scholarly journals Undifferentiated Pleomorphic Sarcoma of Liver: Case Report and Review of the Literature

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Jirong (Betty) Mass ◽  
Geoffrey Talmon
Keyword(s):  
Spindle Cell ◽  
Primary Malignancy ◽  
Ct Guided ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Spindle Cell Neoplasm ◽  
Pleomorphic Sarcoma ◽  
Positron Emission ◽  
Medication Side ◽  
Liver Biopsies ◽  
Immunohistochemical Studies

Undifferentiated pleomorphic sarcoma (UPS), previously known as malignant fibrous histiocytoma (MFH), is rarely reported in the liver as a primary site. We report a case of a previously healthy 56-year-old male, who presented with abdominal pain and jaundice. The patient was originally diagnosed with cholecystitis, treated with cholecystectomy, which was complicated by abdominal abscess. One week following discharge, the patient was readmitted with fever, chills, and leukocytosis. Computed tomography (CT) guided liver biopsies demonstrated an epithelioid to spindle cell neoplasm with markedly atypical nuclei and prominent necrosis infiltrating between hepatocytes. Immunohistochemical studies were negative for epithelial, melanocytic, and hematolymphoid differentiation. Positron emission tomography (PET) was performed, which showed a single markedly hypermetabolic central hepatic mass (14 x 8.5 x 8.5 cm) with likely central necrosis, consistent with primary malignancy. The patient was treated with one cycle of chemotherapy (doxorubicin and ifosfamide), refusing additional cycle due to medication side effects. The patient subsequently succumbed to complications associated with the malignancy and died within 19 days of diagnosis.

scholarly journals Retroperitoneal pelvic schwannoma in pregnancy: a case report

2017 ◽  
Vol 6 (8) ◽  
pp. 3689 ◽  
Author(s):  
Nithya J. ◽  
Banumathy M. ◽  
Radha A.
Keyword(s):  
Spindle Cell ◽  
Surgical Excision ◽  
Needle Aspiration ◽  
Nerve Sheath Tumor ◽  
Ct Guided ◽  
Spindle Cell Neoplasm ◽  
Complete Surgical Excision ◽  
S 100 ◽  
Needle Aspiration Cytology ◽  
In Pregnancy

Solitary nerve sheath tumor such as Benign schwannomas arising in the pelvic retro peritoneum is infrequently reported. Retroperitoneal location accounts for 0.3-3.2% of primary schwannomas. We report a case of benign retroperitoneal pelvic schwannoma in pregnancy that was incidentally diagnosed when it presented with Preterm premature rupture of membranes and mechanical obstruction for labour. She underwent caesarean section and delivered a healthy baby. She was evaluated in the postoperative period by computerized tomography (CT) imaging studies and CT guided fine needle aspiration cytology (FNAC) was not diagnostic. Complete surgical excision of the tumor was achieved in the postpartum period. The adjacent vascular and urinary channels sustained no injuries and she had no neurologic deficit. Histology revealed spindle cell neoplasm composed of interlacing fascicles and sheets of spindle cell with focal areas of nuclear palisading and thick walled blood vessels. Immunohistochemistry was positive for S 100 suggesting schwannoma. Retroperitoneal location of schwannomas is rare and surgery is curative. Prognosis is good, since recurrence is rare. 

Stereotactic body radiation therapy (SBRT) in the management of pulmonary spindle cell carcinoma

2020 ◽  
Vol 13 (4) ◽  
pp. e234779 ◽  
Author(s):  
Moyosore D Awobajo ◽  
Ara A Vaporciyan ◽  
Charles Lu ◽  
Saumil J Gandhi
Keyword(s):  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Stereotactic Body Radiation Therapy ◽  
Spindle Cell ◽  
Primary Tumour ◽  
Spindle Cell Carcinoma ◽  
Ct Guided ◽  
Stereotactic Body Radiation ◽  
Positron Emission ◽  
The Right

