scholarly journals Corrigendum to “Sodium Fluorescein-Guided Resection under the YELLOW 560 nm Surgical Microscope Filter in Malignant Gliomas: Our First 38 Cases Experience”

2018 ◽  
Vol 2018 ◽  
pp. 1-1
Author(s):  
Ningning Zhang ◽  
Hailong Tian ◽  
Dezhang Huang ◽  
Xianbing Meng ◽  
Wenqiang Guo ◽  
...  
Keyword(s):  
Malignant Gliomas ◽  
Sodium Fluorescein ◽  
Surgical Microscope ◽  
Yellow 560

scholarly journals Sodium Fluorescein-Guided Resection under the YELLOW 560 nm Surgical Microscope Filter in Malignant Gliomas: Our First 38 Cases Experience

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Ningning Zhang ◽  
Hailong Tian ◽  
Dezhang Huang ◽  
Xianbing Meng ◽  
Wenqiang Guo ◽  
...  
Keyword(s):  
Malignant Gliomas ◽  
Progression Free Survival ◽  
Extent Of Resection ◽  
Subtotal Resection ◽  
Sodium Fluorescein ◽  
Who Grade ◽  
Free Survival ◽  
Surgical Microscope ◽  
Yellow 560 ◽  
High Fluorescence

Objective. Sodium fluorescein (FL) had been safely used in fluorescence-guided microsurgery for imaging various brain tumors. Under the YELLOW 560 nm surgical microscope filter, low-dose FL as a fluorescent dye helps in visualization. Our study investigated the safety and efficacy of this innovative technique in malignant glioma (MG) patients. Patients and Method. 38 patients suffering from MGs confirmed by pathology underwent FL-guided resection under YELLOW 560 nm surgical microscope filter. We retrospectively analyzed the clinical characters, microsurgery procedure, extent of resection, pathology of MGs, progression-free survival (PFS), and overall survival (OS). Results. Thirty-eight patients had MGs (10 WHO grade III, 28 WHO grade IV). With YELLOW 560 nm surgical microscope filter combined with neuronavigation, sodium fluorescein-guided gross total resection (GTR) was achieved in 35 (92.1%) patients and subtotal resection in 3 (7.69%). The sensitivity and specificity of FL were 94.4% and 88.6% regardless of radiographic localization. Intraoperatively, 10 biopsies (10/28 FL[+]) showed “low” or “high” fluorescence in non-contrast-enhancement region and are also confirmed by pathology. Our data showed 6-month PFS of 92.3% and median survival of 11 months. Conclusion. FL-guided resection of MGs under the YELLOW 560 nm surgical microscope filter combined with neuronavigation was safe and effective, especially in non-contrast-MRI regions. It is feasible for improving the extent of resection in MGs especially during emergency cases.

Use of Sodium Fluorescein in Meningioma Surgery Performed Under the YELLOW-560 nm Surgical Microscope Filter: Feasibility and Preliminary Results

2017 ◽  
Vol 107 ◽  
pp. 966-973 ◽  
Author(s):  
Mehmet Osman Akçakaya ◽  
Burcu Göker ◽  
Mustafa Ömür Kasımcan ◽  
Mustafa Kemal Hamamcıoğlu ◽  
Talat Kırış
Keyword(s):  
Sodium Fluorescein ◽  
Preliminary Results ◽  
Surgical Microscope ◽  
Yellow 560 ◽  
Meningioma Surgery

Sodium fluorescein–guided resection under the YELLOW 560 nm surgical microscope filter in malignant brain tumor surgery—a feasibility study

2013 ◽  
Vol 155 (4) ◽  
pp. 693-699 ◽  
Author(s):  
Karl-Michael Schebesch ◽  
Martin Proescholdt ◽  
Julius Höhne ◽  
Christoph Hohenberger ◽  
Ernil Hansen ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Feasibility Study ◽  
Malignant Brain Tumor ◽  
Sodium Fluorescein ◽  
Tumor Surgery ◽  
Brain Tumor Surgery ◽  
Surgical Microscope ◽  
Yellow 560

scholarly journals Preliminary Report: Rapid Intraoperative Detection of Residual Glioma Cell in Resection Cavity Walls Using a Compact Fluorescence Microscope

2021 ◽  
Vol 10 (22) ◽  
pp. 5375
Author(s):  
Jiro Akimoto ◽  
Shinjiro Fukami ◽  
Megumi Ichikawa ◽  
Kenta Nagai ◽  
Michihiro Kohno
Keyword(s):  
Tumor Cell ◽  
Malignant Glioma ◽  
Tumor Cells ◽  
Malignant Gliomas ◽  
Glioma Cells ◽  
Fluorescence Microscope ◽  
Talaporfin Sodium ◽  
Surgical Microscope ◽  
Resection Cavity ◽  
Intraoperative Detection

