scholarly journals Homocysteine and Digestive Tract Cancer Risk: A Dose-Response Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Jun Xu ◽  
Xin Zhao ◽  
Shanwen Sun ◽  
Peng Ni ◽  
Chujun Li ◽  
...  
Keyword(s):  
Cancer Risk ◽  
Digestive Tract ◽  
Dose Response ◽  
Meta Analysis ◽  
Response Analysis ◽  
Significant Heterogeneity ◽  
Digestive Tract Cancer ◽  
Homocysteine Concentration ◽  
Tract Cancer ◽  
Potential Biomarker

Background. Homocysteine, a key component in one-carbon metabolism, is of great importance in remethylation. Many epidemiologic studies have assessed the association between homocysteine and risk of digestive tract cancer, but the results are inconsistent. Objective. The objective of our meta-analysis is to assess the association between homocysteine and digestive tract cancer risk. Methods. Comprehensive searches were performed on the PubMed, Embase, Cochrane, and Web of Science databases up to September 25, 2018, to identify relevant studies. Thirteen studies were included in the meta-analysis. Odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were used to estimate the strength of the relationship between homocysteine and the risk of digestive tract cancer. Results. The pooled OR of digestive tract cancer risk for patients with the highest categories of blood homocysteine levels versus the lowest categories was 1.27 (95% CI, 1.15, 1.39) with no significant heterogeneity observed (P = 0.798, I2 = 0.0%). Moreover, the dose-response analysis revealed that each 5μmol/L increase in homocysteine increased the incidence of digestive tract cancer by 7%. Conclusion. Generally, our results indicated that elevated homocysteine was associated with higher risk of digestive tract cancer. That is, homocysteine concentration may be a potential biomarker for occurrence of digestive tract cancer.

scholarly journals Effect of Serum SPARC Levels on Survival in Patients with Digestive Tract Cancer: A Post Hoc Analysis of the AMATERASU Randomized Clinical Trial

Cancers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1465
Author(s):  
Taisuke Akutsu ◽  
Eisaku Ito ◽  
Mitsuo Narita ◽  
Hironori Ohdaira ◽  
Yutaka Suzuki ◽  
...  
Keyword(s):  
Vitamin D ◽  
Digestive Tract ◽  
Multivariate Analyses ◽  
Controlled Trial ◽  
Vitamin D Supplementation ◽  
Digestive Tract Cancer ◽  
Post Hoc Analysis ◽  
Tract Cancer ◽  
Potential Biomarker ◽  
Post Hoc

Observational studies suggest that physical activity may improve, whereas sarcopenia may worsen the survival of cancer patients. It has been suggested that secreted protein acidic and rich in cysteine (SPARC), one of the myokines that is secreted into the bloodstream by muscle contraction, has tumor-suppressive effects. Based on the hypothesis that serum SPARC level may be a potential prognostic biomarker, a post hoc analysis of the AMATERASU randomized, double-blind, placebo-controlled trial of postoperative oral vitamin D supplementation (2000 IU/day) in patients with stage I–III digestive tract cancer from the esophagus to the rectum (UMIN000001977) was conducted with the aim of exploring the association between serum SPARC levels after operation and survival. On multivariate analyses adjusting serum 25-hydroxyvitamin D, vitamin D supplementation, sarcopenia, body mass index, age, sex, cancer loci, stage, and adjuvant chemotherapy, patients with SPARC levels lower than the median level had a significantly higher risk for death than those with higher levels (hazard ratio, 2.25; 95% confidence interval, 1.25–4.05; p = 0.007), whereas there were no significant associations with other outcomes including recurrence. However, on the same multivariate analyses, sarcopenia was not a risk factor for death and/or relapse. These results suggest that serum SPARC levels may be a potential biomarker for death but not cancer relapse.

scholarly journals Association of whole grains intake and the risk of digestive tract cancer: a systematic review and meta-analysis

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Xiao-Feng Zhang ◽  
Xiao-Kai Wang ◽  
Yu-Jun Tang ◽  
Xiao-Xian Guan ◽  
Yao Guo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Digestive Tract ◽  
Meta Analysis ◽  
Whole Grains ◽  
Digestive Tract Cancer ◽  
Tract Cancer

