scholarly journals Changes in Echocardiographic Parameters among Beninese Soccer Referees during the Division 1 Championship in 2016

2018 ◽  
Vol 2018 ◽  
pp. 1-5
Author(s):  
Quenum Coffi ◽  
Sonou Arnaud ◽  
Gouthon Polycarpe ◽  
Ahissou Hyacinthe ◽  
Messan Folly ◽  
...  
Keyword(s):  
National Level ◽  
Concentric Hypertrophy ◽  
Division 1 ◽  
National Division ◽  
Eccentric Hypertrophy ◽  
Echocardiographic Parameters ◽  
Lv Ejection Fraction ◽  
A Prospective Study ◽  
And Function ◽  
Intensive Physical Exercise

Introduction. The goal of this study was to describe the echocardiographic parameters of soccer referees and to examine the changes in these parameters after a period of intensive physical exercise. Methods and Patients. We conducted a prospective study that included Beninese soccer referees. The study of the geometry and function of the left ventricle (LV) was made at the beginning and end of the national Division 1 championship, which was held during the course of 10 weeks. Results. There were 37 referees included in this study; 20 at the national level (G1: 27.8 ± 6.6 years) and 17 at the international level (G2: 32.1 ± 6.4 years). Dimensions of the LV were normal for all the referees. At the beginning of the championship, 51.3% of the referees had a normal LV geometry, 37.8% had concentric remodelling, 2.7% had concentric hypertrophy, and 8.1% had eccentric hypertrophy. In the group of referees with normal LV geometry, a modification in concentric remodelling at the end of the championship was seen in 30% of the referees in G1, 33.3% of the referees in G2, and 31.6% of the whole sample. In the group of subjects who presented concentric LV remodelling, a modification in the normal geometry was observed in 37.5% of those in G1, in 0% of those in G2, and in 21.4% of the whole sample. The cases of LV hypertrophy showed no change regardless of the group considered. An LV ejection fraction of more than 50% and an E/E′ ratio less than 8 were found in all referees. Conclusion. All the referees studied had normal cardiac morphology and function. The intensity of the physical load was insufficient to impact this morphology.

scholarly journals P1569 Left ventricle structure and function relations with renin-angiotensin-aldosteron system activity and plasma markers of fibrosis in patients with ACS underwent PCI

2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
M Krestjyaninov ◽  
V A Razin ◽  
R H Gimaev
Keyword(s):  
Left Ventricle ◽  
Statistical Significance ◽  
Structure And Function ◽  
Myocardial Stiffness ◽  
Renin Angiotensin ◽  
Coronary Syndrome ◽  
Concentric Hypertrophy ◽  
Eccentric Hypertrophy ◽  
And Function ◽  
Plasma Markers

