scholarly journals The Relationship between Serum Zinc Level and Heart Failure: A Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Xuefang Yu ◽  
Lei Huang ◽  
Jinyan Zhao ◽  
Zhuoqun Wang ◽  
Wei Yao ◽  
...  
Keyword(s):  
Heart Failure ◽  
Subgroup Analysis ◽  
Meta Analysis ◽  
Serum Zinc ◽  
Idiopathic Dilated Cardiomyopathy ◽  
Case Control Studies ◽  
Control Subjects ◽  
Zinc Levels ◽  
The Relationship ◽  
Serum Zinc Levels

Zinc is essential for the maintenance of normal cellular structure and functions. Zinc dyshomeostasis can lead to many diseases, such as cardiovascular disease. However, there are conflicting reports on the relationship between serum zinc levels and heart failure (HF). The purpose of the present study is to explore the relationship between serum zinc levels and HF by using a meta-analysis approach. PubMed, Web of Science, and OVID databases were searched for reports on the association between serum zinc levels and HF until June 2016. 12 reports with 1453 subjects from 27 case-control studies were chosen for the meta-analysis. Overall, the pooled analysis indicated that patients with HF had lower zinc levels than the control subjects. Further subgroup analysis stratified by different geographic locations also showed that HF patients had lower zinc levels than the control subjects. In addition, subgroup analysis stratified by HF subgroups found that patients with idiopathic dilated cardiomyopathy (IDCM) had lower zinc levels than the control subjects, except for patients with ischemic cardiomyopathy (ICM). In conclusion, the results of the meta-analysis indicate that there is a significant association between low serum zinc levels and HF.

scholarly journals Effect of Zinc Supplementation on Maintenance Hemodialysis Patients: A Systematic Review and Meta-Analysis of 15 Randomized Controlled Trials

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Ling-Jun Wang ◽  
Ming-Qing Wang ◽  
Rong Hu ◽  
Yi Yang ◽  
Yu-Sheng Huang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Nutritional Status ◽  
Subgroup Analysis ◽  
Zinc Supplementation ◽  
Meta Analysis ◽  
Serum Zinc ◽  
Maintenance Hemodialysis ◽  
Randomized Controlled ◽  
Zinc Levels ◽  
Serum Zinc Levels

We aimed to examine the effects of zinc supplementation on nutritional status, lipid profile, and antioxidant and anti-inflammatory therapies in maintenance hemodialysis (MHD) patients. We performed a systematic review and meta-analysis of randomized, controlled clinical trials of zinc supplementation. Metaregression analyses were utilized to determine the cause of discrepancy. Begg and Egger tests were performed to assess publication bias. Subgroup analysis was utilized to investigate the effects of zinc supplementation in certain conditions. In the crude pooled results, we found that zinc supplementation resulted in higher serum zinc levels (weighted mean difference [WMD] = 28.489;P<0.001), higher dietary protein intake (WMD = 8.012;P<0.001), higher superoxide dismutase levels (WMD = 357.568;P=0.001), and lower levels of C-reactive protein (WMD = −8.618;P=0.015) and malondialdehyde (WMD = −1.275;P<0.001). The results showed no differences in lipid profile. In the metaregression analysis, we found that serum zinc levels correlated positively with intervention time (β=0.272;P=0.042) and varied greatly by ethnicity (P=0.023). Results from Begg and Egger tests showed that there was no significant bias in our meta-analysis (P>0.1). Results of subgroup analysis supported the above results. Our analysis shows that zinc supplementation may benefit the nutritional status of MHD patients and show a time-effect relationship.

scholarly journals Nutritional stunting in Egypt: which nutrient is responsible?

2002 ◽  
Vol 8 (2-3) ◽  
pp. 272-280
Author(s):  
S. A. Ibrahim ◽  
A. Abdel Maksoud ◽  
M. F. Nassar
Keyword(s):  
Linear Growth ◽  
Serum Zinc ◽  
Bone Age ◽  
Alpha Tocopherol ◽  
Nutrient Deficiencies ◽  
Egyptian Children ◽  
Laboratory Investigations ◽  
Zinc Levels ◽  
The Relationship ◽  
Serum Zinc Levels

We looked at the relationship between linear growth retardation and deficiencies of certain nutrients in Egyptian children. A group of 107 stunted children aged between 10 and 18 years were subjected to history-taking, physical examination and laboratory investigations. Selected cases were referred to radiology for assessment of bone age. Thirty-nine children were enrolled as controls. Serum haemoglobin, alpha-tocopherol, retinol and magnesium levels were significantly decreased in stunted children compared with the controls. Serum zinc levels were also lower in the stunted group but not significantly so. We conclude that several nutrient deficiencies occur simultaneously in stunted children and all of them may be responsible for stunting.

