite being quite treatable, this case highlights ongoing complexity in the diagnosis and management of syphilis, unfortunately with a poor visual outcome.

scholarly journals Matrine protects retinal ganglion cells from apoptosis in experimental optic neuritis

2019 ◽  
Author(s):  
Jian Kang ◽  
Shu-Qing Liu ◽  
Yi-Fan Song ◽  
Meng-Ru Wang ◽  
Yao-Juan Chu ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Optic Nerve ◽  
Optic Neuritis ◽  
Retinal Ganglion Cells ◽  
Ganglion Cells ◽  
Neuronal Damage ◽  
Disease Onset ◽  
High Dose ◽  
Retinal Ganglion ◽  
Autoimmune Encephalomyelitis

Abstract Background: Inflammatory demyelination and axonal injury of the optic nerve are hallmarks of optic neuritis (ON), which often occurs in multiple sclerosis and is a major cause of blindness in young adults. Although a high dose of corticosteroids can promote visual recovery, it cannot prevent permanent neuronal damage. Novel and effective therapies are thus required. Given the recently defined capacity of matrine (MAT), a quinolizidine alkaloid derived from the herb Radix Sophorae flavescens, in immunomodulation and neuroprotection, we tested in this study the effect of matrine on ON in rats with experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis. Results: MAT administration, started at disease onset, significantly suppressed optic nerve infiltration and demyelination, with reduced numbers of Iba1+ macrophages/microglia and CD4+ T cells, compared to those from vehicle-treated rats. Increased expression of neurofilaments, an axon marker, and decreased apoptosis in retinal ganglion cells (RGCs) were also observed after MAT treatment. Conclusions: Taken as a whole, our results demonstrate that MAT attenuated inflammation, demyelination and axonal loss in the optic nerve, and protected RGCs from inflammation-induced cell death. MAT may therefore have potential as a novel treatment for this disease that causes blindness.

WED 143 Chronic relapsing inflammatory optic neuritis (CRION) in the neuroinflammatory clinic

2018 ◽  
Vol 89 (10) ◽  
pp. A16.4-A17
Author(s):  
Cousins Oliver ◽  
Khan Hina ◽  
Harikrishnan Sreedharan
Keyword(s):  
Multiple Sclerosis ◽  
Visual Acuity ◽  
Optic Nerve ◽  
Optic Neuritis ◽  
Visual Loss ◽  
Correct Diagnosis ◽  
Corticosteroid Treatment ◽  
Oligoclonal Bands ◽  
Short Course

CRION is a rare cause of optic neuritis. It is usually bilateral, painful and associated with profound visual loss. Significant response to corticosteroid treatment is typical but relapse is common when treatment is withdrawn. We present 2 cases of possible CRION and discuss the diagnostic and management considerations.Case 1: 50-year-old woman presented with right optic neuritis which spontaneous recovered. A year later she had left painful visual loss which improved with a short course of corticosteroids. MRI neuroaxis revealed left optic nerve enhancement. Non-specific, faint unmatched OCBs were detected. AQP4-IgG was negative. Nine months later she had further visual loss in her left eye. Prednisolone and azathioprine were commenced.Case 2: 55-year-old woman with bilateral, painless visual acuity deterioration over two weeks. Investigations revealed negative anti-aquaporin 4 antibodies (AQP4-IgG), normal MRI of the neuroaxis, negative oligoclonal bands (OCBs) and visual evoked potentials showed bilateral delay. Serum ACE was slightly elevated. She was started on a tapering course of steroids and had significant visual acuity improvement.The diagnosis of CRION involves the exclusion of other causes of optic neuritis, particularly multiple sclerosis (MS), Neuromyelitis Optica (NMO) and sarcoidosis. Correct diagnosis is important as aggressive and long-term immunosuppression is required.

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