scholarly journals Effect of D-Panthenol on Corneal Epithelial Healing after Surface Laser Ablation

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Islam Mahmoud Hamdi
Keyword(s):  
Laser Ablation ◽  
Laser Surface ◽  
Corneal Epithelial ◽  
Epithelial Regeneration ◽  
Covered Area ◽  
Statistical Relevance ◽  
Surface Laser ◽  
Larger Sample ◽  
Subjective Sensation ◽  
Epithelial Healing

Purpose. To study the effect of D-panthenol (provitamin B5) on corneal epithelial healing, in cases of surface laser ablation. Patients and Methods: 45 eyes, of 45 patients undergoing laser surface ablation, received D-panthenol 2% in one eye and artificial tear drops of similar composition not containing D-panthenol in the other eye, postoperatively, for 2 months. Patients were examined daily for 3 days after the procedure. They were then examined weekly for 1 month. An additional examination was made after 2 months. Visual acuity (Log MAR) was assessed at every visit. Rate of healing (% of covered area) and subjective sensation of discomfort (scale 0–5) were assessed in the 1st 3 visits. Residual manifest cylinder (D) (as a parameter of corneal irregularity) and corneal clarity (epithelial and stromal haze) were assessed from week 1 to month 2. Results. During the first 3 days, both groups showed statistically nonsignificant ( P > 0.05 ) results. From week 1 to month 2, eyes receiving D-panthenol showed better vision and less residual cylinder ( P < 0.05 ) at week 1. For all other parameters, and at different examinations, both groups showed a statistically nonsignificant ( P > 0.05 ) difference. Still, eyes receiving D-panthenol showed better values at the majority of the parameters tested. Conclusion. D-Panthenol effect on corneal epithelial regeneration is of minimal clinical relevance. A different dosage and a larger sample of patients might reveal a statistical relevance. This trial is registered with https://doi.org/10.1186/ISRCTN81441126.

scholarly journals Clinical Outcomes of Aberration-Free All Surface Laser Ablation (ASLA) vs. Aberration-Free ASLA Assisted by Smart Pulse Technology in High Myopia: A One-Year Follow-Up Study

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
XiaoHao Du ◽  
Jia Zhang ◽  
Meng Su ◽  
WenJia Cao ◽  
Shuang Zeng ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Laser Ablation ◽  
High Myopia ◽  
Healing Time ◽  
Spherical Equivalent ◽  
Surface Laser ◽  
Epithelial Healing ◽  
Better Than ◽  
Pulse Technology

Purpose. To compare the clinical outcomes of aberration-free all surface laser ablation (ASLA) with and without the use of smart pulse technology (SPT) in high myopia. Methods. This study retrospectively analyzed 138 eyes (138 patients, only the right eye was selected) treated for high myopia (spherical equivalent ≥−6.00 diopters) using aberration-free ASLA (non-SPT group; 85 eyes) and aberration-free ASLA assisted by SPT (SPT group; 53 eyes). Examinations such as visual acuity, refraction, and haze were performed before the 12-month follow-up. Corneal epithelial healing time was assessed in the first postoperative day. Visual acuity and refraction examination were performed at 7 days and 1, 3, 6, and 12 months postoperatively. Corneal haze was evaluated in 1, 3, 6, and 12 months. Safety, efficacy, and corneal wavefront aberrations were assessed 12 months after the treatment. Results. At 12 months postoperatively, 60% versus 40% of eyes achieved 20/16 Snellen lines or better, and 92% versus 82% of eyes achieved 20/20 Snellen lines or better visual acuity in the SPT and the non-SPT groups, respectively. The average postoperative epithelial healing time was 3.75 ± 1.00 days in the SPT group and 3.73 ± 1.30 days in the non-SPT group ( P ≥ 0.05 ). The safety and the efficacy index of the SPT group were better than those of the non-SPT group in the follow-ups. The attempted spherical equivalent before the surgery and the achieved spherical equivalent at 12 months were comparable between the two groups. Regarding the aberrations, the results of Coma 90° in the SPT group were better than those in the non-SPT group ( P ≤ 0.05 ), but the increase of RMS HOAs (root mean square higher order aberrations), Coma 0°, and spherical aberration postoperatively had no statistical difference between the two groups ( P ≥ 0.05 ). Conclusions: Both aberration-free ASLA with and without SPT showed favorable safety, effectiveness, and predictability within 12 months for high myopia. And, ASLA using SPT might have potential advantages in the long-term visual quality.

