scholarly journals Differentiation and Function of T Cell Subsets in Infectious Diseases

2018 ◽  
Vol 2018 ◽  
pp. 1-2
Author(s):  
Yuejin Liang ◽  
Xiaojun Chen ◽  
Jinling Chen ◽  
Fengliang Liu
Keyword(s):  
T Cell ◽  
Infectious Diseases ◽  
T Cell Subsets ◽  
And Function

T Cell Subsets and Function

1986 ◽  
pp. 941-948 ◽  
Author(s):  
P.C.L. Beverley ◽  
L. Terry ◽  
A. Pickford
Keyword(s):  
T Cell ◽  
T Cell Subsets ◽  
And Function

Cytokines in the generation and function of regulatory T cell subsets in leishmaniasis

Cytokine ◽  
2020 ◽  
pp. 155266 ◽  
Author(s):  
Sanhita Ghosh ◽  
Kamalika Roy ◽  
Radhakrishnan Rajalingam ◽  
Sunil Martin ◽  
Chiranjib Pal
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
T Cell Subsets ◽  
And Function

scholarly journals Increased Activation and Oligoclonality of Peripheral CD8+ T Cells in the Chronic Human Helminth Infection Alveolar Echinococcosis

2002 ◽  
Vol 70 (3) ◽  
pp. 1168-1174 ◽  
Author(s):  
Burkhard J. Manfras ◽  
Stefan Reuter ◽  
Thomas Wendland ◽  
Peter Kern
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Alveolar Echinococcosis ◽  
Ex Vivo ◽  
Active Role ◽  
Cell Receptor ◽  
T Cell Subsets ◽  
And Function

ABSTRACT Alveolar echinococcosis (AE) in humans is a chronic disease characterized by slowly expanding liver lesions. Cellular immunity restricts the spreading of the extracellular pathogen, but functional contributions of CD4+ and CD8+ T cells are not defined. Here we studied ex vivo the phenotype and function of circulating T-cell subsets in AE patients by means of flow cytometry, T-cell receptor spectratyping, and lymphocyte proliferation. AE patients with parasitic lesions displayed a significant increase of activation of predominantly CD8+ T cells compared to healthy controls and AE patients without lesions. In vitro, proliferative T-cell responses to polyclonal stimulation with recall antigens and Echinococcus multilocularis vesicular fluid antigen were sustained during chronic persisting infection in all AE patients. Only in AE patients with parasitic lesions did T-cell receptor spectratyping reveal increased oligoclonality of CD8+ but not CD4+ T cells, suggesting a persistent antigenic drive for CD8+ T cells with subsequent proliferation of selected clonotypes. Thus, our data provide strong evidence for an active role of CD8+ T cells in AE.

Role of Ets Proteins in Development, Differentiation, and Function of T-Cell Subsets

2015 ◽  
Vol 36 (2) ◽  
pp. 193-220 ◽  
Author(s):  
Mian Liu ◽  
Weiwu Gao ◽  
Jennifer C. van Velkinburgh ◽  
Yuzhang Wu ◽  
Bing Ni ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Subsets ◽  
Ets Proteins ◽  
And Function

scholarly journals Phenotypical and Functional Analysis of Intraepithelial Lymphocytes from Small Intestine of Mice in Oral Tolerance

2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Maristela Ruberti ◽  
Luis Gustavo Romani Fernandes ◽  
Patricia Ucelli Simioni ◽  
Dirce Lima Gabriel ◽  
Áureo Tatsumi Yamada ◽  
...  
Keyword(s):  
Small Intestine ◽  
T Cell ◽  
Oral Tolerance ◽  
Cell Subset ◽  
Intraepithelial Lymphocytes ◽  
T Cell Subsets ◽  
T Cell Subset ◽  
Small Intestines ◽  
And Function ◽  
Lower Expression

