scholarly journals A New Approach for the Determination of Benzocaine and Procaine in Pharmaceuticals by Single-Sweep Polarography

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Serhij Plotycya ◽  
Oksana Strontsitska ◽  
Solomiya Pysarevska ◽  
Mykola Blazheyevskiy ◽  
Liliya Dubenska
Keyword(s):  
Quantitative Determination ◽  
Oxidation Products ◽  
Polarographic Reduction ◽  
Polarographic Method ◽  
Experimental Conditions ◽  
New Approach ◽  
Reduction Current ◽  
Product Specifications ◽  
Good Agreement

A new polarographic method for the determination of benzocaine and procaine based on the polarographic reduction of their chemically obtained oxidation products with potassium peroxymonosulfate is developed. Experimental conditions affecting quantitative yield of benzocaine and procaine oxidation products such as рH, oxidation time, reagents’ concentration, and temperature are explored. It is shown that the reduction current changes in a linear fashion (R=0.999) with increasing concentration of anesthetics over a concentration range of 1·10−6 - 5·10−5 mol L−1. The calculated limits of detection (LOD) for benzocaine and procaine are found to be 5.6·10−6 and 6·10−6 mol L−1, respectively. In the present study, quantitative polarographic determination of benzocaine in Farisil tablets and “Septolete Plus” lozenges and procaine in solution for injections is performed. The results of the analysis are in good agreement with the product specifications described in the quality certificates. The possibility of quantitative determination of benzocaine and procaine in pharmaceuticals is confirmed.

Polarographic Determination of Accelerators, Antioxidants, and Other Rubber Chemicals. I.

1959 ◽  
Vol 32 (4) ◽  
pp. 1254-1268
Author(s):  
F. Mocker
Keyword(s):  
Zinc Oxide ◽  
Quantitative Determination ◽  
Raw Materials ◽  
Zinc Stearate ◽  
Zinc Salt ◽  
Polarographic Method ◽  
Experimental Conditions ◽  
Methanolic Extracts ◽  
Rubber Compounds

Abstract The present paper shows that the Polarographic method for the determination of rubber additives (rubber chemicals) delivers fully usable results. The following points are discussed : 1. The method is qualified for a rapid quantitative determination of MBT and 2-mercaptobenzimidazole in raw materials control. 2. The zinc salt of MBT can be indirectly determined after its decomposition with acid. 3. MBT and 2-mercaptobenzimidazole can be determined directly in the methanolic extracts of masterbatches. 4. As with the masterbatches, MBT can be determined directly in the extracts of rubber stocks and vulcanizates when zinc oxide is absent. Magnesium oxide or zinc stearate do not interfere. 5. Experimental conditions are given which permit quantitative determinations of MBT in the presence of zinc oxide in uncured and cured rubber compounds. 6. The experiments have shown that the method is applicable to complex recipes containing MBT as the only accelerator. Of course, the limit of error is higher, that is, around −5%. The investigations are being continued and the results will be presented at a later date.

scholarly journals Quantitative Determination of Terramycin by Polarographic Method

1955 ◽  
Vol 4 (1) ◽  
pp. 30-34 ◽  
Author(s):  
TAKEJI NOTO ◽  
GAKU MATSUOKA
Keyword(s):  
Quantitative Determination ◽  
Polarographic Method

Determination of Subnanosecond Fluorescence Lifetimes with a UHF Television Tuner and a cw or Mode-Locked Laser

1986 ◽  
Vol 40 (5) ◽  
pp. 683-687 ◽  
Author(s):  
Frank V. Bright ◽  
Daniel A. Wilson ◽  
Gary M. Hieftje
Keyword(s):  
High Frequency ◽  
Rhodamine 6G ◽  
Instrument Design ◽  
Fluorescence Lifetimes ◽  
New Approach ◽  
Ion Laser ◽  
Subnanosecond Fluorescence ◽  
Argon Ion ◽  
Good Agreement

An inexpensive ultra-high-frequency (UHF) television tuner and an argon-ion laser are employed for the determination of excited-state lifetimes of a series of common fluorophores. Fluorescence lifetimes are determined in the frequency domain; the results are in good agreement with previously reported values and demonstrate the utility of the new approach for subnanosecond measurements. Binary mixtures of rhodamine 6G and rose bengal can also be resolved with the use of this novel instrument design.

scholarly journals New perspective in the assessment of total intracellular magnesium

2014 ◽  
Vol 87 (1) ◽  
Author(s):  
Azzurra Sargenti ◽  
Lucia Merolle ◽  
Giulia Andreani ◽  
Concettina Cappadone ◽  
Giovanna Farruggia ◽  
...  
Keyword(s):  
Quantitative Determination ◽  
Atomic Absorption Spectroscopy ◽  
Biological Processes ◽  
Intracellular Magnesium ◽  
Qualitative And Quantitative ◽  
High Affinity ◽  
New Family ◽  
New Perspective ◽  
Good Agreement

Magnesium (Mg) is essential for biological processes, but its cellular homeostasis has not been thoroughly elucidated, mainly because of the inadequacy of the available techniques to map intracellular Mg distribution. Recently, particular interest has been raised by a new family of fluorescent probes, diaza-18-crown-hydroxyquinoline (DCHQ), that shows remarkably high affinity and specificity for Mg, thus permitting the detection of the total intracellular Mg. The data obtained by fluori- metric and cytofluorimetric assays performed with DCHQ5 are in good agreement with atomic absorption spectroscopy, confirming that DCHQ5 probe allows both qualitative and quantitative determination of total intracellular Mg.

