scholarly journals Prevalence and Clinical Characteristics of Probable REM Behavior Disorder in Thai Parkinson’s Disease Patients

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Patama Gomutbutra ◽  
Kittika Kanjanaratanakorn ◽  
Nantaporn Tiyapun
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Orthostatic Hypotension ◽  
Clinical Characteristics ◽  
Demographic Data ◽  
Multivariable Analysis ◽  
Behavior Disorder ◽  
Rem Behavior Disorder ◽  
Sleep Questionnaire ◽  
Significant Difference

Background. Previous studies have shown that Parkinson’s disease (PD) patients who have REM behavior disorder (PD with RBD) might be a PD subtype since they have different symptom clusters and disease trajectories from PD without RBD. Objective. To study the prevalence of PD with pRBD and to compare the clinical characteristics with PD without pRBD. The feasibility of clinical interview of items adopted from the Mayo Sleep Questionnaire was also to be determined. Methods. A total of 140 Parkinson's patients visiting neurological clinics during January to December 2016 were enrolled in this study. “Probable RBD (pRBD)” was defined as present when the patient answered “yes” to a question adapted from the first Mayo Sleep Questionnaire (MSQ). The demographic data, motor symptoms, and nonmotor symptoms were obtained. Results. The prevalence of pRBD among this study’s PD patients was 48.5% (68 out of the total of 140). The median onset of RBD before PD diagnosis was 5 years (range: 0–11 years). By comparison of PD with pRBD and PD without pRBD, this study showed significant difference in the levodopa equivalent dose (742 mg/day versus 566 mg/day; p<0.01), prevalence of symptomatic orthostatic hypotension (35.3% versus 8.3%; p<0.01). The multivariable analysis found that pRBD is independently associated with orthostatic hypotension (OR = 5.02, p<0.01). Conclusion. The findings regarding prevalence and main clinical features of PD with pRBD in this study were similar to those of a previous study of PD with polysomnogram- (PSG-) proven RBD. This study hypothesized that interviewing by adopted MSQ may be a cost-effective tool for screening RBD. Further studies with direct comparison are needed.

Lower vascular tone and larger plasma volume in Parkinson's disease with orthostatic hypotension

2011 ◽  
Vol 111 (2) ◽  
pp. 443-448 ◽  
Author(s):  
J. T. Groothuis ◽  
R. A. J. Esselink ◽  
J. P. H. Seeger ◽  
M. J. H. van Aalst ◽  
M. T. E. Hopman ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Blood Flow ◽  
Orthostatic Hypotension ◽  
Vascular Resistance ◽  
Plasma Volume ◽  
Venous Pressure ◽  
Dilution Method ◽  
Significant Difference ◽  
Head Up Tilt

The pathophysiology of orthostatic hypotension in Parkinson's disease (PD) is incompletely understood. The primary focus has thus far been on failure of the baroreflex, a central mediated vasoconstrictor mechanism. Here, we test the role of two other possible factors: 1) a reduced peripheral vasoconstriction (which may contribute because PD includes a generalized sympathetic denervation); and 2) an inadequate plasma volume (which may explain why plasma volume expansion can manage orthostatic hypotension in PD). We included 11 PD patients with orthostatic hypotension (PD + OH), 14 PD patients without orthostatic hypotension (PD − OH), and 15 age-matched healthy controls. Leg blood flow was examined using duplex ultrasound during 60° head-up tilt. Leg vascular resistance was calculated as the arterial-venous pressure gradient divided by blood flow. In a subset of 9 PD + OH, 9 PD − OH, and 8 controls, plasma volume was determined by indicator dilution method with radiolabeled albumin (125I-HSA). The basal leg vascular resistance was significantly lower in PD + OH (0.7 ± 0.3 mmHg·ml−1·min) compared with PD − OH (1.3 ± 0.6 mmHg·ml−1·min, P < 0.01) and controls (1.3 ± 0.5 mmHg·ml−1·min, P < 0.01). Leg vascular resistance increased significantly during 60° head-up tilt with no significant difference between the groups. Plasma volume was significantly larger in PD + OH (3,869 ± 265 ml) compared with PD − OH (3,123 ± 377 ml, P < 0.01) and controls (3,204 ± 537 ml, P < 0.01). These results indicate that PD + OH have a lower basal leg vascular resistance in combination with a larger plasma volume compared with PD − OH and controls. Despite the increase in leg vascular resistance during 60° head-up tilt, PD + OH are unable to maintain their blood pressure.

Rivastigmine as alternative treatment for refractory REM behavior disorder in Parkinson's disease

2012 ◽  
Vol 27 (4) ◽  
pp. 559-561 ◽  
Author(s):  
Raffaella Di Giacopo ◽  
Alfonso Fasano ◽  
Davide Quaranta ◽  
Giacomo Della Marca ◽  
Francesco Bove ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Alternative Treatment ◽  
Behavior Disorder ◽  
Rem Behavior Disorder

Sleep enactment behaviors in Parkinson’s disease and multiple system atrophy: Beyond rem behavior disorder

2013 ◽  
Vol 14 ◽  
pp. e34-e35
Author(s):  
P. Ratti ◽  
M. Sierra-Peña ◽  
J. Bastin ◽  
R. Manni ◽  
M. Simonetta-Moreau ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Multiple System Atrophy ◽  
Behavior Disorder ◽  
Rem Behavior Disorder

REM behavior disorder, hallucinations and cognitive impairment in Parkinson's disease: A two-year follow up

2008 ◽  
Vol 23 (10) ◽  
pp. 1441-1445 ◽  
Author(s):  
Elena Sinforiani ◽  
Claudio Pacchetti ◽  
Roberta Zangaglia ◽  
Chiara Pasotti ◽  
Raffaele Manni ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Impairment ◽  
Behavior Disorder ◽  
Rem Behavior Disorder

S21.3 Rivastigmine treatment for REM behavior disorder in Parkinson's disease (PD)

2011 ◽  
Vol 122 ◽  
pp. S48-S49
Author(s):  
R. Di Giacopo ◽  
P. Mariotti ◽  
G. Della Marca ◽  
D. Quaranta ◽  
A. Bentivoglio
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Behavior Disorder ◽  
Rem Behavior Disorder

scholarly journals Odor Identification Test in Idiopathic REM-Behavior Disorder and Parkinson's Disease in China

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0160199 ◽  
Author(s):  
Si-Fei Huang ◽  
Kui Chen ◽  
Jian-Jun Wu ◽  
Feng-Tao Liu ◽  
Jue Zhao ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Behavior Disorder ◽  
Odor Identification ◽  
Rem Behavior Disorder ◽  
Identification Test

scholarly journals 0304 Do Parkinson’s Disease Patients with Probable REM Behavior Disorder Report Poorer Sleep Quality than Patients without Probable REM Behavior Disorder?

SLEEP ◽  
2019 ◽  
Vol 42 (Supplement_1) ◽  
pp. A124-A124
Author(s):  
Jonathan Trout ◽  
Taylor Christiansen ◽  
Ariel Escobar ◽  
M Brooks Bulkley ◽  
Jared J Tanner ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Sleep Quality ◽  
Behavior Disorder ◽  
Rem Behavior Disorder
Sign in / Sign up

Export Citation Format

Share Document