scholarly journals Omalizumab for Idiopathic Nonhistaminergic Angioedema: Evidence for Efficacy in 2 Patients

2018 ◽  
Vol 2018 ◽  
pp. 1-3 ◽  
Author(s):  
Enrico Brunetta ◽  
Dana Shiffer ◽  
Marco Folci ◽  
Maria I. S. Achenza ◽  
Francesca Puggioni ◽  
...  
Keyword(s):  
Case Report ◽  
Complete Resolution ◽  
Prophylactic Treatment ◽  
The Other ◽  
Therapeutic Application ◽  
Acquired Angioedema ◽  
Entire Duration ◽  
Determining Factors ◽  
Potential Therapeutic Application ◽  
Time To Relapse

Presently, there is inconclusive evidence regarding the most effective treatment for idiopathic nonhistaminergic acquired angioedema (InH-AAE). Omalizumab may, however, prove to be a promising option. This case report describes two patients who presented with recurrent angioedema attacks, which was refractory to antihistamine therapy. Hence, they were treated with 300 mg omalizumab, every 4 weeks, for a period of 6 months. Both patients had shown a rapid response to the treatment and achieved complete resolution of symptoms without further AE attacks throughout the entire duration of the treatment period. After omalizumab’s suspension, one patient remained symptom free for the following 6 months and the other patient had recurrence of symptoms after 2 months for which he was retreated with omalizumab and once again became symptom free. Although omalizumab seems to be effective as a prophylactic treatment for InH-AAE, the determining factors leading to the differences in time-to-relapse between patients after its suspension remain unclear. Further studies are needed in order to better determine the potential therapeutic application of omalizumab and its role in maintenance therapy.

scholarly journals Russell Body Typhlitis: A Case Report and Literature Review

2021 ◽  
pp. 106689692110082
Author(s):  
Sarah Al-Rawaf ◽  
Salem Alowami ◽  
Robert Riddell ◽  
Asghar Naqvi
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Light Chain ◽  
Plasma Cells ◽  
Gastrointestinal Disease ◽  
English Literature ◽  
The Other ◽  
Tubulovillous Adenoma ◽  
Inflammatory Polyp ◽  
Intracytoplasmic Inclusions

Russell bodies are accumulation of immunoglobulin in plasma cells forming intracytoplasmic inclusions. Russell body colitis is rare with only 3 cases described in the English literature up to date. We report a 78-year-old male with cirrhosis showing prominent cecal infiltration of Russell body containing plasma cells. Plasma cells showed no nuclear atypia or mitoses, and no evidence of light chain restriction. In this article, we report a fourth case of Russell body colitis, that is unique in being localized to the cecum in contrast to the other 3, 1 of which was in an inflammatory polyp in the sigmoid colon, 1 in a rectal tubulovillous adenoma and 1 as part of diffuse gastrointestinal disease. This is therefore the first report of localized Russell body typhlitis, occurring in a cirrhotic patient in whom an adjacent erosion was likely nonsteroidal anti-inflammatory drug-associated, a combination that may have facilitated the formation of Russell bodies.

scholarly journals AZP2006, a new promising treatment for Alzheimer’s and related diseases

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
N. Callizot ◽  
C. Estrella ◽  
S. Burlet ◽  
A. Henriques ◽  
C. Brantis ◽  
...  
Keyword(s):  
Therapeutic Application ◽  
Neuroprotective Effects ◽  
Beneficial Effects ◽  
Potential Therapeutic Application ◽  
Promising Treatment ◽  
Central Synapses ◽  
First Time ◽  
Pgrn Level

