scholarly journals A Review on Green Synthesis, Biomedical Applications, and Toxicity Studies of ZnO NPs

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
V. N. Kalpana ◽  
V. Devi Rajeswari

The advance of reliable and eco-friendly strategies for the development of nanoparticles is a fundamental key to the discipline of nanotechnology. Nanoparticles have been continuously evaluated and have been used in many industrial applications for a decade. In particular, the role of zinc oxide nanoparticles (ZnO NPs) has received a great interest because of various properties such as UV filter properties and photochemical, antifungal, high catalyst, and antimicrobial activities. Because of the high rate of poisonous chemicals and the extreme surroundings used within the chemical and physical methods, the green techniques have been adopted using plants, fungi, bacteria, and algae for the synthesis of nanoparticles. Therefore, this paper considers various green synthesis methods to provide the evidence of ZnO NP role to several applications, and in addition, biomedical applications and toxic effect were reviewed. Therefore, the paper used various secondary sources to collect the relevant review articles. From the findings, the green route of synthesis is rather safe and eco-friendly when compared to physical and chemical means of synthesis. On the other hand, its biomedical applications in this sector are increased day by day in various processes including bioimaging, drug delivery, biosensors, and gene delivery. With respect to its toxicity properties, ZnO NPs can act as smart weapons against multiple drug-resistant microorganisms and as a talented substitute for antibiotics.

Author(s):  
João Marcos Pereira Galúcio ◽  
Sorrel Godinho Barbosa de Souza ◽  
Arthur Abinader Vasconcelos ◽  
Alan Kelbis Oliveira Lima ◽  
Kauê Santana da Costa ◽  
...  

: Nanotechnology is a cutting-edge area with numerous industrial applications. Nanoparticles are structures that have dimensions ranging from 1–100 nm which exhibit significantly different mechanical, optical, electrical, and chemical properties when compared with their larger counterparts. Synthetic routes that use natural sources, such as plant extracts, honey, and microorganisms are environmentally friendly and low-cost methods that can be used to obtain nanoparticles. These methods of synthesis generate products that are more stable and less toxic than those obtained using conventional methods. Nanoparticles formed by titanium dioxide, zinc oxide, silver, gold, and copper, as well as cellulose nanocrystals are among the nanostructures obtained by green synthesis that have shown interesting applications in several technological industries. Several analytical techniques have also been used to analyze the size, morphology, hydrodynamics, diameter, and chemical functional groups involved in the stabilization of the nanoparticles as well as to quantify and evaluate their formation. Despite their pharmaceutical, biotechnological, cosmetic, and food applications, studies have detected their harmful effects on human health and the environment; and thus, caution must be taken in uses involving living organisms. The present review aims to present an overview of the applications, the structural properties, and the green synthesis methods that are used to obtain nanoparticles, and special attention is given to those obtained from metal ions. The review also presents the analytical methods used to analyze, quantify, and characterize these nanostructures.


2016 ◽  
Vol 875 ◽  
pp. 24-44
Author(s):  
Ming Guo Ma ◽  
Shan Liu ◽  
Lian Hua Fu

CaCO3 has six polymorphs such as vaterite, aragonite, calcite, amorphous, crystalline monohydrate, and hexahydrate CaCO3. CaCO3 is a typical biomineral that is abundant in both organisms and nature and has important industrial applications. Cellulose could be used as feedstocks for producing biofuels, bio-based chemicals, and high value-added bio-based materials. In the past, more attentions have been paid to the synthesis and applications of CaCO3 and cellulose/CaCO3 nanocomposites due to its relating properties such as mechanical strength, biocompatibility, and biodegradation, and bioactivity, and potential applications including biomedical, antibacterial, and water pretreatment fields as functional materials. A variety of synthesis methods such as the hydrothermal/solvothermal method, biomimetic mineralization method, microwave-assisted method, (co-) precipitation method, and sonochemistry method, were employed to the preparation of CaCO3 and cellulose/CaCO3 nanocomposites. In this chapter, the recent development of CaCO3 and cellulose/CaCO3 nanocomposites has been reviewed. The synthesis, characterization, and biomedical applications of CaCO3 and cellulose/CaCO3 nanocomposites are summarized. The future developments of CaCO3 and cellulose/CaCO3 nanocomposites are also suggested.


Biomolecules ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 1498
Author(s):  
Rimsha Chaudhary ◽  
Khadija Nawaz ◽  
Amna Komal Khan ◽  
Christophe Hano ◽  
Bilal Haider Abbasi ◽  
...  

