scholarly journals Acquired Amegakaryocytic Thrombocytopenia and Pure Red Cell Aplasia in Thymoma

2018 ◽  
Vol 2018 ◽  
pp. 1-3 ◽  
Author(s):  
Sumit Dahal ◽  
Eliza Sharma ◽  
Suyash Dahal ◽  
Binav Shrestha ◽  
Bikash Bhattarai
Keyword(s):  
Aplastic Anemia ◽  
Diagnostic Procedures ◽  
Pure Red Cell Aplasia ◽  
Red Cell ◽  
Early Presentation ◽  
Erythroid Precursor ◽  
Red Cell Aplasia ◽  
History Of ◽  
Intravenous Steroids ◽  
Acquired Amegakaryocytic Thrombocytopenia

Association of thymoma with myasthenia gravis, pure red cell aplasia, and aplastic anemia is well documented. However, thymoma complicated by acquired amegakaryocytic thrombocytopenia (AAMT) is rarely reported. Here, we present a case of a 60-year-old male with past medical history of recurrent invasive thymoma who presented with cough and blood in sputum. He was found to have severe normocytic normochromic anemia and thrombocytopenia that did not improve with intravenous steroids or multiple transfusions of red cells and platelets. Subsequent bone marrow biopsy showed severely depleted megakaryocytes and erythroid precursor cells with relative myeloid hyperplasia suggestive of amegakaryocytic thrombocytopenia and red cell aplasia. He was started on oral cyclosporine but subsequently developed leukopenia and refused any further treatment or diagnostic procedures and left the hospital against medical advice. AAMT, thus, may be a very early presentation of impending aplastic anemia, and treating physicians need to be aware of this entity.

Anemia: Production Defects Generally Associated with Marrow Aplasia or Replacement

2017 ◽  
Author(s):  
Nancy Berliner ◽  
John M Gansner
Keyword(s):  
Bone Marrow ◽  
Differential Diagnosis ◽  
Aplastic Anemia ◽  
Blood Smear ◽  
Pure Red Cell Aplasia ◽  
Red Cell ◽  
Normal Bone Marrow ◽  
Normal Bone ◽  
Red Cell Aplasia

This review focuses on anemia resulting from production defects generally associated with marrow aplasia or replacement. The definition, epidemiology, etiology, pathogenesis, diagnosis, differential diagnosis, management, complications, and prognosis of the following production defects are discussed: Acquired aplastic anemia and acquired pure red cell aplasia. Figures depict a leukoerythroblastic blood smear, a biopsy comparing normal bone marrow and bone marrow showing almost complete aplasia, and a marrow smear. A table lists the causes of aplastic anemia. This review contains 3 figures; 1 table; 108 references.

A trial of immunotherapy in aplastic anemia and pure red cell aplasia

1983 ◽  
Vol 1 (2) ◽  
pp. 95-103 ◽  
Author(s):  
Neal S. Young ◽  
Harvey G. Klein ◽  
Patricia Griffith ◽  
Arthur W. Nienhuis
Keyword(s):  
Aplastic Anemia ◽  
Pure Red Cell Aplasia ◽  
Red Cell ◽  
Red Cell Aplasia

Trend and treatment patterns of aplastic anemia in Korea, pure red cell aplasia and myelodysplastic syndrome in Korea: a nation-wide analysis

2017 ◽  
Vol 106 (4) ◽  
pp. 500-507
Author(s):  
Yunsuk Choi ◽  
Jae-Cheol Jo ◽  
Hee-jeong Jeon ◽  
Dong Wook Kim ◽  
Myung Hee Chang ◽  
...  
Keyword(s):  
Myelodysplastic Syndrome ◽  
Aplastic Anemia ◽  
Pure Red Cell Aplasia ◽  
Treatment Patterns ◽  
Red Cell ◽  
Red Cell Aplasia

Acquired amegakaryocytic thrombocytopenia and pure red cell aplasia associated with an occult large granular lymphocyte leukemia

