scholarly journals The Association between Female Reproductive Factors and Open-Angle Glaucoma in Korean Women: The Korean National Health and Nutrition Examination Survey V

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Yong Un Shin ◽  
Eun Hee Hong ◽  
Min Ho Kang ◽  
Heeyoon Cho ◽  
Mincheol Seong

Purpose. We investigated associations between female reproductive factors and open-angle glaucoma (OAG) in Korean females using the Korea National Health and Nutrition Examination Survey (KNHANES). Methods. A nationwide, population-based, cross-sectional study was conducted. We enrolled 23,376 participants from the KNHANES who had undergone ophthalmologic exams from 2010 through 2012. Associations between undiagnosed OAG and female reproductive factors such as age at menarche and menopause, parity, history of lactation, and administration of oral contraceptives (OC) or hormone replacement therapy (HRT) were determined using stepwise logistic regression analyses. Results. Of the enrolled participants, 6,860 participants (397 with OAG and 6,463 without OAG) met our study criteria and were included in the analyses. In the multivariate logistic regression analysis after adjusting for all potential confounding factors, only early menopause (younger than 45 years) was significantly associated with OAG in participants with natural menopause (OR 2.28, 95% CI 1.17–4.46). Age at menarche, parity, history of lactation, and administration of OC or HRT were not significantly associated with OAG. Conclusions. Only early menopause was associated with an increased risk of OAG in our study, in contrast to previous Western studies reporting both early menopause and late menarche as associated factors.

2020 ◽  
pp. bjophthalmol-2020-317133
Author(s):  
Jae Shin Song ◽  
Young Bok Lee ◽  
Ji-Ah Kim ◽  
Eun Ji Lee ◽  
Hyunjoong Kim

AimTo determine the relationship between corneal refractive surgery and the prevalence of glaucoma in the Korean population.MethodsData were obtained from the Korea National Health and Nutrition Examination Survey (KNHANES), a population-based cross-sectional study using a complex, stratified, multistage, probability-cluster survey. This study included 604 eyes that had undergone myopic corneal refractive surgery, and 3389 control eyes without a history of any ocular surgery and having a spherical equivalent (SE) <−3.00 D, obtained from the KNHANES database for the years 2010–2012. Glaucoma diagnosis was based on the International Society of Geographical and Epidemiological Ophthalmology criteria. The association between a history of corneal refractive surgery and the prevalence of glaucoma was analysed using logistic regression analysis, after adjusting for potential confounding factors.ResultsGlaucoma prevalence did not differ between eyes that had and had not undergone corneal refractive surgery (p=0.675). After adjusting for age, sex, SE, and intraocular pressure, multivariate logistic regression analysis found that corneal refractive surgery was significantly associated with an increased risk of glaucoma (OR 9.14, p=0.002; 95% CI 2.22 to 37.69). Subgroup analysis that only included control eyes with a refraction cut-off <−3.70 D found that corneal refractive surgery was not significantly associated with glaucoma.ConclusionsHistory of corneal refractive surgery was associated with a higher prevalence of glaucoma in the Korean population. However, this association was not observed in eyes with a higher degree of myopia.


2020 ◽  
pp. bjophthalmol-2020-316901
Author(s):  
Jin-soo Kim ◽  
Young Kook Kim ◽  
Yong Woo Kim ◽  
Sung Uk Baek ◽  
Ahnul Ha ◽  
...  

Background/AimsTo evaluate the association between strabismus and primary open-angle glaucoma (POAG) in a representative Korean population.MethodsA total of 11 114 participants aged 20 years or older in the Korea National Health and Nutrition Examination Survey database for the years 2010 through 2011 were reviewed. A standardised protocol was used to interview every participant and to perform comprehensive ophthalmic examinations. Glaucoma diagnosis was based on fundus photography and frequency-doubling technology perimetry results, according to the International Society of Geographical and Epidemiological Ophthalmology criteria. Ocular alignment was evaluated using the alternate prism and cover test, and clinically significant horizontal strabismus was defined as exodeviation of ≥15 prism dioptres (PD) and esodeviation of ≥10 PD. Univariate and multivariate regression analyses were used to evaluate the potential risk factors for POAG.ResultsIn the Korean population, subjects with clinically significant esodeviation had a much higher prevalence of POAG (12.32%) than those without clinically significant esodeviation (3.14%, p=0.016). After adjusting for age and intraocular pressure, clinically significant esodeviation was independently associated with POAG (OR 7.61, p=0.002).ConclusionEsodeviation was independently associated with POAG in the Korean population. This could be the result of, at least in part, ocular-adduction-induced greater strain on the temporal optic nerve head and peripapillary tissues, which makes eyes with esodeviation more vulnerable to POAG.


PLoS ONE ◽  
2020 ◽  
Vol 15 (7) ◽  
pp. e0236152
Author(s):  
Jeong Hun Bae ◽  
Joon Mo Kim ◽  
Jung Min Lee ◽  
Ji Eun Song ◽  
Mi Yeon Lee ◽  
...  

2016 ◽  
Vol 42 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Seong Hee Shim ◽  
Kyung Rim Sung ◽  
Joon Mo Kim ◽  
Hyun Tae Kim ◽  
Jinho Jeong ◽  
...  

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0176894 ◽  
Author(s):  
Jae Yeun Lee ◽  
Tae-Woo Kim ◽  
Hyun Tae Kim ◽  
Mi Yeon Lee ◽  
Hye Won Min ◽  
...  

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