Abstract Renin-angiotensin-aldosterone system (RAAS) plays significant role in development of myocardial fibrosis and LV remodelling which may increase severity of stroke and myocardial infarction. The purpose of the study is to evaluate relations between activity of RAAS and left ventricle structure and function in patients with acute coronary syndrome (ACS) underwent PCI. We examined 204 patients (both men and women) with ACS which were undergoing PCI. The mean age of patients was 51.0 (11) years. In all patients was performed ECG in 12 leads; EchoCG; evaluation plasma levels of aldosterone, angiotensin 2 (AT2), angiotensin-converting enzyme (ACE), tissue inhibitor of metalloproteinases-1 (TIMP-1) and insulin-like growth factor 1 (IGF-1). Statistical significance was defined at the level of methods for p < 0,05. Results of correlative analysis revealed relations between ILV mass and aldosterone (R = 0.57; p < 0.001), ACE (R = 0.59; p < 0.001), AT2 (R = 0.58; p < 0.001) and TIMP-1 (R = 0.54; p < 0.001). There were relations between E/A and AT2 (R = 0.23; p = 0.049), TIMP-1 (R = 0.22; p = 0.038); between IGF-1 and DT (R = 0.21; p = 0.045). This could be due to the growth in fibroblasts and cardiaomyocytes and increase in myocardial stiffness. The results of the comparison of RAAS activity markers, structural and functional parameters of the LV in patients with different LV geometry can be seen in Table 1. Thus, the results of the study show that activation of RAAS leads to increase in myocardial stiffness; and that RAAS activity and plasma markers of fibrosis was significantly higher in patients with concentric and eccentric LV hypertrophy. RAAS activity & LV geometry and function Parameters LV geometry models Normal Geometry n = 25 Concentric Remodelling n = 18 Concentric Hypertrophy n = 89 Eccentric Hypertrophy n = 72 Angiotensin 2 (pg/ml) 36.2 (11.6) 28.2 (5.5) 58.4 (46.; 64.5)*†‡ 45.8 (13.2)*† ACE (u/l) 44.4 (17.4) 30.3 (20.1; 33.0)* 67.6 (28.3)*† 57.1 (39.0; 68.0)† Aldosterone (pg/ml) 111.0 (76.8; 136.6) 101.2 (80.0; 120.5)* 152.4 (135.2; 177.3)*†‡ 136.0 (129.0; 152.0)*† TIMP-1 (ng/ml) 222.9 (80.9) 237.5 (140.0; 322.0)* 358.0 (259.0; 493.0)*†‡ 329.2 (102.5)*† IGF-1 (ng/ml) 174.2 (25.1) 174.5 (160.0; 179.0) 146.0 (129.0; 167.0)*† 148.9 (20.7)*† ILV mass (g/m²) 85.0 (79.1; 92.4) 94.7 (92.4; 97.9)* 146.3 (127.0; 171.1)*†‡ 127.0 (115.7; 149.0)*† E/A 0.7 (0.1) 0.8 (0.7; 0.9) 0.9 (0.8; 1.2)* 0.9 (0.8; 1.1)*† DT (ms) 194.3 (22.2) 185.4 (19.5) 198.9 (44.3)† 179.1 (26.8) E/e" 8.0 (0.9) 6.1 (5.4; 8.6)* 6.9 (5.5; 9.2)* 8.8 (3.0)† * - p < 0.05 in comparison with patients with normal geometry; † - p < 0.05 in comparison with patients with concentric remodelling; ‡ - p < 0.05 in comparison with patients with eccentric hypertrophy.

scholarly journals Uncomplicated Monochorionic Twins: Two Normal Hearts Sharing One Placenta

2020 ◽  
Vol 9 (11) ◽  
pp. 3602
Author(s):  
Ximena Torres ◽  
Mar Bennasar ◽  
Laura García-Otero ◽  
Raigam J. Martínez-Portilla ◽  
Brenda Valenzuela-Alcaraz ◽  
...  
Keyword(s):  
Wall Thickness ◽  
Relative Wall Thickness ◽  
Monochorionic Twins ◽  
Concentric Hypertrophy ◽  
Normal Ranges ◽  
Cardiac Adaptation ◽  
Echocardiographic Parameters ◽  
Z Scores ◽  
And Function ◽  
Right Atria

Cardiovascular dysfunction has been reported in complicated monochorionic diamniotic (MCDA) pregnancies; however, little is known whether hemodynamic changes occur in uncomplicated MCDA twins. A prospective observational study was conducted including 100 uncomplicated MCDA twins matched by gestational age to 200 low-risk singletons. Echocardiography was performed at 26–30 weeks gestation and cord blood B-type natriuretic peptide (BNP) was measured at delivery. In both groups, z-scores for echocardiographic parameters were within normal ranges; however the monochorionic group had larger atrial areas (mean (standard deviation) right atria-to-heart ratio: 17.0 (2) vs. 15.9 (1); p = 0.018; left atria-to-heart ratio: 17.0 (3) vs. 15.8 (2); p < 0.001) and signs of concentric hypertrophy (right relative wall thickness: 0.66 (0.12) vs. 0.56 (0.11); p < 0.001; left relative wall thickness: 0.69 (0.14) vs. 0.58 (0.12); p < 0.001). Longitudinal function was increased in twins, leading to higher tricuspid annular plane systolic excursion (6.9 mm (0.9) vs. 5.9 mm (0.7); p < 0.001) and mitral annular plane systolic excursion (4.9 mm (0.8) vs. 4.4 mm (1.1); p < 0.001. BNP levels at birth were also higher in MCDA twins (median [interquartile range]: 20.81 pg/mL [16.69–34.01] vs. 13.14 pg/mL [9.17–19.84]; p < 0.001). Thus, uncomplicated MCDA fetuses have normal cardiac shape and function, but signs of cardiac adaptation were identified by echocardiographic and biochemical parameters, when compared with singletons.

