scholarly journals Application of Novel Drugs for Corneal Cell Regeneration

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Sang Beom Han ◽  
Yu-Chi Liu ◽  
Karim Mohamed-Noriega ◽  
Jodhbir S. Mehta
Keyword(s):  
Corneal Transplantation ◽  
Surgical Techniques ◽  
Rho Kinase ◽  
Treatment Method ◽  
Cell Regeneration ◽  
Visual Rehabilitation ◽  
Corneal Cell ◽  
Pharmaceutical Technology ◽  
Novel Drugs ◽  
Corneal Blindness

Corneal transplantation has been the only treatment method for corneal blindness, which is the major cause of reversible blindness. However, despite the advancement of surgical techniques for corneal transplantation, demand for the surgery can never be met due to a global shortage of donor cornea. The development of bioengineering and pharmaceutical technology provided us with novel drugs and biomaterials that can be used for innovative treatment methods for corneal diseases. In this review, the authors will discuss the efficacy and safety of pharmacologic therapies, such as Rho-kinase (ROCK) inhibitors, blood-derived products, growth factors, and regenerating agent on corneal cell regeneration. The promising results of these agents suggest that these can be viable options for corneal reconstruction and visual rehabilitation.

scholarly journals Awareness, Knowledge and Willingness Regarding Eye Donation among Dental Students of Kist Medical College and Teaching Hospital, Lalitpur, Nepal

2019 ◽  
Vol 9 (2) ◽  
pp. 47-53
Author(s):  
Anjila Basnet ◽  
Pragya Singh Basnet ◽  
Ram Sudhan Lamichhane ◽  
Prabhat Shrestha
Keyword(s):  
Teaching Hospital ◽  
Corneal Transplantation ◽  
Sampling Technique ◽  
Cross Sectional Study ◽  
Dental Students ◽  
Visual Rehabilitation ◽  
Cross Sectional ◽  
Medical College ◽  
Corneal Blindness ◽  
Eye Donation

Background: Corneal disease constitutes a significant cause for visual im­pairment and blindness in the developing world. Visual rehabilitation by corneal transplantation for which increased awareness regarding an eye donation is essential, remains the only treatment option for restoring sight in those who suffer from corneal blindness. Hence, the present study con­ducted to assess the awareness, knowledge and willingness about eye do­nation among dental students of KIST medical college & teaching hospital, Nepal Methods: A cross-sectional study was carried out in KIST medical college and teaching hospital in Nepal during the period of 21st to 30th April 2019. A total of 185 dental students were selected as study group by con­venience sampling technique. A Semi-structured questionnaire was used for data collection and analyzed by using SPSS 16. Descriptive statistics and Chi square/ Fischer exact tests were used for data analysis. Results: Out of total 185 dental students who participated in this study, 176 (95.1%) were aware about eye donation, 133 (71.9%) knew that the cornea is used for eye donation and 70 (37.8%) knew that ideal time for eye donation is within six hours of death. Awareness regarding eye dona­tion in male and female students was found to be statistically significant (p =0.013). Conclusions: The present study revealed that most of the dental students were aware regarding eye donation and most of them were willing to do­nate their eyes. Awareness regarding eye donation will form the prime base for the elimination of avoidable corneal blindness in Nepal.

scholarly journals Corneal transplantation activity in Catalonia, Spain, from 2011 to 2018: Evolution of indications and surgical techniques

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0249946
Author(s):  
Noelia Sabater-Cruz ◽  
Marc Figueras-Roca ◽  
Lydia Padró-Pitarch ◽  
Jaume Tort ◽  
Ricardo P. Casaroli-Marano
Keyword(s):  
Corneal Transplantation ◽  
Surgical Techniques ◽  
Annual Reports ◽  
Bullous Keratopathy ◽  
Corneal Transplant ◽  
Endothelial Keratoplasty ◽  
Descemet Membrane Endothelial Keratoplasty ◽  
Eye Bank ◽  
Increasing Trend ◽  
Fuchs Endothelial Dystrophy

