scholarly journals A Meta-Analysis of the Clinical Efficacy of TCM Decoctions Made from Formulas in the Liuwei Dihuang Wan Categorized Formulas in Treating Diabetic Nephropathy Proteinuria

2018 ◽  
Vol 2018 ◽  
pp. 1-10
Author(s):  
Xue Gao ◽  
Jianwei Shang ◽  
Hongfang Liu ◽  
Borui Yu
Keyword(s):  
Diabetic Nephropathy ◽  
Clinical Efficacy ◽  
Adverse Reactions ◽  
Meta Analysis ◽  
Microvascular Complications ◽  
Treatment Strategies ◽  
Cochrane Library ◽  
Urinary Protein Level ◽  
The Cochrane Library ◽  
Better Than

Objective. Diabetic nephropathy (DN) is one of the microvascular complications of diabetes mellitus. Proteinuria is the most important clinical characteristics of DN and an independent risk factor for disease progression of DN; reducing urine protein is the primary target of treatment strategies for DN. Liuwei Dihuang Wan Categorized Formulas (LDWCFs), a group of classic traditional Chinese medicine (TCM) formulas aiming at “kidney -tonifying”, have been widely used in the treatment of DN. This study aimed to obtain a comprehensive understanding of the TCM method “kidney-tonifying” in the treatment of DN by conducting a meta-analysis to analyze the clinical efficacy of decoctions made from the LDWCFs in the treatment of DN proteinuria. Methods. CNKI, Wanfang, Weipu, CBM, PubMed, Embase, and the Cochrane Library were searched; 14 studies were included in the meta-analysis. Results. The results showed that the overall efficacy of the LDWCFs in treating DN was significantly better than that of the comparators (OR 2.87, 95% CI 1.98–4.15, P<0.00001). These formulas showed better efficacy than the comparators in reducing 24-hour urinary protein level (MD 0.12, 95% CI 0.06–0.17, P<0.0001) and in reducing urine microalbumin excretion rate (SMD 0.87, 95% CI 0.41–1.32, P<0.0002). No serious adverse reactions were reported. Conclusions. TCM formulas included in the LDWCFs are safe and effective in the treatment of DN proteinuria. These findings suggested that the TCM therapeutic principle of “kidney-tonifying” is a valuable addition to the treatment strategies for DN.

scholarly journals Granisetron plus dexamethasone for prevention of postoperative nausea and vomiting in patients undergoing laparoscopic surgery: A meta-analysis

2017 ◽  
Vol 45 (3) ◽  
pp. 904-911 ◽  
Author(s):  
Min Zhu ◽  
Chengmao Zhou ◽  
Bing Huang ◽  
Lin Ruan ◽  
Rui Liang
Keyword(s):  
Laparoscopic Surgery ◽  
Postoperative Nausea ◽  
Adverse Reactions ◽  
Meta Analysis ◽  
Postoperative Nausea And Vomiting ◽  
Nausea And Vomiting ◽  
Cochrane Library ◽  
Randomized Controlled ◽  
Laparoscopy Surgery ◽  
The Cochrane Library

Objective This study was designed to compare the effectiveness of granisetron plus dexamethasone for preventing postoperative nausea and vomiting (PONV) in patients undergoing laparoscopic surgery. Methods We searched the literature in the Cochrane Library, PubMed, EMBASE, and CNKI. Results In total, 11 randomized controlled trials were enrolled in this analysis. The meta-analysis showed that granisetron in combination with dexamethasone was significantly more effective than granisetron alone in preventing PONV in patients undergoing laparoscopy surgery. No significant differences in adverse reactions (dizziness and headache) were found in association with dexamethasone. Conclusion Granisetron in combination with dexamethasone was significantly more effective than granisetron alone in preventing PONV in patients undergoing laparoscopic surgery, with no difference in adverse reactions between the two groups. Granisetron alone or granisetron plus dexamethasone can be used to prevent PONV in patients undergoing laparoscopic surgery.

scholarly journals Vitamin D Deficiency Increases the Risk of Diabetic Retinopathy: A Meta-Analysis of Observational Studies