The Determination of Free Sulfur in Vulcanizates by a Polarographic Method

1952 ◽  
Vol 25 (1) ◽  
pp. 161-166 ◽  
Author(s):  
F. C. J. Poulton ◽  
L. Tarrant
Keyword(s):  
Quantitative Determination ◽  
Acetone Extract ◽  
Polarographic Method ◽  
The Common ◽  
Free Sulfur ◽  
Working Processes

Abstract The polarographic method offers a rapid and accurate means of determining the “true” free sulfur in vulcanizates. In the case of single estimations, the test takes approximately as long as the copper-spiral method, but for multiple or replicate testing it is much quicker. Since the determination is made directly on the acetone extract, it was necessary to examine at some length the possibility of interference from other ingredients of the extract. It is shown that most of the common accelerators and antioxidants are not likely to interfere, and promising methods of determining certain of these substances were revealed. Thus MBT, MBTS, TCA, A11, ONV, ZDC, TMT, TET, Ureka, and some of the Nonox series of antioxidants give regular Polarographic waves readily distinguishable from that of sulfur, and the development of working processes for their determination should not present any great difficulties. Other accelerators and antioxidants, notably ZIX, some Nonox antioxidants and Agerite White, while showing Polarographic activity, give poor curves in the pyridine electrolyte. No doubt in other base solutions the form of curve could be improved, and their quantitative determination would then follow.

A new approach to the isolation of RNA-DNA hybrids and its application to the quantitative determination of labeled tumor virus RNA

1974 ◽  
Vol 86 (2) ◽  
pp. 373-396 ◽  
Author(s):  
J.M. Coffin ◽  
J.T. Parsons ◽  
L. Rymo ◽  
R.K. Haroz ◽  
C. Weissmann
Keyword(s):  
Quantitative Determination ◽  
New Approach ◽  
Virus Rna ◽  
Tumor Virus

2-(2'- Chloro Phenyl)- 5- (2'-Hydroxyl Phenyl)-1,3,4-Oxadiazole as a Florescent Probe for DNA Determination

2011 ◽  
Vol 301-303 ◽  
pp. 361-365
Author(s):  
Mei Ding ◽  
Ying Jie Lei ◽  
Ou Yang Jie
Keyword(s):  
Experimental Data ◽  
Fluorescence Quenching ◽  
Quantitative Determination ◽  
Fluorescent Probe ◽  
Fluorescence Intensity ◽  
Dna Analysis ◽  
Fluorescence Spectrometry ◽  
Experimental Conditions ◽  
Convenient Synthesis

In recent years, fluorescence spectrometry was widely used in quantitative determination of DNA. In this paper, a convenient synthesis of a new fluorescent 2-(2'- Chloro phenyl)- 5- (2'- hydroxyl phenyl)-1,3,4-oxadiazole (HOXD) was realized. Experimental data showed that fluorescence of HOXD could be quenched by DNA and the decreased fluorescence intensity of HOXD resulting from fluorescence quenching is proportional to DNA concentrations suggesting that HOXD could be used as a new fluorescent probe for quantitative determination of DNA. Optimal experimental conditions for DNA analysis were also studied in the paper.

scholarly journals Energy-dispersive spectroscopy for the quantitative determination of the major chemical elements in milk

2021 ◽  
Vol 10 (10) ◽  
pp. e280101018910
Author(s):  
Igor Lima de Paula ◽  
Isis Rodrigues Toledo Renhe ◽  
Rodrigo Stephani ◽  
Ítalo Tuler Perrone ◽  
Antônio Fernandes de Carvalho ◽  
...  
Keyword(s):  
Quantitative Determination ◽  
Chemical Elements ◽  
Raw Milk ◽  
Energy Dispersive ◽  
Mean Values ◽  
Milk Samples ◽  
Application Potential ◽  
Major Chemical ◽  
Good Agreement

The present preliminary study aims at the rapid quantitative determination of the major chemical elements in the ashes of raw milk samples, using energy dispersive X-ray fluorescence spectrometry. The precision of the method was satisfactory (variation coefficient ≤ 5%). The mean values (in mmol·kg-1) obtained from the analysis of 32 raw milk samples showed good agreement with data from the Brazilian and international literature: K (26.1 ± 4.6), Ca (33.8 ± 3.7), P (28.4 ± 2.7), Na (21 ± 3.3) and Mg (4.7 ± 0.5). Residual Cl concentration (19.0 ± 3.3 mmol·kg-1) was lower than expected due to incineration losses. The results suggest a good application potential of the method for other dairy products.

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