scholarly journals Palmitoylation as a Functional Regulator of Neurotransmitter Receptors

2018 ◽  
Vol 2018 ◽  
pp. 1-18 ◽  
Author(s):  
Vladimir S. Naumenko ◽  
Evgeni Ponimaskin
Keyword(s):  
Posttranslational Modifications ◽  
Current Knowledge ◽  
Point Of View ◽  
Covalent Attachment ◽  
Neurotransmitter Receptors ◽  
Protein Palmitoylation ◽  
Neuronal Proteins ◽  
Functional Point ◽  
Pathological Behavior ◽  
Multiple Signaling

The majority of neuronal proteins involved in cellular signaling undergo different posttranslational modifications significantly affecting their functions. One of these modifications is a covalent attachment of a 16-C palmitic acid to one or more cysteine residues (S-palmitoylation) within the target protein. Palmitoylation is a reversible modification, and repeated cycles of palmitoylation/depalmitoylation might be critically involved in the regulation of multiple signaling processes. Palmitoylation also represents a common posttranslational modification of the neurotransmitter receptors, including G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LICs). From the functional point of view, palmitoylation affects a wide span of neurotransmitter receptors activities including their trafficking, sorting, stability, residence lifetime at the cell surface, endocytosis, recycling, and synaptic clustering. This review summarizes the current knowledge on the palmitoylation of neurotransmitter receptors and its role in the regulation of receptors functions as well as in the control of different kinds of physiological and pathological behavior.

Dental Inclusion of Canine and Wisdom Tooth in Orthodontics Chemical Necroses

2018 ◽  
Vol 69 (8) ◽  
pp. 2191-2196
Author(s):  
Cristian Constantin Budacu ◽  
Nicoleta Ioanid ◽  
Cristian Romanec ◽  
Mihail Balan ◽  
Liliana Lacramioara Pavel ◽  
...  
Keyword(s):  
Third Molar ◽  
Point Of View ◽  
Separate Entity ◽  
Wisdom Tooth ◽  
Facial Aesthetics ◽  
The Third ◽  
Edentulous Mandible ◽  
Canine Guidance ◽  
Upper Jaw ◽  
Functional Point

Canine plays an important role in the dento-maxillary system. From a functional point of view, it provides the canine guidance, by positioning it in the frontal area, has a role in facial aesthetics. It plays an important prosthetic role by having the longest root and one of the longest arcade teeth. Three molars represent the last teeth that erupt in the arches both in the jaw and in the mandible, which is why they remain the most frequently included.Canine incidence is quite common following the wisdom tooth. It can be unilateral or bilateral and is more common in the upper jaw. The canine may remain included at the vestibular, palatal or between the two bones. A separate entity is the incision of the canine in the edentulous mandible or jaw. The study included 213 cases with dento-alveolar pathology, of which 128 patients were selected with dental inclusion. Our study reports that the first three molars are frequent, followed by the canine as opposed to other studies conducted by Guzduz K in 2011 and Fardi A of the same year bringing the canines first (Fardi, Guzduz). Some studies attribute the first place to the superior canine in terms of frequency, but they are abstracted from the molar three inclusion that they consider as most frequently (Compoy). The most common tooth in inclusion is the third molar (lower and upper) followed by the upper canine; the most commonly affected are women for both canine and molar.

scholarly journals The intracellular dynamic of protein palmitoylation

2010 ◽  
Vol 191 (7) ◽  
pp. 1229-1238 ◽  
Author(s):  
Christine Salaun ◽  
Jennifer Greaves ◽  
Luke H. Chamberlain
Keyword(s):  
Posttranslational Modifications ◽  
Posttranslational Modification ◽  
Mammalian Cells ◽  
Protein Functionality ◽  
Peripheral Membrane Proteins ◽  
Protein Palmitoylation ◽  
Thioester Bond ◽  
Intracellular Sorting ◽  
Intracellular Dynamic ◽  
Insight Into

S-palmitoylation describes the reversible attachment of fatty acids (predominantly palmitate) onto cysteine residues via a labile thioester bond. This posttranslational modification impacts protein functionality by regulating membrane interactions, intracellular sorting, stability, and membrane micropatterning. Several recent findings have provided a tantalizing insight into the regulation and spatiotemporal dynamics of protein palmitoylation. In mammalian cells, the Golgi has emerged as a possible super-reaction center for the palmitoylation of peripheral membrane proteins, whereas palmitoylation reactions on post-Golgi compartments contribute to the regulation of specific substrates. In addition to palmitoylating and depalmitoylating enzymes, intracellular palmitoylation dynamics may also be controlled through interplay with distinct posttranslational modifications, such as phosphorylation and nitrosylation.

