scholarly journals Electrochemical Determination of Paracetamol Using Fe3O4/Reduced Graphene-Oxide-Based Electrode

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
Nguyen Thi Anh Thu ◽  
Hoang Van Duc ◽  
Nguyen Hai Phong ◽  
Nguyen Duc Cuong ◽  
Nguyen Thi Vuong Hoan ◽  
...  

The synthesis of magnetic iron oxide/reduced graphene oxide (Fe3O4/rGO) and its application to the electrochemical determination of paracetamol using Fe3O4/rGO modified electrode were demonstrated. The obtained materials were characterized by means of X-ray diffraction (XRD), nitrogen adsorption/desorption isotherms, X-ray photoelectron spectroscopy (XPS), transmission electron microscope (TEM), Fourier transform infrared spectroscopy (FTIR), and magnetic measurement. The results showed that Fe3O4/rGO composite exhibited high specific surface area, and its morphology consists of very fine spherical particles of Fe3O4 in nanoscales. Fe3O4/rGO was used as an electrode modifier for the determination of paracetamol by differential pulse-anodic stripping voltammetry (DP-ASV). The preparation of Fe3O4/rGO-based electrode and some factors affecting voltammetric responses were investigated. The results showed that Fe3O4/rGO is a potential electrode modifier for paracetamol detection by DP-ASV with a low limit of detection. The interfering effect of uric acid, ascorbic acid, and dopamine on the current response of paracetamol has been reported. The repeatability, reproducibility, linear range, and limit of detection were also addressed. The proposed method could be applied to the real samples with satisfactory results.

2020 ◽  
Vol 187 (5) ◽  
Author(s):  
Jagriti Sethi ◽  
Michiel Van Bulck ◽  
Ahmed Suhail ◽  
Mina Safarzadeh ◽  
Ana Perez-Castillo ◽  
...  

AbstractA label-free biosensor is developed for the determination of plasma-based Aβ1–42 biomarker in Alzheimer’s disease (AD). The platform is based on highly conductive dual-layer of graphene and electrochemically reduced graphene oxide (rGO). The modification of dual-layer with 1-pyrenebutyric acid N-hydroxysuccinimide ester (Pyr-NHS) is achieved to facilitate immobilization of H31L21 antibody. The effect of these modifications were studied with morphological, spectral and electrochemical techniques. The response of the biosensor was evaluated using differential pulse voltammetry (DPV). The data was acquired at a working potential of ~ 180 mV and a scan rate of 50 mV s−1. A low limit of detection (LOD) of 2.398 pM is achieved over a wide linear range from 11 pM to 55 nM. The biosensor exhibits excellent specificity over Aβ1–40 and ApoE ε4 interfering species. Thus, it provides a viable tool for electrochemical determination of Aβ1–42. Spiked human and mice plasmas were used for the successful validation of the sensing platform in bio-fluidic samples. The results obtained from mice plasma analysis concurred with the immunohistochemistry (IHC) and magnetic resonance imaging (MRI) data obtained from brain analysis.


2017 ◽  
Vol 164 (7) ◽  
pp. H503-H508 ◽  
Author(s):  
Paramasivam Balasubramanian ◽  
Balamurugan Thirumalraj ◽  
Shen-Ming Chen ◽  
Palani Barathi

2018 ◽  
Vol 5 (5) ◽  
pp. 1145-1155 ◽  
Author(s):  
Thangavelu Kokulnathan ◽  
Subramanian Sakthinathan ◽  
Shen-Ming Chen ◽  
Raj Karthik ◽  
Te-Wei Chiu

The RGO/[Co(NH3)6]3+/GCE modified GCE was potentially applied for the electrochemical detection of MR.


2019 ◽  
Vol 52 (16) ◽  
pp. 2583-2606 ◽  
Author(s):  
Livia Alexandra Gugoasa ◽  
Raluca-Ioana Stefan-van Staden ◽  
Jacobus Frederick van Staden ◽  
Maria Coroș ◽  
Stela Pruneanu

Sign in / Sign up

Export Citation Format

Share Document