2017 ◽  
Author(s):  
Xiang Zhang ◽  
Guo-Tao Pan ◽  
Zeng-Li Zhang ◽  
Shasha Tao
Keyword(s):  
Vitamin D ◽  
Diabetic Retinopathy ◽  
Vitamin D Deficiency ◽  
Observational Studies ◽  
Meta Analysis ◽  
Microvascular Complications ◽  
Final Analysis ◽  
Cochrane Library ◽  
Diabetic Patients ◽  
The Cochrane Library

Background: Diabetic retinopathy (DR) is one of the most prominent pathological microvascular complications in diabetes. A series of studies reported that vitamin D deficiency was associated with increased prevalence of retinopathy in diabetic patients but the results were inconsistent. In this study we focused on evaluating the relationship between vitamin D deficiency and DR by conducting a meta-analysis of observational studies. Methods: Systematic computerized searches were performed in PubMed, MEDLINE, and the Cochrane Library for relevant original articles till November 20, 2016. The pooled odds ratios (ORs) with corresponding confidence intervals (CIs) were calculated to assess the associated value of vitamin D deficiency to the risk of DR. 9 studies including 6332 participants were subjected to final analysis. Results: The results indicated that vitamin D deficiency increases the risk of DR (OR = 1.57, 95% CI 1.32-1.87) with a little heterogeneity (I2 = 23%). In addition, the subgroup analysis demonstrated that there were obvious heterogeneities in T2DM (I2 = 47.8%). Sensitivity analysis showed that the results were relatively stable and reliable. Conclusion: our meta-analysis demonstrated that vitamin D deficiency could increase the risk of DR.

scholarly journals Corticosteroids for Graves’ Ophthalmopathy: Systematic Review and Meta-Analysis

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Xiaofang Tu ◽  
Yan Dong ◽  
Hongmei Zhang ◽  
Qing Su
Keyword(s):  
Mycophenolate Mofetil ◽  
Response Rate ◽  
Meta Analysis ◽  
Corticosteroid Treatment ◽  
Cochrane Library ◽  
Graves Ophthalmopathy ◽  
Oral Corticosteroids ◽  
System Review ◽  
The Cochrane Library ◽  
Better Than

Background. Graves’ ophthalmopathy (GO) is a complicated autoimmune disease. Various therapies have been used to manage GO; however the optimum therapy is not clear. Glucocorticoids (GCs) therapy is the mainstay of treatment especially for active moderate to severe patients, which needs evidence-based support. Method. We searched all the randomized controlled trials (RCTs) involving corticosteroid treatment for patients diagnosed with GO from EMBASE, Medline, and the Cochrane library and then conducted a system review and meta-analysis. The electronic search covered the period from April 1966 to March 2018. Result. Twenty-nine trials were included. GCs were proved to be beneficial for GO patients [response rate, risk ratio (RR) = 1.72, 95% confidence interval (CI): 1.28~2.31, P=0.0003], and intravenous corticosteroids worked significantly better than oral corticosteroids as ever reported. When compared with the single treatment of GCs, the combination of radiotherapy and GCs showed similar effects on response rate (RR=1.25, 95%CI: 0.91~1.73). A study proved the advantage of mycophenolate mofetil over GCs in three outcomes (response rate, RR=0.74, 95%CI: 0.63~0.88). Additional treatments such as technetium-99 methylene diphosphate (99Tc-MDP) or cyclosporine enhanced the effect of GCs on proptosis reduction, respectively (P<0.00001 and P=0.02). Conclusion. Our meta-analysis confirmed the effects of GCs in the management of GO and intravenous GCs are proved to be better than oral GCs as ever reported. Combination of radiotherapy and GCs did not enhance the effects of GCs. However, if proptosis is the main issue, combination of 99Tc-MDP or cyclosporine with GCs may be taken into consideration. The reported advantages of mycophenolate mofetil over GCs are noteworthy and need more RCTs to confirm.

scholarly journals Circulating noncoding RNAs as early predictive biomarkers in preeclampsia: a diagnostic meta-analysis

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Sha Su ◽  
Fang Yang ◽  
Linlin Zhong ◽  
Lihong Pang
Keyword(s):  
Meta Analysis ◽  
Noncoding Rnas ◽  
Predictive Biomarkers ◽  
Cochrane Library ◽  
Clinical Value ◽  
Peripheral Blood Mononuclear ◽  
Meta Regression Analysis ◽  
The Cochrane Library ◽  
Combined Detection ◽  
Better Than

