scholarly journals Association of Urinary Sodium Excretion with Vascular Damage: A Local Kidney Effect, Rather Than a Marker of Generalized Vascular Impairment

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Areti Triantafyllou ◽  
Panagiota Anyfanti ◽  
Eugenia Gkaliagkousi ◽  
Xenophon Zabulis ◽  
Anastasios Vamvakis ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Arterial Stiffness ◽  
Sodium Excretion ◽  
Salt Intake ◽  
Augmentation Index ◽  
Urinary Sodium Excretion ◽  
Capillary Density ◽  
Organ Damage ◽  
Salt Consumption ◽  
Ambulatory Bp Monitoring

Evidence suggests that increased salt consumption induces blood pressure- (BP) mediated organ damage, yet it remains unclear whether it reflects a generalized micro- and macrovascular malfunction independent of BP. We studied 197 newly diagnosed and never-treated individuals with hypertension, intermediate hypertensive phenotypes, and normal BP, classified by use of 24-hour ambulatory BP monitoring. Sodium excretion and microalbuminuria were estimated in 24-hour urine samples, dermal capillary density was estimated from capillaroscopy, and arterial stiffness was estimated with pulse wave velocity (PWV) and augmentation index (AIx). Sodium excretion correlated with microalbuminuria (p<0.001) and 24-hour and day- and nighttime systolic BP, but not with office blood pressure, arterial stiffness, or capillary density. In the multivariate analysis, the association with microalbuminuria was maintained (p=0.007). In a population free from the long-standing effects of hypertension, increased salt intake appears to be associated with early signs of vascular kidney damage, rather than a diffuse micro- and macrovascular impairment.

Blood pressure variability in relation to 24-hour urinary sodium excretion in high salt intake polish population

2015 ◽  
Vol 9 (4) ◽  
pp. e72
Author(s):  
Katarzyna Stolarz-Skrzypek ◽  
Adam Bednarski ◽  
Grzegorz Kiełbasa ◽  
Malgorzata Kloch-Badelek ◽  
Danuta Czarnecka
Keyword(s):  
Blood Pressure ◽  
Sodium Excretion ◽  
Blood Pressure Variability ◽  
Salt Intake ◽  
Urinary Sodium Excretion ◽  
Urinary Sodium ◽  
High Salt ◽  
Polish Population ◽  
High Salt Intake

scholarly journals The Impact of High Dietary Sodium Consumption on Blood Pressure Variability in Healthy, Young Adults

2020 ◽  
Vol 33 (5) ◽  
pp. 422-429 ◽  
Author(s):  
Kamila U Migdal ◽  
Matthew C Babcock ◽  
Austin T Robinson ◽  
Joseph C Watso ◽  
Megan M Wenner ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Blood Pressure Variability ◽  
Salt Intake ◽  
Secondary Analysis ◽  
Organ Damage ◽  
Healthy Adults ◽  
Dietary Sodium ◽  
High Sodium ◽  
Ambulatory Bp Monitoring ◽  
The Impact

Abstract BACKGROUND High sodium (Na+) intake augments blood pressure variability (BPV) in normotensive rodents, without changes in resting blood pressure (BP). Augmented BPV is associated with end-organ damage and cardiovascular morbidity. It is unknown if changes in dietary Na+ influence BPV in humans. We tested the hypothesis that high Na+ feeding would augment BPV in healthy adults. METHODS Twenty-one participants (10 F/11 M; 26 ± 5 years; BP: 113 ± 11/62 ± 7 mm Hg) underwent a randomized, controlled feeding study that consisted of 10 days of low (2.6 g/day), medium (6.0 g/day), and high (18.0 g/day) salt diets. On the ninth day of each diet, 24-h urine samples were collected and BPV was calculated from 24-h ambulatory BP monitoring. On the tenth day, in-laboratory beat-to-beat BPV was calculated during 10 min of rest. Serum electrolytes were assessed. We calculated average real variability (ARV) and standard deviation (SD) as metrics of BPV. As a secondary analysis, we calculated central BPV from the 24-h ambulatory BP monitoring. RESULTS 24-h urinary Na+ excretion (low = 41 ± 24, medium = 97 ± 43, high = 265 ± 92 mmol/24 h, P &lt; 0.01) and serum Na+ (low = 140.0 ± 2.1, medium = 140.7 ± 2.7, high = 141.7 ± 2.5 mmol/l, P = 0.009) increased with greater salt intake. 24-h ambulatory ARV (systolic BP ARV: low = 9.5 ± 1.7, medium = 9.5 ± 1.2, high = 10.0 ± 1.9 mm Hg, P = 0.37) and beat-to-beat ARV (systolic BP ARV: low = 2.1 ± 0.6, medium = 2.0 ± 0.4, high = 2.2 ± 0.8 mm Hg, P = 0.46) were not different. 24-h ambulatory SD (systolic BP: P = 0.29) and beat-to-beat SD (systolic BP: P = 0.47) were not different. There was a trend for a main effect of the diet (P = 0.08) for 24-h ambulatory central systolic BPV. CONCLUSIONS Ten days of high sodium feeding does not augment peripheral BPV in healthy, adults. CLINICAL TRIALS REGISTRATION NCT02881515.

