scholarly journals Retroperitoneal Cystic Nodal Metastasis of Renal Cell Carcinoma

2018 ◽  
Vol 2018 ◽  
pp. 1-3 ◽  
Author(s):  
Takahisa Yamashita ◽  
Makoto Morozumi ◽  
Morihiro Higashi ◽  
Shuji Momose ◽  
Jun-ichi Tamaru
Keyword(s):  
Renal Cell Carcinoma ◽  
Lymph Node ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Renal Cell ◽  
Lymphatic Vessels ◽  
Nodal Metastasis ◽  
Primary Site ◽  
Surgical Case

Cystic nodal metastasis of renal cell carcinoma is very rare. The pathogenesis of cystic nodal metastasis is thought to involve obstruction of a lymphoid vessel draining the kidney by tumor cells and retrograde metastasis from the primary site to the lymph node along the lymphatic vessels. In this study, a surgical case of small renal cell carcinoma with retroperitoneal cystic nodal metastasis is reported.

scholarly journals Tryptophan 2,3‐dioxygenase in tumor cells is associated with resistance to immunotherapy in renal cell carcinoma

2021 ◽  
Author(s):  
Makoto Sumitomo ◽  
Kiyoshi Takahara ◽  
Kenji Zennami ◽  
Tomomi Nagakawa ◽  
Yasuhiro Maeda ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Renal Cell

scholarly journals Cervical Lymph Node Metastasis in Chromophobe Renal Cell Carcinoma: A Case Report and Review of the Literature

2013 ◽  
Vol 2013 ◽  
pp. 1-5
Author(s):  
Noureddine Bouadel ◽  
Fahd El Ayoubi ◽  
A. Anass Bennani-Baiti ◽  
Mohamed Anas Benbouzid ◽  
Leila Essakalli ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Antiangiogenic Therapy ◽  
Neck Region ◽  
Chromophobe Renal Cell Carcinoma ◽  
Head And Neck Region ◽  
Node Metastasis

The metastasis of chromophobe renal cell carcinoma to head and neck region, described herein, has never been reported before to our knowledge. A 56-year-old woman with a history of nephrectomy, that revealed chromophobe renal cell carcinoma six years before, presented left cervical mass. Imaging showed with left cervical lymphadenopathies and thyroid nodule. Surgery with histopathological examination confirmed that it was a left central and lateral jugular lymph node metastasis of chromophobe renal cell carcinoma treated postoperatively by antiangiogenic therapy. The patient was successfully treated by surgery and antiangiogenic drugs with stabilization and no recurrence of the metastatic disease. The case and the literature reported here support that chromophobe renal cell carcinoma can metastasize to the head and neck region and should preferentially be treated with surgery and antiangiogenic therapy because of the associated morbidity and quality-of-life issues.

Diagnostic ability of four cell-free miRNA signatures pre- and post-nephrectomy concordantly found in the tumor and blood from patients with renal cell carcinoma.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e16577-e16577
Author(s):  
Matias Bustos ◽  
Rebecca Gross ◽  
Rebeka Dejenie ◽  
Ryu Suyeon ◽  
Negin Rahimzadeh ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Renal Cell ◽  
Incidental Finding ◽  
Area Under The Curve ◽  
Roc Curves ◽  
Diagnostic Ability ◽  
Paired Samples ◽  
Tumor Tissues