2008 ◽  
Vol 32 (5) ◽  
pp. 823-827 ◽  
Author(s):  
Dominic W. Lai ◽  
Thomas P. Loughran ◽  
Jaroslaw P. Maciejewski ◽  
Sebastian Sasu ◽  
Sophie X. Song ◽  
...  
Keyword(s):  
Pure Red Cell Aplasia ◽  
Large Granular Lymphocyte ◽  
Red Cell ◽  
Large Granular Lymphocyte Leukemia ◽  
Red Cell Aplasia ◽  
Acquired Amegakaryocytic Thrombocytopenia

scholarly journals VI. Pathophysiology and Management of Aplastic Anemia and Pure Red Cell Aplasia

2015 ◽  
Vol 104 (7) ◽  
pp. 1405-1413
Author(s):  
Makoto Hirokawa ◽  
Naohito Fujishima ◽  
Ayumi Omokawa ◽  
Shigeharu Ueki
Keyword(s):  
Aplastic Anemia ◽  
Pure Red Cell Aplasia ◽  
Red Cell ◽  
Red Cell Aplasia

Experience with Ciclosporin (CyA) in the Management of Pure Red-Cell Aplasia (PRCA) and Aplastic Anemia (AA)

1985 ◽  
pp. 261-264 ◽  
Author(s):  
Thomas H. Tötterman ◽  
A. Killander ◽  
A. Kreuger ◽  
G. Gustafsson ◽  
J. Nisell ◽  
...  
Keyword(s):  
Aplastic Anemia ◽  
Pure Red Cell Aplasia ◽  
Red Cell ◽  
Red Cell Aplasia

scholarly journals Pure red cell aplasia and anti-erythropoietin antibodies in patients on hemodialysis: a report of two cases and a literature review

2019 ◽  
Vol 41 (1) ◽  
pp. 145-151 ◽  
Author(s):  
Gabriela Lacreta ◽  
Sérgio Gardano Elias Bucharles ◽  
Gabriela Sevignani ◽  
Miguel Carlos Riella ◽  
Marcelo Mazza do Nascimento
Keyword(s):  
Literature Review ◽  
Subcutaneous Administration ◽  
Rare Condition ◽  
Diagnostic Procedures ◽  
Pure Red Cell Aplasia ◽  
Refractory Anemia ◽  
Red Cell ◽  
Adult Polycystic Kidney Disease ◽  
Red Cell Aplasia ◽  
Choice Of Treatment

ABSTRACT Introduction: Anemia is a frequent multifactorial complication of CKD seen in patients on dialysis derived mainly from impaired erythropoietin (EPO) production. A less common cause of anemia in individuals with CKD is pure red cell aplasia (PRCA) secondary to the production of anti-EPO antibodies. Objective: This paper aimed two describe two cases of PRCA secondary to the production of anti-EPO antibodies including choice of treatment, patient progression, and a literature review. Materials: This study included the cases of two patients with CKD on hemodialysis with severe anemia in need of specific investigation and management. Results: Patient 1 with CKD secondary to hypertension treated with EPO for 7 months showed persistent decreases in hemoglobin (Hb) levels despite the subcutaneous administration of increasing doses of EPO; the patient required recurring blood transfusions. Workup and imaging tests were negative for the main causes of anemia in individuals with CKD on dialysis. Patient 2 with CKD secondary to adult polycystic kidney disease had been taking EPO for 2 years. The patient developed severe abrupt anemia the month he was started on HD, and required recurring transfusions to treat the symptoms of anemia. Workup and imaging findings were inconclusive. Specific laboratory tests confirmed the patients had anti-EPO antibodies. After six months of immunosuppressant therapy (corticosteroids + cyclosporine) the patients were stable with Hb > 9.0 g/dl. Conclusion: PRCA is a rare condition among patients on dialysis treated with rhEPO and should be considered as a possible cause of refractory anemia. Treating patients with PRCA may be challenging, since the specific management and diagnostic procedures needed in this condition are not always readily available.

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