Lifetime alcohol consumption and upper aero-digestive tract cancer risk in the Melbourne Collaborative Cohort Study

2014 ◽  
Vol 26 (2) ◽  
pp. 297-301 ◽  
Author(s):  
Harindra Jayasekara ◽  
Robert J. MacInnis ◽  
Allison M. Hodge ◽  
John L. Hopper ◽  
Graham G. Giles ◽  
...  
Keyword(s):  
Cohort Study ◽  
Alcohol Consumption ◽  
Cancer Risk ◽  
Digestive Tract ◽  
Digestive Tract Cancer ◽  
Tract Cancer ◽  
Melbourne Collaborative Cohort Study

scholarly journals Increased Risk of Developing Digestive Tract Cancer in Subjects Carrying the PLCE1 rs2274223 A>G Polymorphism: Evidence from a Meta-Analysis

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e76425 ◽  
Author(s):  
Xunlei Zhang ◽  
Yangmei Zhang ◽  
Dongying Gu ◽  
Chunxiang Cao ◽  
Qi Zhang ◽  
...  
Keyword(s):  
Digestive Tract ◽  
Meta Analysis ◽  
Digestive Tract Cancer ◽  
Tract Cancer ◽  
Increased Risk

Alcohol Consumption by Beverage Type and Risk of Breast Cancer: A Dose-Response Meta-Analysis of Prospective Cohort Studies

2020 ◽  
Vol 55 (3) ◽  
pp. 246-253 ◽  
Author(s):  
Qiuyu Sun ◽  
Weihong Xie ◽  
Yanli Wang ◽  
Feifei Chong ◽  
Mengmeng Song ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cohort Studies ◽  
Postmenopausal Women ◽  
Dose Response ◽  
Alcohol Intake ◽  
Meta Analysis ◽  
Response Analysis ◽  
Total Alcohol

Abstract Aims Alcohol intake has been shown to increase the risk of breast cancer. However, the dose-response analysis of different alcoholic beverages (spirits, wine and beer) is not clear. Our meta-analysis aims to provide a dose-response estimation between different alcohols and breast cancer risk. Methods Search of PubMed and Web of Science and manual searches were conducted up to 1 December 2018, and summary relative risks (RRs) and attributable risk percentage (ARP) for alcohol intake on the development of breast cancer were calculated. Dose-response meta-analysis modeled relationships between drinking type and breast cancer risk. Sources of heterogeneity were explored, and sensitivity analyses were conducted to test the robustness of findings. Results In total, 22 cohort studies and 45,350 breast cancer cases were included. Current drinkers for ER+ had an increased risk compared with never drinkers. In dose-response analysis, there was a statistically significant linear trend with breast cancer risk increasing gradually by total alcohol and wine dose: when adding 10 g per day, the risk increased by 10.5% (RR = 1.10, 95%CI = 1.08–1.13) in total alcohol and 8.9% (RR = 1.08, 95%CI = 1.04–1.14) in wine. For postmenopausal women, the risk increases by 11.1% (RR = 1.11, 95%CI = 1.09–1.13) with every 10 g of total alcohol increase. Furthermore, the breast cancer alcohol-attributed percentage is higher in Europe than in North America and Asia. Conclusions The effect of drinking on the incidence of breast cancer is mainly manifested in ER+ breast cancer. Quantitative analysis showed total drinking had a significant risk for breast cancer, especially for postmenopausal women. However, for different alcohols, just wine intake has the similar results.

Correlation between TGF-β1-509 C>T polymorphism and risk of digestive tract cancer in a meta-analysis for 21,196 participants

Gene ◽  
2012 ◽  
Vol 505 (1) ◽  
pp. 66-74 ◽  
Author(s):  
Jian Min Zhang ◽  
Xi Jun Cui ◽  
Yun Qiang Xia ◽  
Sen Guo
Keyword(s):  
Digestive Tract ◽  
Meta Analysis ◽  
Digestive Tract Cancer ◽  
Tract Cancer ◽  
Tgf Β1
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