scholarly journals Bortezomib-Induced Pulmonary Toxicity: A Case Report and Review of Literature

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
Prakash Kharel ◽  
Deekchha Uprety ◽  
Abhinav B. Chandra ◽  
Yirui Hu ◽  
Anuradha Avinash Belur ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Lung Injury ◽  
Current Literature ◽  
Proteasome Inhibitor ◽  
Pulmonary Toxicity ◽  
Case Reports ◽  
Review Of Literature ◽  
Multiple Case ◽  
Review Current

Bortezomib, a proteasome inhibitor, is an established therapy against multiple myeloma. Bortezomib-induced lung injury, although not appreciated during the introductory time of the medication, has now been highlighted in multiple case reports. The objective of this study is to report a case of bortezomib-induced lung injury, review current literature, and perform exploratory analysis.

Capecitabine-induced myopericarditis – A case report and review of literature

2018 ◽  
Vol 25 (4) ◽  
pp. 1006-1010 ◽  
Author(s):  
Sydney Saunders ◽  
Maria Anwar
Keyword(s):  
Adverse Drug Reaction ◽  
Drug Reaction ◽  
Case Report ◽  
Literature Search ◽  
Case Reports ◽  
Locally Advanced ◽  
Rectal Adenocarcinoma ◽  
Review Of Literature ◽  
Medication Discontinuation ◽  
Laboratory Investigations

Objective To describe a possible case of capecitabine-induced myopericarditis in a patient at the Cardio-Oncology Clinic in Calgary, AB. Design A literature search and adverse drug reaction assessment with the Naranjo tool was conducted. Results A 39-year-old male with recurrent locally advanced rectal adenocarcinoma presented two days after adjuvant treatment with capecitabine and oxaliplatin complaining of intermittent, severe interscapular pain. Based on symptoms, laboratory investigations, and imaging, the patient was diagnosed with acute myopericarditis. Management included aspirin, colchicine, and discontinuing adjuvant chemotherapy. A literature review revealed one case report of capecitabine-induced myopericarditis; however, more data were found regarding the cardiotoxicity of fluorouracil, for which capecitabine is a pro-drug. No case reports were found for oxaliplatin. Conclusion Due to the timeline of capecitabine administration, symptom onset, and improvement upon medication discontinuation, capecitabine is the probable cause of the myopericarditis. Although rare, it is important to consider the possibility of myopericarditis in patients receiving a fluoropyrimidine who present with cardiovascular symptoms.

scholarly journals Malignant Phyllodes Tumor of the Breast with Metastasis to the Pancreas: A Case Report and Review of Literature

2018 ◽  
Vol 2018 ◽  
pp. 1-5 ◽  
Author(s):  
R. A. Amir ◽  
Rola S. Rabah ◽  
S. S. Sheikh
Keyword(s):  
Case Report ◽  
Breast Neoplasms ◽  
Distant Metastasis ◽  
Case Reports ◽  
Phyllodes Tumor ◽  
Pancreatic Metastasis ◽  
Rare Tumor ◽  
Review Of Literature ◽  
Malignant Phyllodes Tumor ◽  
Phyllodes Tumors

Phyllodes tumor (PT) is a rare tumor of the breast accounting for approximately 1% of all breast neoplasms. In 1838, J. Muller coined the term “cystosarcoma phyllodes” based on the leaf-like projections of the tumor extending into the cystic spaces and sarcomatous stromal growth. However, seeing as up to 70% of phyllodes tumors are benign, “cystosarcoma” was removed, and the tumor is now recognized simply as phyllodes tumor. It is mainly seen in females between the ages of 35 and 55. Although most phyllodes tumors are benign, malignant cases do uncommonly occur, 22% of which have distant metastasis typically to the lungs and bones. Rarely, this tumor metastasizes to other locations. Herein, we report a case of malignant phyllodes tumor with metastasis to the pancreas. According to our knowledge, only 3 case reports of pancreatic metastasis from malignant phyllodes tumor have been reported in literature thus far. We aim to increase awareness among physicians of this rare metastasic potential of the uncommonly encountered malignant phyllodes tumor.

scholarly journals Chlorambucil-Induced Acute Interstitial Pneumonitis

2014 ◽  
Vol 2014 ◽  
pp. 1-5
Author(s):  
Hammad Shafqat ◽  
Adam J. Olszewski
Keyword(s):  
Systematic Review ◽  
Interstitial Pneumonitis ◽  
Pulmonary Toxicity ◽  
Alkylating Agent ◽  
Randomized Trials ◽  
Case Reports ◽  
Lymphocytic Leukemia ◽  
Mechanism Of Injury ◽  
Review Of Literature ◽  
Drug Induced

Chlorambucil is an alkylating agent commonly used in treatment of chronic lymphocytic leukemia (CLL). We report a case of interstitial pneumonitis developing in an 83-year-old man 1.5 months after completing a six-month course of chlorambucil for CLL. The interstitial pneumonitis responded to therapy with prednisone. We performed a systematic review of literature and identified 13 other case reports of chlorambucil-induced pulmonary toxicity, particularly interstitial pneumonitis. No unifying risk factor could be discerned and the mechanism of injury remains unknown. In contrast, major randomized trials of chlorambucil therapy in CLL have not reported interstitial pneumonitis as an adverse effect, which may be due to the rarity of the phenomenon or due to underreporting of events occurring after completion of treatment. Clinicians should consider drug-induced interstitial pneumonitis in the differential diagnosis of a suggestive syndrome developing even after discontinuation of chlorambucil.

Salivary Amylase–Producing Multiple Myeloma: Case Report and Review of the Current Literature

2013 ◽  
Vol 31 (19) ◽  
pp. e309-e311 ◽  
Author(s):  
David R. Sosnoff ◽  
Rahsaan B. Friend ◽  
Michael Berkovic ◽  
Ronald J. Rasansky ◽  
Stephen M.J. Hoffman
Keyword(s):  
Multiple Myeloma ◽  
Case Report ◽  
Current Literature ◽  
Salivary Amylase

scholarly journals RISPERIDONE INDUCED LEUCOPENIA AND NEUTROPENIA: A CASE REPORT AND BRIEF REVIEW OF LITERATURE

2021 ◽  
Vol 9 (02) ◽  
pp. 724-726
Author(s):  
M. Berghalout ◽  
◽  
A. Ait Idar ◽  
H. Guennouni ◽  
K.El Ouazzani ◽  
...  
Keyword(s):  
Case Report ◽  
Antipsychotic Drugs ◽  
Early Recognition ◽  
Case Reports ◽  
Review Of Literature ◽  
Blood Cell Count ◽  
Small Minority ◽  
Hematological Effects ◽  
Life Threatening ◽  
Hematological Abnormalities

Hematological abnormalities are frequently encountered during treatment with antipsychotic drugs. Most of these are mild and of no clinical significance, but in a small minority of patients, hazardous, potentially life-threatening hematological effects, including leucopenia, neutropenia, agranulocytosis, thrombocytopenia, anaemia , leucocytosis, thrombocytosis, eosinophilia and altered platelet function. (1). Clozapine is associated with several well-known abnormalities of blood cell count (2), but some case reports associate novel antipsychotics, such as risperidone with leucopenia and agranulocytosis (3). This report describes a case of leucopenia under treatment with Oral Risperidone , suggesting the necessity of early recognition of leucopenia in order to prevent occurrence of potentially life-threatening agranulocytosis. ( 1) .

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