AbstractProgranulin (PGRN) is a protein with multiple functions including the regulation of neuroinflammation, neuronal survival, neurite and synapsis growth. Although the mechanisms of action of PGRN are currently unknown, its potential therapeutic application in treating neurodegenerative diseases is huge. Thus, strategies to increase PGRN levels in patients could provide an effective treatment. In the present study, we investigated the effects of AZP2006, a lysotropic molecule now in phase 2a clinical trial in Progressive Supranuclear Palsy patients, for its ability to increase PGRN level and promote neuroprotection. We showed for the first time the in vitro and in vivo neuroprotective effects of AZP2006 in neurons injured with Aβ1–42 and in two different pathological animal models of Alzheimer’s disease (AD) and aging. Thus, the chronic treatment with AZP2006 was shown to reduce the loss of central synapses and neurons but also to dramatically decrease the massive neuroinflammation associated with the animal pathology. A deeper investigation showed that the beneficial effects of AZP2006 were associated with PGRN production. Also, AZP2006 binds to PSAP (the cofactor of PGRN) and inhibits TLR9 receptors normally responsible for proinflammation when activated. Altogether, these results showed the high potential of AZP2006 as a new putative treatment for AD and related diseases.

scholarly journals A New Methodology to Study Street Accessibility: A Case Study of Avila (Spain)

2021 ◽  
Vol 10 (7) ◽  
pp. 491
Author(s):  
Manuel Curado ◽  
Rocio Rodriguez ◽  
Manuel Jimenez ◽  
Leandro Tortosa ◽  
Jose F. Vicent
Keyword(s):  
Network Analysis ◽  
The Other ◽  
Centrality Measures ◽  
Innovative Behavior ◽  
Street Network ◽  
Commercial Activity ◽  
Determining Factors ◽  
Combine Network ◽  
The City

Taking into account that accessibility is one of the most strategic and determining factors in economic models and that accessibility and tourism affect each other, we can say that the study and improvement of one of them involved the development of the other. Using network analysis, this study presents an algorithm for labeling the difficulty of the streets of a city using different accessibility parameters. We combine network structure and accessibility factors to explore the association between innovative behavior within the street network, and the relationships with the commercial activity in a city. Finally, we present a case study of the city of Avila, locating the most inaccessible areas of the city using centrality measures and analyzing the effects, in terms of accessibility, on the commerce and services of the city.

scholarly journals Scrotal hematoma as a sign of adrenal hemorrhage in newborns

2011 ◽  
Vol 129 (2) ◽  
pp. 113-115 ◽  
Author(s):  
Renata Gonçalves ◽  
Allan Abuabara ◽  
Rubia Fatima Fuzza Abuabara ◽  
Claudia Aparecida Feron
Keyword(s):  
Case Report ◽  
Inguinal Hernia ◽  
Conservative Treatment ◽  
Complete Resolution ◽  
Testicular Tumor ◽  
Adrenal Hemorrhage ◽  
Meconium Peritonitis ◽  
Scrotal Hematoma ◽  
Bluish Discoloration

CONTEXT: Bluish discoloration and swelling of the scrotum in newborns can arise from a number of diseases, including torsion of the testes, orchitis, scrotal or testicular edema, hydrocele, inguinal hernia, meconium peritonitis, hematocele, testicular tumor and traumatic hematoma. Forty-two cases of scrotal abnormalities as signs of neonatal adrenal hemorrhage were found in the literature. CASE REPORT: We present a case of scrotal hematoma due to adrenal hemorrhage in a newborn. Conservative treatment with clinical follow-up was adopted, with complete resolution within 10 days. The possible differential diagnoses are reviewed and discussed.

Spontaneous cervical surgical emphysema following childbirth

2007 ◽  
Vol 121 (12) ◽  
Author(s):  
S Mylvaganam ◽  
C G L Hobbs
Keyword(s):  
Case Report ◽  
Complete Resolution ◽  
Post Partum ◽  
Neck Swelling ◽  
First Case ◽  
Increased Risk ◽  
Surgical Emphysema