Abstract Background We designed a meta-analysis to evaluate the clinical significance and efficacy of circulating noncoding RNAs (ncRNAs) in the early prediction of preeclampsia. Methods PubMed, Embase and the Cochrane Library were used to search for literature. The combined prediction performance was evaluated by calculating the area under the summary receiver operator characteristic (SROC) curve. The potential sources of heterogeneity were analysed by meta-regression analysis and subgroup analysis. All statistical analyses and mapping were performed by RevMan 5.3 and Stata 12.0. Results A total of 41 studies from 14 articles, including 557 preeclampsia patients and 842 controls, were included in our meta-analysis. All studies collected blood before onset. NcRNAs in blood performed relatively well in predicting preeclampsia. The combined sensitivity was 0.71, the specificity was 0.84, and the area under the SROC curve (AUC) was 0.86. Peripheral blood mononuclear cell (PBMC) samples showed the best diagnostic accuracy. The combined AUC was 0.93. Combined detection was better than single detection, and miRNA was better than circRNA. The heterogeneity of the study was determined by sample size, lncRNA characteristics, lncRNA source and race. Conclusion Circulating ncRNAs can be valuable biomarkers used as candidates for noninvasive early predictive biomarkers of preeclampsia and have great clinical application prospects. The clinical value of ncRNAs needs to be tested by further multicentre, comprehensive and prospective studies, and the test criteria should be established.

scholarly journals Incidences of Adverse Reactions in BNT162b2: A Meta-analysis

2022 ◽  
Author(s):  
Yi Dong ◽  
◽  
LiJia Liu ◽  
Jianing Liu ◽  
Tianqi Liao ◽  
...  
Keyword(s):  
Adverse Reactions ◽  
Web Of Science ◽  
Controlled Trial ◽  
Meta Analysis ◽  
Previous History ◽  
Healthy Adults ◽  
Cochrane Library ◽  
Total Incidence ◽  
Review Question ◽  
The Cochrane Library

Review question / Objective: This study searched PubMed, Cochrane Library, Web of Science, Embase Electronics, and other databases to collect healthy adults aged 16 and older, subjects with no previous history of COVID-19 infection, A randomized controlled trial of Pfizer's vaccine BNT162b2 versus placebo. Using RevMan5.4 software, meta-analysis was conducted to compare the effects of injection of BNT162b2 and placebo on the incidence of adverse reactions in healthy adults over 16 years of age. Main indexes include total incidence of adverse reactions, the incidence of local adverse reactions at the injection site (including red hot accessories), the incidence of systemic adverse reactions, including fever, headache, rash, urticaria, joint pain, muscle pain, gastrointestinal tract reaction, fatigue, cough, etc.), death rate, so as to provide a reference for clinical practice. Information sources: The following electronic databases will be searched from January 2020 to November 2021: PubMed, the Cochrane Library, Web of Science, Embase Electronics. In addition, reference lists of the included studies were manually searched to identify additional relevant studies.

Efficacy and Adverse Events of Intermittent Androgen Deprivation Therapy versus Continuos Androgen Deprivation Therapy on Localized and Metastatic Prostate Cancer: A Meta-Analysis

2018 ◽  
Vol 24 (8) ◽  
pp. 6130-6135
Author(s):  
M. Gozali Arif ◽  
Rizal A. H Hamid
Keyword(s):  
Adverse Events ◽  
Androgen Deprivation Therapy ◽  
Observational Studies ◽  
Meta Analysis ◽  
Androgen Deprivation ◽  
Cochrane Library ◽  
Psa Progression ◽  
The Cochrane Library ◽  
Better Than ◽  
Overall Mortality

To evaluate clinical data from published trials on efficacy and adverse events of intermittent androgen deprivation therapy (IAD) and continuous androgen deprivatin therapy (CAD). This study searched Medline, Sience direct and the Cochrane Library through August 2016 without year restriction but only english journal were included suplemented using Preferred Reporting Items for Systematic Reviews and Meta-analysis of Observational Studies in Epidemiology Guidelines. Result: 10 Studies were identified and up to 4403 patients were pooled. When compared to CAD, IAD was not statistically difference in term of overall mortality and 3 years PSA progression. But when compared to CAD, IAD was statistically better than CAD in the term reduce pain burden. Conclusions: This study conclude that the efficacy between CAD and IAD was not significant different. IAD is better to minimize pain as adverse events than CAD.