A 69-year-old woman underwent routine screening with CT scan of the chest, which showed a new right upper lobe lesion. Interval increase in size of the right upper lobe nodule over 3 months, prompted a CT-guided biopsy of the lung that confirmed a diagnosis of malignant pulmonary spindle cell carcinoma (PSCC) with 90% programmed death ligand 1 expression. Positron emission tomography CT demonstrated localised stage IIA disease. Given histologically proven PSCC and the rapid growth of her tumour, curative radiation with stereotactic body radiation therapy (SBRT) to the right upper lobe primary tumour was planned as patient was deemed not to be a surgical candidate. Repeat imaging with a CT chest 2 months after SBRT demonstrated good local control of the primary disease in the right upper lobe despite rapidly advancing distant metastasis. The patient continues systemic therapy with pembrolizumab, to which she has shown good response.

scholarly journals Solitary Fibrous Tumor of the Kidney: A Case Report

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
Abdullah Demirtaş ◽  
Volkan Sabur ◽  
Hülya Akgün ◽  
Emre Can Akınsal ◽  
Deniz Demirci
Keyword(s):  
Solitary Fibrous Tumor ◽  
Cystic Lesion ◽  
Spindle Cell ◽  
Left Kidney ◽  
Ki 67 ◽  
Spindle Cell Neoplasm ◽  
Cell Neoplasm ◽  
Fibrous Tumor ◽  
Immunohistochemical Studies ◽  
Hmb 45

Solitary fibrous tumor is a spindle cell neoplasm mostly originating from pleura; however, it has also recently been reported to be extrapleural. A 57-year-old man presented with left lumbal pain. Ultrasonography and computed tomography showed a cystic lesion of 14 × 11 cm with solid areas and septations in middle and lower poles of the left kidney. Radical nephrectomy was performed. Immunohistochemical studies showed strong reactions with CD34 and CD99. A nuclear positivity with Ki-67 was observed in less than 1% of cells. Despite repeated stainings with vimentin, no clear tumor evaluation could be made due to artifacts. The tumor was negative with Bcl-2, desmin, HMB-45, S100, FVIII, and CD31. Histopathological and molecular studies made the diagnosis of a solitary fibrous tumor. The patient is now currently free of disease at the 26th month of followup.

scholarly journals Inflammatory Undifferentiated Pleomorphic Sarcoma Mimicking Bacteremia in an Elderly Patient: A Case Report

Medicina ◽  
2021 ◽  
Vol 57 (2) ◽  
pp. 175
Author(s):  
Kazuhiko Hashimoto ◽  
Shunji Nishimura ◽  
Tomohiko Ito ◽  
Naohiro Oka ◽  
Masao Akagi
Keyword(s):  
Soft Tissue Sarcomas ◽  
Standardized Uptake Value ◽  
Unknown Origin ◽  
Major Type ◽  
Wide Margin ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Reactive Protein ◽  
Pleomorphic Sarcoma ◽  
Positron Emission ◽  
Sources Of Infection

Undifferentiated pleomorphic sarcoma (UPS) is major type of soft tissue sarcomas. UPS presenting with inflammation is rare, and its pathophysiology remains unclear. Herein, we report a rare case of UPS with prolonged fever. A 91-year-old female complaining of high fever was referred to our hospital because of a high C-reactive protein (CRP) level of 12.51 mg/dL. She had been experiencing intermittent fevers for approximately 10 years. The fever of unknown origin worsened with time and went into remission with repeated antimicrobial therapy. She also had a mass on her central lower back over the sacral region for 6 years, which showed a gradual increase in size. The blood tests showed that the leukocyte count and neutrophils were 6.51 × 103 /µL and 70.3%, respectively. She had a 10 × 10 cm mass on her buttock that showed 2-[fluorine-18] fluoro-2-deoxy-d-glucose (FDG) accumulation on FDG-positron emission tomography-computed tomography examination (standardized uptake value-max value: 5.4). A blood culture examination was performed to rule out bacteremia, however, no bacteria were identified. We then performed a needle biopsy and confirmed the diagnosis of UPS; subsequently, the patient underwent a wide-margin resection. A few days after the surgery, her CRP, leukocyte, and neutrophil levels decreased to 0.305 mg/dL, 2.83 × 103/uL, and 50.1%, respectively. This case demonstrated that UPS with inflammation should be treated surgically as soon as possible after ruling out other sources of infection to achieve a favorable prognosis.

