scholarly journals Neuronal Specificity of Acupuncture in Alzheimer’s Disease and Mild Cognitive Impairment Patients: A Functional MRI Study

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Yi Shan ◽  
Jing-Juan Wang ◽  
Zhi-Qun Wang ◽  
Zhi-Lian Zhao ◽  
Mo Zhang ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Basal Ganglia ◽  
Functional Mri ◽  
Point Group ◽  
Acupuncture Point ◽  
Sham Acupuncture ◽  
Acupuncture Points ◽  
Real Acupuncture ◽  
Neuronal Specificity

Although acupuncture is considered to be effective and safe for Alzheimer’s disease (AD) and mild cognitive impairment (MCI), the mechanism underlying its therapeutic effect is still unknown. Most studies clarifying the neuronal pathway produced by acupuncture were still applied to healthy subjects with limited single acupuncture point stimulation, which was inconsistency with clinical practice. Thus, in our present study, we investigate the differences between brain activity changes in AD and MCI patients caused by multi-acupuncture point Siguan (four gates), in order to provide visualized evidence for neuronal specificity of clinical acupuncture. Forty-nine subjects were recruited, including 21 AD patients, 14 MCI patients, and 14 healthy controls (HC). AD and MCI patients were randomly divided into two groups, respectively: real acupuncture point group (14 AD and 8 MCI) and sham acupuncture point group (7 AD and 6 MCI). We adopted a 16-minute, single-block, experimental design for acquiring functional MRI images. We found, in AD and MCI patients, Siguan (four gates) elicited extensive activations and deactivations in cognitive-related areas, visual-related areas, the sensorimotor-related area, basal ganglia, and cerebellum. Compared with HC, AD and MCI patients showed similar activations in cognitive-related brain areas (inferior frontal gyrus, supramarginal gyrus, and rolandic operculum) as well as deactivations in cognitive-related areas, visual-related areas, basal ganglia, and cerebellum, which were not found in HC. Compared with sham acupuncture points, real acupuncture points produced more specific brain changes with both activated and deactivated brain activities in AD and MCI. The preliminary results in our study verified the objective evidence for neuronal specificity of acupuncture in AD and MCI patients.

Associative encoding deficits in amnestic mild cognitive impairment: A volumetric and functional MRI study

NeuroImage ◽  
2011 ◽  
Vol 56 (3) ◽  
pp. 1743-1748 ◽  
Author(s):  
Bernard Hanseeuw ◽  
Laurence Dricot ◽  
Martin Kavec ◽  
Cecile Grandin ◽  
Xavier Seron ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Mri ◽  
Amnestic Mild Cognitive Impairment ◽  
Mri Study

scholarly journals Analysis of Grey Matter in Thalamus and Basal Ganglia Based on EEG α3/α2 Frequency Ratio Reveals Specific Changes in Subjects with Mild Cognitive Impairment

ASN NEURO ◽  
2012 ◽  
Vol 4 (7) ◽  
pp. AN20120058 ◽  
Author(s):  
Davide V Moretti ◽  
Donata PaternicoG ◽  
Giuliano Binetti ◽  
Orazio Zanetti ◽  
Giovanni B Frisoni
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Basal Ganglia ◽  
Frequency Ratio ◽  
Grey Matter

Brain Areas Involved in Acupuncture Needling Sensation of de qi: A single-photon emission computed tomography (SPECT) study

2012 ◽  
Vol 30 (4) ◽  
pp. 316-323 ◽  
Author(s):  
Jia-Rong Chen ◽  
Gan-Long Li ◽  
Gui-Feng Zhang ◽  
Yong Huang ◽  
Shu-Xia Wang ◽  
...  
Keyword(s):  
Single Photon ◽  
Photon Emission ◽  
Point Group ◽  
Acupuncture Point ◽  
Sham Acupuncture ◽  
Emission Computed Tomography ◽  
Brodmann Areas ◽  
Spect Scan ◽  
Photon Emission Computed Tomography ◽  
De Qi

