scholarly journals Impaired Inflammatory Response to LPS in Type 2 Diabetes Mellitus

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Lusine Khondkaryan ◽  
Sona Margaryan ◽  
David Poghosyan ◽  
Gayane Manukyan
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Immune Responses ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Lps Challenge ◽  
High Incidence ◽  
Severe Health Problem

Type 2 diabetes mellitus (T2DM) is a severe health problem worldwide, reaching epidemic levels. High susceptibility to infections of T2DM patients indicates dysregulated immune responses to pathogens. However, innate immune responses, including monocyte functions, in T2DM are poorly investigated. Therefore, in this study we aimed to assess lipopolysaccharide- (LPS-) induced immune responses of circulating monocytes from T2DM patients. The results showed that monocytes from T2DM were hyporesponsive to LPS challenge as reflected by significantly suppressed secretion of TNFα (p<0.01) and expression of CD11b (p<0.001) and TLR4 (p<0.001) compared to those in monocytes from healthy subjects. Furthermore, LPS-induced IL-10 levels were similar in diabetic and healthy supernatants, while expression levels of CD163 were found to be downregulated on monocytes from T2DM (p<0.001) suggesting impaired ability of monocytes to switch their phenotype to anti-inflammatory. Taken together, our results suggest compromised function of monocytes in T2DM, which may explain, at least partly, high incidence of infection in these patients.

Innate immunity alterations in Type 2 Diabetes Mellitus: understanding infection susceptibility

2020 ◽  
Vol 20 ◽  
Author(s):  
Ochoa-González Fátima de Lourdes ◽  
González-Curiel Irma Elizabeth ◽  
Cervantes-Villagrana Al-berto Rafael ◽  
Fernández-Ruiz Julio Cesar ◽  
Castañeda-Delgado Julio Enrique
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Immune Response ◽  
Type 2 Diabetes Mellitus ◽  
Innate Immune Response ◽  
Adult Population ◽  
International Diabetes Federation ◽  
Innate Immune ◽  
Cellular Mechanisms

: Diabetes is a chronic disease characterized by marked alterations in the metabolism of glucose andby high con-centrations of glucose in the blood due to a decreased insulin production or resistance to the action of this hormone in pe-ripheral tissues. The International Diabetes Federation estimates a global incidence of diabetes of about 10% in the adult population (20 -79 years old), some 430 million cases reported worldwide in 2018. It is well documented that people with diabetes have a higher susceptibility to infectious diseases and therefore show higher morbidity and mortality compared to the non-diabetic population. Given that the innate immune response plays a fundamental role in protecting against invading pathogens through a myriad of humoral and cellular mechanisms, the present work makes a comprehensive review of the innate immune alterations in patients with type 2 diabetes mellitus (T2D) as well as a brief description of the molecular events leading or associated to such conditions.We show that in these patients a compromised innate immune response in-creases susceptibility to infections.

TO STUDY THE PREVALENCE OF THYROID DYSFUNCTION AND IT'S EFFECTS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS IN TERTIARY CARE HOSPITAL

2021 ◽  
pp. 25-27
Author(s):  
Fouzia Sultana Shaik ◽  
G. Vijaya Kumar
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycemic Control ◽  
General Hospital ◽  
Subclinical Hypothyroidism ◽  
Thyroid Dysfunction ◽  
Thyroid Disorders ◽  
High Incidence

Background: The relationship between normal thyroid function and type 2 diabetes has been a particular focus of concern. Type 2 Diabetes being the most common endocrine, metabolic disorder, there lies a curiosity to understand and learn the association of this disease with another common endocrine gland that is the thyroid gland. This study is aimed to describe the association of poorly controlled diabetes and thyroid dysfunction. OBJECTIVES: Ÿ To study the thyroid functions in patients with type 2 diabetes mellitus. Ÿ To study the spectrum of thyroid dysfunction in patients with type 2 diabetes mellitus. Materials And Methods: A hospital-based observational prospective study was conducted in the Santhiram Medical College and General Hospital for six months. Patients with type 2 diabetes mellitus of age more than 30 years, from OPD and IPD of all the departments in Santhiram General Hospital irrespective of glucose control and treatment, with informed written consent were studied. Thyroid prole tests, target organ evaluation for type 2 diabetes mellitus were performed for all patients in this study group. Thyroid USG was done. Results: 100 cases of type 2 diabetes mellitus without proven thyroid disease were included in the study . Thyroid disorders were diagnosed in 29 % cases . Hypothyroidism in 1 , hyperthyroidism in 13 and subclinical hypothyroidism in 15 cases. In this study 50 patients were male, 50 were females. Females ( 36%) had high incidence of thyroid disorder than males ( 22%). Subclinical hypothyroidism was more common (31.25%) in elderly age group. Elderly females had high incidence of subclinical hypothyroidism (18.2%). Clinical features of hyperthyroidism are seen in 8 patients. In the patients with hyperthyroidism( 55.5%) there was poor glycemic control . Duration of diabetes has no relation with incidence of thyroid disorders. Majority of patients with subclinical hypothyroidism had uncontrolled sugars with microvascular complications. Conclusion: Prevalence of thyroid disorders in diabetes mellitus is 29%. Incidence is higher in elderly population . Duration of diabetes mellitus has no impact on thyroid dysfunction. Severe diabetic complications are noted in patients with subclinical hypothyroidism. Subclinical hypothyroidism is seen commonly among females. Diabetes with hyperthyroidism has poor glycemic control

High incidence of Type 2 diabetes mellitus in South African Indians: a 10-year follow-up study

2003 ◽  
Vol 20 (1) ◽  
pp. 23-30 ◽  
Author(s):  
A. A. Motala ◽  
F. J. Pirie ◽  
E. Gouws ◽  
A. Amod ◽  
M. A. K. Omar
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
South African ◽  
Follow Up Study ◽  
High Incidence

Type 2 diabetes mellitus, resistance training, and innate immunity: is there a common link?