scholarly journals Age-dependent peculiarities of echocardiographic parameters of the heart in patients with nonalcoholic fatty liver disease

2014 ◽  
Vol 18 (4 (72)) ◽  
Author(s):  
V. P. Prysyazhnyuk
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Young Patients ◽  
Progressive Increase ◽  
Nonalcoholic Fatty Liver ◽  
Concentric Hypertrophy ◽  
Eccentric Hypertrophy ◽  
Echocardiographic Parameters

In present study echocardiographic features of the cardiovascular system in patients with nonalcoholic fatty liver disease (NAFLD) of different ages were examined. Structural and functional parameters of the heart change in nonalcoholic fatty liver patients with age: a progressive increase in the size of the left atrium, right ventricle, and decrease of ejection fraction. In young patients the formation of concentric remodeling and eccentric hypertrophy, in elderly patients – development of its concentric hypertrophy was observed. The above-mentioned requires timely use of cardio-protective drugs in the treatment of these patients.

scholarly journals THE 5-YEAR DYNAMICS OF CARDIAC STRUCTURE AND FUNCTION IN PATIENTS WITH CORONARY ARTERY DISEASE AFTER MYOCARDIAL REVASCULARIZATION

2020 ◽  
Vol 73 (4) ◽  
pp. 728-732
Author(s):  
Roksolana R. Guta ◽  
Olena M. Radchenko ◽  
Olga Ya. Korolyuk
Keyword(s):  
Myocardial Revascularization ◽  
Myocardial Mass ◽  
Co Morbidity ◽  
Geometry Estimation ◽  
Echocardiographic Parameters ◽  
Atrial Enlargement ◽  
Group 2 ◽  
Artery Disease ◽  
And Function ◽  
Group 1

The aim: To estimate the dynamics of echocardiographic parameters in patients with CAD within 5 years after revascularization. Material and methods: 50 persons (males/females 39/11; mean age 59.9±9.3 years; STEMI 76%, non-STEMI 24%) were divided into two groups: n=38 after PCI with stenting (PCIwS); n=12 after CABG. Observation included regular echocardiography with LV myocardial mass (LVMM) and geometry estimation. Results: Groups were comparable by age, co-morbidity, BP, heart rate and BMI. Significantly severe baseline LV hypertrophy (LVH) and left atrial enlargement (LAE) in group 2 explained by spread coronary atherosclerosis. Later progressive LAE (4.37±0.22 cm, P0-60<0.05) in group 1, and aortic/LV dilatation (+0.4/+1.0 cm, respectively, both P0-60<0.05) in group 2 developed. In two years LVMM index increased by 13.4/17.5% in groups 1/2, respectively. Normal geometry and concentric remodeling completely disappeared in 3/1.5 years after PCIwS/CABG, respectively. Conclusions: Within the 1st year after revascularization, patients with CABG had more severe LVH. In 5 years after PCIwS the ratio between concentric/eccentric LVH was 2:1, whereas after CABG – 1:2.

scholarly journals p38δ genetic ablation protects female mice from anthracycline cardiotoxicity

2020 ◽  
Author(s):  
Sharon A George ◽  
Alexi Kiss ◽  
Sofian N Obaid ◽  
Aileen Venegas ◽  
Trisha Talapatra ◽  
...  
Keyword(s):  
Cardiac Injury ◽  
Mapk Signaling ◽  
Anthracycline Cardiotoxicity ◽  
Genetic Ablation ◽  
Female Mice ◽  
Echocardiographic Parameters ◽  
The Individual ◽  
And Function ◽  
First Time ◽  
Dose Dependent

