scholarly journals Testing rTMS-Induced Neuroplasticity: A Single Case Study of Focal Hand Dystonia

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Sonia Betti ◽  
Andrea Spoto ◽  
Umberto Castiello ◽  
Luisa Sartori

Focal hand dystonia in musicians is a neurological motor disorder in which aberrant plasticity is caused by excessive repetitive use. This work’s purposes were to induce plasticity changes in a dystonic musician through five daily thirty-minute sessions of 1 Hz repetitive transcranial magnetic stimulation (rTMS) applied to the left M1 by using neuronavigated stimulation and to reliably measure the effect of these changes. To this aim, the relationship between neuroplasticity changes and motor recovery was investigated using fine-grained kinematic analysis. Our results suggest a statistically significant improvement in motor coordination both in a task resembling the dystonic-inducing symptoms and in a reach-to-grasp task. This single case study supports the safe and effective use of noninvasive brain stimulation in neurologic patients and highlights the importance of evaluating outcomes in measurable ways. This issue is a key aspect to focus on to classify the clinical expression of dystonia. These preliminary results promote the adoption of kinematic analysis as a valuable diagnostic tool.

2003 ◽  
Vol 1 (2) ◽  
pp. 148-159
Author(s):  
Keith V. Bletzer

Migratory farm labor like other forms of migrant work both in and outside agriculture impedes on the opportunity to make choices. The following essay explores particular phases in the life of one man (a single case study) and examines how he considers turning points in his life that led to a long period of substance use, both as an immigrant in the country and as a working man in his home country, followed by a cessation of use and the beginning stages of recovery. / Para el migrante, viajar en busca de trabajo es díficil, ya sea que trabaje en agricultura o en otras labores. Este ensayo examina ciertas etapas en la vida de un hombre (estudio de un solo caso) que examina los cambios que le han ocurrido durante un período en que él consumía grandes cantidades de alcohol en los estados y en su país, seguido por un período de sobriedad (no tomaba alcohol, no usaba drogas) en este país en que él comienza una etapa de rehabilitación.


Author(s):  
Dr. Akshay H. Malshikare ◽  
Dr. Sharada Chikurte

Diabetes is a major health problem in whole world. In spite of many drugs available, uncontrolled diabetes remains a challenge. Moreover, some anti-diabetic drugs are on the verge of withdrawal due to its adverse effects. So, there is an acute need for a new effective and safe drug. So in this case study we used Ayurvedic medicine ‘Mustadi Kwatha’ mentioned in Bhaishajya Ratnawali in Prameha Chikitsa. A single case study was done on use of Mustadi Kwatha on Type II Diabetes Mellitus. Significant reduction was seen in blood sugar level fasting and post-prandial.


Author(s):  
Nicolás J.B. Wiedemann ◽  
Leona Wiegmann ◽  
Juergen Weber

Organizational routines can constitute a temporary settlement of individual actors’ diverging interests, described as a truce that enables the routine as a collective accomplishment to proceed. In this regard, scholars have recognized the central but ambiguous role of artefacts; they may be used to coordinate the interactions in routines but may also be mobilized to serve individual interests. Following this line of thinking, this chapter assumes a process perspective to advance our understanding of how such temporal settlements are continuously formed and in particular, the role artefacts play in this process. Based on a single case study over a period of thirty-three months, it analyses the use of a newly implemented artefact that inadvertently impeded smooth routine functioning as the artefact provided content that gave actors leeway to act out their interests in enacting the routine.


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