Effects of the Mat Pilates Method on Body Composition: Systematic Review With Meta-Analysis

2020 ◽  
Vol 17 (6) ◽  
pp. 673-681
Author(s):  
Allysiê Priscilla de Souza Cavina ◽  
Eduardo Pizzo Junior ◽  
Aryane Flauzino Machado ◽  
Taíse Mendes Biral ◽  
Leonardo Kesrouani Lemos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Body Composition ◽  
Healthy Adult ◽  
Meta Analysis ◽  
Abdominal Circumference ◽  
Cochrane Library ◽  
Fat Percentage ◽  
Pilates Method ◽  
The Cochrane Library ◽  
Better Than

Background: The objective of this systematic review was to determine the efficacy of the mat Pilates method on body composition in healthy adult subjects compared with traditional exercise or control condition models. Design: Systematic review with meta-analysis. Data sources: MEDLINE, EMBASE, SPORTDiscus, PEDro, SciELO, CINAHAL, and the Cochrane Library. Results: A total of 10 eligible studies were selected for revision. The findings of this review demonstrated that the mat Pilates method was not more effective than the traditional exercise or control condition models for the analyzed variables (body mass index, lean mass, body fat percentage, and abdominal circumference). Moreover, in the exploratory analysis with older people, adults, and overweight/obese individuals, the mat Pilates method was also not superior for the analyzed outcomes. Conclusion: The findings of this study suggest that the mat Pilates method is no better than the control condition or other types of training to reduce body composition.

scholarly journals Curative Effect and Safety of Tolvaptan Combined with Traditional Diuretics in Treatment of Patients with Cirrhotic Ascites and Relevant Research on its Dose: A Systematic Review with Meta-Analysis of Randomized Controlled Trials

2020 ◽  
Author(s):  
Xin Li ◽  
Shidong Liu ◽  
Hui Zhang ◽  
Fuxiang Liang ◽  
Long Miao ◽  
...  
Keyword(s):  
Adverse Reactions ◽  
Meta Analysis ◽  
Drug Dose ◽  
Ion Concentration ◽  
Cochrane Library ◽  
Curative Effect ◽  
Total Incidence ◽  
Liquid Discharge ◽  
Blood Uric Acid ◽  
The Cochrane Library

Abstract Background Tolvaptan is a receptor antagonist of highly selective vasopressin V2, and it can promote excretion of water without electrolyte.Aims To evaluated curative effect and safety of Tolvaptan in treatment of cirrhotic ascites, and its relationship with drug dose.Methods Computer retrieval of PubMed, EMbase and The Cochrane Library was carried out to search the clinical trials of cirrhotic ascites treatment by Tolvaptan. The time limit of retrieval is from the database setup to May 31, 2019. 2 researchers independently screened studies, extracted the data and crosschecked. RevMan 5.3 software was used for Meta-analysis.Results Finally, 6 articles and 848 patients were included in the study. Meta-analysis indicates that after the intervention for 7 days, serum sodium ion concentration of the combined diuretic group obviously increased, compared with the traditional diuretic group (WMD=2.92mmol/L, 95%CI [2.15, 3.70], P<0.001). In addition, Tolvaptan also can decrease patients’ ascites amount through increasing liquid discharge. However, the drug dose has no obvious correlation with the reduction degree of ascites amount. The rise of blood uric acid is the major adverse event in the treatment of cirrhotic ascites patients by Tolvaptan (OR=6.01, 95%CI [1.11, 32.56], P=0.04). When the dose of Tolvaptan rose to 15mg or 30mg, the total incidence of adverse events was obviously higher than it of traditional diuretic group.Conclusion Tolvaptan combined with traditional diuretics has good curative effect for the patients with cirrhotic ascites. As its adverse reactions, the recommended dose of Tolvaptan is 7.5mg in the combined therapy.Registration number: The meta-analysis was registered prospectively on the PROSPERO database (ID: CRD42019143480).