ABSTRACTBACKGROUNDThe efficacy of an anthracycline antibiotic doxorubicin (DOX) as a chemotherapeutic agent is limited by dose-dependent cardiotoxicity. DOX is associated with activation of intracellular stress signaling pathways including p38 MAPKs. While previous studies have implicated p38 MAPK signaling in DOX-induced cardiac injury, the roles of the individual p38 isoforms, specifically, of the alternative isoforms p38γ and p38δ, remain uncharacterized.OBJECTIVESTo determine the potential cardioprotective effects of p38γ and p38δ genetic deletion in mice subjected to acute DOX treatment.METHODSMale and female wild-type (WT), p38γ-/-, p38δ-/- and p38γ-/-δ-/- mice were injected with 30 mg/kg DOX and their survival was tracked for ten days. During this period cardiac function was assessed by echocardiography and electrocardiography and fibrosis by PicroSirius Red staining. Immunoblotting was performed to assess the expression of signaling proteins and markers linked to autophagy.RESULTSSignificantly improved survival was observed in p38δ-/- female mice post-DOX relative to WT females, but not in p38γ-/- or p38γ-/-δ-/- male or female mice. The improved survival in DOX-treated p38δ-/- females was associated with decreased fibrosis, increased cardiac output and LV diameter relative to DOX-treated WT females, and similar to saline-treated controls. Structural and echocardiographic parameters were either unchanged or worsened in all other groups. Increased autophagy, as evidenced by increased LC3-II level, and decreased mTOR activation was also observed in DOX-treated p38δ-/- females.CONCLUSIONSp38δ plays a crucial role in promoting DOX-induced cardiotoxicity in female mice by inhibiting autophagy. Therefore, p38δ targeting could be a potential cardioprotective strategy in anthracycline chemotherapy.NEW AND NOTEWORTHYThis study for the first time identifies the roles of the alternative p38γ and p38δ MAPK isoforms in promoting DOX-cardiotoxicity in a sex-specific manner. While p38γ systemic deletion did not affect DOX-cardiotoxicity, p38δ systemic deletion was cardioprotective in female but not in male mice. Cardiac structure and function were preserved in DOX-treated p38δ-/- females and autophagy was increased.

scholarly journals Effects of the cervical headgear in growing Angle Class II malocclusion patients: a prospective study

2020 ◽  
Vol 25 (2) ◽  
pp. 25-31
Author(s):  
Anderson Jaña Rosa ◽  
Rizomar Ramos do Nascimento ◽  
José Nelson Mucha ◽  
Oswaldo de Vasconcellos Vilella
Keyword(s):  
Significant Variation ◽  
Class Ii ◽  
Control Group ◽  
Class Ii Malocclusion ◽  
Angle Class Ii ◽  
Skeletal Changes ◽  
Division 1 ◽  
A Prospective Study ◽  
Untreated Individuals ◽  
Experimental Group

ABSTRACT Objective: Evaluate dental and skeletal changes resulting from the exclusive use of the cervical headgear for 15 ± 4 months in the treatment of patients with Class II division 1 malocclusion. Methods: Differences between the beginning (T1) and immediately after the end of the therapy (T2) with the cervical headgear in growing patients (Experimental Group, EG, n = 23) were examined and compared, during compatible periods, with those presented by a group of untreated individuals (Control Group, CG, n =22) with similar malocclusions and chronological age. The cephalometric variables evaluated were: ANB, GoGn.SN, AO-BO, S'-ANS, S'-A, S'-B, S'-Pog and S'-U6 (maxillary first molar). The Shapiro-Wilk and Levene tests were used to evaluate the results. Results: Significant differences were found relative to the ANB, S'-U6, AO-BO, S'-ANS, S'-A, S'-B and S'-Pog variables between T1 and T2 when comparing both groups. No statistically significant variation was found regarding the GoGn.SN angle. Conclusions: The use of cervical headgear promoted distal movement of the maxillary first molars and restricted the anterior displacement of the maxilla, without significantly affecting the GoGn.SN angle.

scholarly journals Echocardiographic Assessment of Left Ventricular Geometric Patterns in Hypertensive Patients in Nigeria

