scholarly journals Clinical Predictors of Pseudomonas aeruginosa Bacteremia in Emergency Department

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Yongsoon Choi ◽  
Jin Hui Paik ◽  
Ji Hye Kim ◽  
Seung Baik Han ◽  
Areum Durey
Keyword(s):  
Emergency Department ◽  
Pseudomonas Aeruginosa ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Antimicrobial Agents ◽  
Empirical Treatment ◽  
Control Group ◽  
Case Group ◽  
Clinical Predictors

Objectives. Pseudomonas aeruginosa shows higher mortality rate compared to other bacterial infections and is susceptible to a limited number of antimicrobial agents. Considering inadequate empirical treatment of Pseudomonas bacteremia has been associated with increased mortality, it is important for emergency physicians to identify infections by P. aeruginosa. Methods. This was a single-center retrospective case-control study to investigate the clinical predictors of patients diagnosed as Pseudomonas bacteremia in the emergency department (ED) from June 2012 to December 2016. Patients with blood culture positive for Escherichia coli in the same period were chosen as the control group, and type of infection was matched for each patient. Results. A total of 54 cases with Pseudomonas bacteremia and 108 controls with E. coli bacteremia were included. In the case group, 76% was community-acquired infection, 44% received inappropriate empirical treatment in the ED, and in-hospital mortality was 30%. Multiple logistic regression showed that respiratory tract infection was an independent risk factor for Pseudomonas bacteremia (OR 6.56, 95% CI 1.78-23.06; p = 0.004), whereas underlying diabetes mellitus (OR 0.22, 95% CI 0.07-0.61; p = 0.004) and presentation as urinary tract infection (OR 0.06, 95% CI 0.02-0.18; p < 0.001) were negative clinical predictors. Conclusions. We suggest that antipseudomonal antibiotics should be considered beyond simple coverage of Gram-negative bacteria in the ED, especially if the patient is likely to have pneumonia. Having diabetes or presenting with urinary tract infection could be clinical factors unfavorable to use of antipseudomonal antibiotics.

scholarly journals Study of urinary tract infection in febrile children below 2 years of age

2018 ◽  
Vol 6 (11) ◽  
pp. 3657
Author(s):  
P. L. Prasad ◽  
Aditi Gupta ◽  
Gaurav Mukhija
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Infants And Children ◽  
Control Group ◽  
Case Group ◽  
Study Group ◽  
Age Group ◽  
Group A ◽  
Age And Sex

Background: Urinary Tract Infection (UTI) in age group 0-2 years is of special interest to clinicians and assumes importance as it can lead to pyelonephritis, septicemia or meningitis in newborn and infants which can be fatal. This study is undertaken to calculate the incidence of UTI in febrile children less than 2 years of age and to compare the incidence with afebrile children visiting pediatric OPD and IPD of SRMS IMS.Methods: Two hundred and two febrile infants and children constituted the case group. A control group, constituted of one hundred and ninety seven, age and sex matched afebrile patients from IPD/OPD. Urine collected was subjected to microscopic and microbiological examination.Results: There were ten cases of UTI in the study group and none was found in the control group. The overall incidence of UTI in febrile infants and children less than 2 years was 4.95%. Infants and children admitted with diagnosis other than UTI were screened for UTI and it was found in 4.6% of the cases whereas babies admitted without definite focus had an incidence of 5.56% which signifies that UTI should be screened in all febrile infants irrespective of their other etiologies of fever. Maternal illiteracy was found to be statistically significant as 5 out of 10 cases of UTI were associated with illiterate mothers.Conclusions: In the present study, we found that the screening of the infants for identification of UTI is useful irrespective of the presence of other etiologies thus early initiation of treatment prevents most complications of UTI, so the importance of early diagnosis cannot be overemphasized.

scholarly journals Community-onset ESBL– producing enterobacteriaceae urinary tract infection in pediatric patients: Retrospective case control study

2021 ◽  
Vol 2021 (2) ◽  
Author(s):  
Soliman Aly ◽  
Ahmed Al Homosy
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Antibiotic Prophylaxis ◽  
Pediatric Patients ◽  
Case Control ◽  
Control Group ◽  
Case Group ◽  
Retrospective Case ◽  
Community Onset

