scholarly journals Altered Salivary Alpha-Amylase Secretion in Patients with Ulcerative Colitis

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Zhuoni Xu ◽  
Baoping Wei ◽  
Yanting Qiu ◽  
Tao Zhang
Keyword(s):  
Ulcerative Colitis ◽  
Nervous System ◽  
Copy Number ◽  
Nervous Activity ◽  
Alpha Amylase ◽  
Gene Copy ◽  
Anxiety And Depression ◽  
Amylase Secretion ◽  
Salivary Alpha Amylase ◽  
Sympathetic Nervous

Purpose. Patients with ulcerative colitis (UC) frequently present with psychological disturbances as well as dysfunctions of autonomic nervous system (ANS). Salivary alpha-amylase (sAA) secretion is predominantly controlled by sympathetic nervous activity, while salivary fluid secretion is by parasympathetic nervous activity. Thus, it is speculated that alterations of salivary secretion may be addressed in UC populations. Methods. Thirty-five UC patients as well as 32 age- and sex-matched healthy controls were enrolled. Saliva samples before and after citric acid stimulation were collected from each participant, and salivary flow rate (SFR) was calculated accordingly. Western blotting and quantitative PCR were applied to measure the sAA level and sAA gene (AMY1) copy number, respectively. The psychological disorders, anxiety and depression, were evaluated by the scoring system of Hospital Anxiety and Depression Scale (HADS) for each participant. Results. We observed robustly increased prevalence of anxiety (p<0.001) as well as depression (p<0.001) in UC patients relative to controls. Interestingly, we detected elevated basal (p=0.015) and stimulated (p=0.021) sAA levels in the UC populations compared to controls. However, no differences were found for basal (p=0.643) or stimulated (p=0.402) SFR between the two study groups. Besides, AMY1 gene copy number was comparable between UC patients and controls. Conclusions. Our results reveal an overactivity of the sympathetic nervous system and a normal activity of the parasympathetic nervous system in the UC population.

Enhancement of the efficiency of a salivary alpha amylase biomarker for the sympathetic nervous system by a nano-optical sensor Tb–acetyl acetone complex

2016 ◽  
Vol 40 (9) ◽  
pp. 7529-7535 ◽  
Author(s):  
Mohamed S. Attia ◽  
Ahmed O. Youssef
Keyword(s):  
Nervous System ◽  
Sympathetic Nervous System ◽  
Optical Sensor ◽  
Alpha Amylase ◽  
Salivary Alpha Amylase ◽  
Acetyl Acetone ◽  
Sympathetic Nervous

A new nano-optical sensor Tb–acetylacetone (Tb–ACAC) complex is developed for assessing the activity of a salivary alpha amylase enzyme.

THE INFLUENCE OF EXAMINATION STRESS ON VEGETATIVE INDICATORS IN 17-21-YEAR-OLD STUDENTS WITH A MELANCHOLIC TYPE OF HIGHER NERVOUS ACTIVITY

2021 ◽  
Vol 23 (6) ◽  
pp. 18-29
Author(s):  
Rustamova T.V.
Keyword(s):  
Nervous System ◽  
Nervous Activity ◽  
Age Groups ◽  
Learning Activities ◽  
Male Students ◽  
Before And After ◽  
Personal Anxiety ◽  
Examination Stress ◽  
Sympathetic Nervous ◽  
Examination Process

The article is devoted to the influence of an increased level of situational and personal anxiety of examination stress on the indices of the autonomic nervous system in 17-21-year-old male students (I and V courses) with a melancholic type of nervous system. In the course of the conducted studies, it was found that in 17- and 21-year-old students-melancholic during the examination process between heart rate and blood pressure there are some differences that do not normalize after the exam. Vegetative indicators in 21-year-old students in the periods before and after the exam are slightly increased, relative to indicators in 17-year-old students. The Kerdo vegetative index (VIC) in both age groups was in a state of sympathicotonia, which is an indicator of the superiority of the sympathetic nervous system throughout the entire examination process. The results obtained in the course of this study can be used to optimize learning activities, relieve stress in exams and protect students' health.

scholarly journals Relationships of Adrenoceptor Polymorphisms with Obesity

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Kazuko Masuo ◽  
Gavin W. Lambert
Keyword(s):  
Type 2 Diabetes ◽  
Nervous System ◽  
Sympathetic Nervous System ◽  
Vascular Reactivity ◽  
Nervous Activity ◽  
Epidemiological Studies ◽  
Sympathetic Nervous Activity ◽  
Sympathetic Nervous ◽  
Obesity Hypertension

Obesity, hypertension, and type 2 diabetes are rapidly growing public health problems. Heightened sympathetic nerve activity is a well-established observation in obesity, hypertension, and type 2 diabetes. Human obesity, hypertension, and diabetes have strong genetic as well as environmental determinants. Reduced energy expenditure and resting metabolic rate are predictive of weight gain, and the sympathetic nervous system participates in regulating energy balance through thermogenesis. The thermogenic effects of catecholamines in obesity are mainly mediated via the β2, and β3-adrenergic receptors in humans. Further, β2-adrenoceptors importantly influence vascular reactivity and may regulate blood pressure. β-adrenoceptor polymorphisms have also been associated with adrenoceptor desensitization, increased adiposity, insulin resistance, and enhanced sympathetic nervous activity. Many epidemiological studies have shown strong relationships between adrenoceptor polymorphisms and obesity, but the observations have been discordant. This paper will discuss the current topics involving the influence of the sympathetic nervous system and β2- and β3-adrenoceptor polymorphisms in obesity.

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