scholarly journals Back to the Future: Very High-Energy Electrons (VHEEs) and Their Potential Application in Radiation Therapy

Cancers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 4942
Author(s):  
Maria Grazia Ronga ◽  
Marco Cavallone ◽  
Annalisa Patriarca ◽  
Amelia Maia Leite ◽  
Pierre Loap ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Current Knowledge ◽  
High Energy ◽  
High Dose Rate ◽  
Point Of View ◽  
High Dose ◽  
Dose Rates ◽  
High Energy Electrons ◽  
Very High Energy ◽  
Very High

The development of innovative approaches that would reduce the sensitivity of healthy tissues to irradiation while maintaining the efficacy of the treatment on the tumor is of crucial importance for the progress of the efficacy of radiotherapy. Recent methodological developments and innovations, such as scanned beams, ultra-high dose rates, and very high-energy electrons, which may be simultaneously available on new accelerators, would allow for possible radiobiological advantages of very short pulses of ultra-high dose rate (FLASH) therapy for radiation therapy to be considered. In particular, very high-energy electron (VHEE) radiotherapy, in the energy range of 100 to 250 MeV, first proposed in the 2000s, would be particularly interesting both from a ballistic and biological point of view for the establishment of this new type of irradiation technique. In this review, we examine and summarize the current knowledge on VHEE radiotherapy and provide a synthesis of the studies that have been published on various experimental and simulation works. We will also consider the potential for VHEE therapy to be translated into clinical contexts.

scholarly journals Aurones: A Golden Resource for Active Compounds

Molecules ◽  
2021 ◽  
Vol 27 (1) ◽  
pp. 2
Author(s):  
Ilaria Mazziotti ◽  
Giovanni Petrarolo ◽  
Concettina La Motta
Keyword(s):  
Functional Properties ◽  
Scientific Community ◽  
Recent Literature ◽  
Biological Pathways ◽  
Point Of View ◽  
Drug Candidates ◽  
The Past ◽  
Comprehensive Picture ◽  
Functional Point ◽  
Chemical Strategies

Deemed as poorly represented in nature, aurones have been often overlooked by researchers compared to other members of the flavonoid superfamily. However, over the past two decades, they have been reassessed by the scientific community, who are increasingly appreciating their ability to modulate several biological pathways. This review summarizes the recent literature on this class of compounds, which has been analyzed from both a chemical and a functional point of view. Original articles, reviews and editorials featured in Pubmed and Scifinder over the last twenty years have been taken into account to provide the readers with a view of the chemical strategies to obtain them, their functional properties, and their potential of technological use. The resulting comprehensive picture aims at raising the awareness of these natural derivatives as effective drug candidates, fostering the development of novel synthetic analogues.

scholarly journals Automatic Fire Detection and Extinction with Infrared Multispectrum Electro-Optical Technology with Watch-Dog Timer Control, for a 220KV to 33KV Transformer

2021 ◽  
Vol 11 (11) ◽  
pp. 101-113
Author(s):  
Yesica Pamela Leandro Chacon ◽  
◽  
Omar Chamorro Atalaya
Keyword(s):  
Detection System ◽  
Fire Detection ◽  
Automatic Detection ◽  
Point Of View ◽  
Coefficient Of Determination ◽  
Functional Tests ◽  
Optical Technology ◽  
Optimal Response ◽  
Flow Parameters ◽  
Functional Point

The present research aims to design an automatic fire detection and extinction system, developed with infrared multi-spectrum electro-optical technology with watch-dog timer control, for an electrical transformer from 220KV to 33KV. Upon its development, it is concluded that the automatic detection and extinction system has a deluge system with sprayed water, which will be activated by a detection system with flame sensors, this system has infrared multispectrum Electro-Optical Technology and will be controlled by through the Timer Watch-Dog, which will automatically detect and report any failure in the state-of-theart microprocessor. By subjecting the detection and extinguishing system to operational and functional tests, an optimal response of the deluge sprinklers was obtained, through the pressure and flow parameters, also a coefficient of determination R2 equal to 0.991 is obtained, which represents that the design is optimal, evidencing feasibility from the operational and functional point of view. Keywords— Detection, Extinction, Automatic, ElectroOptical, Multispectral, Infrared, Timer Watch-Dog, Transformer

scholarly journals Recursos estilísticos de creación humorística en los debates parlamentarios españoles: una clasificación morfo-funcional

2021 ◽  
Vol 23 ◽  
pp. 395-419
Author(s):  
Alejandro Romero Nieto
Keyword(s):  
Point Of View ◽  
Parliamentary Debates ◽  
Functional Point ◽  
The Way