Background: Urinary tract infection (UTI) is a common childhood disease with a prevalence of 7.8% that can lead to serious complications including renal scarring.Approximately 80% of UTIs in children are caused by Escherichia coli that are unfortunately accompanied by an increased prevalence of extended-spectrum beta-lactamases (ESBL) - producing strains. This study tries to determine the incidence of ESBL-producing Enterobacteriaceae (PE) UTIs among the pediatric population in Qatar, and predict the relation between multiple antibiotics exposure, antibiotic prophylaxis, recurrent UTIs, prior hospitalizations, prior urinary tract abnormalities as risk factors, and the development of ESBL-PE UTI in the same population. Methods: This is a retrospective case control and cross-sectional study conducted over a period of one year from January 2018 to January 2019. The inclusion criteria were infants and children from 0 month to 14 years old diagnosed with community-onset of urinary tract infection however, exclusion criteria were immunocompromised or cancer patients. Case group was defined as patients who developed ESBL-PE UTI (n = 135), while the control group were patients who developed sensitive Enterobacteriaceae UTI (n = 219). Results: 406 patients were included, 33% of them had ESBL-PE UTI and 51 were excluded (infection caused by another organism). Regarding antibiotics exposure during the preceding 6 months, 28% of the case group patients were prescribed multiple courses of antibiotics versus 10% in the control group. 21% within the case group patients received antibiotic prophylaxis versus 6% in the control group. Furthermore, 21% of case group patients were diagnosed with urinary tract anomalies versus 4.5% in the control group, however no significant statistical difference regarding UTI recurrence was found (p>0.05). 17% of case group patients were hospitalized previously versus 7% in the control group. Conclusion: The study found that ESBL-PE UTI incidence among pediatric patients was high. Repeated exposure to antibiotics courses, antibiotic prophylaxis, previous hospitalization, and prior UT anomalies may have an impact on this resistance rate.

Detection of tox A gene in Pseudomonas aeruginosa that isolates from different clinical cases by using PCR.

2018 ◽  
pp. 26
Author(s):  
Rana M. Abdullah Al-Shwaikh ◽  
Abbas Falih Alornaaouti
Keyword(s):  
Molecular Weight ◽  
Pseudomonas Aeruginosa ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Otitis Media ◽  
Urinary Tract Infections ◽  
Gel Electrophoresis ◽  
Wound Infections ◽  
Tract Infections

       Current study obtained (75) isolate of Pseudomonas aeruginosa collected from different cases included : 28 isolates from otitis media, 23 isolates from burn infections, 10 isolates from wound infections, 8 isolates from urinary tract infections and 6 isolates from blood, during the period between 1/9/2014 to 1/11/2014        The result revealed that the tox A gene was present in 54 isolates (72%) of Pseudomonas aeruginosa. The gel electrophoresis showed that the molecular weight of tox A gene was 352 bp. The result shows 17 isolates (60.71%) from otitis media has tox A gene, 18 isolates (78.26%) from burn followed by 8 isolate (80%) from wound infection and 5 isolates (62.5%) from urinary tract infection , finally 6 isolates (100%) from blood have this gene.

scholarly journals Risk of Cancer after Lower Urinary Tract Infection: A Population-Based Cohort Study

2019 ◽  
Vol 16 (3) ◽  
pp. 390 ◽  
Author(s):  
Chia-Hung Huang ◽  
Ying-Hsiang Chou ◽  
Han-Wei Yeh ◽  
Jing-Yang Huang ◽  
Shun-Fa Yang ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Cohort Study ◽  
Urinary Tract ◽  
Urinary Bladder ◽  
Tract Infection ◽  
Lower Urinary Tract ◽  
Population Based ◽  
Control Group ◽  
Lower Urinary Tract Infection ◽  
Lower Urinary

To investigate the association among lower urinary tract infection (UTI), the type and timing of antibiotic usage, and the subsequent risk of developing cancers, especially genitourinary cancers (GUC), in Taiwan. This retrospective population-based cohort study was conducted using 2009–2013 data from the Longitudinal Health Insurance Database. This study enrolled patients who were diagnosed with a UTI between 2010 and 2012. A 1:2 propensity score-matched control population without UTI served as the control group. Multivariate analysis with a multiple Cox regression model was applied to analyze the data. A total of 38,084 patients with UTI were included in the study group, and 76,168 participants without UTI were included in the control group. The result showed a higher hazard ratio of any cancer in both sexes with UTI (for males, adjusted hazard ratio (aHR) = 1.32; 95% confidence interval (CI) = 1.12–1.54; for females, aHR = 1.21; 95% CI = 1.08–1.35). Patients with UTI had a higher probability of developing new GUC than those without UTI. Moreover, the genital organs, kidney, and urinary bladder of men were significantly more affected than those of women with prior UTI. Furthermore, antibiotic treatment for more than 7 days associated the incidence of bladder cancer in men (7–13 days, aHR = 1.23, 95% CI = 0.50–3.02; >14 days, aHR = 2.73, CI = 1.32–5.64). In conclusion, UTI is significantly related to GUC and may serve as an early sign of GUC, especially in the male genital organs, prostate, kidney, and urinary bladder. During UTI treatment, physicians should cautiously prescribe antibiotics to patients.

