scholarly journals Performance of Urinary Markers for Detection of Upper Tract Urothelial Carcinoma: Is Upper Tract Urine More Accurate than Urine from the Bladder?

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Simone Bier ◽  
Jörg Hennenlotter ◽  
Michael Esser ◽  
Sarah Mohrhardt ◽  
Steffen Rausch ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Matrix Protein ◽  
Upper Urinary Tract ◽  
Urine Samples ◽  
Nuclear Matrix Protein ◽  
Upper Tract ◽  
Lower Specificity ◽  
Recent Diagnosis ◽  
Urine Markers

Objectives. To assess the performance of urine markers determined in urine samples from the bladder compared to samples collected from the upper urinary tract (UUT) for diagnosis of UUT urothelial carcinoma (UC). Patients and Methods. The study comprised 758 urine samples either collected from the bladder (n=373) or UUT (n=385). All patients underwent urethrocystoscopy and UUT imaging or ureterorenoscopy. Cytology, fluorescence in situ hybridization (FISH), immunocytology (uCyt+), and nuclear matrix protein 22 (NMP22) were performed. Results. UUT UC was diagnosed in 59 patients (19.1%) (UUT urine) and 27 patients (7.2%) (bladder-derived urine). For UUT-derived samples, sensitivities for cytology, FISH, NMP22, and uCyt+ were 74.6, 79.0, 100.0, and 100.0, while specificities were 66.6, 50.7, 5.9, and 66.7%, respectively. In bladder-derived samples, sensitivities were 59.3, 52.9, 62.5, and 50.0% whereas specificities were 82.9, 85.0, 31.3, and 69.8%. In UUT-derived samples, concomitant bladder cancer led to increased false-positive rates of cytology and FISH. Conclusions. Urine markers determined in urine collected from the UUT exhibit better sensitivity but lower specificity compared to markers determined in bladder-derived urine. Concomitant or recent diagnosis of UC of the bladder can further influence markers determined in UUT urine.

EVALUATION OF URINARY NUCLEAR MATRIX PROTEIN 22 TEST FOR DETECTION OF UPPER TRACT UROTHELIAL CARCINOMA

2008 ◽  
Vol 179 (4S) ◽  
pp. 69-69
Author(s):  
Ithaar H Derweesh ◽  
Jim Y Wan ◽  
Christopher J DiBlasio ◽  
John B Malcolm ◽  
Reza Mehrazin ◽  
...  
Keyword(s):  
Urothelial Carcinoma ◽  
Nuclear Matrix ◽  
Matrix Protein ◽  
Upper Tract Urothelial Carcinoma ◽  
Nuclear Matrix Protein ◽  
Upper Tract

A review of the contemporary management of upper urinary tract urothelial carcinoma

2017 ◽  
Vol 11 (1) ◽  
pp. 51-57
Author(s):  
Abhishek Reekhaye ◽  
Seshadri Sriprasad ◽  
Sanjeev Madaan
Keyword(s):  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Treatment Options ◽  
Treatment Strategies ◽  
Upper Urinary Tract ◽  
Rare Tumour ◽  
Endoscopic Techniques ◽  
Upper Tract ◽  
Urothelial Carcinomas ◽  
Urinary Tract Urothelial Carcinoma

Upper tract urothelial carcinoma (UTUC) is relatively rare and accounts for approximately 5% of all urothelial carcinomas. The estimated annual incidence of UTUC in Western countries is about two new cases per 100,000 inhabitants. The management of patients with upper tract urothelial carcinomas has changed significantly over the last decade with improved diagnostic techniques and treatment options. The gold-standard treatment used to be open radical nephroureterectomy with removal of the ipsilateral bladder cuff. The use of minimally invasive techniques for the diagnosis and management of upper urinary tract urothelial carcinoma is however expanding and has led to a paradigm shift in treatment strategies of upper tract urothelial carcinomas. In this article, we review the current diagnostic modalities and various endoscopic techniques being currently used in the management of this relatively rare tumour.

scholarly journals Use of the Nuclear Matrix Protein 22 BladderChek Test for the Detection of Primary and Recurrent Urothelial Carcinoma

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Chang-sheng Xia ◽  
Chun-hong Fan ◽  
Ming Su ◽  
Qing-song Wang ◽  
Hui-zhang Bao
Keyword(s):  
Urothelial Carcinoma ◽  
Sensitivity And Specificity ◽  
Nuclear Matrix ◽  
Matrix Protein ◽  
Benign Disease ◽  
Urine Cytology ◽  
Nuclear Matrix Protein ◽  
Combined Use ◽  
Significant Difference ◽  
Low Sensitivity

Objective. To evaluate the performance of the nuclear matrix protein 22 (NMP22) BladderChek test in urothelial carcinoma (UC). Methods. We retrospectively analyzed 1318 patients who performed the NMP22 BladderChek tests. Of them, 103 were primary UC patients, 90 were surgical treatment UC patients, and 1125 were benign disease patients. The performance of the NMP22 BladderChek test for the diagnosis of primary and recurrent UC was evaluated. Moreover, the performance of urine cytology and the NMP22 BladderChek test for the diagnosis of primary UC was compared in 90 available subjects including 48 primary UC patients and 42 benign disease patients. Results. The sensitivity and specificity of the NMP22 BladderChek test were 37.9% and 95.8%, respectively, for the diagnosis of primary UC (n=1228). The corresponding parameters of the NMP22 BladderChek test were 31.0% and 88.5%, respectively, for the diagnosis of recurrent UC (n=90). The sensitivity and specificity of urine cytology were 54.2% and 97.6%, respectively, for the diagnosis of primary UC (n=90); the corresponding parameters of the NMP22 BladderChek test were 41.7% and 83.3%, respectively; the corresponding parameters of the two tests combination were 64.6% and 83.3%, respectively. There was a significant difference in the performance between the NMP22 BladderChek test and urine cytology or the combination of two tests (P=0.017 and 0.001, respectively). Conclusions. The NMP22 BladderChek test has a low sensitivity for detecting primary and recurrent UC. Urine cytology is superior to the NMP22 BladderChek test, and combined use of the two tests improves the sensitivity in the detection of primary UC.

scholarly journals Upper urinary tract urothelial carcinoma with loco-regional nodal metastases: insights from the Upper Tract Urothelial Carcinoma Collaboration

2011 ◽  
Vol 108 (8) ◽  
pp. 1286-1291 ◽  
Author(s):  
Ramy F. Youssef ◽  
Shahrokh F. Shariat ◽  
Yair Lotan ◽  
Christopher G. Wood ◽  
Arthur I. Sagalowsky ◽  
...  
Keyword(s):  
Urinary Tract ◽  
Urothelial Carcinoma ◽  
Upper Urinary Tract ◽  
Upper Tract Urothelial Carcinoma ◽  
Nodal Metastases ◽  
Upper Tract ◽  
Urinary Tract Urothelial Carcinoma
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