scholarly journals Successful Multidisciplinary Treatment for Aggressive Primary Pulmonary Undifferentiated Pleomorphic Sarcoma

2020 ◽  
Vol 13 (1) ◽  
pp. 385-391 ◽  
Author(s):  
Mitsunori Higuchi ◽  
Hitoshi Yamada ◽  
Kakeru Machino ◽  
Ikuro Oshibe ◽  
Nobutoshi Soeta ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Multidisciplinary Treatment ◽  
Stage Iv ◽  
Resected Specimen ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Pleomorphic Sarcoma ◽  
18F Fluorodeoxyglucose ◽  
Positron Emission ◽  
Left Upper Lobectomy ◽  
Almost All

Undifferentiated pleomorphic sarcoma (UPS) was previously known as malignant fibrous histiocytoma (MFH). This sarcoma occurs preferentially in the extremities and retroperitoneal space; primary pulmonary UPS/MFH is rare. We report a 52-year-old woman referred to our hospital with dyspnea and severe cough. Chest computed tomography (CT) revealed a pulmonary mass in the left upper lobe and pleural effusion. Cytology of the effusion showed no malignancy; however, the tumor increased rapidly in size, and the patient’s respiratory symptoms worsened. The tumor occupied almost all of the left upper lobe and involved the adjacent pericardium. She underwent left upper lobectomy with pericardial resection and reconstruction. Postoperative pathology of the resected specimen showed undifferentiated pulmonary sarcoma, pT4N0M1a stage IV A, and genetic analyses revealed the v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation. The patient’s dyspnea recurred 1 month postoperatively, and CT showed marked pleural effusion. An 18F-fluorodeoxyglucose positron emission tomography demonstrated abnormal diffuse accumulation of 18F-fluorodeoxyglucose in the left pleural cavity. We initiated five cycles of chemotherapy with doxorubicin and ifosfamide, and the patient has been well without recurrence for 24 months after multidisciplinary treatment with surgery followed by systemic combination chemotherapy. We successfully treated our patient with primary pulmonary UPS/MFH using a multidisciplinary approach, even though this sarcoma carries a poor prognosis and is insensitive to both chemotherapy and radiotherapy.

scholarly journals A Rare Solitary Fibrous Tumour of Kidney

2013 ◽  
Vol 52 (190) ◽  
Author(s):  
Tilak Bahadur Pathak ◽  
Umesh Nepal
Keyword(s):  
Renal Cell Carcinoma ◽  
Renal Pelvis ◽  
Spindle Cell ◽  
Pleural Cavity ◽  
Solitary Fibrous Tumour ◽  
Solid Mass ◽  
Spindle Cell Neoplasm ◽  
Published Report ◽  
Cell Neoplasm ◽  
Immunohistochemical Studies

A solitary fibrous tumour (SFT) is an unusual spindle cell neoplasm. It frequently arises from the serosal surface of pleural cavity but has recently been described in diverse extrapleural sites. Urogenital localization is rare and only 36 cases of SFTs of the kidney have been described on published report.  We report a case of a large SFT clinically and radiologically thought to be renal cell carcinoma arising in the kidney of a 30- year-old female. The radical nephrectomy was performed. The tumour was a well- circumscribed, solid mass attached to the renal pelvis without necrosis and haemorrhage. Histopathologically, a spindle cell neoplasia with alternating hypo and hypercellular areas, storiform, fascicular and hemangipericytoma- like growth pattern and less cellular dense collagen deposits were observed. Immunohistochemical studies revealed reactivity for CD34, CD99 and Bcl-2 protein. 

Undifferentiated Pleomorphic Sarcoma of Lower Extremity

2017 ◽  
Vol 4 (2) ◽  
pp. 102-104
Author(s):  
Sunil Vitthalrao Jagtap ◽  
◽  
Cyrus Dara Jokhi ◽  
Swati S Jagtap ◽  
Ritvij Patankar ◽  
...  
Keyword(s):  
Lower Extremity ◽  
Undifferentiated Pleomorphic Sarcoma ◽  
Pleomorphic Sarcoma
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