scholarly journals Patients With Primary Aldosteronism Respond to Unilateral Adrenalectomy With Long-Term Reduction in Salt Intake

2019 ◽  
Vol 105 (3) ◽  
pp. e484-e493
Author(s):  
Christian Adolf ◽  
Daniel A Heinrich ◽  
Finn Holler ◽  
Benjamin Lechner ◽  
Nina Nirschl ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Primary Aldosteronism ◽  
Sodium Excretion ◽  
Salt Intake ◽  
Urinary Sodium Excretion ◽  
Urinary Sodium ◽  
Care Hospital ◽  
Unilateral Adrenalectomy ◽  
The Impact

Abstract Context High dietary salt intake is known to aggravate arterial hypertension. This effect could be of particular relevance in the setting of primary aldosteronism (PA), which is associated with cardiovascular damage independent of blood pressure levels. The aim of this study was to determine the impact of therapy on salt intake in PA patients. Patients and Methods A total of 148 consecutive PA patients (66 with unilateral and 82 with bilateral PA) from the database of the German Conn’s Registry were included. Salt intake was quantified by 24-hour urinary sodium excretion before and after initiation of PA treatment. Study design Observational longitudinal cohort study. Setting Tertiary care hospital. Results At baseline, unilateral PA patients had a significantly higher urinary sodium excretion than patients with bilateral disease (205 vs 178 mmol/d, P = 0.047). Higher urinary sodium excretion correlated with an increased cardiovascular risk profile including proteinuria, impaired lipid, and glucose metabolism and was associated with higher daily doses of antihypertensive drugs to achieve blood pressure control. In unilateral disease, urinary sodium excretion dropped spontaneously to 176 mmol/d (P = 0.012) 1 year after unilateral adrenalectomy and remained low at 3 years of follow-up (174 mmol/d). In contrast, treatment with mineralocorticoid receptor antagonists (MRA) in bilateral PA patients was not associated with a significant change in urinary sodium excretion at follow-up (179 mmol/d vs 183 mmol/d). Conclusion PA patients consuming a high-salt diet, estimated based on urinary sodium excretion, respond to adrenalectomy with a significant reduction of salt intake, in contrast to MRA treatment.

scholarly journals Knowledge and behaviors regarding salt intake according to urinary Na excretion and blood pressure

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
T Silva-Santos ◽  
P Moreira ◽  
P Padrão ◽  
S Abreu ◽  
O Pinho ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Sodium Excretion ◽  
Salt Intake ◽  
Disease Risk ◽  
Salt Content ◽  
Urinary Sodium Excretion ◽  
Processed Foods ◽  
Salt Reduction ◽  
High Salt Intake ◽  
And Behaviors

