scholarly journals No Association of CALCA Polymorphisms and Aseptic Loosening after Primary Total Hip Arthroplasty

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Tünay Aydin-Yüce ◽  
Gina Kurscheid ◽  
Hagen Sjard Bachmann ◽  
Thorsten Gehrke ◽  
Marcel Dudda ◽  
...  
Keyword(s):  
Total Hip Arthroplasty ◽  
Aseptic Loosening ◽  
Hip Arthroplasty ◽  
Fragment Length Polymorphism ◽  
Genotype Distribution ◽  
Chain Reaction ◽  
Total Hip ◽  
Polymerase Chain ◽  
European Group ◽  
Primary Total Hip Arthroplasty

Studies of aseptic loosening showed an influence of calcitonin andα-CGRP, both encoded from the calcitonin/α-CGRP (CALCA) gene by alternative splicing. The aim of this study was to detect a possible association of the CALCA polymorphisms P1(rs1553005), P2(rs35815751), P3(rs5240), and P4(rs2956) with the time to aseptic loosening after THA. 320 patients suffering from aseptic loosening after primary total hip arthroplasty were genotyped for CALCA-P1 polymorphism and 161 patients for CALCA-P2 and CALCA-P3 polymorphisms and 160 patients for CALCA-P4 polymorphism. CALCA genotypes were determined by polymerase chain reaction and restriction-fragment length polymorphism. The genotype distribution of CALCA-P1 was CC 10%, CT 43%, and 46% TT. CALCA-P2 showed a distribution of 90.7%II, 8.7% ID, and 0.6% DD. The CALCA-P3 genotype distribution was 97.5% TT and 2.5% TC. The CALCA-P4 genotype distribution was 48.1% AA, 40% AT, and 11.9% TT. Significant differences between the CALCA genotypes were not found concerning age at implantation and replantation, BMI, gender, and cementation technique. No associations of the time for aseptic loosening were found. In conclusion, we did not find a significant association of CALCA polymorphisms and the time to aseptic loosening after primary THA in a Western European group.

Obesity Is Independently Associated With Early Aseptic Loosening in Primary Total Hip Arthroplasty

2018 ◽  
Vol 33 (3) ◽  
pp. 882-886 ◽  
Author(s):  
Lawrence H. Goodnough ◽  
Andrea K. Finlay ◽  
James I. Huddleston ◽  
Stuart B. Goodman ◽  
William J. Maloney ◽  
...  
Keyword(s):  
Total Hip Arthroplasty ◽  
Aseptic Loosening ◽  
Hip Arthroplasty ◽  
Total Hip ◽  
Primary Total Hip Arthroplasty

scholarly journals The role of hereditary hemochromatosis in aseptic loosening following primary total hip arthroplasty

2005 ◽  
Vol 23 (3) ◽  
pp. 542-548 ◽  
Author(s):  
J. V. Lunn ◽  
P. M. Gallagher ◽  
S. Hegarty ◽  
M. Kaliszer ◽  
J. Crowe ◽  
...  
Keyword(s):  
Total Hip Arthroplasty ◽  
Aseptic Loosening ◽  
Hip Arthroplasty ◽  
Hereditary Hemochromatosis ◽  
Total Hip ◽  
Primary Total Hip Arthroplasty

scholarly journals Is the use of antibiotic-loaded bone cement associated with a lower risk of revision after primary total hip arthroplasty?

2020 ◽  
Vol 102-B (8) ◽  
pp. 997-1002
Author(s):  
Justin W. Leong ◽  
Michael J. Cook ◽  
Terence W. O’Neill ◽  
Timothy N. Board
Keyword(s):  
Total Hip Arthroplasty ◽  
Bone Cement ◽  
Aseptic Loosening ◽  
Hip Arthroplasty ◽  
Proportional Hazards ◽  
Joint Infection ◽  
Cox Proportional Hazards ◽  
Total Hip ◽  
Joint Registry ◽  
Primary Total Hip Arthroplasty

Aims The aim of this study was to investigate whether the use of antibiotic-loaded bone cement influenced the risk of revision surgery after primary total hip arthroplasty (THA) for osteoarthritis. Methods The study involved data collected by the National Joint Registry (NJR) for England and Wales, Northern Ireland and the Isle of Man between 1 September 2005 and 31 August 2017. Cox proportional hazards were used to investigate the association between use of antibiotic-loaded bone cement and the risk of revision due to prosthetic joint infection (PJI), with adjustments made for the year of the initial procedure, age at the time of surgery, sex, American Society of Anesthesiologists (ASA) grade, head size, and body mass index (BMI). We looked also at the association between use of antibiotic-loaded bone cement and the risk of revision due to aseptic loosening or osteolysis. Results The cohort included 418,857 THAs of whom 397,896 had received antibiotic-loaded bone cement and 20,961 plain cement. After adjusting for putative confounding factors, the risk of revision for PJI was lower in those in whom antibiotic-loaded bone cement was used (hazard ration (HR) 0.79; 95% confidence interval (CI) 0.64 to 0.98). There was also a protective effect on the risk of revision due to aseptic loosening or osteolysis, in the period of > 4.1 years after primary THA, HR 0.57, 95% CI 0.45, 0.72. Conclusion Within the limits of registry analysis, this study showed an association between the use of antibiotic-loaded bone cement and lower rates of revision due to PJI. The findings support the continued use of antibiotic-loaded bone cement in cemented THA. Cite this article: Bone Joint J 2020;102-B(8):997–1002.

