scholarly journals Washout Duration of Prostaglandin Analogues: A Systematic Review and Meta-analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Vlad Diaconita ◽  
Matthew Quinn ◽  
Dania Jamal ◽  
Brad Dishan ◽  
Monali S. Malvankar-Mehta ◽  
...  
Keyword(s):  
Systematic Review ◽  
Intraocular Pressure ◽  
Open Angle Glaucoma ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Long Term Effects ◽  
Prostaglandin Analogues ◽  
Pertinent Data ◽  
Treatment Naïve

Topic. Prostaglandin analogues (PGAs) are first-line medical therapy for primary open angle glaucoma (POAG) and ocular hypertension (OHT). Intraocular pressure (IOP) lowering effects in full responders are known to be 25–33% for this class; however, partial responders and nonresponders do exist. In clinical trials or prospective series, discontinuation and washout of PGAs is necessary to evaluate true change in IOP from novel surgeries and medical therapies. Clinical Relevance. To identify all relevant papers with pertinent data on washout of PGAs and quantify the duration and long-term effect of reported PGA washout periods in glaucoma and OHT patients. Methods. A systematic review and meta-analysis was conducted to investigate the long-term effects on IOP after discontinuation of topical PGAs POAG and OHT patients. The main search was conducted in MEDLINE/PubMed, EMBASE, Cochrane Library, CINAHL, Web of Science, and BIOSIS Previews and conference proceedings. Results. 1055 papers were identified, 548 were independently screened by two physicians., and 56 papers were analyzed for washout durations. The mean washout was found to be 4.56 weeks (±1.25), with the mode and median being 5 weeks. Five studies were analyzed as randomized control trials in which latanoprost was discontinued for 4 weeks prior to restarting another intraocular pressure-lowering drug. Meta-analysis revealed a 4-week discontinuation of latanoprost, on average, subjects returned to their baseline IOP. Conclusion. A significant IOP-lowering effect of latanoprost was not observed beyond 4 weeks, suggesting this may be an appropriate washout period for latanoprost. We could not identify appropriate washout periods for either travoprost or bimatoprost, although a majority of articles had 4-week washout durations for the two drugs. Despite the widespread use of this class of medication, there is a paucity of literature on the effects of PGA washout in patients that are treatment naïve to other topical medications.

scholarly journals More than 50 long-term effects of COVID-19: a systematic review and meta-analysis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sandra Lopez-Leon ◽  
Talia Wegman-Ostrosky ◽  
Carol Perelman ◽  
Rosalinda Sepulveda ◽  
Paulina A. Rebolledo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Management Strategies ◽  
Original Data ◽  
Long Term Effects ◽  
Pooled Prevalence ◽  
Attention Disorder ◽  
Initial Recovery ◽  
Meta Analyses

AbstractCOVID-19 can involve persistence, sequelae, and other medical complications that last weeks to months after initial recovery. This systematic review and meta-analysis aims to identify studies assessing the long-term effects of COVID-19. LitCOVID and Embase were searched to identify articles with original data published before the 1st of January 2021, with a minimum of 100 patients. For effects reported in two or more studies, meta-analyses using a random-effects model were performed using the MetaXL software to estimate the pooled prevalence with 95% CI. PRISMA guidelines were followed. A total of 18,251 publications were identified, of which 15 met the inclusion criteria. The prevalence of 55 long-term effects was estimated, 21 meta-analyses were performed, and 47,910 patients were included (age 17–87 years). The included studies defined long-COVID as ranging from 14 to 110 days post-viral infection. It was estimated that 80% of the infected patients with SARS-CoV-2 developed one or more long-term symptoms. The five most common symptoms were fatigue (58%), headache (44%), attention disorder (27%), hair loss (25%), and dyspnea (24%). Multi-disciplinary teams are crucial to developing preventive measures, rehabilitation techniques, and clinical management strategies with whole-patient perspectives designed to address long COVID-19 care.

scholarly journals Immediate and long-term effects of mechanical loading on Achilles tendon volume: A systematic review and meta-analysis

2021 ◽  
Vol 118 ◽  
pp. 110289
Author(s):  
Eman Merza ◽  
Stephen Pearson ◽  
Glen Lichtwark ◽  
Meg Ollason ◽  
Peter Malliaras
Keyword(s):  
Systematic Review ◽  
Achilles Tendon ◽  
Mechanical Loading ◽  
Meta Analysis ◽  
Long Term Effects

scholarly journals Relationship between exclusive breast feeding and cardiorespiratory fitness in children and adolescents: a protocol for a systematic review and meta-analysis

