scholarly journals Primary Cardiac Lymphoma: Importance of Tissue Diagnosis

2018 ◽  
Vol 2018 ◽  
pp. 1-3 ◽  
Author(s):  
Lauren Mendelson ◽  
Emily Hsu ◽  
Hojune Chung ◽  
Andrew Hsu
Keyword(s):  
Mediastinal Mass ◽  
Liposomal Doxorubicin ◽  
Soft Tissue Mass ◽  
Treatment Options ◽  
Disease Entity ◽  
Tissue Mass ◽  
Cardiac Lymphoma ◽  
Primary Cardiac Lymphoma ◽  
Progressive Heart Failure ◽  
History Of

Primary cardiac lymphoma (PCL) is a rare disease entity that can present with severe cardiac and cardioembolic symptoms. We present a 79-year-old male with history of polymalgia rheumatica on chronic prednisone who presented with a two-week history of progressively worsening dyspnea, cough, and a 10 pound weight loss. Transthoracic echocardiogram (TTE) and computed tomography (CT) of the chest showed a large mediastinal mass with invasion of the pericardium. A biopsy of an abdominal soft-tissue mass confirmed the diagnosis of PCL. The patient was treated with two cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) which was complicated by progressive heart failure requiring substitution of liposomal doxorubicin. The epidemiology, presentation, diagnosis, and treatment options of PCL are discussed.

scholarly journals Thymoma in an aged backyard Leghorn chicken, with reviews of a database and literature

2021 ◽  
Vol 33 (2) ◽  
pp. 336-339
Author(s):  
Julia Blakey ◽  
Carmen Jerry ◽  
Ana da Silva ◽  
Simone Stoute
Keyword(s):  
Soft Tissue Mass ◽  
Animal Health ◽  
Postmortem Examination ◽  
Cervical Region ◽  
Laboratory System ◽  
Unexpected Death ◽  
Tissue Mass ◽  
Microscopic Features ◽  
History Of ◽  
Backyard Chickens

A 7-y-old backyard Leghorn chicken ( Gallus domesticus) was submitted to the California Animal Health and Food Safety Laboratory System (CAHFS)–Turlock branch for postmortem examination, with a history of unexpected death. At postmortem examination, a hemorrhagic soft tissue mass was observed in the cervical region. Microscopically, a densely cellular neoplasm of polygonal epithelial cells and small lymphocytes was observed. The microscopic features of the neoplasm in combination with positive immunohistochemistry for pancytokeratin and CD3 were used to classify the lesion as a thymoma. Thymoma was diagnosed in only 5 birds submitted to CAHFS from 1990 to 2019. Thymoma has been described only rarely in birds, and is an unusual diagnosis in backyard chickens.

scholarly journals Mediastinal Hibernoma: A Rare Case with Radiologic-Pathologic Correlation

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Maxine Darke ◽  
Anil Dasyam ◽  
Matthew Then ◽  
Kavita Varma ◽  
Amir A. Borhani ◽  
...  
Keyword(s):  
Rare Case ◽  
Mediastinal Mass ◽  
Malignant Tumors ◽  
Soft Tissue Mass ◽  
Benign Tumors ◽  
Tissue Mass ◽  
Neck And Shoulder Pain ◽  
Normal Chest Radiograph ◽  
Normal Chest ◽  
Posterior Mediastinal

Hibernomas, especially located in the mediastinum, are extremely rare benign tumors, which are important to consider in the differential diagnosis of a heterogeneously enhancing mass with areas of fat attenuation on imaging of an often incidentally discovered mass. Other common possibilities in the differential include malignant tumors, such as liposarcoma, hence histopathology is usually required to confirm the diagnosis. Hibernomas often follow the distribution of sites of persistence of brown fat in adults, and intrathoracic locations are unusual. We present a very rare case of a mediastinal hibernoma in a 53-year-old woman. She presented to the emergency department with severe, progressive right neck and shoulder pain with radiation down her arm and was found to have a right apical posterior mediastinal mass on imaging. Initial radiographs of the shoulder showed a soft tissue mass within the apical right hemithorax. Further imaging with CT revealed a well circumscribed, heterogeneously enhancing mass with areas of fat attenuation. Pathology confirmed the diagnosis of mediastinal hibernoma, and the mass was completely excised. Fourteen months after surgery, the patient had a normal chest radiograph, and thirty-two months after surgery, she remains asymptomatic.

Vulval myxoid liposarcoma

2001 ◽  
Vol 11 (4) ◽  
pp. 321-322 ◽  
Author(s):  
R. Donnellan ◽  
M. Moodley
Keyword(s):  
Differential Diagnosis ◽  
Soft Tissue ◽  
Lymph Nodes ◽  
Soft Tissue Mass ◽  
Myxoid Liposarcoma ◽  
Complete Resection ◽  
Tissue Mass ◽  
History Of ◽  
Labium Majus ◽  
Draining Lymph Nodes

Abstract.Donnellan R, Moodley M. Vulval myxoid liposarcoma.A 26 year old woman presented with a 4-year history of a gradually enlarging fluctuant mass on the left labium majus. Histologic examination following excision revealed myxoid liposarcoma. Following the diagnosis, further surgery was performed to ensure complete resection. Routine excision of draining lymph nodes is not advocated. Although rare, myxoid liposarcoma should be considered in the differential diagnosis of a vulval soft tissue mass.