scholarly journals Serum Zinc Levels and in Vivo Beta-Amyloid Deposition in the Human Brain

2021 ◽  
Author(s):  
Jee Wook Kim ◽  
Min Soo Byun ◽  
Dahyun Yi ◽  
Jun Ho Lee ◽  
Min Jung Kim ◽  
...  
Keyword(s):  
Serum Zinc ◽  
Beta Amyloid ◽  
Zinc Level ◽  
Amyloid Deposition ◽  
Serum Zinc Level ◽  
Positron Emission ◽  
Zinc Levels ◽  
The Relationship ◽  
Serum Zinc Levels

Abstract Background: Despite the known associations between zinc levels and Alzheimer’s disease (AD) dementia and related cognitive impairment, the underlying neuropathological links remain poorly understood. We tested the hypothesis that serum zinc level is associated with cerebral beta-amyloid protein (Ab) deposition. Additionally, we explored associations between serum zinc levels and other AD pathologies [i.e., tau deposition and AD-signature cerebral glucose metabolism (AD-CM)] and white matter hyperintensities (WMHs), which are measures of cerebrovascular injury. Methods: A total of 241 cognitively normal older adults between 55 and 90 years of age were enrolled. All the participants underwent comprehensive clinical assessments, serum zinc level measurement, and multimodal brain imaging, including Pittsburgh compound B-positron emission tomography (PET), AV-1451 PET, fluorodeoxyglucose (FDG)-PET, and magnetic resonance imaging. Zinc levels were stratified into three categories: < 80 µg/dL (low), 80 to 90 µg/dL (medium), and > 90 µg/dL (high). Results: A low serum zinc level was significantly associated with increased Ab retention. In addition, apolipoprotein E ε4 allele (APOE4) status moderated the association: the relationship between low zinc level and Ab retention was significant only in APOE4 carriers. Although a low zinc level appeared to reduce AD-CM, the relationship became insignificant on sensitivity analysis including only individuals with no nutritional deficiency. The serum zinc level was associated with neither tau deposition nor the WMH volume. Conclusions: Our findings suggest that decreased serum zinc levels are associated with elevation of brain amyloid deposition. In terms of AD prevention, more attention needs to be paid to the role of zinc.

scholarly journals SMALL BABIES

2005 ◽  
Vol 12 (03) ◽  
pp. 336-339
Author(s):  
MUHAMMAD ASHRAF ◽  
Zamir Ahmad ◽  
MUHAMMAD NASARULLAH KHAN ◽  
Tariq Ferroz Khawaja ◽  
MUHAMMAD AYUB KHAN ◽  
...  
Keyword(s):  
Dna Polymerase ◽  
Gestational Age ◽  
Serum Zinc ◽  
Maternal Serum ◽  
Maternal Complications ◽  
Metallic Component ◽  
Zinc Levels ◽  
Relationship Of ◽  
The Relationship ◽  
Serum Zinc Levels

Zinc is an essential trace mineral. It is considered a growth factor as it isthe metallic component of enzymes DNA polymerase, DNA dependent RNA polymerase and thymidine kinase.Objective: To find out the relationship of maternal serum zinc levels with birth weight of the babies. Period: January1989 to May, 1991. Setting: Lady Wellingdon Hospital Lahore, King Edward College, Lahore and MetallurgyDepartment PCSIR Laboratories, Lahore. Design: Prospective study Patients & methods: Among the 216 registeredpregnant women 46 subjects had no feto-maternal complications during pregnancy and they delivered babies havingbirth weight adequate for Gestational Age (AGA). Thirteen women gave birth to babies Small for Gestational Age(SGA). Blood samples were taken at the end of each trimester and serum zinc was measured by atomic absorptionspectrophotometer. Results: Serum zinc levels were significantly low (P<0.001) throughout pregnancy in women givingbirth to SGA babies. Conclusion: Serum zinc levels throughout the course of pregnancy are associated with intrauterinegrowth of the babies.b

scholarly journals Higher serum zinc levels may reduce the risk of cervical cancer in Asian women: A meta-analysis

2018 ◽  
Vol 46 (12) ◽  
pp. 4898-4906 ◽  
Author(s):  
Yueying Xie ◽  
Junjie Wang ◽  
Xiaoya Zhao ◽  
Xuli Zhou ◽  
Xiaohui Nie ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cancer Risk ◽  
Protective Factor ◽  
Meta Analysis ◽  
Serum Zinc ◽  
Asian Women ◽  
China National Knowledge Infrastructure ◽  
Cervical Cancer Risk ◽  
Zinc Levels ◽  
Serum Zinc Levels