BMJ Open ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. e023223 ◽  
Author(s):  
Carlos Berlanga-Macías ◽  
Diana P. Pozuelo-Carrascosa ◽  
Celia Álvarez-Bueno ◽  
Jose Alberto Martínez-Hortelano ◽  
Miriam Garrido-Miguel ◽  
...  
Keyword(s):  
Systematic Review ◽  
Quality Assessment ◽  
Children And Adolescents ◽  
Cardiorespiratory Fitness ◽  
Breast Feeding ◽  
Exclusive Breastfeeding ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Exclusive Breast Feeding

IntroductionBreast feeding has been considered important due to its short-term and long-term benefits on infant and maternal health. Regarding the long-term benefits, the influence of exclusive breastfeeding on cardiorespiratory fitness (CRF) during childhood and adolescence has been studied, although with controversial conclusions. This study protocol aims to provide a clear and standardised procedure for systematically reviewing the relationship between breast feeding, in terms of duration and exclusivity, and CRF in children and adolescents.Methods and analysisThis systematic review and meta-analysis protocol is reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols. A literature search will be conducted in MEDLINE, EMBASE, Web of Science and Cochrane Library. Observational studies regarding the association between breast feeding and CRF in children and adolescents written in English or Spanish will be included. A Critical Appraisal Checklist for Analytical Cross Sectional Studies and The Newcastle-Ottawa Quality Assessment Scale for longitudinal studies will be used for quality assessment of included studies. Standardised mean differences of CRF by exclusive breastfeeding categories will be calculated as the primary outcome. Subgroup analyses and meta-regression will be performed based on the sources of heterogeneity.Ethics and disseminationThis evidence-based systematic review will summarise the relevant information on the association of exclusive breast feeding and CRF in children and adolescents. The results will be disseminated by publication in a peer-reviewed journal. Given that the data used for this systematic review will be exclusively extracted from published studies, ethical approval will not be required.PROSPERO registration numberCRD42018082642.

scholarly journals Long-term Short Implants Performance: Systematic Review and Meta-Analysis of the Essential Assessment Parameters

2015 ◽  
Vol 26 (4) ◽  
pp. 325-336 ◽  
Author(s):  
Thais Marques Simek Vega Gonçalves ◽  
Sergio Bortolini ◽  
Matteo Martinolli ◽  
Bruna Fernandes Moreira Alfenas ◽  
Daiane Cristina Peruzzo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Survival Rate ◽  
Clinical Performance ◽  
Meta Analysis ◽  
Implant Failure ◽  
Cochrane Library ◽  
Implant Survival ◽  
Implant Survival Rate ◽  
Short Implants

<p>Lack of standard criteria in the outcome assessment makes it difficult to draw conclusions on the clinical performance of short implants and, under these circumstances, determine the reasons for implant failure. This study evaluated, through a systematic review of the literature and meta-analysis, the essential parameters required to assess the long-term clinical performance of short and extra-short implants. Electronic databases (Pubmed-MEDLINE, Cochrane Library Database, Embase, and Lilacs) were searched by two independent reviewers, without language limitation, to identify eligible papers. References from the selected articles were also reviewed. The review included clinical trials involving short dental implants placed in humans, published between January 2000 and March 2014, which described the parameters applied for outcome's measurements and provided data on survival rates. Thirteen methodologically acceptable studies were selected and 24 parameters were identified. The most frequent parameters assessed were the marginal bone loss and the cumulative implant survival rate, followed by implant failure rate and biological complications such as bleeding on probing and probing pocket depths. Only cumulative implant survival rate data allows meta-analysis revealing a positive effect size (from 0.052 (fixed) to 0.042 (random)), which means that short implant appears to be a successful treatment option. Mechanical complications and crown-to-implant (C/I) ratio measurement were also commonly described, however, considering the available evidence; no strong conclusions could be drawn since different methods were used to assess each parameter. By means of this literature review, a standard evaluation scheme is proposed, being helpful to regiment further investigations and comparisons on future studies.</p>

scholarly journals Preoperative Somatostatin Analogues in Patients with Newly-diagnosed Acromegaly: A Systematic Review and Meta-analysis of Comparative Studies

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Chengxian Yang ◽  
Ge Li ◽  
Shenzhong Jiang ◽  
Xinjie Bao ◽  
Renzhi Wang
Keyword(s):  
Systematic Review ◽  
Comparative Studies ◽  
Meta Analysis ◽  
Somatostatin Analogues ◽  
Long Term Results ◽  
Current Evidence ◽  
Cochrane Library ◽  
Cure Rate ◽  
Short Term