In this work, we evaluated the effects of administration of OVA on phenotype and function of intraepithelial lymphocytes (IELs) from small intestine of transgenic (TGN) DO11.10 and wild-type BALB/c mice. While the small intestines from BALB/c presented a well preserved structure, those from TGN showed an inflamed aspect. The ingestion of OVA induced a reduction in the number of IELs in small intestines of TGN, but it did not change the frequencies of CD8+and CD4+T-cell subsets. Administration of OVA via oral + ip increased the frequency of CD103+cells in CD4+T-cell subset in IELs of both BALB/c and TGN mice and elevated its expression in CD8β+T-cell subset in IELs of TGN. The frequency of Foxp3+cells increased in all subsets in IELs of BALB/c treated with OVA; in IELs of TGN, it increased only in CD25+subset. IELs from BALB/c tolerant mice had lower expression of all cytokines studied, whereas those from TGN showed high expression of inflammatory cytokines, especially of IFN-γ, TGF-β, and TNF-α. Overall, our results suggest that the inability of TGN to become tolerant may be related to disorganization and altered proportions of inflammatory/regulatory T cells in its intestinal mucosa.

scholarly journals γδ T cell subsets: A link between TCR and function?

2010 ◽  
Vol 22 (4) ◽  
pp. 193-198 ◽  
Author(s):  
Rebecca L. O’Brien ◽  
Willi K. Born
Keyword(s):  
T Cell ◽  
T Cell Subsets ◽  
Γδ T Cell ◽  
And Function

scholarly journals Studies on some immunological profile of patients infected with tuberculosis attending infectious diseases hospital, Kano

2020 ◽  
Vol 12 (1) ◽  
pp. 5-12
Author(s):  
A.I. Aminu ◽  
N.L. Habib
Keyword(s):  
T Cell ◽  
Infectious Diseases ◽  
Bacterial Load ◽  
Latent Tuberculosis ◽  
Cross Sectional Study ◽  
T Cell Subsets ◽  
Cell Mediated Immunity ◽  
Cross Sectional ◽  
Cell Counts ◽  
Immunological Profile

The magnitude of the immune response to tuberculosis (TB) infection also involves cell-mediated immunity comprising numerous types of T-cell subsets and this reflects the magnitude of the bacterial load and those with the highest load are at a greater risk of developing TB disease. The study assesses the immunological profile (CD4+, CD8+, CD3+, CD45+) of TB infected individuals with drug sensitive TB (DS-TB) and compares it with that of subjects with Latent Tuberculosis Infection (LTBI) and those with Rifampicin Resistant TB (RR-TB). The study was a cross-sectional study conducted at Infectious Diseases Hospital (IDH), Kano. Two hundred and five (205) subjects participated in the study. Collected sputum samples were subjected to Ziehl-Neelsen (ZN) staining and cultured on Lowenstein Jensen medium for the identification of Mycobacteria tuberculosis. Molecular detection of M. tuberculosis and RR-TB was performed using Xpert® MTB/RIF. Blood samples were also collected and the T-cell counts were determined using flow cytometry. The result of the study indicated that 131 of the studied subjects were males and 74 were females and that majority of them were in the group 14-24years (41.0%), 25-34 years (35.6%) and 35-44 years (13.7%) respectively. Among the DS-TB and RR-TB groups majority were males (70.8% and 66.7% respectively). It was shown that 86.2% and 88.9% of the samples from the DS-TB and RR-TB were AFB positive.  However, all the 65 samples of DS-TB and 54 samples of the RR-TB were identified as MTB by culture. All the DS-TB samples were detected as susceptible TB by Xpert® MTB/RIF, and all the samples of the RR-TB were confirmed as rifampicin resistant by the Xpert® MTB/RIF. The study also revealed that the T-cell (CD4+, CD8+, CD3+ and CD45+) counts of the studied subjects varied significantly among the different groups of the study (p<0.05) and that compared to the control and the LTBI groups the DS-TB and the RR-TB groups recorded the lowest counts in the order; Control>LTBI>DS-TB>RR-TB. Key words: Tuberculosis, T-cells counts, Drug susceptible TB, Latent TB, RR-TB.

Evaluation of the expression and function of the P2X7 receptor and ART1 in human regulatory T-cell subsets

Immunobiology ◽  
2016 ◽  
Vol 221 (1) ◽  
pp. 84-93 ◽  
Author(s):  
Juan D. Cortés-Garcia ◽  
Cintya López-López ◽  
Nancy Cortez-Espinosa ◽  
Mariana H. García-Hernández ◽  
Juan M. Guzmán-Flores ◽  
...  
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
P2x7 Receptor ◽  
T Cell Subsets ◽  
And Function
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