scholarly journals The Adaptive Complexity of Cancer

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Youcef Derbal
Keyword(s):  
Complex Adaptive System ◽  
Treatment Options ◽  
Cancer Therapies ◽  
Cancer Resistance ◽  
Dynamic Coupling ◽  
Effective Immune Response ◽  
Complex Adaptive ◽  
New Cancer Therapies ◽  
Adaptive Complexity ◽  
Survival Mechanisms

Cancer treatment options are expanding to the benefit of significant segments of patients. However, their therapeutic power is not equally realized for all cancer patients due to drug toxicity and disease resistance. Overcoming these therapeutic challenges would require a better understanding of the adaptive survival mechanisms of cancer. In this respect, an integrated view of the disease as a complex adaptive system is proposed as a framework to explain the dynamic coupling between the various drivers underlying tumor growth and cancer resistance to therapy. In light of this system view of cancer, the immune system is in principal the most appropriate and naturally available therapeutic instrument that can thwart the adaptive survival mechanisms of cancer. In this respect, new cancer therapies should aim at restoring immunosurveillance by priming the induction of an effective immune response through a judicious targeting of immunosuppression, inflammation, and the tumor nutritional lifeline extended by the tumor microenvironment.

Mathematical Formalism and Political-Economic Content

2012 ◽  
pp. 82-95 ◽  
Author(s):  
D. Foley
Keyword(s):  
Political Economy ◽  
Statistical Methods ◽  
Complex Adaptive System ◽  
Economic Modeling ◽  
Qualitative Properties ◽  
Mathematical Methods ◽  
Econometric Methods ◽  
Statistical Fluctuations ◽  
Complex Adaptive ◽  
New Thinking

Mathematical methods are only one moment in a layered process of theory generation in political economy, which starts from Schumpeterian vision, progresses to the identification of relevant abstractions, the development of mathematical and quantitative models, and the confrontation of theories with empirical data through statistical methods. But today the relevant abstract problems of political economy are modified to fit available mathematical tools. The role of empirical research in disciplining theoretical speculation, on which the scientific traditions integrity rests, was undermined by specific limitations of nascent econometric methods, and usurped by ex cathedra methodological fiats of theorists. These developmentssystematically favored certain ideological predispositions of economicsas a discipline. There is abundant room for New Thinking in political economy starting from the vision of the capitalist economy as a complex, adaptive system far from equilibrium, including the development of the theory of statistical fluctuations for economic interactions, redirection of macroeconomics and financial economics from path prediction toward an understanding of the qualitative properties of the system, introduction of constructive and computable methods into economic modeling, and the critical reconstruction of econometric statistical methods.

Using Naïve Bayes Algorithm to Estimate the Response to Drug in Lung Cancer Patients

2019 ◽  
Vol 21 (10) ◽  
pp. 734-748 ◽  
Author(s):  
Baoling Guo ◽  
Qiuxiang Zheng
Keyword(s):  
Lung Cancer ◽  
Side Effects ◽  
Cancer Patients ◽  
Drug Response ◽  
Treatment Options ◽  
Clinical Manifestations ◽  
Treatment Strategies ◽  
Cancer Resistance ◽  
Lung Cancer Patients ◽  
Bayes Algorithm

Aim and Objective: Lung cancer is a highly heterogeneous cancer, due to the significant differences in molecular levels, resulting in different clinical manifestations of lung cancer patients there is a big difference. Including disease characterization, drug response, the risk of recurrence, survival, etc. Method: Clinical patients with lung cancer do not have yet particularly effective treatment options, while patients with lung cancer resistance not only delayed the treatment cycle but also caused strong side effects. Therefore, if we can sum up the abnormalities of functional level from the molecular level, we can scientifically and effectively evaluate the patients' sensitivity to treatment and make the personalized treatment strategies to avoid the side effects caused by over-treatment and improve the prognosis. Result & Conclusion: According to the different sensitivities of lung cancer patients to drug response, this study screened out genes that were significantly associated with drug resistance. The bayes model was used to assess patient resistance.

