scholarly journals Toxoplasma gondiiin Blood Donors: A Study in Boyer-Ahmad County, Southwest Iran

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Abdolali Moshfe ◽  
Nasir Arefkhah ◽  
Bahador Sarkari ◽  
Saadat Kazemi ◽  
Ahmad Mardani
Keyword(s):  
Risk Factors ◽  
Blood Donors ◽  
Buffy Coat ◽  
Seroprevalence Rate ◽  
Sample Collection ◽  
Infected Blood ◽  
Blood Samples ◽  
Related Risk ◽  
Independent Risk Factors ◽  
Southwest Iran

Toxoplasma gondiiis an important foodborne protozoan that can be transmitted through infected blood containing tachyzoite form of the parasite. The current study aimed to evaluate the prevalence ofT. gondiiinfection and related risk factors among healthy blood donors in Boyer-Ahmad County, southwest Iran. Blood samples were taken from 285 healthy blood donors who voluntarily agreed to participate in this study. Sera and buffy coat were isolated from the blood samples for serological and molecular evaluations. The sera were tested for anti-T. gondiiantibodies (both IgG and IgM), using a commercial ELISA kit. The buffy coat of seropositive cases was evaluated for detection ofT. gondiiDNA by PCR. Moreover, a structured questionnaire, containing socioepidemiological data and possible risk factors, was filled out by each participant during sample collection. Anti-T. gondiiantibodies were detected in sera of 48/285 (16.8%) participants. Only two of the subjects (0.7%) were seropositive for both IgG and IgM antibodies.T. gondiiDNA was not detected in buffy coat of any of the seropositive cases. Risk factors such as contact with soil (OR, 9.7; 95% CI, 4.9–19.4) and consumption of semicooked meat (OR, 2.5; 95% CI, 1.2–5.03) were statistically associated with seropositivity toT. gondii. The seroprevalence rate ofT. gondiiantibodies in the blood donors of Boyer-Ahmad County was not high in comparison with other regions in Iran. In this study, consumption of undercooked meats, job, and contact with soil were independent risk factors associated withT. gondiiinfection, which can be considered as potential sources ofT.gondiiinfection.

scholarly journals The prevalence of antibodies to SARS-CoV-2 among blood donors in China

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Le Chang ◽  
Wangheng Hou ◽  
Lei Zhao ◽  
Yali Zhang ◽  
Yanbin Wang ◽  
...  
Keyword(s):  
Public Health ◽  
Risk Factors ◽  
Blood Donors ◽  
Antibody Testing ◽  
Old Adults ◽  
Viral Spread ◽  
Health Measures ◽  
Independent Risk Factors ◽  
Effective Public Health ◽  
Age And Sex

AbstractIn this study, we investigate the seroprevalence of SARS-CoV-2 antibodies among blood donors in the cities of Wuhan, Shenzhen, and Shijiazhuang in China. From January to April 2020, 38,144 healthy blood donors in the three cities were tested for total antibody against SARS-CoV-2 followed by pseudotype SARS-CoV-2 neutralization tests, IgG, and IgM antibody testing. Finally, a total of 398 donors were confirmed positive. The age- and sex-standardized SARS-CoV-2 seroprevalence among 18–60 year-old adults (18–65 year-old in Shenzhen) was 2.66% (95% CI: 2.24%–3.07%) in Wuhan, 0.033% (95% CI: 0.0029%–0.267%) in Shenzhen, and 0.0028% (95% CI: 0.0001%–0.158%) in Shijiazhuang, respectively. Female sex and older-age were identified to be independent risk factors for SARS-CoV-2 seropositivity among blood donors in Wuhan. As most of the population of China remained uninfected during the early wave of the COVID-19 pandemic, effective public health measures are still certainly required to block viral spread before a vaccine is widely available.

scholarly journals Prevalence of Haemoplasma Infections in Stray Cats in Northern Italy

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Eva Spada ◽  
Daniela Proverbio ◽  
Paola Galluzzo ◽  
Alessandra Della Pepa ◽  
Giada Bagnagatti De Giorgi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Donors ◽  
Northern Italy ◽  
Negative Association ◽  
Domestic Cats ◽  
Conventional Pcr ◽  
Blood Samples ◽  
Stray Cats ◽  
Stray Cat