2013 ◽  
Vol 7 ◽  
pp. CMC.S12727 ◽  
Author(s):  
Rasaaq A. Adebayo ◽  
Olaniyi J. Bamikole ◽  
Michael O. Balogun ◽  
Anthony O. Akintomide ◽  
Victor O. Adeyeye ◽  
...  
Keyword(s):  
Diastolic Dysfunction ◽  
Systolic Function ◽  
Left Ventricular ◽  
Geometric Pattern ◽  
Color Flow ◽  
Hypertensive Patients ◽  
Geometric Patterns ◽  
Concentric Hypertrophy ◽  
Eccentric Hypertrophy ◽  
Lv Systolic Function

Left ventricular (LV) hypertrophy is an important predictor of morbidity and mortality in hypertensive patients, and its geometric pattern is a useful determinant of severity and prognosis of heart disease. Studies on LV geometric pattern involving large number of Nigerian hypertensive patients are limited. We examined the LV geometric pattern in hypertensive patients seen in our echocardiographic laboratory. A two-dimensional, pulsed, continuous and color flow Doppler echocardiographic evaluation of 1020 consecutive hypertensive patients aged between 18 and 91 years was conducted over an 8-year period. LV geometric patterns were determined using the relationship between the relative wall thickness and LV mass index. Four patterns of LV geometry were found: 237 (23.2%) patients had concentric hypertrophy, 109 (10.7%) had eccentric hypertrophy, 488 (47.8%) had concentric remodeling, and 186 (18.2%) had normal geometry. Patients with concentric hypertrophy were significantly older in age, and had significantly higher systolic blood pressure (BP), diastolic BP, and pulse pressure than those with normal geometry. Systolic function index in patients with eccentric hypertrophy was significantly lower than in other geometric patterns. Doppler echocardiographic parameters showed some diastolic dysfunction in hypertensive patients with abnormal LV geometry. Concentric remodeling was the most common LV geometric pattern observed in our hypertensive patients, followed by concentric hypertrophy and eccentric hypertrophy. Patients with concentric hypertrophy were older than those with other geometric patterns. LV systolic function was significantly lower in patients with eccentric hypertrophy and some degree of diastolic dysfunction were present in patients with abnormal LV geometry.

Abstract P092: Longitudinal Impact Of Blood Pressure On Left Ventricular Geometry In The Hispanic Community Health Study/Study Of Latinos: Echocardiographic Study Of Latinos (Echo-SOL) Ancillary Study

Circulation ◽  
2021 ◽  
Vol 143 (Suppl_1) ◽  
Author(s):  
Jennifer McLeod ◽  
Barry E Hurwitz ◽  
Daniela Sotres-Alvarez ◽  
Mayank M Kansal ◽  
Katrina Swett ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Left Ventricular ◽  
Health Study ◽  
Left Ventricular Geometry ◽  
Longitudinal Impact ◽  
Ventricular Geometry ◽  
Concentric Hypertrophy ◽  
Echocardiographic Study ◽  
Eccentric Hypertrophy ◽  
Latino Adults

Introduction: Abnormal left ventricular geometry (LVG) is an independent predictor of cardiovascular mortality. We assessed the longitudinal transitions of LVG among Hispanic/Latino adults. Methods: Echo-SOL provided serial 2D echocardiograms of Hispanic adults. Each subject was identified as hypertensive or normotensive and categorized into four LVG patterns: normal, concentric remodeling (CR), concentric hypertrophy (CH), or eccentric hypertrophy (EH). Hypertensive adults were stratified on whether they maintained blood pressure (BP) control (<140/90mmHg) by visit 2. The normotensive adults were stratified on whether they developed incident hypertension (HTN) by visit 2. Logistic regression was used to evaluate the outcome of normal vs. abnormal LVG at visit 2 adjusting for age, sex, and follow-up time. Results: There were 1818 adults at visit 1 (mean age 56 years; 42.6% male, 44.7% hypertensive), with 1643 obtaining serial echocardiograms an average of 4.3 years later. At visit 1, LVG was distributed as follows: normal, 65.3%; CR, 30.6%, CH 3.1%, and EH 1.1%. Among hypertensive adults at visit 1, 59.7% had normal LVG and 34.1% had CR. By visit 2, there was a progression from normal LVG to CR among those with and without BP control; CR prevalence increased to 58.5% and 55.2%, respectively (Fig. 1). For visit 1 hypertensive adults, the incidence of abnormal LVG did not differ with regards to BP control (adjusted OR 1.1, 95% CI: 0.7-1.7). Among normotensive adults at visit 1, 69.8% had normal LVG. If they remained normotensive by visit 2, this prevalence decreased to 52.2%. If they developed HTN, there was an associated progression toward abnormal geometry (adjusted OR 2.5, 95% CI: 1.4-4.2), with the majority (59.2%) demonstrating a CR phenotype. Conclusion: Our findings suggest that BP control to 140mmHg is not adequate to prevent progressive LV remodeling among Hispanic/Latino adults. Further study is needed to understand this maladaptive process and how it contributes to cardiovascular disease in this population.