Breast Cancer Resistance Protein: A Potential Therapeutic Target for Cancer

2020 ◽  
Vol 21 ◽  
Author(s):  
Sonali Mehendale-Munj
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Resistance Protein ◽  
Protein A ◽  
The Body ◽  
Cancer Therapies ◽  
Cancer Resistance ◽  
Lung Cancers ◽  
Resistance Protein ◽  
Atp Regulation ◽  
Treatment Procedures

: Breast Cancer Resistance Protein (BCRP) is an efflux transporter responsible for causing multidrug re-sistance(MDR). It is known to expel many potent antineoplastic drugs, owing to its efflux function. Efflux of chemothera-peutics because of BCRP develops resistance to manydrugs, leading to failure in cancer treatment. BCRP plays an important role in physiology by protecting the organism from xenobiotics and other toxins. It is a half-transporter affiliated to theATP-binding cassette (ABC) superfamily of transporters, encoded by the gene ABCG2 and functions in response to adenosine triphosphate (ATP). Regulation of BCRP expression is critically controlled at molecular levels which help in maintaining the balance of xenobiotics and nutrients inside the body. Expression of BCRP can be found in brain, liver, lung cancers and acute myeloid leukemia (AML). Moreover, it is also expressed at high levels in stem cells and many cell lines. This frequent expression of BCRP has an impact on the treatment procedures and if not scrutinized may lead to failure of many cancer therapies.

Hybridität als Motor und als Ergebnis von Sprachwandel

Glottotheory ◽  
2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Csaba Földes
Keyword(s):  
Language Development ◽  
Cultural Production ◽  
Language Change ◽  
Adaptive System ◽  
Complex Adaptive System ◽  
Explanatory Variable ◽  
Essential Factor ◽  
Language Functions ◽  
Complex Adaptive ◽  
Linguistic Innovation

AbstractThis paper deals with constellations in which, as consequences of linguistic interculturality, elements of two or more languages encounter each other and result in something partially or completely new, an – occasionally temporary – “third quality”, namely hybridity. The paper contributes to the meta-discourse and theory formation by questioning the concept, term and content of “linguistic hybridity”. It also submits a proposal for a typology of linguistic-communicative hybridity that consists of the following prototypical main groups, each with several subtypes: (1) language-cultural, (2) semiotic, (3) medial, (4) communicative, (5) systematic, (6) paraverbal and (7) nonverbal hybridity. At last, the paper examines hybridity as an explanatory variable for language change. In conclusion, hybridity is generally a place of cultural production, with special regard to communication and language it is potentially considered as an incubator of linguistic innovation. Hybridity can be seen as the engine and as the result of language change, or language development. It represents an essential factor by which language functions and develops as a complex adaptive system. Hybridity operates as a continuous cycle. By generating innovation, it triggers language change, which in turn, leads to further and new hybridizations. The processuality of hybridity creates diversity, while at the same time it can cause the vanishing of diversity.

scholarly journals Update on the role of pembrolizumab in patients with unresectable or metastatic colorectal cancer

2021 ◽  
Vol 14 ◽  
pp. 175628482110244
Author(s):  
Vanessa Wookey ◽  
Axel Grothey
Keyword(s):  
Colorectal Cancer ◽  
Immune Checkpoint ◽  
Checkpoint Inhibitors ◽  
Treatment Options ◽  
Standard Of Care ◽  
Cancer Type ◽  
Cancer Therapies ◽  
Multiple Cancer ◽  
Multiple Treatment

Colorectal cancer (CRC) is the third most common cancer type in both men and women in the USA. Most patients with CRC are diagnosed as local or regional disease. However, the survival rate for those diagnosed with metastatic disease remains disappointing, despite multiple treatment options. Cancer therapies for patients with unresectable or metastatic CRC are increasingly being driven by particular biomarkers. The development of various immune checkpoint inhibitors has revolutionized cancer therapy over the last decade by harnessing the immune system in the treatment of cancer, and the role of immunotherapy continues to expand and evolve. Pembrolizumab is an anti-programmed cell death protein 1 immune checkpoint inhibitor and has become an essential part of the standard of care in the treatment regimens for multiple cancer types. This paper reviews the increasing evidence supporting and defining the role of pembrolizumab in the treatment of patients with unresectable or metastatic CRC.

Application of Complex Adaptive System Theory to Water Resources Allocation in Dianchi Basin

2012 ◽  
Vol 212-213 ◽  
pp. 536-542
Author(s):  
Qiong Su ◽  
Shi Hua He
Keyword(s):  
System Theory ◽  
Water Resources ◽  
Adaptive System ◽  
Complex Adaptive System ◽  
Resources Allocation ◽  
Water Resources Allocation ◽  
Evolutionary Mechanisms ◽  
Reservoir Water ◽  
Allocation System ◽  
Complex Adaptive

Based on complex adaptive system theory, the characteristics of water resources allocation system of river basin are analyzed. Evolutionary mechanisms and process of complex adaptive water resources allocation system in Dianchi basin are researched, and also characteristics of "learning". A complex adaptive system model of water-resource allocation is established during analyzing the influence factors and the reaction rules of water consumer agents and water provider agents. And based on this model, water resources in Dianchi basin is allocated only under Dianchi water provider and Zhangjiu river Yunlong reservoir water provider by using the platform of matlab. Finally, corresponding calculation results and conclusions are concluded.

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