Algae have long been exploited commercially and industrially as food, feed, additives, cosmetics, pharmaceuticals, and fertilizer, but now the trend is shifting towards the algae-mediated green synthesis of nanoparticles (NPs). This trend is increasing day by day, as algae are a rich source of secondary metabolites, easy to cultivate, have fast growth, and are scalable. In recent era, green synthesis of NPs has gained widespread attention as a safe, simple, sustainable, cost-effective, and eco-friendly protocol. The secondary metabolites from algae reduce, cap, and stabilize the metal precursors to form metal, metal oxide, or bimetallic NPs. The NPs synthesis could either be intracellular or extracellular depending on the location of NPs synthesis and reducing agents. Among the diverse range of algae, the most widely investigated algae for the biosynthesis of NPs documented are brown, red, blue-green, micro and macro green algae. Due to the biocompatibility, safety and unique physico-chemical properties of NPs, the algal biosynthesized NPs have also been studied for their biomedical applications, which include anti-bacterial, anti-fungal, anti-cancerous, anti-fouling, bioremediation, and biosensing activities. In this review, the rationale behind the algal-mediated biosynthesis of metallic, metallic oxide, and bimetallic NPs from various algae have been reviewed. Furthermore, an insight into the mechanism of biosynthesis of NPs from algae and their biomedical applications has been reviewed critically.


2021 ◽  
Vol 3 (1) ◽  
pp. 1-25
Author(s):  
Hemra Hamrayev ◽  
Kamyar Shameli ◽  
Mostafa Yusefi ◽  
Serdar Korpayev

Zinc oxide is of significant importance for many industries due to its versatile properties, which have been enhanced with the production of this material in the nanoscale. Recent interest in the preparation of metal oxide nanoparticles using biological approaches has been reported in the literature. This technique known as “green synthesis” is an environmentally benign process than conventional methods like physical and chemical synthesis methods. Zinc oxide nanoparticles (ZnO-NPs) have been successfully obtained by green synthesis using different biological substrates like chitosan. Chitosan is biocompatible, biodegradable polymer having exclusive physical and chemical properties. Chitosan/metal oxide nanocomposite is a promising nanomaterial with enhanced properties for multiple functionalities. Therefore, this review discusses favorable approach in the formation of cross-linked Chitosan/ZnO nanocomposites attracting significant attention in various fields such biomedical due to their unique biodegradable, biocompatible, non-toxic nature. The use of biological sources, fabrication of green synthesized ZnO nanoparticles and its applications is briefly discussed. Overall, this review is a comprehensive study for the synthesis of ZnO-NPs using biological sources counting on their features and applications.


2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Duhita G. Sant ◽  
Tejal R. Gujarathi ◽  
Shrikant R. Harne ◽  
Sougata Ghosh ◽  
Rohini Kitture ◽  
...  

Development of an ecofriendly, reliable, and rapid process for synthesis of nanoparticles using biological system is an important bulge in nanotechnology. Antioxidant potential and medicinal value of Adiantum philippense L. fascinated us to utilize it for biosynthesis of gold and silver nanoparticles (AuNPs and AgNPs). The current paper reports utility of aqueous extract of A. philippense L. fronds for the green synthesis of AuNPs and AgNPs. Effect of various parameters on synthesis of nanoparticles was monitored by UV-Vis spectrometry. Optimum conditions for AuNPs synthesis were 1 : 1 proportion of original extract at pH 11 and 5 mM tetrachloroauric acid, whereas optimum conditions for AgNPs synthesis were 1 : 1 proportion of original extract at pH 12 and 9 mM silver nitrate. Characterization of nanoparticles was done by TEM, SAED, XRD, EDS, FTIR, and DLS analyses. The results revealed that AuNPs and AgNPs were anisotropic. Monocrystalline AuNPs and polycrystalline AgNPs measured 10 to 18 nm in size. EDS and XRD analyses confirmed the presence of elemental gold and silver. FTIR analysis revealed a possible binding of extract to AuNPs through –NH2 group and to AgNPs through C=C group. These nanoparticles stabilized by a biological capping agent could further be utilized for biomedical applications.


2021 ◽  
Vol 7 (1) ◽  
pp. 18-27
Author(s):  
Mohammad Asif

Purpose: The chemistry society has activated to expand new chemistry that is less destructive to the environment and human health. This approach has extensive interest and designated as green chemistry, environmentally friendly chemistry, clean chemistry, and atom economy. Methodology: There is advancement toward involved chemistry with the facts and do not prevent the properties of the target compound or the efficacy of particular solvents or reagents. The use of chemistry in a way that maximizes benefits while reducing adverse effects has come to be green chemistry. Main findings: Reduce the use and formation of harmful products or by-products. Presently maximum pollution to the environment is caused by some chemical industries. So, need to design and develop synthetic methods in such a way that the waste products are lowest and have no effect on the environment and their handy disposal. Applications of the work: Green chemistry plays a vital role in pharmaceuticals for developing new drugs which are less toxic, more effective with low side effects. The novelty of the work: The industries performing manufacturing using green synthesis methods to carrying out their productions have positive impacts on environmental sustainability. This review is looking ahead at longer-term challenges and prospects in research, industrial applications, and education.