Abstract Background Understanding salt-related knowledge, attitudes and behaviors can help the design of effective health interventions. Therefore, our objective was to describe knowledge and behaviors related to salt intake according to urinary sodium excretion and blood pressure in University workers. Methods We performed our study in a subsample of the participants of the iMC Salt project (n = 60 subjects, 60.5% women, mean age 48±9.5 years). Sodium excretion were measured by one 24-h urinary collection, validated by creatinine excretion and participants were grouped according to the WHO sodium recommendations (&lt;2.0 g/day; high, ≥2.0 g/day). Subjects were classified as hypertensive if the systolic blood pressure was ≥130 mmHg and/or diastolic blood pressure was ≥80mmHg. Knowledge and behaviors regarding salt intake were assessed by the WHO Stepwise Approach to Chronic Disease Risk Factor Surveillance. Results About 74.6% of the participants reported that reducing salt in their diet was very important and 93.2% think that salt is harmful to health. However, 76.3% always add salt during cooking, 42.4% said that they always or often consume processed foods high in salt, 79.7% reported that they don't look at the salt on food labels, 50.8% don't buy low salt alternatives and 30.5% don't use spices as one substitute for salt when cooking. Hypertensive subjects had a higher mean sodium excretion (3710±1508mg/day vs 2478±871mg/day, p = 0.002) and reported a significant higher frequency of consumption of processed foods high in salt (53.1% vs 29.6%, p = 0.024). No significant differences were found with the other variables. Conclusions Most university workers were aware that high salt intake can cause health problems, but they reported low adherence to behaviors to control their salt intake. Hypertensive subjects recognized that frequently consume processed foods high in salt, so reduce salt content on those products could have important impact on their daily salt consumption. Key messages This study provides evidence on knowledge and behaviors regarding salt intake to guide salt reduction policies. Hypertensive participants reported a higher frequency of eating processed foods rich in salt.

scholarly journals An Assessment of Usual Salt Intake among Older Normotensive Adults in Atonsu, a Suburb of Kumasi in the Ashanti Region of Ghana

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Rufai Safianu ◽  
Jacob Plange-Rhule
Keyword(s):  
Blood Pressure ◽  
Informed Consent ◽  
Diastolic Blood Pressure ◽  
Sodium Excretion ◽  
Salt Intake ◽  
Urinary Sodium Excretion ◽  
The Body ◽  
Urinary Sodium ◽  
Ashanti Region ◽  
Urinary Potassium

Background. Globally, sodium intake has been found to be far above the normal level required by the body. Within countries, variations in salt intake exist between rural communities and urban communities. Experimental and epidemiological studies as well as studies involving clinical trials show the existence of adverse effect of salt consumption on the blood pressure of adults. The study evaluated salt intake among older normotensive adults in Atonsu, a suburb of Kumasi in the Ashanti region of Ghana. Methods. Participants were randomly selected from five churches which constituted cluster samples. A questionnaire was administered to participants for demographic information and dietary and lifestyle assessments. The study targeted 100 participants, twenty from each of the five churches. Eighty-two individuals gave their informed consent. Out of the 82 who gave their informed consent, 15 withdrew and 67 completed the course. The 67 participants comprised 36 (53.7%) men and 31 (46.3%) women. Systolic and diastolic blood pressure, BMI, urinary sodium, urinary potassium, serum creatinine, serum sodium, and serum potassium concentrations were also measured. Results. Participants’ mean age was 52.3 ± 8.7 years. Participants had 24 hr urinary sodium excretion of 153.0 ± 26.9 mmol/day. All participants indicated that they consume foods high in salt even though none of them added salt to their diet at table. Mean 24 hr urinary potassium was 52.5 ± 12.9 mmol/day. Mean systolic blood pressure was 119.9 ± 10.8 mmHg and mean diastolic blood pressure was 72.5 ± 7.3 mmHg. Their mean BMI was 23.7 ± 3.5 kg/m2. Conclusion. The participants who can be described as quite old and normotensive were high salt consumers, indicated by their dietary assessment and urinary sodium excretion, even though they had normal blood pressure.

scholarly journals Knowledge, Attitudes, and Behavior Towards Salt Intake and Association With 24-hour Urinary Sodium Excretion in an Adult Population Cohort in Uruguay

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1062-1062
Author(s):  
Paula Moliterno ◽  
Carmen Marino Donangelo ◽  
Luciana Borgarello ◽  
Alicia Olascoaga ◽  
José Boggia
Keyword(s):  
Blood Pressure ◽  
Sodium Excretion ◽  
Salt Intake ◽  
Adult Population ◽  
Urinary Sodium Excretion ◽  
Urinary Sodium ◽  
Attitudes And Behaviors ◽  
And Behaviors ◽  
And Behavior ◽  
Attitudes And Behavior