Abstract Biochemical remission after transsphenoidal surgery is still unsatisfied in acromegaly patients with macroadenomas, especially with invasive macroadenomas. Concerning the impact of preoperative somatostatin analogues (SSAs) on surgical outcomes, previous studies with limited cases reported conflicting results. To assess current evidence of preoperative medical treatment, we performed a systematic review and meta-analysis of comparative studies. A literature search was conducted in Pubmed, Embase, and the Cochrane Library. Five randomized controlled trials (RCT) and seven non-RCT comparative studies were included. These studies mainly focused on pituitary macroadenomas though a small number of microadenoma cases were included. For safety, preoperative SSAs were not associated with elevated risks of postoperative complications. With respect to efficacy, the short-term cure rate was improved by preoperative SSAs, but the long-term cure rate showed no significant improvement. For invasive macroadenomas, the short-term cure rate was also improved, but the long-term results were not evaluable in clinical practice because adjuvant therapy was generally required. In conclusion, preoperative SSAs are safe in patients with acromegaly, and the favorable impact on surgical results is restricted to the short-term cure rate in macroadenomas and invasive macroadenomas. Further well-designed RCTs to examine long-term results are awaited to update the finding of this meta-analysis.

Systematic review and meta-analysis investigating moderators of long-term effects of exercise on cognition in healthy individuals

2020 ◽  
Vol 4 (6) ◽  
pp. 603-612 ◽  
Author(s):  
Sebastian Ludyga ◽  
Markus Gerber ◽  
Uwe Pühse ◽  
Vera N. Looser ◽  
Keita Kamijo
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Healthy Individuals ◽  
Long Term Effects

scholarly journals Long-Term Effects of Oral Antidiabetic Drugs During Pregnancy on Offspring: A Systematic Review and Meta-analysis of Follow-up Studies of RCTs

2018 ◽  
Vol 9 (5) ◽  
pp. 1811-1829 ◽  
Author(s):  
Wenneke van Weelden ◽  
Vincent Wekker ◽  
Leon de Wit ◽  
Jacqueline Limpens ◽  
Hilkka Ijäs ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Antidiabetic Drugs ◽  
Long Term Effects ◽  
Oral Antidiabetic Drugs ◽  
Oral Antidiabetic ◽  
Follow Up Studies

scholarly journals The Long-Term Efficacy of Working Memory Training in Healthy Older Adults: A Systematic Review and Meta-Analysis of 22 Randomized Controlled Trials

2020 ◽  
Vol 75 (8) ◽  
pp. e174-e188
Author(s):  
Jianhua Hou ◽  
Taiyi Jiang ◽  
Jiangning Fu ◽  
Bin Su ◽  
Hao Wu ◽  
...  
Keyword(s):  
Older Adults ◽  
Working Memory ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Memory Training ◽  
Long Term Effects ◽  
Healthy Older Adults ◽  
Randomized Controlled ◽  
Randomized Controlled Studies

Abstract Objectives The long-lasting efficacy of working memory (WM) training has been a controversial and still ardently debated issue. In this meta-analysis, the authors explored the long-term effects of WM training in healthy older adults on WM subdomains and abilities outside the WM domain assessed in randomized controlled studies. Method A systematic literature search of PubMed, Web of Science, PsycINFO, Cochrane Library, ProQuest, clinicaltrials.gov, and Google Scholar was conducted. Random-effects models were used to quantitatively synthesize the existing data. Results Twenty-two eligible studies were included in the meta-analysis. The mean participant age ranged from 63.77 to 80.1 years. The meta-synthesized long-term effects on updating were 0.45 (95% confidence interval = 0.253–0.648, &lt;6 months: 0.395, 0.171–0.619, ≥6 months: 0.641, 0.223–1.058), on shifting, 0.447 (0.246–0.648, &lt;6 months: 0.448, 0.146–0.75, ≥6 months: 0.446, 0.176–0.716); on inhibition, 0.387 (0.228–0.547, &lt;6 months: 0.248, 0.013–0.484, ≥6 months: 0.504, 0.288–0.712); on maintenance, 0.486 (0.352–0.62, &lt;6 months: 0.52, 0.279–0.761, ≥6 months: 0.471, 0.31–0.63). Discussion The results showed that WM training exerted robust long-term effects on enhancing the WM system and improving processing speed and reasoning in late adulthood. Future studies are needed to use different tasks of the same WM construct to evaluate the WM training benefits, to adopt more ecological tasks or tasks related to daily life, to improve the external validity of WM training, and to identify the optimal implementation strategy for WM training.

scholarly journals Long-Term Effects of Whole-Body Vibration on Human Gait: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 10 ◽  
Author(s):  
Matthieu Fischer ◽  
Thomas Vialleron ◽  
Guillaume Laffaye ◽  
Paul Fourcade ◽  
Tarek Hussein ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Whole Body Vibration ◽  
Whole Body ◽  
Human Gait ◽  
Long Term Effects ◽  
Body Vibration
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