scholarly journals Response to: Comment on “Role of Mitochondrial Genome Mutations in Pathogenesis of Carotid Atherosclerosis”

2018 ◽  
Vol 2018 ◽  
pp. 1-3 ◽  
Author(s):  
Igor A. Sobenin ◽  
Margarita A. Sazonova ◽  
Vasily V. Sinyov ◽  
Anastasia I. Ryzhkova ◽  
Elena V. Galitsyna ◽  
...  
Keyword(s):  
Mitochondrial Genome ◽  
Carotid Atherosclerosis

scholarly journals Role of Mitochondrial Genome Mutations in Pathogenesis of Carotid Atherosclerosis

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Margarita A. Sazonova ◽  
Vasily V. Sinyov ◽  
Anastasia I. Ryzhkova ◽  
Elena V. Galitsyna ◽  
Zukhra B. Khasanova ◽  
...  
Keyword(s):  
Mitochondrial Genome ◽  
Carotid Atherosclerosis ◽  
Nuclear Dna ◽  
Nucleotide Substitutions ◽  
Single Nucleotide ◽  
Atherosclerotic Lesions ◽  
Dna Mutations ◽  
Blood Leukocyte ◽  
Study Participants

Mutations of mtDNA, due to their higher frequency of occurrence compared to nuclear DNA mutations, are the most promising biomarkers for assessing predisposition of the occurrence and development of atherogenesis. The aim of the present article was an analysis of correlation of several mitochondrial genome mutations with carotid atherosclerosis. Leukocytes from blood of study participants from Moscow polyclinics were used as research material. The sample size was 700 people. The sample members were diagnosed with “atherosclerosis” on the basis of ultrasonographic examination and biochemical and molecular cell tests. DNA was isolated from blood leukocyte samples of the study participants. PCR fragments of DNA, containing the region of 11 investigated mutations, were pyrosequenced. The heteroplasmy level of these mutations was detected. Statistical analysis of the obtained results was performed using the software package SPSS 22.0. According to the obtained results, an association of mutations m.652delG, m.3336C>T, m.12315G>A, m.14459G>A m.15059G>A with carotid atherosclerosis was found. These mutations can be biomarkers for assessing predisposition to this disease. Additionally, two single nucleotide substitutions (m.13513G>A and m.14846G>A), negatively correlating with atherosclerotic lesions, were detected. These mutations may be potential candidates for gene therapy of atherosclerosis and its risk factors.

Using serum biomarkers for identifying unstable carotid plaque: update of current evidence

2020 ◽  
Vol 26 ◽  
Author(s):  
Areti Sofogianni ◽  
Konstantinos Tziomalos ◽  
Triantafyllia Koletsa ◽  
Apostolos G. Pitoulias ◽  
Lemonia Skoura ◽  
...  
Keyword(s):  
High Risk ◽  
Great Proportion ◽  
Current Literature ◽  
Early Identification ◽  
Carotid Plaque ◽  
Potential Role ◽  
Carotid Atherosclerosis ◽  
Serum Biomarkers ◽  
Current Evidence

: Carotid atherosclerosis is responsible for a great proportion of ischemic strokes. Early identification of unstable or vulnerable carotid plaques and therefore of patients at high risk for stroke is of significant medical and socioeconomical value. We reviewed the current literature and discuss the potential role of the most important serum biomarkers in identifying patients with carotid atherosclerosis who are at high risk for atheroembolic stroke.

A ROLE OF TRYGLICERIDES IN THE GENESIS OF CAROTID ATHEROSCLEROSIS IN PATIENTS WITH NORMALISED ARTERIAL HYPERTENSION: PP.2.64

2010 ◽  
Vol 28 ◽  
pp. e66
Author(s):  
F Capasso ◽  
M DʼAvino ◽  
A Ilardi ◽  
U Valentino ◽  
G Caruso ◽  
...  
Keyword(s):  
Arterial Hypertension ◽  
Carotid Atherosclerosis

scholarly journals Role of HCV infection in the development of carotid atherosclerosis in a cohort of HIV-infected patients

2010 ◽  
Vol 13 (Suppl 4) ◽  
pp. P204
Author(s):  
S Ferrara ◽  
A Tartaglia ◽  
T Santantonio ◽  
B Grisorio
Keyword(s):  
Carotid Atherosclerosis ◽  
Hcv Infection

scholarly journals Quality of Life in Carotid Atherosclerosis: The Role of Co-morbid Mood Disorders

2016 ◽  
Vol 12 (1) ◽  
pp. 1-8 ◽  
Author(s):  
Maria Lecca ◽  
Luca Saba ◽  
Roberto Sanfilippo ◽  
Elisa Pintus ◽  
Michela Cadoni ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Central Nervous System ◽  
Nervous System ◽  
Mood Disorders ◽  
Carotid Atherosclerosis ◽  
Short Form ◽  
The Central Nervous System ◽  
Dsm Iv

Introduction/Objective: To study in severe carotid atherosclerosis (CA): the frequency of mood disorders (MD); the impairment of quality of life (QoL); the role of co-morbid MD in such impairment. Methods: Case-control study. Cases: consecutive in-patients with CA (stenosis ≥ 50%). Controls: subjects with no diagnosis of CA randomized from a database of a community survey. Psychiatric diagnosis according to DSM-IV made by clinicians and semi-structured interview, QoL measured by the Short Form Health Survey (SF-12). Results: This is the first study on comorbidity on CA disease and MD in which psychiatric diagnoses are conducted by clinicians according to DSM-IV diagnostic criteria. Major Depressive Disorder (MDD) (17.4% vs 2.72%, P <0.0001) but not Bipolar Disorders (BD) (4.3% vs 0.5%, P = 0.99) was higher in cases (N=46) than in controls (N= 184). SF-12 scores in cases were lower than in controls (30.56±8.12 vs 36.81±6:40; p <0.001) with QoL comparable to serious chronic diseases of the central nervous system. The burden of a concomitant MDD or BD amplifies QoL impairment. Conclusion: Comorbid MD aggravates the impairment of QoL in CA. Unlike autoimmune diseases or degenerative diseases of the Central Nervous System, CA shows a strong risk of MDD than BD.

The Role of Carotid Atherosclerosis in Alzheimer's Disease Progression

2011 ◽  
Vol 25 (4) ◽  
pp. 719-726 ◽  
Author(s):  
Mauro Silvestrini ◽  
Giovanna Viticchi ◽  
Lorenzo Falsetti ◽  
Clotilde Balucani ◽  
Fabrizio Vernieri ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Progression ◽  
Carotid Atherosclerosis
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