Abstract Objectives To examine the association between knowledge, attitudes and behavior towards salt use and its consumption estimated by urinary sodium excretion in a population adult cohort from Uruguay (Genotype Phenotype and Environment of Hypertension Study - GEFA-HT-UY). Methods Participants [n = 243; age 18–89y (min-max); 61.9% women], provided a single 24-hour urine sample validated according to volume and creatinine excretion. A questionnaire describing knowledge, attitudes and behaviors (KAB) was adapted from the WHO/PAHO protocol for population level sodium determination where participants answered on a range of scales. Anthropometric and blood pressure measurements were also taken. Associations between KAB categories and estimated salt intake were examined by general linear models, adjusted for sex, age tertiles and body mass index (BMI) categories. Results Considering all participants, 35.8% were hypertensive (77% on antihypertensive treatment). Systolic/diastolic blood pressure was 125.6 ± 23.4/79.7 ± 9.9 mmHg, with no difference between sexes. Estimated salt intake was 7.8 ± 3.6 g (3116 ± 1433 mg sodium), higher in men (8.9 ± 3.9 g) compared to women (7.3 ± 3.3 g) (P = 0.0013). Salt intake decreased with age tertiles (P = 0.0001), and increased with BMI categories (P = 0.0067). The majority (88.5%) of participants acknowledge that a high salt diet may cause serious health problems, 92.2% were unaware of WHO salt intake recommendation (&lt;5 g/d) and 78.6% had intake over that limit. Only 12.4% considered they consumed “too much salt”. Although 74.7% reported that limiting salt intake was important for their health, only 56% reported taking regular actions to control its intake. No difference in salt intake was found between participants who considered they use salt “too much” (8.5 ± 0.62 g), “the right amount” (7.9 ± 0.28 g), or “too little” (7.6 ± 0.52 g) (P = 0.56). However, those who reported following a healthy diet had 1.4g lower salt intake than those who reported not doing so (P = 0.016). There was no difference in salt intake between those who reported using/not using salt when cooking (P = 0.65), and adding/not adding salt to food at table (P = 0.087). Conclusions No associations were found between knowledge, attitudes and behaviors towards salt use and intake. Perceived salt consumption underestimated salt intake. Funding Sources CSIC, ANII, Uruguay.

scholarly journals The Effect of Dietary Sodium Restriction on Vascular Stiffness in Hypertension

2020 ◽  
Author(s):  
Henrique Cotchi Simbo Muela ◽  
Mujimbi José Viana ◽  
António Gerson Bastos Francisco ◽  
Isaura da Conceição Almeida Lopes ◽  
Valeria Aparecida Costa-Hong
Keyword(s):  
Blood Pressure ◽  
Risk Factor ◽  
Arterial Stiffness ◽  
Cardiovascular Events ◽  
Sodium Intake ◽  
Target Organ Damage ◽  
Organ Damage ◽  
Target Organ ◽  
Dietary Sodium ◽  
Salt Consumption

Increased salt consumption is believed to induce high blood pressure (BP)-mediated organ damage, although it is not yet clear whether it reflects a generalized micro- and macrovascular malfunction independent of BP. Exceeding dietary sodium intake is acknowledged to be the main modifiable environmental risk factor for cardiovascular events that accounts for an increase in blood pressure and induces hypertension (HTN)-related target organ damage. Arterial stiffness is well known as an independent cardiovascular risk factor, and sodium intake may be a determinant of arterial stiffness. Even so, the studies that investigated the effect of dietary sodium reduction intake on arterial stiffness in humans provided inconclusive results. Therefore, we aim to perform a review of the available evidence of salt restriction and arterial stiffness and its impact on hypertensive patients.