scholarly journals Liuwei Dihuang Pills Enhance the Effect of Western Medicine in Treating Diabetic Nephropathy: A Meta-Analysis of Randomized Controlled Trials

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Lan Lin ◽  
Qiuhong Wang ◽  
Yongxin Yi ◽  
Shihan Wang ◽  
Zonglin Qiu
Keyword(s):  
Diabetic Nephropathy ◽  
Western Medicine ◽  
Data Extraction ◽  
Meta Analysis ◽  
Scientific Journal ◽  
Cochrane Library ◽  
Renal Functions ◽  
Study Selection ◽  
The Cochrane Library ◽  
Liuwei Dihuang Pills

Objectives.To assess the effectiveness and adverse effects of adding Liuwei Dihuang Pills (LDP) to Western medicine for treating diabetic nephropathy.Methods.Studies were retrieved from seven electronic databases, including PubMed, Embase, The Cochrane Library, CBM, CNKI, Chinese Scientific Journal Database (VIP), and Wanfang Data until November 2015. Study selection, data extraction, quality assessment, and data analyses were conducted according to Cochrane standards. Meta-analysis was performed on the overall therapeutic efficacy of hyperglycemia and renal functions, and the study also analyzed adverse events.Results.A total of 1,275 patients from 18 studies were included. The methodological quality of these included trials was generally low. We found that adding LDP can lower patients’ FBG (MD: −0.36 [−0.46, −0.25],P<0.00001), PBG (MD: −1.10 [−1.35, −0.85],P<0.00001), and HbA1c (MD: −0.14 [−0.49, 0.21],P=0.43). There were also improvements in lowering patients’ BUN (MD: −0.67 [−0.89, −0.45],P<0.00001), SCr (MD: −0.96 [−1.53, −0.39],P<0.00001), 24 h UTP (SMD: −1.26 [−2.38, −0.15],P<0.00001), UAER (MD: −26.18 [−27.51, −24.85],P<0.00001), and UmAlb (SMD: −1.72 [−2.67, −0.77],P<0.00001).Conclusion.There is encouraging evidence that adding LDP to Western medicine might improve treatment outcomes of diabetic nephropathy, including hyperglycemia and renal functions. However, the evidence remains weak. More rigorous high-quality trials are warranted to substantiate or refute the results.

scholarly journals The preventive effect of dexmedetomidine on adverse reactions induced by uterotonics in cesarean section: a meta-analysis

2019 ◽  
Author(s):  
Lingxi Kong(Former Corresponding Author) ◽  
Xuefeng Shan ◽  
Hongmei Wang ◽  
Yingying Ren ◽  
Yang Yang ◽  
...  
Keyword(s):  
Cesarean Section ◽  
Adverse Reactions ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Controlled Trials ◽  
Drug Reactions ◽  
Preventive Effect ◽  
Facial Flushing ◽  
Randomized Controlled ◽  
The Cochrane Library

Abstract Background: To evaluate the preventive effect of dexmedetomidine(DEX) on adverse reactions induced by uterotonics used in cesarean section. Methods: Randomized controlled trials(RCTs) comparing dexmedetomidine with placebo on preventing the side effects of uterotonics in cesarean section were searched in PubMed, The Cochrane Library, and CNKI. Results: Fifteen articles with 1174 patients were included in this study. Compared with placebo, DEX significantly reduced the incidence of adverse drug reactions, such as nausea, vomiting, facial flushing, chest distress, hypertension and tachycardia ([OR = 0.12, 95% CI (0.09, 0.17), P < 0.00001], [OR = 0.12, 95% CI (0.09, 0.18), P < 0.00001], [OR = 0.21, 95% CI (0.16, 0.29), P < 0.00001], [OR = 0.19,95%CI (0.12,0.30), P < 0.00001], [OR=0.09, 95%CI (0.05,0.14), P < 0.00001], [OR=0.04, 95%CI (0.02,0.07), P < 0.00001]),which were induced by uterotonics used in cesarean section. Conclusion: Dexmedetomidine can prevent adverse reactions including nausea, vomiting, facial flushing, chest distress, hypertension and tachycardia caused by uterotonics used in cesarean section.

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