Purpose To report corneal transplant activity carried out in Catalonia (Spain) and the evolving indications for keratoplasty over an 8-year period. Methods Annual reports from the Catalan Transplant Organization, Spain, on corneal graft indications and techniques from 2011 to 2018 were reviewed. Results A total of 9457 keratoplasties were performed in Catalonia, from January 2011 to December 2018. The most frequent indications were bullous keratopathy (BK; 20.5%), Fuchs endothelial dystrophy (FED; 17.9%), re-graft (13.7%), and keratoconus (11.3%). Penetrating keratoplasty (PKP) accounted for 63.4% of all performed keratoplasties. Since the introduction of eye bank precut tissue for Descemet stripping automated endothelial keratoplasty (DSAEK) in 2013 and for Descemet membrane endothelial keratoplasty (DMEK) in 2017 the number of endothelial keratoplasties has drastically increased. An increasing trend of posterior lamellar techniques over the total of keratoplasties was found (p<0.001). Endothelial keratoplasties for different endothelial diseases indications (BK, FED, and re-graft), also showed and increasing trend (p<0.001). DMEK is the technique with the highest increase (statistically significantly different from linearity) over other endothelial keratoplasties in FED (p<0.001) but not in BK (p = 0.67) or re-grafts (p = 0.067). Conclusion Endothelial diseases represented the top indication for keratoplasty over the 8-year period. PKP is still the most used technique in Catalonia, but endothelial keratoplasties and especially DMEK showed a significant increasing trend over the last years. This is congruent with the main rationale nowadays for keratoplasties: to customize and transplant as less tissue as possible. Therefore, the availability of precut tissue could have definitely enforced such approach.

Evolving surgical techniques of and indications for corneal transplantation in Ontario: 2000 - 2012

2013 ◽  
Vol 48 (3) ◽  
pp. 153-159 ◽  
Author(s):  
Angela Qiao Zhang ◽  
Darya Rubenstein ◽  
Aryeh Joshua Price ◽  
Elie Côté ◽  
Max Levitt ◽  
...  
Keyword(s):  
Corneal Transplantation ◽  
Surgical Techniques

scholarly journals Paradigmaváltás a csontmetasztázisok sebészetében. II. Gerincmetasztázisok kezelése

2018 ◽  
Vol 159 (8) ◽  
pp. 297-302
Author(s):  
Áron Lazáry ◽  
Zsolt Szövérfi ◽  
Péter Pál Varga
Keyword(s):  
Minimally Invasive ◽  
Spinal Metastasis ◽  
Treatment Options ◽  
Surgical Techniques ◽  
Spinal Metastases ◽  
Treatment Method ◽  
Minimally Invasive Surgical ◽  
Published Evidence ◽  
Minimally Invasive Stabilization ◽  
Oncologic Treatment

Abstract: The incidence of spinal metastases is constantly growing, but due to the advancements in oncologic treatment methods, the survival and the quality of life of the patients are persistently improving. Choosing the optimal treatment method is essential, and several factors should be considered: type of the primary tumor, segmental stability, the symptoms caused by the metastasis and the general condition of the patient. Using modern radiotherapeutic methods combined with minimally invasive surgical techniques (minimally invasive stabilization, separation surgery) in the majority of patients permits adequate local control with low complication rate. In our review, we describe the state-of-the-art, modern spinal metastasis treatment options based on the recently published evidence. Orv Hetil. 2018; 159(8): 297–302.

scholarly journals Evolution of therapies for the corneal endothelium: past, present and future approaches

2020 ◽  
pp. bjophthalmol-2020-316149
Author(s):  
Hon Shing Ong ◽  
Marcus Ang ◽  
Jodhbir S Mehta
Keyword(s):  
Corneal Endothelium ◽  
Medical Science ◽  
Corneal Transplantation ◽  
Surgical Techniques ◽  
Corneal Transplant ◽  
Endothelial Keratoplasty ◽  
Descemet Membrane Endothelial Keratoplasty ◽  
Immunological Rejection ◽  
Transplantation Procedures ◽  
Rejection Rates