Crystalline SiC thin film deposition by laser ablation: influence of laser surface activation

1998 ◽  
Vol 66 (2) ◽  
pp. 183-187 ◽  
Author(s):  
M. Diegel ◽  
F. Falk ◽  
R. Hergt ◽  
H. Hobert ◽  
H. Stafast
Keyword(s):  
Thin Film ◽  
Laser Ablation ◽  
Thin Film Deposition ◽  
Film Deposition ◽  
Laser Surface ◽  
Surface Activation

scholarly journals Crosslinking kezelés hatása a szaruhártya hámosodására

2017 ◽  
Vol 158 (10) ◽  
pp. 376-379
Author(s):  
Andrea Gyenes ◽  
Nóra Szentmáry ◽  
Gábor Tóth ◽  
Huba Kiss ◽  
Csaba Szekrényesi ◽  
...  
Keyword(s):  
Beneficial Effect ◽  
Observation Time ◽  
Test Results ◽  
Epithelial Defect ◽  
Corneal Epithelial ◽  
Fluorescein Staining ◽  
Time Points ◽  
Significant Difference ◽  
Epithelial Healing

Abstract: Introduction and aim: To analyse the effect of crosslinking (CXL) on corneal epithelial healing. Patients and method: 39 keratoconus patients following CXL and 11 patients following PRK were enrolled in this study. 21, 45 and 69 hours after CXL and 16, 37 and 61 hours following PRK slitlamp photographs were taken using fluorescein staining and the size of the epithelial defect and the time of epithelial closure was determined. As the observation time-points differed in both groups, the size of the epithelial defect following PRK was calculated for the time points used for analysis of CXL patients. These data were compared using chi-quadrat test. Results: Following crosslinking, epithelial closure occured within 3, following PRK within 4 days. In the area of epithelial erosion 45 and 69 hours after CXL or PRK treatment statistically significant difference (p = 0.005 and p<0.001) was verified. Conclusion: Our results show beneficial effect of crosslinking on corneal epithelial healing. Orv. Hetil., 2017, 158(10), 376–379.

scholarly journals Corneal epithelial healing in rabbit eyes with partial corneal-conjunctival and conjunctival limbal deficiency

1998 ◽  
Vol 61 (5) ◽  
Author(s):  
Diane Ruschel Marinho ◽  
Ana Luisa Hõfling de Lima ◽  
Sérgio Kwitko ◽  
Martin Kirst ◽  
Jeanine Mársico ◽  
...  
Keyword(s):  
Corneal Epithelial ◽  
Limbal Deficiency ◽  
Epithelial Healing

scholarly journals Transcriptional Network Analysis Reveals the Role of miR-223-5p During Diabetic Corneal Epithelial Regeneration

2021 ◽  
Vol 8 ◽  
Author(s):  
Yuan Zhang ◽  
Shengqian Dou ◽  
Xia Qi ◽  
Zhenzhen Zhang ◽  
Yujie Qiao ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Network Analysis ◽  
Nerve Regeneration ◽  
Corneal Epithelial ◽  
Beneficial Effects ◽  
Epithelial Regeneration ◽  
Epithelial Wound Healing ◽  
Direct Target Gene ◽  
Inflammatory Processes