This study investigated the prevalence of feline haemoplasma infections in a number of stray cat colonies in Milan, Northern Italy. Blood samples from 260 stray cats were evaluated, with conventional PCR, for the presence of DNA associated with Mycoplasma haemofelis (Mhf) and “Candidatus Mycoplasma haemominutum” (CMhm). Odd ratios (OR) were calculated to identify risk factors for haemoplasma infections. PCR was positive in 86 out of 260 subjects (33.1%), with a prevalence of 10.8% (28/260 cats) for Mhf and 22.3% (58/260 cats) for CMhm. No coinfections were registered. There were significant associations between infections and season of sampling, that is, a negative association between winter sampling and a haemoplasma positive status (OR=0.29, P=0.001), or CMhm positive status (OR=0.29, P=0.01). Haemoplasma infections are common in stray cats in Milan. Thus, domestic cats with outdoor access should be routinely monitored and treated for ectoparasites to minimize risks of disease acquisition. Moreover, as these infections are transmitted via blood, feline blood donors from this area should be screened by PCR and preferably be drawn from a population of indoor cats regularly treated for fleas.

scholarly journals Age-Related Risk Factors and Complications of Patients With COVID-19: A Population-Based Retrospective Study

2022 ◽  
Vol 8 ◽  
Author(s):  
Han Zhang ◽  
Yingying Wu ◽  
Yuqing He ◽  
Xingyuan Liu ◽  
Mingqian Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Retrospective Study ◽  
Age Groups ◽  
Clinical Manifestations ◽  
Population Based ◽  
Male Gender ◽  
Poor Correlation ◽  
Age Related ◽  
Related Risk ◽  
Independent Risk Factors

Objective: To study the differences in clinical characteristics, risk factors, and complications across age-groups among the inpatients with the coronavirus disease 2019 (COVID-19).Methods: In this population-based retrospective study, we included all the positive hospitalized patients with COVID-19 at Wuhan City from December 29, 2019 to April 15, 2020, during the first pandemic wave. Multivariate logistic regression analyses were used to explore the risk factors for death from COVID-19. Canonical correlation analysis (CCA) was performed to study the associations between comorbidities and complications.Results: There are 36,358 patients in the final cohort, of whom 2,492 (6.85%) died. Greater age (odds ration [OR] = 1.061 [95% CI 1.057–1.065], p < 0.001), male gender (OR = 1.726 [95% CI 1.582–1.885], p < 0.001), alcohol consumption (OR = 1.558 [95% CI 1.355–1.786], p < 0.001), smoking (OR = 1.326 [95% CI 1.055–1.652], p = 0.014), hypertension (OR = 1.175 [95% CI 1.067–1.293], p = 0.001), diabetes (OR = 1.258 [95% CI 1.118–1.413], p < 0.001), cancer (OR = 1.86 [95% CI 1.507–2.279], p < 0.001), chronic kidney disease (CKD) (OR = 1.745 [95% CI 1.427–2.12], p < 0.001), and intracerebral hemorrhage (ICH) (OR = 1.96 [95% CI 1.323–2.846], p = 0.001) were independent risk factors for death from COVID-19. Patients aged 40–80 years make up the majority of the whole patients, and them had similar risk factors with the whole patients. For patients aged <40 years, only cancer (OR = 17.112 [95% CI 6.264–39.73], p < 0.001) and ICH (OR = 31.538 [95% CI 5.213–158.787], p < 0.001) were significantly associated with higher odds of death. For patients aged >80 years, only age (OR = 1.033 [95% CI 1.008–1.059], p = 0.01) and male gender (OR = 1.585 [95% CI 1.301–1.933], p < 0.001) were associated with higher odds of death. The incidence of most complications increases with age, but arrhythmias, gastrointestinal bleeding, and sepsis were more common in younger deceased patients with COVID-19, with only arrhythmia reaching statistical difference (p = 0.039). We found a relatively poor correlation between preexisting risk factors and complications.Conclusions: Coronavirus disease 2019 are disproportionally affected by age for its clinical manifestations, risk factors, complications, and outcomes. Prior complications have little effect on the incidence of extrapulmonary complications.

