scholarly journals Corrigendum to “Overexpression of Cholesteryl Ester Transfer Protein Increases Macrophage-Derived Foam Cell Accumulation in Atherosclerotic Lesions of Transgenic Rabbits”

2018 ◽  
Vol 2018 ◽  
pp. 1-1
Author(s):  
Shoucui Gao ◽  
Xiaojing Wang ◽  
Daxin Cheng ◽  
Jiayan Li ◽  
Lu Li ◽  
...  
Keyword(s):  
Cholesteryl Ester ◽  
Cholesteryl Ester Transfer Protein ◽  
Foam Cell ◽  
Transfer Protein ◽  
Atherosclerotic Lesions ◽  
Cell Accumulation ◽  
Transgenic Rabbits

scholarly journals Overexpression of Cholesteryl Ester Transfer Protein Increases Macrophage-Derived Foam Cell Accumulation in Atherosclerotic Lesions of Transgenic Rabbits

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Shoucui Gao ◽  
Xiaojing Wang ◽  
Daxing Cheng ◽  
Jiayan Li ◽  
Lu Li ◽  
...  
Keyword(s):  
Cholesteryl Ester ◽  
Cholesteryl Ester Transfer Protein ◽  
Plasma Lipids ◽  
Foam Cell ◽  
Atherosclerotic Lesion ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
High Cholesterol Diet ◽  
Transfer Protein ◽  
Transgenic Rabbits

High levels of plasma high-density lipoprotein-cholesterol (HDL-C) are inversely associated with the risk of atherosclerosis and other cardiovascular diseases; thus, pharmacological inhibition of cholesteryl ester transfer protein (CETP) is considered to be a therapeutic method of raising HDL-C levels. However, many CETP inhibitors have failed to achieve a clinical benefit despite raising HDL-C. In the study, we generated transgenic (Tg) rabbits that overexpressed the human CETP gene to examine the influence of CETP on the development of atherosclerosis. Both Tg rabbits and their non-Tg littermates were fed a high cholesterol diet for 16 weeks. Plasma lipids and body weight were measured every 4 weeks. Gross lesion areas of the aortic atherosclerosis along with lesional cellular components were quantitatively analyzed. Overexpression of human CETP did not significantly alter the gross atherosclerotic lesion area, but the number of macrophages in lesions was significantly increased. Overexpression of human CETP did not change the plasma levels of total cholesterol or low-density lipoprotein cholesterol but lowered plasma HDL-C and increased triglycerides. These data revealed that human CETP may play an important role in the development of atherosclerosis mainly by decreasing HDL-C levels and increasing the accumulation of macrophage-derived foam cells.

Expression of cholesteryl ester transfer protein in human atherosclerotic lesions and its implication in reverse cholesterol transport

2001 ◽  
Vol 159 (1) ◽  
pp. 67-75 ◽  
Author(s):  
Zhongyan Zhang ◽  
Shizuya Yamashita ◽  
Ken-ichi Hirano ◽  
Yumiko Nakagawa-Toyama ◽  
Akifumi Matsuyama ◽  
...  
Keyword(s):  
Cholesteryl Ester ◽  
Cholesteryl Ester Transfer Protein ◽  
Reverse Cholesterol Transport ◽  
Cholesterol Transport ◽  
Transfer Protein ◽  
Atherosclerotic Lesions

scholarly journals Cholesteryl Ester Transfer Protein Expression Prevents Diet-Induced Atherosclerotic Lesions in Male db/db Mice

2003 ◽  
Vol 23 (8) ◽  
pp. 1412-1415 ◽  
Author(s):  
Paul S. MacLean ◽  
Joseph F. Bower ◽  
Satyaprasad Vadlamudi ◽  
Jody N. Osborne ◽  
John F. Bradfield ◽  
...  
Keyword(s):  
Protein Expression ◽  
Cholesteryl Ester ◽  
Cholesteryl Ester Transfer Protein ◽  
Transfer Protein ◽  
Atherosclerotic Lesions
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