Objective: The surgical eradication of malignant glioma cells is theoretically impossible. Therefore, reducing the number of remaining tumor cells around the brain–tumor interface (BTI) is crucial for achieving satisfactory clinical results. The usefulness of fluorescence–guided resection for the treatment of malignant glioma was recently reported, but the detection of infiltrating tumor cells in the BTI using a surgical microscope is not realistic. Therefore, we have developed an intraoperative rapid fluorescence cytology system, and exploratorily evaluated its clinical feasibility for the management of malignant glioma. Materials and methods: A total of 25 selected patients with malignant glioma (newly diagnosed: 17; recurrent: 8) underwent surgical resection under photodiagnosis using photosensitizer Talaporfin sodium and a semiconductor laser. Intraoperatively, a crush smear preparation was made from a tiny amount of tumor tissue, and the fluorescence emitted upon 620/660 nm excitation was evaluated rapidly using a compact fluorescence microscope in the operating theater. Results: Fluorescence intensities of tumor tissues measured using a surgical microscope correlated with the tumor cell densities of tissues evaluated by measuring the red fluorescence emitted from the cytoplasm of tumor cells using a fluorescence microscope. A “weak fluorescence” indicated a reduction in the tumor cell density, whereas “no fluorescence” did not indicate the complete eradication of the tumor cells, but indicated that few tumor cells were emitting fluorescence. Conclusion: The rapid intraoperative detection of fluorescence from glioma cells using a compact fluorescence microscope was probably useful to evaluate the presence of tumor cells in the resection cavity walls, and could provide surgical implications for the more complete resection of malignant gliomas.

scholarly journals Intracranial Sonodynamic Therapy With 5-Aminolevulinic Acid and Sodium Fluorescein: Safety Study in a Porcine Model

2021 ◽  
Vol 11 ◽  
Author(s):  
Luca Raspagliesi ◽  
Antonio D’Ammando ◽  
Matteo Gionso ◽  
Natasha D. Sheybani ◽  
Maria-Beatriz Lopes ◽  
...  
Keyword(s):  
Brain Tissue ◽  
Aminolevulinic Acid ◽  
Malignant Gliomas ◽  
Experimental Studies ◽  
Sodium Fluorescein ◽  
Periventricular White Matter ◽  
Large Animal ◽  
Sonodynamic Therapy ◽  
Low Intensity

BackgroundSonodynamic therapy (SDT) is an emerging ultrasound-based treatment modality for malignant gliomas which combines ultrasound with sonosensitizers to produce a localized cytotoxic and modulatory effect. Tumor-specificity of the treatment is achieved by the selective extravasation and accumulation of sonosensitizers in the tumor-bearing regions. The aim of this study is to demonstrate the safety of low-intensity ultrasonic irradiation of healthy brain tissue after the administration of FDA-approved sonosensitizers used for SDT in experimental studies in an in vivo large animal model.MethodsIn vivo safety of fluorescein (Na-Fl)- and 5 aminolevulinic acid (5-ALA)-mediated low-intensity ultrasound irradiation of healthy brain parenchyma was assessed in two sets of four healthy swine brains, using the magnetic resonance imaging (MRI)-guided Insightec ExAblate 4000 220 kHz system. After administration of the sonosensitizers, a wide fronto-parietal craniotomy was performed in pig skulls to allow transmission of ultrasonic beams. Sonication was performed on different spots within the thalamus and periventricular white matter with continuous thermal monitoring. Sonication-related effects were investigated with MRI and histological analysis.ResultsPost-treatment MRI images acquired within one hour following the last sonication, on day one, and day seven did not visualize any sign of brain damage. On histopathology, no signs of necrosis or apoptosis attributable to the ultrasonic treatments were shown in target areas.ConclusionsThe results of the present study suggest that either Na-FL or 5-ALA-mediated sonodynamic therapies under MRI-guidance with the current acoustic parameters are safe towards healthy brain tissue in a large in vivo model. These results further support growing interest in clinical translation of sonodynamic therapy for intracranial gliomas and other brain tumors.

scholarly journals The use of fluorescein sodium in the biopsy and gross-total resection of a tectal plate glioma

2015 ◽  
Vol 16 (6) ◽  
pp. 732-735 ◽  
Author(s):  
Timothy H. Ung ◽  
Christopher Kellner ◽  
Justin A. Neira ◽  
Shih-Hsiu J. Wang ◽  
Randy D’Amico ◽  
...  
Keyword(s):  
Intravenous Administration ◽  
Pilocytic Astrocytoma ◽  
Complete Resection ◽  
Fluorescein Sodium ◽  
Tissue Sampling ◽  
Total Resection ◽  
Surgical Microscope ◽  
Tectal Plate ◽  
Yellow 560 ◽  
Intraoperative Guidance

Intravenous administration of fluorescein sodium fluoresces glioma burden tissue and can be visualized using the surgical microscope with a specialized filter. Intraoperative guidance afforded through the use of fluorescein may enhance the fidelity of tissue sampling, and increase the ability to accomplish complete resection of tectal lesions. In this report the authors present the case of a 19-year-old man with a tectal anaplastic pilocytic astrocytoma in which the use of fluorescein sodium and a Zeiss Pentero surgical microscope equipped with a yellow 560 filter enabled safe complete resection. In conjunction with neurosurgical navigation, added intraoperative guidance provided by fluorescein may be beneficial in the resection of brainstem gliomas.

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