scholarly journals The Clinical Characteristics of Acute Myocardial Infarction with Ventricular Septal Perforation and the Prognosis Comparison of Different Treatment Methods

2020 ◽  
Author(s):  
Chun Fu ◽  
Zhou Zhao ◽  
Yu Chen ◽  
Youzhong An ◽  
Jian Liu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Characteristics ◽  
Complete Revascularization ◽  
Septal Perforation ◽  
Survival Group ◽  
Term Survival ◽  
Related Risk ◽  
Incomplete Revascularization ◽  
Independent Risk Factors

Abstract Background: To explore the clinical characteristics of acute myocardial infarction (AMI) with ventricular septal perforation (VSR) and the prognosis comparison of different treatment methods, as well as the analysis of related risk factors.Methods: From January 2006 to February 2020, 29 patients with AMI and VSR diagnosed in the people's Hospital of Peking University were selected as the study object, among them, 16 cases were male (55.2%), 13 cases were female (44.8%), the average age was 64.69 ± 10.32 years old, and they were divided into survival group (n=16) and non-survival group (n=13) according to whether they survive within 30 days of surgical or drug conservative treatment.The clinical characteristics, coronary angiography and treatment of the two groups were summarized, and the prognosis and related risk factors were analyzed.Results: There was no significant difference in the basic clinical characteristics between the two groups(P>0.05)；Compared with the results of coronary angiography in the two groups, the proportion of the culprit vessel which was a simple anterior descending branch in the non-survival group was higher than that in the survival group, there was a statistical difference between the two groups(P<0.05)；The peri-operative data of the two groups showed that the proportion of patients with complete revascularization, simultaneous bypass and recanalization of culprit vessels in the survival group was significantly higher than that in the non- survival group (P < 0.05)；However, the incidence of postoperative low cardiac output and mortality during hospitalization in the survival group were significantly lower than those in the non-survival group (P < 0.05)；Logistic regression analysis showed that complete revascularization (OR = 0.021, 95% CI 0.001-0.374, P = 0.009), recanalization of culprit vessels (OR = 0.045, 95% CI 0.004-0.548, P = 0.015) were independent risk factors for 30 day mortality。Kaplan-Meier survival curve showed that during the follow-up period, the long-term survival rate of patients with operation and complete revascularization was significantly higher than that of patients with drug conservative treatment and incomplete revascularization, there was a statistical difference between the two groups (P < 0.05).Conclusions: Whether complete revascularization and recanalization of culprit vessels or not are independent risk factors for 30 day mortality in patients with AMI and VSR；the long-term survival rate of patients after surgery and complete revascularization is significantly higher than that of patients with conservative medical treatment and incomplete revascularization. Surgery and complete revascularization are important factors affecting the long-term prognosis of patients with AMI and VSR.

scholarly journals Distribution of Hepatitis C Virus Genotypes and Related Risk Factors Among Iranian Blood Donors: A Penalized Logistic Regression

2018 ◽  
Vol 11 (12) ◽  
Author(s):  
Fahimeh Ranjbar Kermani ◽  
Sedigheh Amini-Kafiabad ◽  
Kamran Mousavi Hosseini ◽  
Mahtab Maghsudlu ◽  
Zohreh Sharifi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Blood Donors ◽  
Related Risk ◽  
Virus Genotypes ◽  
Hepatitis C Virus Genotypes ◽  
Penalized Logistic Regression

scholarly journals Detection of Anti-Toxoplasma gondii IgG and IgM Antibodies and Associated Risk Factors during Pregnancy in Southwest Iran

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Shahrzad Soltani ◽  
Ali Dalir Ghaffari ◽  
Mehdi Sagha Kahvaz ◽  
Mohamad Sabaghan ◽  
Marzieh Pashmforosh ◽  
...  
Keyword(s):  
Risk Factors ◽  
Toxoplasma Gondii ◽  
Pregnant Women ◽  
Cross Sectional Study ◽  
Screening Tests ◽  
Enzyme Linked Immunosorbent Assay ◽  
Cross Sectional ◽  
Related Risk ◽  
Associated Risk Factors ◽  
Southwest Iran