Corneal endothelial diseases are leading indications for corneal transplantations. With significant advancement in medical science and surgical techniques, corneal transplant surgeries are now increasingly effective at restoring vision in patients with corneal diseases. In the last 15 years, the introduction of endothelial keratoplasty (EK) procedures, where diseased corneal endothelium (CE) are selectively replaced, has significantly transformed the field of corneal transplantation. Compared to traditional penetrating keratoplasty, EK procedures, namely Descemet’s stripping automated endothelial keratoplasty (DSAEK) and Descemet membrane endothelial keratoplasty (DMEK), offer faster visual recovery, lower immunological rejection rates, and improved graft survival. Although these modern techniques can achieve high success, there are fundamental impediments to conventional transplantations. A lack of suitable donor corneas worldwide restricts the number of transplants that can be performed. Other barriers include the need for specialized expertise, high cost, and risks of graft rejection or failure. Research is underway to develop alternative treatments for corneal endothelial diseases, which are less dependent on the availability of allogeneic tissues – regenerative medicine and cell-based therapies. In this review, an overview of past and present transplantation procedures used to treat corneal endothelial diseases are described. Potential novel therapies that may be translated into clinical practice will also be presented.

scholarly journals Changing indications and surgical techniques for corneal transplantation between 2004 and 2009 at a tertiary referral center

2012 ◽  
Vol 19 (3) ◽  
pp. 323 ◽  
Author(s):  
Sepehr Feizi ◽  
MohammadA Javadi ◽  
Farid Karimian ◽  
AliR. B. Rafie ◽  
Mohammad Zare ◽  
...  
Keyword(s):  
Corneal Transplantation ◽  
Surgical Techniques ◽  
Tertiary Referral ◽  
Tertiary Referral Center ◽  
Referral Center

scholarly journals Evolution of cataract surgery: Smaller incision - less complications

2012 ◽  
Vol 69 (5) ◽  
pp. 385-388 ◽  
Author(s):  
Vladimir Draganic ◽  
Miroslav Vukosavljevic ◽  
Milorad Milivojevic ◽  
Mirko Resan ◽  
Nenad Petrovic
Keyword(s):  
Cataract Surgery ◽  
Surgical Techniques ◽  
Visual Outcome ◽  
Cataract Extraction ◽  
Extracapsular Cataract Extraction ◽  
Corneal Incision ◽  
Visual Rehabilitation ◽  
Operative Trauma ◽  
Iol Implantation

Background/Aim. Cataract surgery has become one of the safest procedures in medicine thanks to advances in technology and surgical techniques. Although minimal, we still witness different complications. The aim of this study was to compare visual outcome and complication rate in different techniques of cataract surgery, ie in cataract surgeries with various corneal incision width. Methods. The study included 3,457 consecutive patients, ie 4,670 eyes that had undergone cataract surgery. The used surgical techniques were: extracapsular cataract extraction, phacoemulsification/ forceps IOL implantation, phacoemulsification/ injector IOL implantation, microincision cataract surgery (MICS). Patient follow up was 6 months. Patients were evaluated for: visual aquity, corneal astigmatism, cellular reaction in the anterior chamber, IOL position. Results. Uncorrected visual aquity 30 days postoperatively was ? 0.5 in 30% of the eyes - ECCE; 54.7% of the eyes - phacoemulsification/forceps IOL implantation; 63.0% of the eyes - phacoemulsification/injector IOL implantation; 5/8 of the eyes - MICS. Endophthalmitis was detected in 0.15% of the eyes - ECCE and 0.1% of the eyes - phacoemulsification/forceps IOL implantation. In eyes with phacoemulsification/injector IOL implantation or microincision cataract surgery (MICS) there were no cases of endophthalmitis. After a 6-month period intraocular lens were dislocated in 7.2% of the eyes - ECCE, and 0.6% of the eyes - phacoemulsification/PMMA IOL. There was no IOL dislocation in other surgical techniques. Conclusion. Shorter corneal incision implies less complications, less operative trauma, faster visual rehabilitation and better visual outcome.