El funcionamiento del humor en entornos serios es un asunto de relativo interés para la Pragmática. Este trabajo se inscribe dentro de este contexto: su objetivo es clasificar y analizar los principales recursos estilísticos de creación humorística utilizados en los debates parlamentarios españoles desde un punto de vista morfo-funcional. Dicha clasificación se ha realizado en función de la manera en que se resuelve el conflicto que provoca el marco humorístico: bien mediante la sustitución de un marco por otro, o bien mediante la oposición de ambos. La conclusión extraída ha sido que el comportamiento humorístico en los parlamentos españoles tiende a activar dispositivos lingüísticos relacionados con la confrontación y la exageración. The functioning of humour in serious frames is an issue of relative interest to Pragmatics. This work is inscribed within this context: its aim is to classify and analyse the main stylistic resources of humorous creation used in Spanish parliamentary debates from a functional point of view. Such classification was made according with the way in which the conflict caused by the humorous frame is resolved: either by substituting one frame by another, or through the opposition of both frames. The conclusion was that humorous behaviour in Spanish parliaments tends to activate linguistic devices related with confrontation and exaggeration.

scholarly journals Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation

2015 ◽  
Vol 2015 ◽  
pp. 1-23 ◽  
Author(s):  
Michael Schnoor ◽  
Pilar Alcaide ◽  
Mathieu-Benoit Voisin ◽  
Jaap D. van Buul
Keyword(s):  
Rheumatoid Arthritis ◽  
Current Knowledge ◽  
Leukocyte Adhesion ◽  
Vascular Wall ◽  
Point Of View ◽  
Regulatory Mechanisms ◽  
Integrin Receptors ◽  
Endothelial Monolayers ◽  
Leukocyte Extravasation ◽  
Endothelial Adhesion Molecules

Leukocyte extravasation is one of the essential and first steps during the initiation of inflammation. Therefore, a better understanding of the key molecules that regulate this process may help to develop novel therapeutics for treatment of inflammation-based diseases such as atherosclerosis or rheumatoid arthritis. The endothelial adhesion molecules ICAM-1 and VCAM-1 are known as the central mediators of leukocyte adhesion to and transmigration across the endothelium. Engagement of these molecules by their leukocyte integrin receptors initiates the activation of several signaling pathways within both leukocytes and endothelium. Several of such events have been described to occur during transendothelial migration of all leukocyte subsets, whereas other mechanisms are known only for a single leukocyte subset. Here, we summarize current knowledge on regulatory mechanisms of leukocyte extravasation from a leukocyte and endothelial point of view, respectively. Specifically, we will focus on highlighting common and unique mechanisms that specific leukocyte subsets exploit to succeed in crossing endothelial monolayers.

ALL-OPTICAL ON-BOARD NETWORKS PROTOCOLS

2021 ◽  
Vol 4 (30) ◽  
pp. 87-98
Author(s):  
V. L. Olenev ◽  
◽  
N. Y. Chumakova ◽  
N. I. Sinyov ◽  
A. Y. Syschikov ◽  
...  
Keyword(s):  
Point Of View ◽  
Transport Layer ◽  
Protocol Stack ◽  
Data Link ◽  
Link Layer ◽  
Data Link Layer ◽  
Software Model ◽  
All Optical ◽  
Functional Point ◽  
Board Networks

The article presents the concept of all-optical on-board networks (AOON). AOON protocol stack is described, the operation of the transport layer, data link layer and the management layer of the AOON protocol stack is considered in details. The article also describes a software model designed to check the correctness of operation of the AOON protocol stack from a functional point of view, and an example of the developed software model is provided.

Screw-Retained Implant-Supported Fixed Dental Restorations: A Rational Method to Overcome Esthetic Issues with the Screw-Access Hole

2021 ◽  
Vol 7 (4) ◽  
Author(s):  
Etienne O ◽  
◽  
Waltmann E ◽  
Serfaty R ◽  
◽  
...  
Keyword(s):  
Bacterial Contamination ◽  
Point Of View ◽  
Dental Restoration ◽  
Rational Method ◽  
Rational Analysis ◽  
Dental Restorations ◽  
Access Hole ◽  
Functional Point ◽  
New Perspective ◽  
Materials Used

Achieving both esthetics and a perfect seal of the screw-access hole in a screw-retained implant-supported fixed dental restoration is a great challenge. From a functional point of view, a perfect seal needs to be obtained to prevent bacterial contamination along the screw access canal and the occlusion shall be addressed. Such a challenging procedure has to be based on a rational analysis of the different materials used. Screw-retained zirconia-based restorations offer a new perspective for esthetic and biocompatible results. The aim of this article is to describe an easy and reproducible clinical procedure to esthetically seal the screw-access hole of screw-retained implant-supported fixed dental restorations.

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