National Trends in Emergency Department Antibiotic Prescribing for Elders with Urinary Tract Infection, 1996-2005

2009 ◽  
Vol 16 (6) ◽  
pp. 500-507 ◽  
Author(s):  
Jeffrey M. Caterino ◽  
Sarah Grace Weed ◽  
Janice A. Espinola ◽  
Carlos A. Camargo, Jr
Keyword(s):  
Emergency Department ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Antibiotic Prescribing ◽  
National Trends

scholarly journals Bacteriophage therapy for refractory Pseudomonas aeruginosa urinary tract infection

2011 ◽  
Vol 60 (11) ◽  
pp. 1697-1700 ◽  
Author(s):  
A. Khawaldeh ◽  
S. Morales ◽  
B. Dillon ◽  
Z. Alavidze ◽  
A. N. Ginn ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Bacteriophage Therapy

Molecular detection of six virulence genes in Pseudomonas aeruginosa isolates detected in children with urinary tract infection

2017 ◽  
Vol 107 ◽  
pp. 44-47 ◽  
Author(s):  
Ali Badamchi ◽  
Hossein Masoumi ◽  
Shima Javadinia ◽  
Ramin Asgarian ◽  
Azardokht Tabatabaee
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Virulence Genes ◽  
Molecular Detection

scholarly journals Trends in Antibiotic Resistance of Major Uropathogens

2020 ◽  
Author(s):  
Falah Hasan Obayes AL-Khikani
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Antimicrobial Susceptibility ◽  
Bacterial Species ◽  
High Rate ◽  
Control Group ◽  
Microbiological Methods ◽  
Antimicrobial Susceptibility Tests ◽  
Susceptibility Tests

Around the world, there is no population clear from urinary tract infection (UTI), particularly among women. UTI is considered the most predominant bacterial infection. This study aimed to detect the incidence of the most common major uropathogens in patients severe from urinary tract infection with antibiotic sensitivity tests that assist urologist doctors for appropriate antimicrobial empirical therapy.Methods: This study was carried in a private laboratory in Babil city, Iraq from May 2019 to May 2020. Totally 70 individuals suffering from clear symptoms of UTI, as well as, 20 healthy persons participated in this study as a control group. Then, the standard microbiological methods carried out to isolate and identify bacterial species. Antimicrobial susceptibility tests were performed using different antimicrobial discs by applying the Kirby&ndash;Bauer disc diffusion method.Results: Totally, 90 specimens were obtained from them 20 control group, 19 with no growth, and 51 patients with bacterial growth distributed as 43 (83%) females and 8 (17%) males. E. coli were the most common predominant organisms. All isolates were showed a high rate of resistance to evaluated cephalosporins 100% and 82% to cefotaxime and ceftriaxone respectively, while very low resistance recorded in Aminoglycosides 20% and 13% to Gentamicin and amikacin respectively. Most age group infected with UTI was 21-40 years old.Conclusion: The current study showed an increasing burden of urinary tract infection caused by various bacteria implicated in UTI that causes changeable sensitivity to various antimicrobial agents. Therefore, in clinical use appropriate medications should be selected based on the data obtained from antimicrobial susceptibility tests.

Therapeutic Efficacy of Sitafloxacin Against Pseudomonas aeruginosa in a Rat Model of Urinary Tract Infection

Drugs ◽  
1999 ◽  
Vol 58 (Supplement 2) ◽  
pp. 412-414 ◽  
Author(s):  
Yuichi Kurosaka ◽  
Yoshihisa Ishida ◽  
Eiko Yamamura ◽  
Tsuyoshi Otani ◽  
Hiromi Kumon
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Rat Model ◽  
Therapeutic Efficacy
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