Rare case of metastatic small cell carcinoma of the nasopharynx to the pancreas

2020 ◽  
Vol 13 (6) ◽  
pp. e235054 ◽  
Author(s):  
Jonathan Teinor ◽  
Lara Groshek ◽  
Jin He
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Primary Tumour ◽  
Treatment Options ◽  
Needle Aspiration ◽  
Concurrent Chemotherapy ◽  
Small Cell ◽  
Tissue Mass ◽  
Positron Emission ◽  
History Of

We present a 49-year-old woman with a history of an unresectable nasopharyngeal small cell carcinoma (SCC) who was treated with concurrent chemotherapy and radiation therapy. On surveillance positron emission tomography scan 14 months after diagnosis, her primary tumour appeared stable, but there was fludeoxyglucose uptake in the pancreas. A CT scan demonstrated a 3.4×2.1 cm ill-defined soft tissue mass at the tail of the pancreas, which was concerning for adenocarcinoma. However, further workup including endoscopic ultrasound and fine needle aspiration confirmed the mass to be a metastasis from her nasopharyngeal SCC. Because there have been no previously reported cases of a metastatic small cell carcinoma to the pancreas, there are no data about prognosis. Thus treatment options were tailored to the patient. Distal pancreatectomy, splenectomy and cholecystectomy were performed. The patient recovered from surgery without complication.

Unusual cause of a painless soft tissue mass of the scalp: a rare presentation of primary intracranial neuroendocrine neoplasm

2021 ◽  
Vol 14 (2) ◽  
pp. e236856
Author(s):  
Susruta Manivannan ◽  
Feras Sharouf ◽  
George Lammie ◽  
Paul Leach
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Mass ◽  
Neuroendocrine Tumour ◽  
Clinical Findings ◽  
Neuroendocrine Neoplasm ◽  
Tumour Resection ◽  
Rare Presentation ◽  
Tissue Mass ◽  
Left Hand ◽  
History Of

Incidental soft tissue lumps in the scalp are a common presenting complaint in clinical practice. However, they may signify more sinister underlying pathologies. Our report examines a 63-year-old man presenting with impaired co-ordination in his left hand following a 3-month history of a painless left retroauricular scalp lump. MRI revealed a large left occipital soft tissue mass eroding through the underlying skull with infiltration into the underlying cerebellum and temporal lobe. Open biopsy confirmed a diagnosis of high-grade intracranial neuroendocrine tumour (NET). At approximately 5 months following successful tumour resection and adjuvant chemotherapy, he developed tumour recurrence and was subsequently palliated, and died at 1 year post diagnosis. Herein, we review other cases of primary intracranial NET, clinical findings, histopathological features and prognosis.

Neurofibroma of the hard palate

2021 ◽  
Vol 14 (4) ◽  
pp. e239887
Author(s):  
Bethany Cartwright ◽  
Kenneth Corsar
Keyword(s):  
Soft Tissue ◽  
Hard Palate ◽  
Soft Tissue Mass ◽  
Treatment Options ◽  
Neurofibromatosis Type ◽  
Incisional Biopsy ◽  
Tissue Mass ◽  
Benign Tumours

Neurofibromas are defined as benign tumours arising from peripheral nerve sheaths. Few intraoral palatal cases have been reported. Neurofibromas can occur as part of neurofibromatosis, type 1 (NF1) or type 2 (NF2). A 41-year-old patient presented with a slowly enlarging soft tissue mass on the hard palate. An incisional biopsy was performed, which confirmed the diagnosis of a neurofibroma associated with NF1. It should be considered that there is a chance of malignant transformation. Here, we discuss the clinical features, types, diagnosis, histopathology and treatment options.

Olfactory ganglioneuroblastoma in a dog: case report and literature review

2021 ◽  
pp. 104063872110228
Author(s):  
Ashley M. Romano ◽  
Chad B. Frank
Keyword(s):  
Computed Tomography ◽  
Case Report ◽  
Ganglion Cells ◽  
Soft Tissue Mass ◽  
Neoplastic Cell ◽  
Cell Populations ◽  
Intact Male ◽  
Tissue Mass ◽  
Immunohistochemical Markers ◽  
History Of

A 7-y-old, intact male Alaskan Malamute was presented with a 3-mo history of stertor and epistaxis. Computed tomography of the skull revealed generalized loss of gas throughout both nasal passages with replacement by a soft tissue mass that traversed the cribriform plate. Histopathology revealed neoplastic neuroblast cells arranged in anastomosing cords, as well as separately located aggregates of ganglion cells. Both neoplastic cell populations demonstrated immunoreactivity to MAP-2, TuJ-1, and synaptophysin. Neuroblastic cells additionally exhibited punctate immunoreactivity to MCK and CK8/18. We document here both the positive neural immunohistochemical markers for this neoplasm, as well as propose possible histomorphologic variants.