A New Additive-Manufactured Cementless Highly Porous Titanium Acetabular Cup for Primary Total Hip Arthroplasty—Early Two-Year Follow Up

2021 ◽  
Author(s):  
Mohammad Abdelaal ◽  
Ilan Small ◽  
Camilo Restrepo ◽  
William Hozack
Keyword(s):  
Additive Manufacturing ◽  
Total Hip Arthroplasty ◽  
Aseptic Loosening ◽  
Acetabular Component ◽  
Hip Arthroplasty ◽  
Porous Titanium ◽  
Total Hip ◽  
Highly Porous ◽  
Primary Total Hip Arthroplasty

Introduction: Additive-manufacturing technologies are increasingly being used, not only to create acetabular components with porous coating architecture very similar to the complex trabecular structure of cancellous bone, but also for producing the entire implant in a single step. The aim of this study is to assess two-year clinical and radiological outcomes of a new additive-manufactured cup in primary total hip arthroplasty (THA). Materials and Methods: We reviewed 266 primary THAs (254 patients) performed in our institution between December 2016 and December 2018 using a new highly porous titanium acetabulum shell fabricated via additive manufacturing. Clinical and functional outcomes were measured using SF/VR-12 and HOOS JR to determine patient satisfaction with surgery. Radiographs were assessed to determine the presence of migration, radiolucency, and loosening. Patients records were reviewed to assess cup survivorship in terms of all-cause revisions and revision for aseptic cup loosening. Results: At a minimum of two-year follow up (range: 2–3.45 years), the patient cohort demonstrated significant improvement in postoperative functional scores (hip disability and osteoarthritis outcome score for joint replacement [HOOS JR.] and clinical scores (12-item short-form health survey [SF/VR-12]) (p<0.001). One cup developed progressive radiolucent lines at the prosthesis-bone interface consistent with loosening and was revised. The overall acetabular component two-year survivorship free of all-cause failure was 97.4% (95% confidence interval [CI]: 95.5–99.4%). When aseptic loosening of the acetabular component was used as the failure endpoint, the two-years survivorship rate was 99.6% (95% CI: 98.9–100%). Conclusion: Highly porous titanium cementless acetabular cups produced via additive-manufacturing showed promising early clinical and radiological results in primary THA with low rates of aseptic loosening. Further follow-up studies are needed to assess the long-term survivorship and outcomes of this new acetabular component.

scholarly journals LONG-TERM RESULTS OF ENHANCED TAPERED STEM VerSys ET USE IN PRIMARY TOTAL HIP ARTHROPLASTY

2010 ◽  
Vol 16 (3) ◽  
pp. 7-15
Author(s):  
R. M. Tikhilov ◽  
V. M. Shapovalov ◽  
I. I. Artyukh ◽  
V. A. Shubnyakov
Keyword(s):  
Total Hip Arthroplasty ◽  
Aseptic Loosening ◽  
Hip Arthroplasty ◽  
High Efficiency ◽  
Long Term Results ◽  
Harris Hip Score ◽  
Total Hip ◽  
The Mean ◽  
Primary Total Hip Arthroplasty

The authors reported the outcome at a minimum of five years of 130 consecutive arthroplasties of VerSys ET (Zimmer) in 111 patients. The procedures were performed between 2001 and 2004. In 129 cases (99.2%) Trilogy cup (Zimmer) was used in one case - Muller's acetabular cage (Mathys). The mean age of patients was 49.5 (SD 11.5) (23 to 73), male 76 (58.5%), female - 54 (41.5%), overweight patients 109 (83.8%). Majority of patients had activity in Charnley class A. The most frequent was femur Dorr type A (27,0%) and Dorr type В (66,1%). The mean follow-up was 76 months (60 to 96). The outcomes assessed in 103 patients (120 hips) (92.3%). Outcomes of ten cases were not determined. The mean Harris Hip score improves from 35.1 (SD 8.3) preoperatively to 94.3 (SD 8.5) post-operatively. Kaplan-Meier analysis with revision of the stem as the end-point demonstrated 97,7% survival in term 60 to 96 months, for aseptic loosening - 99,2%. Subsidence of the implants in 61 (50.8%) patients was fixed at a mean follow-up 18.3 (SD3.7) months after surgery and did not progress further. After surgery stem position was neutral 91(75.8%) patients, varus - 14 (12.1%) and valgus - 14 (12.1%). Complications were observed in 8 (6.7%) cases: among them - periprosthetic fractures 6 (5.0%), stem aseptic loosening - 1 (0.8%), recurrent dislocation - 1 (0.8%). Four patients undergone revision surgery We consider the high efficiency of VerSys ET stem use for primary total hip arthroplasty.

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