Estimation of salt intake of normotensive subjects of Jaipur City

2016 ◽  
Vol 46 (6) ◽  
pp. 766-777 ◽  
Author(s):  
Sonal Dhemla ◽  
Kanika Varma
Keyword(s):  
Blood Pressure ◽  
Sodium Excretion ◽  
Salt Intake ◽  
Sodium Intake ◽  
Urinary Sodium Excretion ◽  
Small Sample ◽  
Urinary Sodium ◽  
Content Type ◽  
Males And Females ◽  
Jaipur City

Purpose There has been a dramatic increase in hypertension in developing countries along with changes in food consumption patterns contributing to higher levels of sodium. Evidence shows that a high level of sodium intake is a major cause of high blood pressure and other heart diseases along with other associated diseases. Therefore, it is important to determine current consumption levels of sodium in a population to facilitate the development and implementation of any specific salt reduction program. Design/methodology/approach The study was conducted among 60 subjects (25-45 years) residing in Jaipur City. Subjects’ sodium consumption levels were assessed via assessment of 24-h urinary sodium excretion levels, the “gold standard” method advocated by WHO/PAHO (2010) and 24-h dietary recall for three days including one holiday. Findings The findings of the study indicated that the subjects were found to be consuming higher levels of sodium (males, 5,792 mg/d; females, 5,911 mg/d) than recommended by WHO, i.e. less than 2,300 mg/d. Completeness of urine was confirmed by fat-free mass determined by electrical bio-impedance (47.6 ± 7.6 kg) and determined by using 24-h urinary excretion of creatinine (33.7 ± 10.1 kg). Two variables were found to be significantly correlated (r = 0.52, p = 0.00). Assuming that the sodium eliminated in the urine comes from the salt only, this excretion would correspond with a dietary salt intake of 14.71 and 15.01 g/d in males and females, respectively. Dietary sodium intake was reported to be 4,133 ± 1,111 mg/day and 3,953 ± 945 mg/d in males and females, respectively. A non-significant difference was found between the two variables. Urinary sodium excretion correlated non-significantly with systolic and diastolic blood pressure figures (r = 0.09 and r = −0.02, respectively). Research limitations/implications The limitations of this study included the small sample size. Purposive sampling was adopted due to difficulty in obtaining urine sample and required willingness of the respondent. This may give fair robust estimate. Originality/value The present results will help provide new data about the baseline salt intake in young and middle-aged population of Jaipur City and will further help the concerned agencies to plan meaningful strategies to reduce salt intake, and it must involve public education and awareness to change the consumption pattern.

Prevalence, Biochemical and Clinical Characteristics of Resistant Hypertension

2018 ◽  
Vol 69 (10) ◽  
pp. 2845-2849
Author(s):  
Daniela Gurgus ◽  
Elena Ardeleanu ◽  
Carmen Gadau ◽  
Roxana Folescu ◽  
Ioan Tilea ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Resistant Hypertension ◽  
Clinical Characteristics ◽  
Salt Intake ◽  
Target Organ Damage ◽  
Multivariate Logistic Regression Analysis ◽  
Organ Damage ◽  
Left Ventricular ◽  
High Salt Intake

The objectives of the present study were to evaluate the prevalence of resistant hypertension (RH) in primary care setting and to analyse its biochemical and clinical characteristics. After 3 months of treatment and evaluation, 721 (14.01%) of 5,146 patients with hypertension did not reach target office blood pressure of [ 140/90 mmHg. After exclusion of �white-coat effect� with ambulatory blood pressure, of secondary and pseudo- resistant hypertension, prevalence of RH was 6.74%. Lifestyle factors associated with RH were physical inactivity, obesity, high salt intake, smoking and excessive alcohol ingestion. Compared to controlled hypertension, RH patients presented higher incidence of family history of cardiovascular disease (38.90% vs 25.94%), diabetes mellitus (34.87% vs 19.01%), impaired fasting glucose (21.91% vs 19.07%), target organ damage (29.1% vs 15.95%), and cardiovascular disease (27.09% vs 17.06%). Dyslipidaemia (52.90% vs 42.03%), fasting plasma glucose (116.10�38.9 vs 107.80�37.2), HbA1c (6.41�1.42 vs 5.96�0.94), serum creatinine (1.09�0.27 vs 1.03�0.24) and microalbuminuria (21.90% vs 10.95%) were significantly higher in RH. Predictors of RH, determined by a multivariate logistic regression analysis were left ventricular hypertrophy (OD 2.14, 95% CI 1.32-3.69), renal impairment expressed as eGFR [ 60 ml/min/1.73m2 (OD 1.62, 95% CI 1.21-2.21) and the presence of cardiovascular disease (OD 1.48, 95% CI 1.02-2.16).

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