scholarly journals The Comparison of Regional RNFL and Fundus Vasculature by OCTA in Chinese Myopia Population

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Yuanjun Li ◽  
Hamza Miara ◽  
Pingbo Ouyang ◽  
Bing Jiang
Keyword(s):  
Significant Positive Correlation ◽  
Optical Coherence Tomography Angiography ◽  
Retinal Vessel ◽  
Retinal Nerve Fibre Layer ◽  
Vessel Density ◽  
Spherical Equivalent ◽  
Positive Correlation ◽  
Rnfl Thickness ◽  
Nerve Fibre Layer ◽  
Retinal Vessel Density

Purpose. To determine the correlations between peripapillary vessel density, retinal nerve fibre layer (RNFL) thickness, and myopic indices at retina quadrants with optical coherence tomography angiography (OCTA) in Chinese. Methods. Fifty-six subjects with a mean spherical equivalent (MSE) of −3.63 ± 0.29 D were included. Peripapillary RNFL thickness and retinal vessel density in four sectors (superior, nasal, inferior, and temporal quadrants) were determined by OCTA, and correlations of the main outcomes were analyzed. Results. Negative correlations were found between the peripapillary RNFL thickness and axial length (AL) at superior (r=−0.335, P=0.001) and inferior (r=−0.551, P<0.001) quadrants. There was a significant positive correlation with spherical equivalent (SE) at the corresponding quadrants as well as at the nasal quadrant (r=0.339, P=0.001; r=0.379, P<0.001; and r=0.209, P=0.039, resp.). Peripapillary retinal vessel density was also negatively correlated with AL at the nasal quadrant (r=−0.392, P<0.001), and only at the nasal quadrant, there was a positive correlation between the peripapillary vessel density and SE (r=0.319, P=0.001). Conclusions. The degree of myopia and elongation of AL were negatively correlated with peripapillary RNFL thickness at superior and inferior quadrants and with peripapillary retinal vessel density at the nasal quadrant.

scholarly journals Compensation of retinal nerve fibre layer thickness as assessed using optical coherence tomography based on anatomical confounders

2019 ◽  
Vol 104 (2) ◽  
pp. 282-290 ◽  
Author(s):  
Jacqueline Chua ◽  
Florian Schwarzhans ◽  
Duc Quang Nguyen ◽  
Yih Chung Tham ◽  
Josh Tjunrong Sia ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Disc ◽  
Retinal Vessel ◽  
Retinal Nerve Fibre Layer ◽  
Eye Diseases ◽  
Vessel Density ◽  
Rnfl Thickness ◽  
Nerve Fibre Layer ◽  
Retinal Vessel Density ◽  
Sd Oct

Background/AimsTo compensate the retinal nerve fibre layer (RNFL) thickness assessed by spectral-domain optical coherence tomography (SD-OCT) for anatomical confounders.MethodsThe Singapore Epidemiology of Eye Diseases is a population-based study, where 2698 eyes (1076 Chinese, 704 Malays and 918 Indians) with high-quality SD-OCT images from individuals without eye diseases were identified. Optic disc and macular cube scans were registered to determine the distance between fovea and optic disc centres (fovea distance) and their respective angle (fovea angle). Retinal vessels were segmented in the projection images and used to calculate the circumpapillary retinal vessel density profile. Compensated RNFL thickness was generated based on optic disc (ratio, orientation and area), fovea (distance and angle), retinal vessel density, refractive error and age. Linear regression models were used to investigate the effects of clinical factors on RNFL thickness.ResultsRetinal vessel density reduced significantly with increasing age (1487±214 µm in 40–49, 1458±208 µm in 50–59, 1429±223 µm in 60–69 and 1415±233 µm in ≥70). Compensation reduced the variability of RNFL thickness, where the effect was greatest for Chinese (10.9%; p<0.001), followed by Malays (6.6%; p=0.075) and then Indians (4.3%; p=0.192). Compensation reduced the age-related RNFL decline by 55% in all participants (β=−3.32 µm vs β=−1.50 µm/10 years; p<0.001). Nearly 62% of the individuals who were initially classified as having abnormally thin RNFL (outside the 99% normal limits) were later reclassified as having normal RNFL.ConclusionsRNFL thickness compensated for anatomical parameters reduced the variability of measurements and may improve glaucoma detection, which needs to be confirmed in future studies.

scholarly journals Quantification of Optical Coherence Tomography Angiography in Age and Age-related Macular Degeneration using Vessel Density analysis

2019 ◽  
Author(s):  
Ehsan Vaghefi ◽  
Sophie Hill ◽  
Hannah M Kersten ◽  
David Squirrell
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Optical Coherence Tomography Angiography ◽  
Retinal Vessel ◽  
Vessel Density ◽  
Age Related Macular Degeneration ◽  
Optical Coherence ◽  
Age Related ◽  
Capillary Plexus ◽  
Retinal Vessel Density

AbstractPurposeTo determine whether vessel density (VD) as measured by optical coherence tomography angiography (OCT-A) provide insights into retinal and choriocapillaris vascular changes with ageing and intermediate dry age related macular degeneration (AMD).MethodsSeventy-five participants were recruited into three cohorts; young healthy (YH) group, old healthy (OH) and those at high-risk for exudative AMD. Raw OCT and OCT-A data from TOPCON DRI OCT Triton were exported using Topcon IMAGENET 6.0 software, and 3D datasets were analysed to determine retinal thickness and vessel density.ResultsCentral macular thickness measurements revealed a trend of overall retinal thinning with increasing age. VD through the full thickness of the retina was highest in ETDRS sector 4 (the inferior macula) in all the cohorts. Mean VD was significantly higher in the deep capillary plexus than the superficial capillary plexus in all ETDRS sectors in all cohorts but there was no significant difference noted between groups. Choriocapillaris VD was significantly lower in all ETDRS sectors in the in the AMD group compared with the YH and the OH groups.ConclusionsRetinal vessel density maps, derived from the retinal plexi are not reliable biomarkers for assessing the ageing macular. Our non-proprietary analysis of the vascular density of the choriocapillaris revealed a significant drop off of VD with age and disease but further work is required to corroborate this finding. If repeatable, choriocapillaris VD may provide a non-invasive biomarker of healthy ageing and disease.Brief SummaryIn this manuscript, we have studied the potential of retinal vessel density as measured by optical coherence tomography angiography (OCT-A), as a biomarker for detection of high-risk of developing exudative age-related macular degeneration (AMD).

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