Background. This research was aimed at evaluating the seroprevalence of acute and chronic Toxoplasma gondii (T. gondii) infection in pregnant women and related risk factors in southwest Iran. Methods. In this cross-sectional study, eighty-eight pregnant women were included from October 2019 to December 2019. The presence of anti-T. gondii IgM and IgG antibodies was measured using the enzyme-linked immunosorbent assay (ELISA). In addition, a questionnaire consisting of demographic information was completed for each subject. Results. The overall seroprevalence of T. gondii infection was estimated to be 34.09% (30/88). Of these, 1 (1.13%) and 29 (32.95%) samples were found positive for IgM and IgG, respectively. Regarding the risk factors, the consumption of raw/undercooked meat ( P value = 0.007) and history of abortion ( P value = 0.017) were significantly associated with IgG seroprevalence in pregnant women. Conclusion. The results showed that the pregnant women of southwest Iran might be moderately exposed to T. gondii. Since the risk of acute T. gondii infection in this susceptible group is very important, regular screening tests to diagnose the infection are recommended before pregnancy.

Medical Comorbidity Related Risk Factors For Hospital-Based Mortality In Psychiatric Disorders of Icd-10 Classes F1–F4: A Comparative Overview of Five Studies In General Hospital Admissions

2016 ◽  
Vol 33 (S1) ◽  
pp. S485-S485
Author(s):  
D. Schoepf ◽  
R. Heun
Keyword(s):  
Risk Factors ◽  
Psychiatric Disorders ◽  
General Hospital ◽  
Mortality Risk ◽  
Hospital Admissions ◽  
Medical Comorbidity ◽  
Medical Comorbidities ◽  
Related Risk ◽  
Icd 10 ◽  
Independent Risk Factors

IntroductionUp to 60% of the non-suicide related premature mortality of individuals with major psychiatric disorders is said to be mainly due to medical diseases.Objectives and aimsBased on five representative studies in general hospital admissions over 12.5-year observation, we will represent a comparative overview of medical comorbidity related risk factors for general hospital-based mortality in prevalent psychiatric disorders of ICD-10 major classes F1–F4.MethodsIn the original studies, medical comorbidities that increased the risk for hospital-based mortality were identified using multivariate forward logistic regression analysis. In secondary analysis, independent risk factors for general hospital-based mortality were compared between studies using the OR and the 95% CI.ResultsA total of fifteen medical comorbidities represented independent risk factors for general hospital-based mortality in more than one psychiatric disorder of ICD-10 major classes F1–F4. Infectious lung diseases and chronic obstructive pulmonary disease were mortality risk factors in all diagnostic classes. Type 2 diabetes mellitus represented a risk factor for general hospital-based mortality in individuals with schizophrenia (SCH), bipolar disorder (BD), and major depressive disorder (MDD). Atrial fibrillation was a mortality risk factor in individuals with MDD, anxiety disorder (ANX), and alcohol dependence (AD). In addition, nineteen medical comorbidities represented independent mortality risk factors in only one of the diagnostic classes, i.e. two in individuals with SCH, three in individuals with MDD, three in ANX, and eleven in AD.ConclusionsIn general hospitals, the pattern of medical comorbidities that explain the outcome of in-hospital deaths differs considerably between psychiatric disorders of ICD-10 major classes F1–F4.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Identification of risk factors in blood donors found to have HIV infection

2000 ◽  
Vol 11 (11) ◽  
pp. 728-730 ◽  
Author(s):  
C M Bates ◽  
P B Carey ◽  
V J Martlew ◽  
A J N Shepherd
Keyword(s):  
Risk Factors ◽  
Blood Donors ◽  
Transmitted Infection ◽  
Infected Blood ◽  
Hiv Rna ◽  
North Wales ◽  
Transfusion Transmitted Infection ◽  
Immunodeficiency Virus ◽  
Donated Blood ◽  
Made In

To ascertain whether current screening procedures for human immunodeficiency virus (HIV) infected blood can be improved, a study of blood donors found by Mersey and North Wales Blood Centre to be HIV positive was made. In total 22 donors were identified, of which 16 were referred to the Department of Genito-Urinary Medicine (GUM) in Liverpool. Most (9/16) should have been excluded from donating because of recognized risk factors. However, in 7 cases no such identifiable factors were found. Although the risk of transfusion transmitted infection is small, there is an argument for testing donated blood for HIV RNA by nucleic acid technology.