Author(s):  
Lavanya Krishnadhas ◽  
Santhi R. ◽  
Annapurani S.

Nanoparticles are gaining interest in biomedical applications due to its importance such as anti-bacterial, anti-fungal and anti-cancer agents. Conventional methods for the synthesis of metal nanoparticles involves toxic reagents which produce harmful by-products and are hazardous to the environment. To overcome these limitations, green synthesis of nanoparticles was established. Eco-friendly methods using plant extracts are gaining popularity due to the abundance of raw materials and the production of non-toxic by-products threatening to the environment. Moreover, the nanoparticles synthesized from the plant extract are cost-effective. In addition, nanoparticles produced by green synthesis methods produces synergetic effect where both the nanoparticles as well as the natural bioactive constituents of the plant influence the biocidal properties. Different methods namely heating in water bath, microwave oven and exposure to bright sunlight were adopted for the synthesis of silver nanoparticles. Plant extract based synthesis of silver nanoparticles was eco-friendly and shows an alternative promise in bio-medical applications and it undertakes the negative effects of synthetic drugs.


2019 ◽  
Vol 7 (7) ◽  
pp. 186 ◽  
Author(s):  
Ramesh ◽  
Vinithkumar ◽  
Kirubagaran ◽  
Venil ◽  
Dufossé

Microbial oddities such as versatile pigments are gaining more attention in current research due to their widely perceived applications as natural food colorants, textiles, antimicrobial activities, and cytotoxic activities. This indicates that the future generation will depend on microbial pigments over synthetic colorants for sustainable livelihood. Although several reviews have detailed the comprehensive applications of microbial pigments extensively, knowledge on several aspects of pigmented microbes is apparently missing and not properly reviewed anywhere. Thus, this review has been made to provide overall knowledge on biodiversity, distribution, pathogenicity, and ecological and industrial applications of microbial pigments as well as their challenges and future directions for food, industrial, and biomedical applications. Meticulously, this compendious review treatise on the pigments from bacteria, fungi, yeasts, and microalgae includes reports from the 1970s to 2018. A total of 261 pigment compounds produced by about 500 different microbial species are included, and their bioactive nature is described.


2021 ◽  
Author(s):  
Gulzar Ahmed Rather ◽  
Anima Nanda ◽  
Arghya Chakravorty ◽  
Saima Hamid ◽  
Johra Khan ◽  
...  

Abstract Nanobiotechnology has been achieved great significance in terms of nanomedicine & many others. But the first challenge in nanobiotechnology science is the preparation of stable nanoparticles. Presently, many preparation methods have been developed like different chemical & physical processes, but the main drawbacks of these processes are required hazardous chemicals, environmental impact, and ultimately expenses a lot. To overcome these challenges another advanced technology has been developed, which is termed green or biogenic synthesis. This review is discussing the modern approaches of the eco-friendly and cost-effective methodology of green synthesis of nanoparticles by using different eukaryotic & prokaryotic agents like plants, human cell lines, diatoms, algae, fungi, bacteria, viruses, and other organisms. Also, this review gives a clear idea of the different applications of those nanoparticles in drug delivery, dentistry, labeling, diagnostics & sensors.


Author(s):  
Selvaraj Arokiyaraj ◽  
Muthupandian Saravanan ◽  
Rajaraman Bharanidharan ◽  
Villianur Ibrahim Hairul Islam ◽  
Mohamed Bououdina ◽  
...  

The advancement in nanoparticulate system has a great impact in many scientific areas. Metallic nanoparticles (NPs) such as silver, gold and copper were found to exhibit antibacterial and other biological activities. The phytochemical constituents (Tannins, flavonoids, terpenoids, saponins and glycosides) present in the plant extracts were used for the green synthesis of NPs of desired size and morphology. Moreover, these active molecules act as reducing and capping agents for the synthe¬sis of NPs, which makes them suitable for biomedical applications. Apart from many approach on synthesis of nanoparticles, green synthesis method becomes more preferable because of its ecofriendly and nontoxic approach. This approach might pave the path for researchers across the globe to explore the potential of different herbs in the synthesis of NPs. This chapter will discuss the synthesis of various metal NPs using plants and their phytochemical constituent's involved during the synthesis. A section devoted to the different applications will be presented.


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