e16577 Background: Renal cell carcinoma (RCC) has shown an increase in incidence based on continued incidental finding of these tumors by imaging. There is a need for reliable biomarkers like MicroRNAs (miRNA) that are released by the tumor cells and can be detected in assays using blood or urine samples. The first aim of the present pilot study is to determine the diagnostic ability of cell-free miRNA (cfmiR) biomarkers released by RCC tumor cells in urine and plasma samples. The secondary aim was to determine cfmiRs utility in monitoring RCC before and after radical or partial nephrectomy. Methods: We profiled tumor tissues (n = 11), pre-operative (pre-P n = 18; pre-U n = 17) and post-operative (post-P n = 18; post-U n = 17) plasma and urine paired samples from 18 RCC patients with a median follow-up of 18.4 months. As a control, we utilized plasma (n = 73) and urine (n = 16) samples taken from normal healthy donors (NHD). All specimens (n = 170) were processed and analyzed using HTG EdgeSeq miRNA whole transcriptome assay. All of the samples were normalized and DESeq2. Only miRNAs with a FC < -1.5 or > 1.5, FDR < 0.05, normalized counts > 30 were considered Results: We assessed urine, plasma, and tissue for 2083 miRNAs. The pre-U profiles from patients with RCC and NHD were compared to find differentially expressed (DE) cfmiRs. We found 182 cfmiRs DE in pre-U RCC, of which 106 were upregulated and 76 were downregulated. Similarly, we found 830 cfmiRs DE in the pre-P from RCC compared to NHD, of which 192 were upregulated and 638 were downregulated. We then searched for the top 100 miRNAs most frequently detected and identified in the tumor and in pre-P and pre-U samples. Forty miRNAs were consistently found and highly detected in all of the specimens. Of those 40 miRNAs, 33 cfmiRs were found DE in pre-P and 9 cfmiRs significantly decreased in post-P samples after surgery to the level values observed in the plasma from NHD. In the pre-P and pre-U samples from RCC patients, let-7a-5p, let-7b-5p, miR-23b-3p, and miR-30d-5p were found to be consistently upregulated compared to their respective controls. By using receiving operating characteristic (ROC) curves we assessed the area under the curve (AUC) of all the four cfmiRs in detecting RCC patients. The values of AUC for the four cfmiRs detected in pre-P ranged from 76.2-81% [sensitivity, 61.1-83.3%; specificity, 74-86.3%] and in pre-U samples ranged from 76.1-82.4% [sensitivity, 64.7-70.6%; specificity, 100%]. We observed that the four cfmiRs significantly decreased in the post-U samples from RCC patients after surgery to the level values observed in urine from NHD. Conclusions: Our results propose a four cfmiR signature as a potential diagnostic/monitoring urine biomarker that is also detectable in the plasma and tumor tissues from RRC. Further studies to validate these cfmiRNAs as biomarkers for RCC in blood and urine are ongoing.

Antibodies to Cultured Tumor Cells Detected in Sera of Renal Cell Carcinoma Patients by a Quantitative Avidin-Biotin Method

1986 ◽  
Vol 136 (4) ◽  
pp. 795-798
Author(s):  
Jean B. deKernion ◽  
Laszlo Lovrekovich ◽  
Dominique Chopin ◽  
Urs E. Studer
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Renal Cell ◽  
Cultured Tumor Cells

2001 NODAL DISEASE IN THE SETTING OF METASTATIC RENAL CELL CARCINOMA CAN A LYMPH NODE DISSECTION POTENTIALLY ALTER PATIENT OUTCOMES?

2012 ◽  
Vol 187 (4S) ◽  
Author(s):  
Brian F. Chapin ◽  
Scott E. Delacroix ◽  
Patrick A. Kemney ◽  
Graciela M. Nogueras-Gonzalez ◽  
Pheroze Tamboli ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Lymph Node ◽  
Cell Carcinoma ◽  
Patient Outcomes ◽  
Lymph Node Dissection ◽  
Metastatic Renal Cell Carcinoma ◽  
Renal Cell ◽  
Node Dissection ◽  
Nodal Disease ◽  
Alter Patient

Renal cell carcinoma with retroperitoneal lymph nodes: role of lymph node dissection

2004 ◽  
Vol 22 (1) ◽  
pp. 73-74
Author(s):  
A.J Pantuck ◽  
A Zisman ◽  
F Dorey ◽  
D.H Chao ◽  
K.R Han ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Cell Carcinoma ◽  
Lymph Node Dissection ◽  
Renal Cell ◽  
Node Dissection
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