Background De qi is a sensory response elicited by acupuncture stimulation. According to traditional Chinese medicine (TCM), de qi is essential for clinical efficacy. However, the understanding of the neurobiological basis of de qi is still limited. Objective To investigate the relationship between brain activation and de qi by taking a single-photon emission computed tomography (SPECT) scan while applying acupuncture at TE5. Methods A total of 24 volunteers were randomly divided into 4 groups, and received verum or sham acupuncture at true acupuncture point TE5 or a nearby sham point according to grouping. All subjects then received a 99mTc-ethylcysteinate dimer (ECD) SPECT scan. Results All six subjects in the verum acupuncture at true acupuncture point group experienced de qi sensation; in contrast, all six subjects in the sham acupuncture at the sham point group responded with nothing other than non-sensation. Compared to the scan results from subjects who experienced non-sensation, SPECT scans from subjects with de qi sensation demonstrated significant activated points mainly located in brodmann areas 6, 8, 19, 21, 28, 33, 35, 37, 47, the parahippocampal gyrus, lentiform nucleus, claustrum and red nucleus; deactivated points were seen in brodmann areas 9 and 25. Conclusions Verum acupuncture at true acupuncture points is more likely to elicit de qi sensation. De qi sensations mainly resulted in brain area activations, but not deactivations. These brain areas are related to the curative effect of Te5. The acupuncture needle sensations of de qi and sharp pain are associated with different patterns of activations and deactivations in the brain.

scholarly journals Effects of Smoking on Regional Homogeneity in Mild Cognitive Impairment: A Resting-State Functional MRI Study

2020 ◽  
Vol 12 ◽  
Author(s):  
Tianyi Zhang ◽  
Xiao Luo ◽  
Qingze Zeng ◽  
Yanv Fu ◽  
Zheyu Li ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Mri ◽  
Resting State ◽  
Brain Activity ◽  
Verbal Learning ◽  
Regional Homogeneity ◽  
Angular Gyrus ◽  
Healthy Elderly ◽  
Intrinsic Brain Activity

BackgroundSmoking is a modifiable risk factor for Alzheimer’s disease (AD). However, smoking-related effects on intrinsic brain activity in high-risk AD population are still unclear.ObjectiveWe aimed to explore differences in smoking effects on brain function between healthy elderly and amnestic mild cognitive impairment (aMCI) patients using ReHo mapping.MethodsWe identified 64 healthy elderly controls and 116 aMCI patients, including 98 non-smoking and 18 smoking aMCI. Each subject underwent structural and resting-state functional MRI scanning and neuropsychological evaluations. Regional homogeneity (ReHo) mapping was used to assess regional brain synchronization. After correction for age, gender, education, and gray matter volume, we explored the difference of ReHo among groups in a voxel-wise way based on analysis of covariance (ANCOVA), followed by post hoc two-sample analyses (p < 0.05, corrected). Further, we correlated the mean ReHo with neuropsychological scales.ResultsThree groups were well-matched in age, gender, and education. Significant ReHo differences were found among three groups, located in the left supramarginal gyrus (SMG) and left angular gyrus (AG). Specifically, non-smoking aMCI had lower ReHo in SMG and AG than smoking aMCI and controls. By contrast, smoking aMCI had greater AG ReHo than healthy controls (p < 0.05). Across groups, correlation analyses showed that left AG ReHo correlated with MMSE (r = 0.18, p = 0.015), clock drawing test (r = 0.20, p = 0.007), immediate recall (r = 0.36, p < 0.001), delayed recall (r = 0.34, p < 0.001), and auditory verbal learning test (r = 0.20, p = 0.007).ConclusionSmoking might pose compensatory or protective effects on intrinsic brain activity in aMCI patients.

P2-378: FUNCTIONAL MRI OF THE CLOCK-DRAWING TEST IN MILD COGNITIVE IMPAIRMENT

2006 ◽  
Vol 14 (7S_Part_15) ◽  
pp. P841-P842
Author(s):  
Natasha A. Talwar ◽  
Nathan W. Churchill ◽  
Megan A. Hird ◽  
Tahira Tasneem ◽  
Iryna Pshonyak ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Functional Mri ◽  
Clock Drawing Test ◽  
Clock Drawing ◽  
Drawing Test
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