scholarly journals Exercise Training under Exposure to Low Levels of Fine Particulate Matter: Effects on Heart Oxidative Stress and Extra-to-Intracellular HSP70 Ratio

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Aline Sfalcin Mai ◽  
Analu Bender dos Santos ◽  
Lílian Corrêa Costa Beber ◽  
Renan Daniel Bueno Basso ◽  
Lucas Machado Sulzbacher ◽  
...  

Fine particulate matter (PM2.5) promotes heart oxidative stress (OS) and evokes anti-inflammatory responses observed by increased intracellular 70 kDa heat shock proteins (iHSP70). Furthermore, PM2.5 increases the levels of these proteins in extracellular fluids (eHSP70), which have proinflammatory roles. We investigated whether moderate and high intensity training under exposure to low levels of PM2.5 modifies heart OS and the eHSP70 to iHSP70 ratio (H-index), a biomarker of inflammatory status. Male mice (n=32), 30 days old, were divided into six groups for 12 weeks: control (CON), moderate (MIT) and high intensity training (HIT), exposure to 5 μg of PM2.5 daily (PM2.5), and moderate and high intensity training exposed to PM2.5 (MIT + PM2.5 and HIT + PM2.5 groups). The CON and PM2.5 groups remained sedentary. The MIT + PM2.5 group showed higher heart lipid peroxidation levels than the MIT and PM2.5 groups. HIT and HIT + PM2.5 showed higher heart lipid peroxidation levels and lower eHSP70 and H-index levels compared to sedentary animals. No alterations were found in heart antioxidant enzyme activity or iHSP70 levels. Moderate exercise training under exposure to low levels of PM2.5 induces heart OS but does not modify eHSP70 to iHSP70 ratio (H-index). High intensity exercise training promotes anti-inflammatory profile despite exposure to low levels of PM2.5.

1998 ◽  
Vol 4 (1) ◽  
pp. 49-51
Author(s):  
Cho Yim LO

LANGUAGE NOTE | Document text in English; abstract also in Chinese.The present paper attempts to discuss the relationship between the Growth Hormone and exercise intensity. Growth Hormone causes growth, enhances fat utilization and glycogen deposition, decreases use of glucose, etc. The high intensity training physical training may increase the release of Growth Hormone.本文章嘗試探討生長激素與運動訓練的關係。生長激素能促進人體生長、增加蛋白質的合成、和減低糖原的消耗。在高運動強度的訓練時,人體分泌生長激素會增加,此增長也有利蛋白質的合成。


2019 ◽  
Vol 2019 ◽  
pp. 1-13 ◽  
Author(s):  
Iberê Machado Kostrycki ◽  
Guilherme Wildner ◽  
Yohanna Hannah Donato ◽  
Analú Bender dos Santos ◽  
Lílian Corrêa Costa Beber ◽  
...  

Obesity, air pollution, and exercise induce alterations in the heat shock response (HSR), in both intracellular 70 kDa heat shock proteins (iHSP70) and the plasmatic extracellular form (eHSP72). Extra-to-intracellular HSP70 ratio (H-index = eHSP70/iHSP70 ratio) represents a candidate biomarker of subclinical health status. This study investigated the effects of moderate- and high-intensity exercise in the HSR and oxidative stress parameters, in obese mice exposed to fine particulate matter (PM2.5). Thirty-day-old male isogenic B6129F2/J mice were maintained for 16 weeks on standard chow or high-fat diet (HFD). Then, mice were exposed to either saline or 50 μg of PM2.5 by intranasal instillation and subsequently maintained at rest or subjected to moderate- or high-intensity swimming exercise. HFD mice exhibited high adiposity and glucose intolerance at week 16th. HFD mice submitted to moderate- or high-intensity exercise were not able to complete the exercise session and showed lower levels of eHSP70 and H-index, when compared to controls. PM2.5 exposure modified the glycaemic response to exercise and modified hematological responses in HFD mice. Our study suggests that obesity is a critical health condition for exercise prescription under PM2.5 exposure.


2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Diego Fernando Batista ◽  
Bertha Furlan Polegato ◽  
Renata Candido da Silva ◽  
Renan Turini Claro ◽  
Paula Shmidt Azevedo ◽  
...  

The objective of this study was to analyze the impact of different modalities and intensities of exercise training on cardiac remodeling started early after experimental myocardial infarction (MI). Male Wistar rats, weighing 200–250 g, were subjected to experimental MI. After 5 days, the animals were allocated into three experimental groups and observed for three months: S (sedentary control animals), C (animals subjected to continuous low-intensity training), and HIT (animals subjected to high-intensity interval training). Low-intensity exercise training was performed at a treadmill speed corresponding to 40% VO2 max, which was kept unchanged throughout the entire session (i.e., continuous low-intensity training). High-intensity interval training was performed in such a way that rats run during 3 min at 60% VO2 max, followed by 4-minute intervals at 85% VO2 max (i.e., high-intensity interval training). After the follow-up period, we studied hypertrophy and ventricular geometry, functional alterations in vivo and in vitro, oxidative stress, apoptosis, and cardiac energetic metabolism. Our data showed that both high-intensity interval and continuous low-intensity modalities improved cardiac energetic metabolism variables in comparison with sedentary infarcted animals. In addition, high-intensity interval training decreased cardiac oxidative stress, associated with improved diastolic function. On the other hand, the continuous low-intensity group showed impairment of cardiac function. Therefore, altogether, our data suggest that high-intensity interval training could be the best modality for early physical exercise after MI and should be better studied in this clinical scenario.


Global Heart ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e20
Author(s):  
Vitor G. Angarten ◽  
Almir Schmitt Netto ◽  
Anderson Z. Ulbrich ◽  
Sabrina W. Sties ◽  
Lourenço S. de Mara ◽  
...  

2020 ◽  
Vol 52 (7S) ◽  
pp. 1099-1099
Author(s):  
Camilla R. Holland ◽  
Michael G. Roberts ◽  
Matthew W. Furber ◽  
Lindsy S. Kass ◽  
Lindsay Bottoms

2015 ◽  
Vol 27 (4) ◽  
pp. 510-517 ◽  
Author(s):  
Wagner Luiz Prado ◽  
Mara Cristina Lofrano-Prado ◽  
Lila Missae Oyama ◽  
Michelle Cardel ◽  
Priscyla Praxedes Gomes ◽  
...  

Little is known about how the intensity of aerobic training influences appetite-regulating hormones in obese adolescents. Our goal was to assess the effect of low and high intensity aerobic trainings on food intake and appetite-regulating hormones in obese adolescents. Forty three obese adolescents (age: 13–18y, BMI: 34.48 ± 3.94 kg/m2) were randomized into high intensity training (HIT; n = 20) or low intensity training (LIT; n = 23) groups for 12 weeks. All participants also received the same nutritional, psychological and clinical counseling. Pre- and postintervention energy intake (EI) and circulating levels of insulin, leptin, peptide YY3–36 (PYY3–36) and ghrelin were measured. Adolescents in the HIT showed a reduction in total EI and an increase in PYY3–36 (p < .05). Aerobic exercise training performed at ventilatory threshold 1 intensity, reduced EI and augmented PYY3–36 in obese adolescents, compared with LIT. The data suggest that HIT and LIT have differential effects in the regulation of appetite signals and subsequent EI in obese adolescents.


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