2007 ◽  
Vol 32 (6) ◽  
pp. 1025-1035 ◽  
Author(s):  
Jennifer M. DiPenta ◽  
Julia M. Green-Johnson ◽  
René J.L. Murphy
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Older Adults ◽  
Innate Immunity ◽  
Type 2 Diabetes Mellitus ◽  
Resistance Training ◽  
Innate Immune ◽  
Diabetic Patients ◽  
Positive Effects

Type 2 diabetes mellitus is a serious chronic disease that is very prevalent in the developed world. The etiology of this disease is not well understood. Recently, the role of the innate immune system in the pathogenesis of type 2 diabetes and its complications has received a great deal of attention. Cytokines, acute phase proteins, and phagocytes have been implicated in this model. Resistance training has known benefits in type 2 diabetic patients and older adults, such as improved insulin action, insulin sensitivity, fasting blood glucose and insulin, and glucose tolerance levels. Actions of pro-inflammatory mediators linked to dysregulated innate immune activity have been associated with type 2 diabetes. The immunomodulatory effects of exercise, and in particular approaches such as resistance training, may provide a strategy to counter these pro-inflammatory effectors. However, the effects of resistance training on innate immunity have not been studied extensively in adults with type 2 diabetes or in older adults who are at increased risk for development of type 2 diabetes. This review discusses the possibility that resistance training may have positive effects on innate immunity in this population and so may provide benefits in addition to improving strength and functional abilities. In particular, the potential of resistance training to modulate pro-inflammatory parameters associated with type 2 diabetes, as a strategy that could provide multiple beneficial health outcomes, is addressed.

scholarly journals Glucagon-like peptide 1 analogue therapy directly modulates innate immune-mediated inflammation in individuals with type 2 diabetes mellitus

Diabetologia ◽  
2013 ◽  
Vol 57 (4) ◽  
pp. 781-784 ◽  
Author(s):  
Andrew E. Hogan ◽  
Gadintshware Gaoatswe ◽  
Lydia Lynch ◽  
Michelle A. Corrigan ◽  
Conor Woods ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Innate Immune ◽  
Immune Mediated ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals Type 2 Diabetes Mellitus and Latent Tuberculosis Infection Moderately Influence Innate Lymphoid Cell Immune Responses in Uganda

2021 ◽  
Vol 12 ◽  
Author(s):  
Phillip Ssekamatte ◽  
Marjorie Nakibuule ◽  
Rose Nabatanzi ◽  
Moses Egesa ◽  
Carol Musubika ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Glycaemic Control ◽  
Immune Responses ◽  
Cytokine Production ◽  
Latent Tuberculosis ◽  
Healthy Controls ◽  
Ifn Γ

BackgroundType 2 diabetes mellitus (T2DM) is a major risk factor for the acquisition of latent tuberculosis (TB) infection (LTBI) and development of active tuberculosis (ATB), although the immunological basis for this susceptibility remains poorly characterised. Innate lymphoid cells (ILCs) immune responses to TB infection in T2DM comorbidity is anticipated to be reduced. We compared ILC responses (frequency and cytokine production) among adult patients with LTBI and T2DM to patients (13) with LTBI only (14), T2DM only (10) and healthy controls (11).MethodsUsing flow cytometry, ILC phenotypes were categorised based on (Lin−CD127+CD161+) markers into three types: ILC1 (Lin−CD127+CD161+CRTH2-CD117−); ILC2 (Lin−CD127+CD161+CRTH2+) and ILC3 (Lin−CD127+CD161+CRTH2−NKp44+/−CD117+). ILC responses were determined using cytokine production by measuring percentage expression of interferon-gamma (IFN-γ) for ILC1, interleukin (IL)-13 for ILC2, and IL-22 for ILC3. Glycaemic control among T2DM patients was measured using glycated haemoglobin (HbA1c) levels. Data were analysed using FlowJo version 10.7.1, and GraphPad Prism version 8.3.ResultsCompared to healthy controls, patients with LTBI and T2DM had reduced frequencies of ILC2 and ILC3 respectively (median (IQR): 0.01 (0.005-0.04) and 0.002 (IQR; 0.002-0.007) and not ILC1 (0.04 (0.02-0.09) as expected. They also had increased production of IFN-γ [median (IQR): 17.1 (5.6-24.9)], but decreased production of IL-13 [19.6 (12.3-35.1)]. We however found that patients with T2DM had lower ILC cytokine responses in general but more marked for IL-22 production (median (IQR): IFN-γ 9.3 (4.8-22.6); IL-13 22.2 (14.7-39.7); IL-22 0.7 (IQR; 0.1-2.1) p-value 0.02), which highlights the immune suppression status of T2DM. We also found that poor glycaemic control altered ILC immune responses.ConclusionThis study demonstrates that LTBI and T2DM, and T2DM were associated with slight alterations of ILC immune responses. Poor T2DM control also slightly altered these ILC immune responses. Further studies are required to assess if these responses recover after treatment of either TB or T2DM.

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