Schwannoma with Psammoma Body

2021 ◽  
Vol 111 (1) ◽  
Author(s):  
Lindsay M. Hummel ◽  
Susan Gamble ◽  
Robert Krouse ◽  
Darshana Jhala ◽  
Sharvari Dalal ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Soft Tissue ◽  
Soft Tissue Mass ◽  
Carney Complex ◽  
Psammoma Body ◽  
Psammoma Bodies ◽  
Tissue Mass ◽  
Pathologic Evaluation ◽  
History Of ◽  
Male Veteran

We present a case of a 59-year-old male veteran with a chronic history of right foot soft-tissue mass that was causing pain in his shoes, but not functional or neurologic symptoms. Excision of the mass and pathologic evaluation resulted in multidisciplinary involvement and evaluation. In this example, the mass was found to be either an unusual schwannoma that happens to be psammoma body–rich or an unusual psammomatous melanocytic schwannoma that deviates from conventional examples, as a diagnostic consensus was unable to be reached. Schwannomas are an uncommon finding in the foot, and even more uncommon are those that contain psammoma bodies. Although rare, these tumors can be concerning for more systemic, life-altering diseases such as Carney complex, for which our patient refused genetic testing.

Extraskeletal mesenchymal chondrosarcoma mimicking a thrombosed venous aneurysm with femoral vein involvement: A case report

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S25-S25
Author(s):  
J Muldoon ◽  
L Warmke
Keyword(s):  
Case Report ◽  
Gene Fusion ◽  
Soft Tissue Mass ◽  
Femoral Vein ◽  
Mesenchymal Chondrosarcoma ◽  
Venous Aneurysm ◽  
Tissue Mass ◽  
Common Femoral Vein ◽  
Extraskeletal Mesenchymal Chondrosarcoma ◽  
History Of

Abstract Introduction/Objective Mesenchymal chondrosarcoma is a high-grade primitive mesenchymal tumor, which accounts for <5% of all chondrosarcomas and commonly affects young adults (peak incidence in second to third decade of life). The tumor has a widespread anatomic distribution, frequently involving the craniofacial bones as well as extraskeletal sites. The clinical presentation of an inguinal mass mimicking a thrombosed venous aneurysm is unusual and represents a potential diagnostic pitfall. Methods/Case Report A 42-year-old female with hypertension and obesity initially presented with a two-week history of left lower leg swelling. Venous doppler revealed presumed venous thrombosis, and she was prescribed apixaban while no history of coagulopathy, immobility, or recent surgery was noted. Two months later, she had residual swelling. Follow-up CT scan favored a large, peripherally thrombosed venous aneurysm arising from the left common femoral vein, while MRI showed a lobulated, inguinal soft tissue mass abutting the vein. Biopsy of the mass demonstrated a spindle cell mesenchymal neoplasm; subsequent resection revealed a pink-to-tan, well-circumscribed, and encapsulated mass (5.2 cm) with focal left common femoral vein invasion. Microscopically, the lesion demonstrated poorly-differentiated, oval-to-spindle cells with prominent staghorn vasculature interspersed were focal areas of well-differentiated hyaline cartilage. Immunohistochemical stains showed that the lesional cells were negative for cytokeratin cocktail, EMA, SMA, desmin, S100 protein, SOX10, STAT6, MUC4, MDM2, and ER. Next-generation sequencing (NGS) revealed a HEY1-NCOA2 gene fusion, confirming the diagnosis of extraskeletal mesenchymal chondrosarcoma. Results (if a Case Study enter NA) N/A Conclusion Extraskeletal mesenchymal chondrosarcoma can rarely present as an inguinal soft tissue mass with vascular invasion, mimicking a thrombosed venous aneurysm. Molecular confirmation of HEY1-NCOA2 gene fusion can help confirm the diagnosis in unusual clinical presentations.

scholarly journals Lágyéksérvet utánzó gigantikus méretű myxoid leiomyoma

2016 ◽  
Vol 157 (10) ◽  
pp. 392-395
Author(s):  
Orsolya Huszár ◽  
Attila Zaránd ◽  
Gyöngyi Szántó ◽  
Viktória Juhász ◽  
Eszter Székely ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Smooth Muscle ◽  
Soft Tissue Mass ◽  
Smooth Muscle Tumour ◽  
Tissue Mass ◽  
Abdominal Symptoms ◽  
History Of ◽  
The Right

Leiomyoma is a rare, smooth muscle tumour that can occur everywhere in the human body. The authors present the history of a 60-year-old female, who had a giant, Mullerian type myxoid leiomyoma in the inguinal region mimicking acute abdominal symptoms. After examination the authors removed the soft tissue mass in the right femoral region reaching down in supine position to the middle third of the leg measuring 335 × 495 × 437 mm in greatest diameters in weight 33 kg. Reconstruction of the tissue defect was performed using oncoplastic guidelines. During the follow-up time no tumour recurrence was detected and the quality of life of the patient improved significantly. Orv. Hetil., 2016, 157(10), 392–395.

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