scholarly journals Cultivated autologous oral mucosal epithelial transplantation

2021 ◽  
Vol 23 (1) ◽  
pp. 171-177
Author(s):  
S. A. Borzenok ◽  
B. E. Malyugin ◽  
M. Yu. Gerasimov ◽  
D. S. Ostrovsky
Keyword(s):  
Visual Acuity ◽  
Cell Therapy ◽  
Visual Impairment ◽  
Treatment Method ◽  
World Health ◽  
Epithelial Culture ◽  
The World ◽  
Corneal Blindness ◽  
New Treatment ◽  
Health Organization

According to the World Health Organization, corneal blindness is the fourth most common cause of blindness and visual impairment worldwide. In Russia, up to 18% of blindness is caused by corneal damage. Limbal stem cell deficiency (LSCD) is one of the causes of corneal blindness and visual impairment due to anterior epithelial replacement with fibrovascular pannus. Bilateral LSCD may develop in patients with aniridia, Steven-Jones syndrome, and severe corneal burns of both eyes, leading to severe decrease in visual acuity in both eyes and, as a consequence, physical disability associated with blindness. In such cases, cell therapy, based on autologous oral epithelial culture as an alternative to allogeneic limbus transplants, is proposed for reconstruction of the anterior corneal epithelium. This new treatment method promotes corneal reepithelization, better visual acuity, reduced nonspecific ocular complaints and improved quality of life of patients. The effectiveness and significant increase in the frequency of transparent engraftment of donor corneas after cell therapy drives huge interest in this topic all over the world. This review presents literature data on the features of histotopography and methods for obtaining a cultured autologous oral mucosal epithelium, on cell markers that are used to identify epithelial cells, and on methods for creating cell grafts for subsequent transplantation to the corneal surface in LSCD patients.

scholarly journals Eye donation: awareness and willingness among shopkeepers

2017 ◽  
Vol 4 (6) ◽  
pp. 2056 ◽  
Author(s):  
Reshma Patil ◽  
Jayashree Gothankar ◽  
Prerna Bhat ◽  
Jitesh Saluja ◽  
Shrivallabh Sane
Keyword(s):  
Urban Health ◽  
Corneal Transplantation ◽  
Age Group ◽  
Training Center ◽  
Transfer Of Knowledge ◽  
Medical College ◽  
Field Practice ◽  
Corneal Transplants ◽  
Corneal Blindness ◽  
Eye Donation

Background: Corneal blindness is one of the important causes of blindness in India that can be conventionally cured by corneal transplantation. The number of corneal transplants done is less than the actual requirement in India due to inadequate number of corneas collected. Therefore increasing awareness regarding eye donation and also willingness to pledge for the same is the today’s need. Hence current study was undertaken to assess the awareness regarding eye donation and the willingness to pledge the eye for donation amongst the shopkeepers in urban area of Pune city.Methods: Total 1014 shopkeepers above 15 years of age from field practice area of Urban Health Training Center of a private medical college, Pune were interviewed regarding awareness of eye donation and willingness to pledge eye for eye donation.Results: Out of total 1014 subjects, 752 (74.16%) were aware of eye donation amongst which males were maximum (75.13%) compared to females (24.87%). Awareness was more in the age group >40 years i.e. 47.87%. Willingness to pledge eyes for eye donation was 19.83%.Conclusions: Though the awareness regarding eye donation is high very few of them are ready to donate their eyes. Therefore more transfer of knowledge is needed to motivate people for eye donation which will be helpful in reducing the gap between the availability of corneas and actual requirement. 

Sign in / Sign up

Export Citation Format

Share Document