scholarly journals Collection of samples from women at different stages of pregnancy to search for early biomarkers of preterm birth

2020 ◽  
Vol 19 (6) ◽  
pp. 2708
Author(s):  
R. A. Illarionov ◽  
O. V. Kosyakova ◽  
E. S. Vashukova ◽  
N. O. Yurkina ◽  
M. O. Bakleicheva ◽  
...  
Keyword(s):  
Quality Control ◽  
Preterm Birth ◽  
Quality Criteria ◽  
Buffy Coat ◽  
Sample Type ◽  
Sample Collection ◽  
Blood Samples ◽  
Early Biomarkers ◽  
Long Term Storage ◽  
Depth Study

Aim. To create a collection of samples from women at different stages of pregnancy to search for early biomarkers of preterm birth.Material and methods. In order to standardize the sample collection, standard operation procedures have been developed with a step-by-step protocol for each research member at the clinical (collection of medical data and biological material) and laboratory (transportation, sample preparation, storage, quality control) stages.Results. As of October 1, 2020, the collection includes peripheral blood samples from 182 women. Whole blood, serum, plasma, buffy coat and urine were collected during pregnancy, and placenta and umbilical cord blood samples — during labor. Clinical and medical history data was obtained about each pregnant woman, which includes data on the woman’s health status, the course and outcome of pregnancy. An electronic catalog has been created with information on samples (data on clinical characteristics and the number of aliquots of each sample type). The quality control (assessment of DNA and microRNA) was carried out, which showed the compliance of the obtained samples with the quality criteria and the preservation of initial characteristics during long-term storage. On the basis of collection, a study has begun to assess the level of microRNA expression in various types of biomaterial, in order to search for early biomarkers of premature birth.Conclusion. The creation of a collection of samples from pregnant women is a significant groundwork for future fundamental and applied research in various fields of biomedicine. This collection may provide an in-depth study of the pathogenesis of various pregnancy complications and the development of new methods for their diagnosis and treatment.-

scholarly journals Disease-Related Risk Factors for CVC-Related Symptomatic Thrombosis in Surgical ICU Inpatients

2020 ◽  
Author(s):  
Xiaochun Liu ◽  
Yunlin Zhu ◽  
Zhiming Kuang ◽  
Guofu Zheng ◽  
Yuanfei Liu
Keyword(s):  
Risk Factors ◽  
Electronic Medical Record System ◽  
Major Surgery ◽  
Surgical Intensive Care Unit ◽  
Surgical Intensive Care ◽  
Record System ◽  
Related Risk ◽  
Medical Record System ◽  
Surgical Icu ◽  
Independent Risk Factors

Abstract To report the rate of symptomatic catheter-related venous thrombosis (CRVT) in surgical intensive care unit patients receiving central venous catheters (CVC) and analyze the disease-related risk factors for symptomatic CRVT in SICU patients. A retrospective analysis was performed on 1643 critically ill patients admitted to the SICU from January 2015 to December 2019. Cases were divided into two groups based on the presence of symptomatic CRVT, and the variables of interest were extracted from the electronic medical record system. Logistic univariate and multivariate regression analyses were used to determine the risk factors of SCRVT. A total of 209 symptomatic CRVT events occurred among 2114 catheters. Multivariate analysis showed that trauma (odds ratio [OR], 2.046; 95% confidence interval [CI] [1.325-3.160], P = 0.001), major surgery (OR, 2.457; 95% CI [1.641-3.679], P = 0.000), and heart failure (OR, 2.087; 95% CI [1.401-3.111], P = 0.000) were independent risk factors for symptomatic CRVT in SICU. The AUROC for this model was 0.610 (95% CI [0.569-0.651], P=0.000). The incidence rate was 9.89%. For patients hospitalized in the SICU, especially those admitted with these three conditions, thromboprophylaxis and/or mechanical prophylaxis should be actively provided to reduce the occurrence of symptomatic CRVT.

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