Co-morbidity (HFrEF and HFpEF): hypertension

ESC CardioMed ◽  
2018 ◽  
pp. 1808-1812
Author(s):  
Francesco Paneni ◽  
Massimo Volpe
Keyword(s):  
Blood Pressure ◽  
Ejection Fraction ◽  
Left Ventricular ◽  
Ventricular Dilation ◽  
Hypertensive Patients ◽  
Reduced Ejection Fraction ◽  
Concentric Hypertrophy ◽  
Drug Classes ◽  
Left Ventricular Dilation ◽  
Eccentric Hypertrophy

Hypertensive heart disease is a major cause of heart failure (HF) and mortality. Hypertension precedes HF occurrence in 75% of cases, and carries a sixfold increase in HF risk as compared to non-hypertensive individuals. Most importantly, a minority of patients survive 5 years after the onset of hypertensive HF. In hypertensive patients, the heart may present different patterns of adaptive remodelling: concentric remodelling, concentric hypertrophy, and eccentric hypertrophy. Although most hypertensive patients are at high risk of developing concentric hypertrophy, a growing proportion of subjects display a concentric-to-eccentric progression eventually leading to left ventricular dilation and systolic dysfunction. Several factors including myocardial ischaemia, ethnicity, genetic background, history of diabetes, and blood pressure pattern may significantly influence the pathway from hypertension to left ventricular dilation. Patients with a concentric hypertrophy usually develop HF with preserved ejection fraction (HFpEF), whereas those with an eccentric (dilated) phenotype develop HF with reduced ejection fraction (HFrEF). Lowering blood pressure has a striking effect in reducing the risk of HF. Although available antihypertensive drugs are all successful in lowering blood pressure, angiotensin-converting enzyme inhibitors, angiotensin receptor blocker (ARBs), and diuretics are more effective than other drug classes in preventing HF. The combination of the neprilysin inhibitor sacubitril with the ARB valsartan (LCZ696) has recently been shown to be highly effective in reducing HF-related outcomes in hypertensive subjects. An individualized treatment scheme taking into account blood pressure levels, type of HF (HFpEF or HFrEF), and relevant co-morbidities (i.e. renal disease, diabetes) is currently the best approach to improve morbidity and mortality in hypertensive patients with HF.

Aortic regurgitation

2015 ◽  
pp. 141-147
Author(s):  
Raphael Rosenhek
Keyword(s):  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Aortic Valve ◽  
Aortic Regurgitation ◽  
Cardiac Computed Tomography ◽  
Transoesophageal Echocardiography ◽  
Left Ventricular ◽  
Disease Aetiology ◽  
Echocardiographic Parameters ◽  
And Function

The workup of patients with aortic regurgitation is routinely based on echocardiography and includes a detailed morphologic assessment of the aortic valve with the determination of disease aetiology. The quantification of aortic regurgitation is based on an integration of qualitative and quantitative parameters. Haemodynamic consequences of aortic valve disease on left ventricular size, hypertrophy, and function, as well as potentially coexisting valve lesions, are assessed. Predictors of outcome and indications for surgery are substantially defined by echocardiographic parameters. Cardiac magnetic resonance has become an important complementary technique, both for the quantification of regurgitant severity and for the assessment of ventricular function. While the proximal parts of the ascending aorta are routinely visualized by transthoracic echocardiography, transoesophageal echocardiography (TOE) and in particular cardiac magnetic resonance (CMR) and cardiac computed tomography (CT) allow a more comprehensive assessment of the thoracic aorta.

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