Objective This meta-analysis was conducted to examine the possible association between serum zinc concentration and cervical cancer risk. Methods PubMed, WanFang, China National Knowledge Infrastructure, and SinoMed databases were searched for relevant articles published between January 1980 and September 2017. Results were combined using a random-effects model, and pooled standardized mean differences (SMD) and 95% confidence intervals (CI) were calculated to compare serum zinc levels in patients with cervical cancer versus controls. Publication bias was evaluated using Begg’s funnel plot and Egger’s regression asymmetry test. Results Twelve articles regarding serum zinc levels and cervical cancer were included in this meta-analysis. Combined results showed that serum zinc levels in cervical cancer cases were significantly lower than in controls without cervical cancer (summary SMD –1.379, 95% CI –1.527, –1.231), with high heterogeneity ( I2 = 98.8%). Analysis of data stratified by geographic location showed a significant association between serum zinc levels and cervical cancer risk in Asian populations (summary SMD –1.391, 95% CI –1.543, –1.239). Conclusions Higher serum zinc levels may be a protective factor for cervical cancer in Asian women.

The relationship between serum zinc levels and rheumatoid arthritis activity

2018 ◽  
Vol 13 (1) ◽  
pp. 51-55
Author(s):  
Elham Rajaee ◽  
Karim Mowla ◽  
Ali Ghorbani ◽  
Mehrdad Dargahi-Malamir ◽  
Marzieh Zarei ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Serum Zinc ◽  
Zinc Levels ◽  
The Relationship ◽  
Rheumatoid Arthritis Activity ◽  
Serum Zinc Levels

Association between serum zinc levels and recurrent aphthous stomatitis: a meta-analysis with trial sequential analysis

2021 ◽  
Vol 25 (2) ◽  
pp. 407-415
Author(s):  
Sadeq A. Al-Maweri ◽  
Esam Halboub ◽  
Hesham Mohammed Al-Sharani ◽  
Anas Shamala ◽  
Ahlam Al-Kamel ◽  
...  
Keyword(s):  
Sequential Analysis ◽  
Meta Analysis ◽  
Serum Zinc ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Trial Sequential Analysis ◽  
Zinc Levels ◽  
Serum Zinc Levels

scholarly journals Low Serum Zinc Level May be Related to Higher Doses of EPO in Hemodialysis Patients

2015 ◽  
Vol 12 (1) ◽  
pp. 40-44
Author(s):  
Itir Yegenaga ◽  
Zeki Aydin
Keyword(s):  
Serum Zinc ◽  
Zinc Level ◽  
Control Group ◽  
Inadequate Response ◽  
Recombinant Erythropoietin ◽  
Serum Zinc Level ◽  
Human Recombinant Erythropoietin ◽  
Zinc Levels ◽  
The Relationship ◽  
Serum Zinc Levels

AbstractIntroduction.Anemia is a complication of chronic renal failure observed in patients on hemodialysis (HD) affecting morbidity and mortality of these patients. It is associated with erythropoietin (EPO) deficiency and can be treated by human recombinant erythropoietin (hrEPO). Iron deficiency has been reported as the first line cause for inadequate response to this treatment. Zinc deficiency in hemodialysis (HD) patients was previously reported and the relationship between iron and zinc deficiencies has been known for years. The aim of this study was to find out the relationship between serum zinc level, anemia and rhEPO consuming in HD patients.Methods.A total of 69 HD patients and 34 healthy individuals were included in the study. Serum zinc levels, clinical, hematologic, biochemical parameters and rhEPO doses were evaluated.Results.Serum zinc levels were found to be lower in HD patients in comparison to those in the control group (29.92±12.94, 44.82±27.69μg/dL, respectively) (p<0.001). There was a positive correlation between serum zinc and hemoglobin (Hb) in the control group (R2=0.06). In HD patients who needed less then 8000U/week rhEPO, Hb levels (p<0.05) and serum zinc levels were higher. Serum zinc and Hb levels were found to be higher in patients who were under HD treatment for more than 12 months (10.05±1.06 vs 10.69±1.29; p=0.022 and 26.96±13.29 vs 30.88±12.61; p=0.178).Conclusions.HD patients who needed lower dose of EPO had higher serum zinc levels. Although the difference was not statistically significant, these results provide evidence that serum zinc level should be taken into consideration especially in HD patients resistant to EPO therapy.

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