AbstractObjective:We report a case of post-partum surgical cervical emphysema, which is a rare but well recognised complication of labour. By reporting the first case in the ENT literature, we aim to raise awareness of this complication, particularly amongst trainees, to ensure that patients are managed most appropriately.Case report:A 36-year-old, primigravida woman developed neck swelling and odynophagia post-partum. Surgical cervical emphysema was palpated, with further examination excluding pneumomediastinum and pneumothorax. The patient was managed conservatively, with complete resolution of symptoms within a week.Conclusions:Surgical cervical emphysema, pneumothorax and pneumomediastinum are all well recognised post-partum complications. The vast majority of cases do not present with respiratory or cardiac compromise and can be appropriately managed conservatively, with expectation of resolution in a fortnight. There is no evidence that such patients are at increased risk during subsequent pregnancies.

scholarly journals A Giant Cell Fibroma and Focal Fibrous Hyperplasia in a Young Child: A Case Report

2012 ◽  
Vol 2012 ◽  
pp. 1-5 ◽  
Author(s):  
Rodney J. Vergotine
Keyword(s):  
African American ◽  
Case Report ◽  
Young Child ◽  
Giant Cell ◽  
Clinical Impact ◽  
The Other ◽  
African American Female ◽  
Distinct Entity ◽  
Anterior Maxilla ◽  
Attached Gingiva

A case of two fibrotic lesions of the oral mucosa in a 17-month-old African-American female is reported. Both lesions occurred on the anterior maxilla, one lesion pedunculated on the buccal attached gingiva and the other lesion sessile on the palate. Histological examination characterized the buccal lesion as focal fibrous hyperplasia (FFH) and the palatal lesion as a giant cell fibroma (GCF). A case is made for continuing the consideration of GCF as a histologically distinct entity from FFH but that no difference in clinical impact between the two lesions exists.

A new immunomodulating compound (AS-101) with potential therapeutic application

Nature ◽  
1987 ◽  
Vol 330 (6144) ◽  
pp. 173-176 ◽  
Author(s):  
B. Sredni ◽  
R. R. Caspi ◽  
A. Klein ◽  
Y. Kalechman ◽  
Y. Danziger ◽  
...  
Keyword(s):  
Therapeutic Application ◽  
Potential Therapeutic Application ◽  
Immunomodulating Compound

Metabolic Alkalosis Secondary to Baking Soda Treatment of a Diaper Rash

PEDIATRICS ◽  
1981 ◽  
Vol 67 (6) ◽  
pp. 820-822
Author(s):  
Jose Gonzalez ◽  
Ronald J. Hogg
Keyword(s):  
Case Report ◽  
Side Effects ◽  
Sodium Bicarbonate ◽  
Complete Resolution ◽  
Metabolic Alkalosis ◽  
Acid Base ◽  
Prior Application ◽  
Acid Base Disturbance ◽  
Base Disturbance

A 4-month-old infant was seen with hypokalemic metabolic alkalosis that was associated with prior application of liberal amounts of sodium bicarbonate (baking soda) to a diaper rash. After exclusion of other etiologies of the infant's acid-base disturbance, a complete resolution occurred following discontinuation of the baking soda applications. This case report provides a reminder of the significant side effects that may result from the excessive use of a seemingly harmless household substance.

Letters to the Editor

PEDIATRICS ◽  
1967 ◽  
Vol 39 (5) ◽  
pp. 792-792
Author(s):  
C. Bozic
Keyword(s):  
Case Report ◽  
Respiratory Tract ◽  
Blood Supply ◽  
Left Lung ◽  
The Other ◽  
Letters To The Editor ◽  
Direct Communication ◽  
Inferior Lobe ◽  
Other Hand

I have read with interest Doctors Adams' and El-Salawy's comments on my case report identified in their letter as the "Lausanne baby." I do think that the "Lausanne baby" represents a case of pulmonary vascular sequestration inasmuch as the inferior lobe of the left lung received its blood supply by means of three arterial branches coming off directly from the aorta. On the other hand, I do not think that the "Lausanne baby" is a case of pulmonary parenchymal sequestration and this because the inferior lobe of the left lung was proven to be, at least to my satisfaction, in direct communication with the remainder of the respiratory tract.

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