Diabetes mellitus (DM) is a complex metabolic disorder. Long-term hyperglycemia may induce diabetic keratopathy (DK), which is mainly characterized by delayed corneal epithelial regeneration. MicroRNAs (miRNAs) have been reported to play regulatory roles during tissue regeneration. However, the molecular mechanism by which miRNAs influence epithelial regeneration in DK is largely unknown. In this study, we performed miRNA and mRNA sequencing of regenerative corneal epithelium tissue from streptozotocin-induced type 1 diabetic (T1DM) and wild-type mice to screen for differentially expressed miRNAs and mRNAs. Based on regulatory network analysis, miR-223-5p was selected for subsequent experiments and Hpgds was then identified as a direct target gene. MiR-223-5p downregulation significantly promoted diabetic corneal epithelial wound healing and nerve regeneration. However, the beneficial effects of miR-223-5p inhibition were abolished by an Hpgds inhibitor. Furthermore, mechanistic studies demonstrated that miR-223-5p suppression ameliorated inflammation and enhanced cell proliferation signaling in DK. Taken together, our findings revealed that the regulatory role of miR-223-5p in diabetic corneal epithelial and nerve regeneration by mediating inflammatory processes and cell proliferation signaling. And silencing miR-223-5p may contribute to the development of potential therapeutic strategies for DK.

scholarly journals Percutaneous ultrasound-guided laser ablation for the treatment of cervical tuberculous lymphadenitis: a pilot study

2019 ◽  
Vol 47 (4) ◽  
pp. 1512-1520
Author(s):  
Gaoyi Yang ◽  
Jianhua Fang ◽  
Tianzhuo Yu ◽  
Ying Zhang ◽  
Wenzhi Zhang ◽  
...  
Keyword(s):  
Laser Ablation ◽  
Adverse Effects ◽  
Lymph Nodes ◽  
Tuberculous Lymphadenitis ◽  
Good Tolerability ◽  
Minimal Invasiveness ◽  
Contrast Enhanced ◽  
The Mean ◽  
Larger Sample

Objective This study was performed to assess the feasibility, effectiveness, and safety of percutaneous ultrasound (US)-guided laser ablation (LA) for the treatment of cervical tuberculous lymphadenitis (CTBL). Methods We retrospectively reviewed 11 patients with CTBL (mean age, 32.0 ± 8.6 years; range, 18–47 years) who underwent percutaneous US-guided LA from June 2014 to December 2016 with a subsequent 12-month follow-up. We assessed the mean volume reduction and contrast-enhanced US (CEUS) changes of the target lymph nodes as well as the tolerability and adverse effects of LA. Results The mean ablation energy was 522 ± 312 J (range, 204–1317 J). All 17 enrolled target lymph nodes were completely non-enhanced after LA treatment as detected by CEUS, indicating complete ablation of all lymph nodes (100%). The target lymph nodes significantly decreased in volume by a mean of 74.0% ± 15.6% from baseline to 12 months after LA. The LA procedure was well tolerated, and none of the 11 patients developed severe complications during the 12-month follow-up. Conclusion Percutaneous US-guided LA for the treatment of CTBL exhibits good tolerability, minimal invasiveness, and few adverse effects. Further investigations with larger sample sizes and longer follow-up periods are warranted to confirm these findings.

Effects of Eye Registration on the Astigmatism Correction in the Surface Laser Ablation

2010 ◽  
Vol 51 (6) ◽  
pp. 809
Author(s):  
Deoksun Cha ◽  
Sang Kyoon Kim ◽  
Gyeoung Hwan Roh ◽  
Hyo Myung Kim ◽  
Jong Suk Song
Keyword(s):  
Laser Ablation ◽  
Astigmatism Correction ◽  
Surface Laser

Effect of cytochrome c peroxidase on corneal epithelial healing process after photorefractive keratectomy

2005 ◽  
Vol 31 (10) ◽  
pp. 1928-1931 ◽  
Author(s):  
Sergio Zaccharia Scalinci ◽  
Lucia Scorolli ◽  
Liberatina De Martino ◽  
Daniele Corazza ◽  
Mariachiara Morara ◽  
...  
Keyword(s):  
Cytochrome C ◽  
Healing Process ◽  
Cytochrome C Peroxidase ◽  
Photorefractive Keratectomy ◽  
Corneal Epithelial ◽  
Epithelial Healing
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